| Definition | Kosmotoga olearia TBF 19.5.1, complete genome. |
|---|---|
| Accession | NC_012785 |
| Length | 2,302,126 |
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The map label for this gene is dnaE [H]
Identifier: 239618295
GI number: 239618295
Start: 2051550
End: 2054294
Strand: Reverse
Name: dnaE [H]
Synonym: Kole_1932
Alternate gene names: 239618295
Gene position: 2054294-2051550 (Counterclockwise)
Preceding gene: 239618296
Following gene: 239618294
Centisome position: 89.23
GC content: 40.77
Gene sequence:
>2745_bases ATGAGGGTCGCTTTTGTTGTCACCTCTCATGAGCTTTACGCTTCTATTCTGAATCCTAAAGAAACGGCATTTGCTCTCAA AAAAGAAGGATACGATACTTGTATACTCATAGATTCCTCCCTATCCTCATCGATTCTCTGGTTCAGAATGCTCAAAGAAC AGGGGATTAATGTTATTCCTGGACTAAAAAAGGAAACCAGGTATTACATCCCGACGTCGTCTCAAGGTTTCTTACAACTA ATAGCTCTGGAAAATGAACTGACAGATTCTCCAGAAGATGTGGTGGTCATCGAGGGAGTACCCAAGAATCTGGATGAGAC TTCGGAGATTCCTGTATGGGAAAGCAGGTATGTGGATCCCAGGCAAAAAAACCTCTTTAAAATATATATTTCACTTGGAG AAAAAAATATCCCCGAAGCGGATTACCATCTTCTAACCGAAGAAGAATACAAAAAAATCATCCAACCGAATATCGGCGTT CTAGAATCGGCACTAAAAGAACCTTTTGAATTACCCAGATTCAAACATAAAATTCCAGTTCACACCACAATAGAAGAACT AAGGGCACTTGCCATTGAAGGCCTTAAAGAGGCTGGAATAACAGATAAGAAATATCTCGAAAGACTTGATAAGGAACTCA AAATAGTTCAGGACAAAGGATTTCAGGATTATTTTCTTCTTATTGCTGAAATAGTCAAGCTGGCAAAAAGTATCGGGTGC TGGGTAGGGCCCGGAAGAGGTTCTGCCGTTGGTTCATTACTCGTTAGAGCCCTTGGAATCACGGCTGTAGATCCTCTGAA ATACGATCTTTACTTTGAAAGGTTCTTGAATCCAGCAAGGGAAGATTTCCCCGATATAGACCTCGATGTTGAAGATGAAA AAAGGCCAGAGTTGATTCATAAAATCACTGAACATTTCTCCAGTGAAAAGGTCTGCCTTATACAAACCATGGGGACCTTT TCTTTCAGGTCCGCCGCAAGAGCCCTCGCAAGAAAGATGAAAGTCTCCGAATCGGAAATTCGCAACCTTATCTCCTGGAG CAGAAATGGAAAATTTCTGCCATCTTCTCTGTCAAAAGATAAACGCATGACTTCAATCTTCAAATTCGCAAACCAGCTAT CAGGACTTTATAGCACTCTTTCGGTACATGCAGCCGGGATAATACTTTCAGAAGAAGATCTGAGAACCATCATTCCCCTC AGGAAAAGCGATGAAATATACATATCGCAATGGGACATGAAATCCCTCGAATATCTGGGATTTCAAAAGGTTGATTTACT GGGATTGAGAAATCTTTCCCTCTTAAGAAAATTATGCGAAGGAAAAGAACCATGGAACAAAAATCCCGATAACAGAAAAA GTTTCGCCATTCTTTCCCGGGGTTACACCACGGGAATCTTCCAGATTGAAGGTAATGAAGCAACAGCAATAATAAAAAAG ATTTCTCCTGAAAACCTCGAGGACCTCGCAATTGGAATTGCCCTGAACAGACCCGGCCCTATATCCTCCGGGATAACAAG AGAATACATAAGACGAAGACGTTTCTTGAAGGCAATTGGAAATTACACAGCCGGAGAGCACATTGCTTCTCTGGAAGATA CATTGGGATTGCTCATATTCCAGGAGCAGGTAATAAGACTGGCCATTTCTGAACTGAAGCTCAAACCAGAAGAAGGTGAA