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The map label for this gene is dtd

Identifier: 239618317

GI number: 239618317

Start: 2071082

End: 2071528

Strand: Reverse

Name: dtd

Synonym: Kole_1954

Alternate gene names: 239618317

Gene position: 2071528-2071082 (Counterclockwise)

Preceding gene: 239618318

Following gene: 239618316

Centisome position: 89.98

GC content: 43.62

Gene sequence:

>447_bases
ATGAGAGCAGTCGTACAAAGGGTAAGTGAAGCCGAAGTAAAGGTAGACGGAAAGATTGTTGGTAAAATATCCGATGGTTT
GATGGTACTTCTCGGCGTTCAAAAAGATGACACTGAAAAGGATCTGGATTGGATGCTCGAGAAAATACTCAACCTCAGGA
TATTCGAAGATGAAACTGGTAAGATGAATCTCTCCCTTCTTGAAAAAGGCGGGCAACTTATGCTCGTTTCACAGTTCACT
CTCCTGGGAGATGCGCGCAAAGGCAGGAGACCTTCTTTTACCGAAGCCGCGCCGCCAGATAAAGCTAAAGAAATTTTCGA
CCGTTTTGTAAAAAAAGCTTCCGAGAGAGTGCATGTTGAAACAGGCGTTTTCCAGGCTCATATGCTGGTAAGTTTGACCA
ACGATGGACCTGTTACCATTCTTCTCGATTCTCGTAAACAATTTTAA

Upstream 100 bases:

>100_bases
CGAATCTGCTGGTCAAAGATATAGGTCATTTAACATCCGTAATGGAAAGCATTAGAGGCATTAGAGGAGTGCAAGCAGTT
GCCAGAACAGGAGGGTTGCC

Downstream 100 bases:

>100_bases
TCTCATAAATTTTATATAGGAGGTGCTCCAATGAAAAAGTCAATACTCATTCTTTCATTGATCGTTGTCCTTTTGACGGC
TATTGTCGCCATATCCGGAA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MRAVVQRVSEAEVKVDGKIVGKISDGLMVLLGVQKDDTEKDLDWMLEKILNLRIFEDETGKMNLSLLEKGGQLMLVSQFT
LLGDARKGRRPSFTEAAPPDKAKEIFDRFVKKASERVHVETGVFQAHMLVSLTNDGPVTILLDSRKQF

Sequences:

>Translated_148_residues
MRAVVQRVSEAEVKVDGKIVGKISDGLMVLLGVQKDDTEKDLDWMLEKILNLRIFEDETGKMNLSLLEKGGQLMLVSQFT
LLGDARKGRRPSFTEAAPPDKAKEIFDRFVKKASERVHVETGVFQAHMLVSLTNDGPVTILLDSRKQF
>Mature_148_residues
MRAVVQRVSEAEVKVDGKIVGKISDGLMVLLGVQKDDTEKDLDWMLEKILNLRIFEDETGKMNLSLLEKGGQLMLVSQFT
LLGDARKGRRPSFTEAAPPDKAKEIFDRFVKKASERVHVETGVFQAHMLVSLTNDGPVTILLDSRKQF

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=43.9189189189189, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=48.2517482517483, Blast_Score=147, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI115533292, Length=151, Percent_Identity=40.3973509933775, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=41.8918918918919, Blast_Score=114, Evalue=8e-27,
Organism=Drosophila melanogaster, GI281361569, Length=150, Percent_Identity=40, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_KOSOT (C5CGW6)

Other databases:

- EMBL:   CP001634
- RefSeq:   YP_002941639.1
- GeneID:   7968445
- GenomeReviews:   CP001634_GR
- KEGG:   kol:Kole_1954
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16601; Mature: 16601

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVVQRVSEAEVKVDGKIVGKISDGLMVLLGVQKDDTEKDLDWMLEKILNLRIFEDETG
CCHHHHHHHHCCEEECCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCC
KMNLSLLEKGGQLMLVSQFTLLGDARKGRRPSFTEAAPPDKAKEIFDRFVKKASERVHVE
CEEHEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEE
TGVFQAHMLVSLTNDGPVTILLDSRKQF
CCCEEEEEEEEEECCCCEEEEECCCCCC
>Mature Secondary Structure
MRAVVQRVSEAEVKVDGKIVGKISDGLMVLLGVQKDDTEKDLDWMLEKILNLRIFEDETG
CCHHHHHHHHCCEEECCEEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCEEEEECCCC
KMNLSLLEKGGQLMLVSQFTLLGDARKGRRPSFTEAAPPDKAKEIFDRFVKKASERVHVE
CEEHEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCEEEEE
TGVFQAHMLVSLTNDGPVTILLDSRKQF
CCCEEEEEEEEEECCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA