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The map label for this gene is capL [H]

Identifier: 239618011

GI number: 239618011

Start: 1759826

End: 1761130

Strand: Direct

Name: capL [H]

Synonym: Kole_1639

Alternate gene names: 239618011

Gene position: 1759826-1761130 (Clockwise)

Preceding gene: 239618010

Following gene: 239618012

Centisome position: 76.44

GC content: 39.85

Gene sequence:

>1305_bases
ATGCTGAAAGAGAAGATTCTCAATAAAGAGGCTGTGGTAGGTGTTATTGGCCTGGGATATGTAGGGCTGCCTCTGGCCGT
GGAAAAAGCAAAAGCTGGATTTAAGGTCATTGGATTTGATATTCAGCAAAAAAAGGTTGACATGGTAAACAGAGGAGAAA
ATTACATCGGTGATGTTGTAAATGAAGATCTCGAACAGATTGTCAAAGATGGAATGCTTAGAGCTACGACTGATTTCGAT
GAATTGAAAAACTGTGATGTGGTTGCAATATGTGTTCCAACACCTTTGGACAAATACAAACAACCAGATTTGACTTATGT
TGTGAATTCCACAAAAGAAGTGGCTAAAAGGCTTCACAAAGATATGTTGGTTGTTCTCGAATCAACAACGTATCCGGGAA
CTACCGAAGAAGTCATGAAACCCATCCTTGAAGAAACCGGTTTGAAATGCGGTGAGGATTTTTATCTTGCTTTTAGTCCT
GAAAGAGTTGATCCAGGAAATATCAGATACAAAACCAAGAATACCCCGAAAGTTGTTGGAGGGATAGGTGAAAAATCAAC
AGAAGTAGCGAAACTCCTGTACGAGTCTGTACTTGATGCTGAGGTTTTTGTAGTTTCTTCGCCAAAAGAAGCTGAAATGA
CGAAGATCCTTGAAAATACTTTCAGAATAGTGAACATAGCTCTAATAAACGAGATGGCGATTGTTGCGAACAAGATGGGA
ATAAATATATGGGAGGTTGTGAATGCAGCTTCCACCAAACCCTTTGGTTTTATGCCTTTTTATCCTGGTCCGGGAGTTGG
GGGACATTGTATTCCCATCGATCCTTTCTACCTTACCTATATTGCCCGAAAGTACAATTATCATACCCGCCTTATAGAAC
TGGCAGGAGAGATAAATGACTTCATGCCTGAATATGTTGTTGACAGGCTTATGAAACTCCTGAATGAACAGAAAAAATGC
ATGAATGGTGCGAAGATTGTAATGCTGGGTATCGCTTACAAAGGTGATATAGACGATATGAGAGAATCCCCAGCCCTTAA
GGTCCTTGGACATTTAGAAAGAAATTTAGCTGATGTTACCGTTGTTGATCCTTATGTGAGTGAGTTTAGATGGAACGGTG
AAATAATAAAAACCGCAAAACTCACTGCCGAGCTCATTAAAGAGGCTGATGCAGTTATTATCACCACTGCTCATAAACAT
AAAGTTGATTACAAGCTTGTTGTTGACAATGCCAAGCTGATATTCGATACAAAGAATATCCTGAAAACCCTGGGAATCAG
TGGAGAGAATGTGGAAGTACTGTAA

Upstream 100 bases:

>100_bases
GCTTAGCGTGCTTACCGGATTCTCGCCTTCTCGGCTCTCGATGTTTTTTCGTACAACGCACAACGTACAACCAACAACGA
AATATAAGGGAGGGAAGAAC

Downstream 100 bases:

>100_bases
GTACATTGTTCGAGAGTCCGAGAAGGCGAGAATCCGAGATGAAATTTAATGGGAAGGATGATTTCCTTGGCTTTTTCTGA
TATGGAGCTTTATGAGGTCG

Product: nucleotide sugar dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLKEKILNKEAVVGVIGLGYVGLPLAVEKAKAGFKVIGFDIQQKKVDMVNRGENYIGDVVNEDLEQIVKDGMLRATTDFD
ELKNCDVVAICVPTPLDKYKQPDLTYVVNSTKEVAKRLHKDMLVVLESTTYPGTTEEVMKPILEETGLKCGEDFYLAFSP
ERVDPGNIRYKTKNTPKVVGGIGEKSTEVAKLLYESVLDAEVFVVSSPKEAEMTKILENTFRIVNIALINEMAIVANKMG
INIWEVVNAASTKPFGFMPFYPGPGVGGHCIPIDPFYLTYIARKYNYHTRLIELAGEINDFMPEYVVDRLMKLLNEQKKC
MNGAKIVMLGIAYKGDIDDMRESPALKVLGHLERNLADVTVVDPYVSEFRWNGEIIKTAKLTAELIKEADAVIITTAHKH
KVDYKLVVDNAKLIFDTKNILKTLGISGENVEVL

Sequences:

>Translated_434_residues
MLKEKILNKEAVVGVIGLGYVGLPLAVEKAKAGFKVIGFDIQQKKVDMVNRGENYIGDVVNEDLEQIVKDGMLRATTDFD
ELKNCDVVAICVPTPLDKYKQPDLTYVVNSTKEVAKRLHKDMLVVLESTTYPGTTEEVMKPILEETGLKCGEDFYLAFSP
ERVDPGNIRYKTKNTPKVVGGIGEKSTEVAKLLYESVLDAEVFVVSSPKEAEMTKILENTFRIVNIALINEMAIVANKMG
INIWEVVNAASTKPFGFMPFYPGPGVGGHCIPIDPFYLTYIARKYNYHTRLIELAGEINDFMPEYVVDRLMKLLNEQKKC
MNGAKIVMLGIAYKGDIDDMRESPALKVLGHLERNLADVTVVDPYVSEFRWNGEIIKTAKLTAELIKEADAVIITTAHKH
KVDYKLVVDNAKLIFDTKNILKTLGISGENVEVL
>Mature_434_residues
MLKEKILNKEAVVGVIGLGYVGLPLAVEKAKAGFKVIGFDIQQKKVDMVNRGENYIGDVVNEDLEQIVKDGMLRATTDFD
ELKNCDVVAICVPTPLDKYKQPDLTYVVNSTKEVAKRLHKDMLVVLESTTYPGTTEEVMKPILEETGLKCGEDFYLAFSP
ERVDPGNIRYKTKNTPKVVGGIGEKSTEVAKLLYESVLDAEVFVVSSPKEAEMTKILENTFRIVNIALINEMAIVANKMG
INIWEVVNAASTKPFGFMPFYPGPGVGGHCIPIDPFYLTYIARKYNYHTRLIELAGEINDFMPEYVVDRLMKLLNEQKKC
MNGAKIVMLGIAYKGDIDDMRESPALKVLGHLERNLADVTVVDPYVSEFRWNGEIIKTAKLTAELIKEADAVIITTAHKH
KVDYKLVVDNAKLIFDTKNILKTLGISGENVEVL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=462, Percent_Identity=22.5108225108225, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI296040438, Length=371, Percent_Identity=22.1024258760108, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI296040443, Length=308, Percent_Identity=23.0519480519481, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI48994968, Length=408, Percent_Identity=36.2745098039216, Blast_Score=231, Evalue=9e-62,
Organism=Escherichia coli, GI1788340, Length=404, Percent_Identity=23.019801980198, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560350, Length=386, Percent_Identity=26.1658031088083, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136908, Length=371, Percent_Identity=26.1455525606469, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48403; Mature: 48403

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKEKILNKEAVVGVIGLGYVGLPLAVEKAKAGFKVIGFDIQQKKVDMVNRGENYIGDVV
CCHHHHCCHHHHEEEEECCHHCCCCEEHHHCCCEEEEEECHHHHHHHHHHCCCHHHHHHH
NEDLEQIVKDGMLRATTDFDELKNCDVVAICVPTPLDKYKQPDLTYVVNSTKEVAKRLHK
HHHHHHHHHCCCEEECCCHHHHCCCCEEEEEECCCHHHHCCCCEEEEECCHHHHHHHHHH
DMLVVLESTTYPGTTEEVMKPILEETGLKCGEDFYLAFSPERVDPGNIRYKTKNTPKVVG
HEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCEEE
GIGEKSTEVAKLLYESVLDAEVFVVSSPKEAEMTKILENTFRIVNIALINEMAIVANKMG
CCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCC
INIWEVVNAASTKPFGFMPFYPGPGVGGHCIPIDPFYLTYIARKYNYHTRLIELAGEIND
CHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHH
FMPEYVVDRLMKLLNEQKKCMNGAKIVMLGIAYKGDIDDMRESPALKVLGHLERNLADVT
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCEE
VVDPYVSEFRWNGEIIKTAKLTAELIKEADAVIITTAHKHKVDYKLVVDNAKLIFDTKNI
EECHHHHHHCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEEECHHH
LKTLGISGENVEVL
HHHHCCCCCCEEEC
>Mature Secondary Structure
MLKEKILNKEAVVGVIGLGYVGLPLAVEKAKAGFKVIGFDIQQKKVDMVNRGENYIGDVV
CCHHHHCCHHHHEEEEECCHHCCCCEEHHHCCCEEEEEECHHHHHHHHHHCCCHHHHHHH
NEDLEQIVKDGMLRATTDFDELKNCDVVAICVPTPLDKYKQPDLTYVVNSTKEVAKRLHK
HHHHHHHHHCCCEEECCCHHHHCCCCEEEEEECCCHHHHCCCCEEEEECCHHHHHHHHHH
DMLVVLESTTYPGTTEEVMKPILEETGLKCGEDFYLAFSPERVDPGNIRYKTKNTPKVVG
HEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCEEEECCCCCCEEE
GIGEKSTEVAKLLYESVLDAEVFVVSSPKEAEMTKILENTFRIVNIALINEMAIVANKMG
CCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCC
INIWEVVNAASTKPFGFMPFYPGPGVGGHCIPIDPFYLTYIARKYNYHTRLIELAGEIND
CHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHH
FMPEYVVDRLMKLLNEQKKCMNGAKIVMLGIAYKGDIDDMRESPALKVLGHLERNLADVT
CCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHCCCHHHHHHHHHHCCCCEE
VVDPYVSEFRWNGEIIKTAKLTAELIKEADAVIITTAHKHKVDYKLVVDNAKLIFDTKNI
EECHHHHHHCCCCCEEEHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCEEEEECHHH
LKTLGISGENVEVL
HHHHCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]