CTTCTTCGTAGAGCGTTATCTAAAAAAGATACCGAAACCATTGAAAAGCTCGCTGAAGTTGTTCAAGAAAGAAGTCCGGA AAATTCTGAAAAAATAAGCAAATATCTTGAGTTTCTGAGGGATTTCTCTGGATACAGCTTCAACAAGTCCCATAGCATCG CTTATTCATTGTTATCCTATTGGATCGCTTATCATAAGGCAAATAATCCCGTACTCTTCTACAAACTTCTGATCCCGTTG ATGGATAGTGGTTCTCGACTACGTGCGGCGGCAGAGGCCCGGGAATTGGGACTCAAGTTCTCAATTTTTAACCCTGGAAA TAGAAACAACATAATCCTTGTACCGGGTGATTTCAGACCATCTCTAACAAAGATAGATACCTCCAAACCACCCAAGGAGG AAAACTTCTTTGCTTACGTACGAAAAAATCGTAATTATCTCACTGCCGCTGATCTCGAATTCTTAATAAAAACAGGATTC TTTGATCAATACGGAAGCAGGATCAAGCTGCTCAAAGACATAAACAATGCCCTTTCCGGCGTTGATCCTGACCTGAAATC CGTTCTGAAAGTCTTTGGGTACAAGGAGGAAGAAATAACTGAAGAAATGGAGTCACTGGTTGAAAAAGCTGCCATGGAAT TTGAAACCTTCGGATTCAACCTTACGGAATTTGAGGTAGAACTTGATGAAAAAAACAAAGATTTCGTTGACGGAACATTG ACTTCCTTGGTTGCTGGCTCTTGCACAGGAATTGCTGCTTTCGTTGCGATAAATGCTAGCGGAAAAAAATTCATAACCGA TGGGCGAACCCTTCTTCCAGTAAAATTTCGCGTTCCAGAAAAAGGCTTCGTGGTTTTCAAAAAGGGACATTTTGGAGAAA AATCGATTTTTAGTGAAATACATACAGTAACGAGGATAATAAACGGACCGGTACCTATAGACCATCTTGAAAAAGCATCC GAAAAAAACACACTCATCATTGACACAGGCAAAAAAATAAAACTACATGGTATGAAAACCAGAGATTTTGAAGTTGATGA AATAGTCATTGGAGGTGAATCATGA
Upstream 100 bases:
>100_bases ACCATCCCCGGACAGGGGAAAAAATGACCTTTGTCGCACGCGTTCCAGAAGATATGCTAAAGGTCATCAGAAACCTTTTT GAGTTAAGGAGAAAACAATT
Downstream 100 bases:
>100_bases GAGTTTACATAGTCAGACATGGCTCAACAGAATGGAATCTTACCGGGAAATGGCAGGGAAGCTCTGACGTTCCTCTAAGC GCTATCGGTATAAGAGACGC
Product: DNA-directed DNA polymerase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 914; Mature: 914
Protein sequence:
>914_residues MRVAFVVTSHELYASILNPKETAFALKKEGYDTCILIDSSLSSSILWFRMLKEQGINVIPGLKKETRYYIPTSSQGFLQL IALENELTDSPEDVVVIEGVPKNLDETSEIPVWESRYVDPRQKNLFKIYISLGEKNIPEADYHLLTEEEYKKIIQPNIGV LESALKEPFELPRFKHKIPVHTTIEELRALAIEGLKEAGITDKKYLERLDKELKIVQDKGFQDYFLLIAEIVKLAKSIGC WVGPGRGSAVGSLLVRALGITAVDPLKYDLYFERFLNPAREDFPDIDLDVEDEKRPELIHKITEHFSSEKVCLIQTMGTF SFRSAARALARKMKVSESEIRNLISWSRNGKFLPSSLSKDKRMTSIFKFANQLSGLYSTLSVHAAGIILSEEDLRTIIPL RKSDEIYISQWDMKSLEYLGFQKVDLLGLRNLSLLRKLCEGKEPWNKNPDNRKSFAILSRGYTTGIFQIEGNEATAIIKK ISPENLEDLAIGIALNRPGPISSGITREYIRRRRFLKAIGNYTAGEHIASLEDTLGLLIFQEQVIRLAISELKLKPEEGE LLRRALSKKDTETIEKLAEVVQERSPENSEKISKYLEFLRDFSGYSFNKSHSIAYSLLSYWIAYHKANNPVLFYKLLIPL MDSGSRLRAAAEARELGLKFSIFNPGNRNNIILVPGDFRPSLTKIDTSKPPKEENFFAYVRKNRNYLTAADLEFLIKTGF FDQYGSRIKLLKDINNALSGVDPDLKSVLKVFGYKEEEITEEMESLVEKAAMEFETFGFNLTEFEVELDEKNKDFVDGTL TSLVAGSCTGIAAFVAINASGKKFITDGRTLLPVKFRVPEKGFVVFKKGHFGEKSIFSEIHTVTRIINGPVPIDHLEKAS EKNTLIIDTGKKIKLHGMKTRDFEVDEIVIGGES
Sequences:
>Translated_914_residues MRVAFVVTSHELYASILNPKETAFALKKEGYDTCILIDSSLSSSILWFRMLKEQGINVIPGLKKETRYYIPTSSQGFLQL IALENELTDSPEDVVVIEGVPKNLDETSEIPVWESRYVDPRQKNLFKIYISLGEKNIPEADYHLLTEEEYKKIIQPNIGV LESALKEPFELPRFKHKIPVHTTIEELRALAIEGLKEAGITDKKYLERLDKELKIVQDKGFQDYFLLIAEIVKLAKSIGC WVGPGRGSAVGSLLVRALGITAVDPLKYDLYFERFLNPAREDFPDIDLDVEDEKRPELIHKITEHFSSEKVCLIQTMGTF SFRSAARALARKMKVSESEIRNLISWSRNGKFLPSSLSKDKRMTSIFKFANQLSGLYSTLSVHAAGIILSEEDLRTIIPL RKSDEIYISQWDMKSLEYLGFQKVDLLGLRNLSLLRKLCEGKEPWNKNPDNRKSFAILSRGYTTGIFQIEGNEATAIIKK ISPENLEDLAIGIALNRPGPISSGITREYIRRRRFLKAIGNYTAGEHIASLEDTLGLLIFQEQVIRLAISELKLKPEEGE LLRRALSKKDTETIEKLAEVVQERSPENSEKISKYLEFLRDFSGYSFNKSHSIAYSLLSYWIAYHKANNPVLFYKLLIPL MDSGSRLRAAAEARELGLKFSIFNPGNRNNIILVPGDFRPSLTKIDTSKPPKEENFFAYVRKNRNYLTAADLEFLIKTGF FDQYGSRIKLLKDINNALSGVDPDLKSVLKVFGYKEEEITEEMESLVEKAAMEFETFGFNLTEFEVELDEKNKDFVDGTL TSLVAGSCTGIAAFVAINASGKKFITDGRTLLPVKFRVPEKGFVVFKKGHFGEKSIFSEIHTVTRIINGPVPIDHLEKAS EKNTLIIDTGKKIKLHGMKTRDFEVDEIVIGGES >Mature_914_residues MRVAFVVTSHELYASILNPKETAFALKKEGYDTCILIDSSLSSSILWFRMLKEQGINVIPGLKKETRYYIPTSSQGFLQL IALENELTDSPEDVVVIEGVPKNLDETSEIPVWESRYVDPRQKNLFKIYISLGEKNIPEADYHLLTEEEYKKIIQPNIGV LESALKEPFELPRFKHKIPVHTTIEELRALAIEGLKEAGITDKKYLERLDKELKIVQDKGFQDYFLLIAEIVKLAKSIGC WVGPGRGSAVGSLLVRALGITAVDPLKYDLYFERFLNPAREDFPDIDLDVEDEKRPELIHKITEHFSSEKVCLIQTMGTF SFRSAARALARKMKVSESEIRNLISWSRNGKFLPSSLSKDKRMTSIFKFANQLSGLYSTLSVHAAGIILSEEDLRTIIPL RKSDEIYISQWDMKSLEYLGFQKVDLLGLRNLSLLRKLCEGKEPWNKNPDNRKSFAILSRGYTTGIFQIEGNEATAIIKK ISPENLEDLAIGIALNRPGPISSGITREYIRRRRFLKAIGNYTAGEHIASLEDTLGLLIFQEQVIRLAISELKLKPEEGE LLRRALSKKDTETIEKLAEVVQERSPENSEKISKYLEFLRDFSGYSFNKSHSIAYSLLSYWIAYHKANNPVLFYKLLIPL MDSGSRLRAAAEARELGLKFSIFNPGNRNNIILVPGDFRPSLTKIDTSKPPKEENFFAYVRKNRNYLTAADLEFLIKTGF FDQYGSRIKLLKDINNALSGVDPDLKSVLKVFGYKEEEITEEMESLVEKAAMEFETFGFNLTEFEVELDEKNKDFVDGTL TSLVAGSCTGIAAFVAINASGKKFITDGRTLLPVKFRVPEKGFVVFKKGHFGEKSIFSEIHTVTRIINGPVPIDHLEKAS EKNTLIIDTGKKIKLHGMKTRDFEVDEIVIGGES
Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase [H]
COG id: COG0587
COG function: function code L; DNA polymerase III, alpha subunit
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DNA polymerase type-C family. DnaE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786381, Length=643, Percent_Identity=30.1710730948678, Blast_Score=251, Evalue=1e-67,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011708 - InterPro: IPR003141 - InterPro: IPR004805 [H]
Pfam domain/function: PF07733 DNA_pol3_alpha [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 103548; Mature: 103548
Theoretical pI: Translated: 7.04; Mature: 7.04
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 1.6 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 1.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVAFVVTSHELYASILNPKETAFALKKEGYDTCILIDSSLSSSILWFRMLKEQGINVIP CEEEEEEECHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCC GLKKETRYYIPTSSQGFLQLIALENELTDSPEDVVVIEGVPKNLDETSEIPVWESRYVDP CCCCCCEEECCCCCCCCEEEEEEHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHCCCCCH RQKNLFKIYISLGEKNIPEADYHLLTEEEYKKIIQPNIGVLESALKEPFELPRFKHKIPV HHCCEEEEEEEECCCCCCCCHHEECCHHHHHHHHCCCHHHHHHHHHCHHHCCCCCCCCCC HTTIEELRALAIEGLKEAGITDKKYLERLDKELKIVQDKGFQDYFLLIAEIVKLAKSIGC HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC WVGPGRGSAVGSLLVRALGITAVDPLKYDLYFERFLNPAREDFPDIDLDVEDEKRPELIH EECCCCCHHHHHHHHHHHCCCEECCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHH KITEHFSSEKVCLIQTMGTFSFRSAARALARKMKVSESEIRNLISWSRNGKFLPSSLSKD HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHH KRMTSIFKFANQLSGLYSTLSVHAAGIILSEEDLRTIIPLRKSDEIYISQWDMKSLEYLG HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCCCEEEEECCHHHHHHCC FQKVDLLGLRNLSLLRKLCEGKEPWNKNPDNRKSFAILSRGYTTGIFQIEGNEATAIIKK CCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHEEEEECCCEEEEEEEECCCCEEHEEC ISPENLEDLAIGIALNRPGPISSGITREYIRRRRFLKAIGNYTAGEHIASLEDTLGLLIF CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH QEQVIRLAISELKLKPEEGELLRRALSKKDTETIEKLAEVVQERSPENSEKISKYLEFLR HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH DFSGYSFNKSHSIAYSLLSYWIAYHKANNPVLFYKLLIPLMDSGSRLRAAAEARELGLKF HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCHHHHHHHHHHCCCEE SIFNPGNRNNIILVPGDFRPSLTKIDTSKPPKEENFFAYVRKNRNYLTAADLEFLIKTGF EEECCCCCCCEEEECCCCCCCCEECCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHCC FDQYGSRIKLLKDINNALSGVDPDLKSVLKVFGYKEEEITEEMESLVEKAAMEFETFGFN HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC LTEFEVELDEKNKDFVDGTLTSLVAGSCTGIAAFVAINASGKKFITDGRTLLPVKFRVPE EEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCEEEEEEEECCC KGFVVFKKGHFGEKSIFSEIHTVTRIINGPVPIDHLEKASEKNTLIIDTGKKIKLHGMKT CCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCEEEEECCCC RDFEVDEIVIGGES CCCCCCEEEECCCC >Mature Secondary Structure MRVAFVVTSHELYASILNPKETAFALKKEGYDTCILIDSSLSSSILWFRMLKEQGINVIP CEEEEEEECHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCC GLKKETRYYIPTSSQGFLQLIALENELTDSPEDVVVIEGVPKNLDETSEIPVWESRYVDP CCCCCCEEECCCCCCCCEEEEEEHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHCCCCCH RQKNLFKIYISLGEKNIPEADYHLLTEEEYKKIIQPNIGVLESALKEPFELPRFKHKIPV HHCCEEEEEEEECCCCCCCCHHEECCHHHHHHHHCCCHHHHHHHHHCHHHCCCCCCCCCC HTTIEELRALAIEGLKEAGITDKKYLERLDKELKIVQDKGFQDYFLLIAEIVKLAKSIGC HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC WVGPGRGSAVGSLLVRALGITAVDPLKYDLYFERFLNPAREDFPDIDLDVEDEKRPELIH EECCCCCHHHHHHHHHHHCCCEECCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHHH KITEHFSSEKVCLIQTMGTFSFRSAARALARKMKVSESEIRNLISWSRNGKFLPSSLSKD HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHH KRMTSIFKFANQLSGLYSTLSVHAAGIILSEEDLRTIIPLRKSDEIYISQWDMKSLEYLG HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHCCCCCCCCEEEEECCHHHHHHCC FQKVDLLGLRNLSLLRKLCEGKEPWNKNPDNRKSFAILSRGYTTGIFQIEGNEATAIIKK CCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCHHEEEEECCCEEEEEEEECCCCEEHEEC ISPENLEDLAIGIALNRPGPISSGITREYIRRRRFLKAIGNYTAGEHIASLEDTLGLLIF CCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH QEQVIRLAISELKLKPEEGELLRRALSKKDTETIEKLAEVVQERSPENSEKISKYLEFLR HHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH DFSGYSFNKSHSIAYSLLSYWIAYHKANNPVLFYKLLIPLMDSGSRLRAAAEARELGLKF HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCHHHHHHHHHHCCCEE SIFNPGNRNNIILVPGDFRPSLTKIDTSKPPKEENFFAYVRKNRNYLTAADLEFLIKTGF EEECCCCCCCEEEECCCCCCCCEECCCCCCCCCCCEEEEEECCCCEEEHHHHHHHHHHCC FDQYGSRIKLLKDINNALSGVDPDLKSVLKVFGYKEEEITEEMESLVEKAAMEFETFGFN HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCC LTEFEVELDEKNKDFVDGTLTSLVAGSCTGIAAFVAINASGKKFITDGRTLLPVKFRVPE EEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCEEEEEEEECCC KGFVVFKKGHFGEKSIFSEIHTVTRIINGPVPIDHLEKASEKNTLIIDTGKKIKLHGMKT CCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCCEEEEECCCC RDFEVDEIVIGGES CCCCCCEEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9826752; 10360571 [H]