Click here to switch to the map view.

The map label for this gene is glmS [H]

Identifier: 239617909

GI number: 239617909

Start: 1647043

End: 1648869

Strand: Direct

Name: glmS [H]

Synonym: Kole_1537

Alternate gene names: 239617909

Gene position: 1647043-1648869 (Clockwise)

Preceding gene: 239617908

Following gene: 239617910

Centisome position: 71.54

GC content: 45.27

Gene sequence:

>1827_bases
GTGTGCGGGATAGTTGGGATAGTTGGTAGAGAGTTCTACCTGGAGCAACTCATGAAGGGGCTTAAGAAACTCGAATACAG
AGGATACGATTCTTCAGGTGTGGCTTATGTTGAAAACGGGGAACTTATTATAAGGAAAGCCGTTGGAAGGATAGCTGCTC
TTGAGGAGAAACTTGGAAAGGAAAACAAAAATAAGATACCTATTGGGATAGCACATACGCGCTGGGCCACACACGGGATC
CCATCTGATGTAAACGCTCATCCACATATAGACTGCTCCGGCAAACTTGCTGTGGTTCATAATGGGATTATAGAAAATCA
TACGGAATTAAAAGCAAGGCTTCAGAGAAAAGGGCACGTTTTCAAATCTGATACGGATACGGAGGTTATTGCACACCTTA
TAGAGGAGCATTTTAATGGGTCTCTCCTTGATGCCGTCAGACATGCGCTTGTGGACCTTGAGGGTGCTTATGCCATAGCG
GTGGTTCATGTGGACGTTCCGGATAGAATTGTTGCCGCACGAAAGGGAAGTCCTCTTGTTGTTGGTGCGAATGGCGATGG
TGCATACCTCGCATCCGATGTTACTCCATTGCTACATTACATACGGGATGTTTATTTCATAGAGGATGGAGATGTGGCAC
TTCTGAGTGCAGGCGAGGTCAAAATTTTCAGGACTGATGGCACACGTGTTTCCAGACCTTTAACTCATATAAATTGGACG
GAGGATGCTGCGGAGAAAGGCGGATATCCTCATTTTATGTTGAAAGAGATCTTTGAAGAACCACAGGTTATCAGAAATGC
CATAACCGGAAGAGTAAAGAACGGGAAAACAATTATAGCGGAACTGGAATCGATAGCCGATAAACTCAAAACCACCCGTA
ATGTGCAGGTAGTTGCCTGTGGCACCAGTTATCATGCCGGGCTCGTTTTCAAGAGATTTCTTGAAGAATATGCGGCGTTG
AATGTTGAGATCGATGTGGCTTCAGAGTTCAGATATAGAAAGATAAAATTCGATGAAGATACCATCGTTGTCGCTATATC
CCAATCGGGAGAAACAGCTGATACCCTTGAAGGGATTAGAATCGCAAAGGCTAGAGGTGCTACGATAATCGCGGTGACGA
ATGTTGTTGGTTCAACGATTTCTCGTGAAAGTCATGCTGTTGTTTATCTCAACGCGGGACCTGAAATAGGCGTCGCCGCA
ACGAAAACCTATGTTTCTCAATTGACAGTTTTGTTATTGATAGCCAGTTATATCGCCCAGCTCCGAGGTTTCGGGGATAA
AAAGCTGATGCAGATAGTAAATGAAATCGAAGGTATGCCAACGATATTTGAAAGCATTCTCGCTACTTCAAATGACCTGA
CCCGGGAACTGGCGAAGGAGTACTTCGATTACATTCATTTCATGTACATAGGGCGTGGATACGGTTATCCGAGTGCACTT
GAAGGCGCGTTGAAACTCAAAGAGATAAGTTACATCCATGCATCAGCTTATCAGGCTGGTGAGCTGAAACACGGGCCTAT
CGCGCTTTTAGATAGGAAGTTTCCGGTGTTTGCAATTGTTCCTGATGATTCGTTGAAAACTAAAACCCTTTCAAACATAA
TGGAGACCCGTGCGCGCGACGCCAAAGTGGTAGCGATTTGTACTGAAGGCGACCAGGCGGTTGCGCGTATAGTTAATAGC
AGAATTGAGGTTCCGAAGGTATCAGAGCCGTTGTATCCGCTTGTTATGTCGCCCTATCTACAGTTGTTTGCTTATCATGT
TGCTGTTATGCGCGGCCATGATCCGGATAAGCCGAGGAATCTCGCGAAAAGCGTAACCGTTGAATAA

Upstream 100 bases:

>100_bases
CTGATGCGCTGGCGATTTCAAATGCCATAAAAGTGGCTTGTAACGGTGTCAAAGGCAGACTCGTGGAGAAGTTGGAAGCA
CGATTTGGGAGTGAATAGGT

Downstream 100 bases:

>100_bases
AAAACATAACCCAACAAATCGGGAGGTGACCTTTTGGACGGGAATATAAGAGAGATTGTAAAGATTCTTTATGACAAGGA
GGCAGCGGATATCGTTCTTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGIVGREFYLEQLMKGLKKLEYRGYDSSGVAYVENGELIIRKAVGRIAALEEKLGKENKNKIPIGIAHTRWATHGI
PSDVNAHPHIDCSGKLAVVHNGIIENHTELKARLQRKGHVFKSDTDTEVIAHLIEEHFNGSLLDAVRHALVDLEGAYAIA
VVHVDVPDRIVAARKGSPLVVGANGDGAYLASDVTPLLHYIRDVYFIEDGDVALLSAGEVKIFRTDGTRVSRPLTHINWT
EDAAEKGGYPHFMLKEIFEEPQVIRNAITGRVKNGKTIIAELESIADKLKTTRNVQVVACGTSYHAGLVFKRFLEEYAAL
NVEIDVASEFRYRKIKFDEDTIVVAISQSGETADTLEGIRIAKARGATIIAVTNVVGSTISRESHAVVYLNAGPEIGVAA
TKTYVSQLTVLLLIASYIAQLRGFGDKKLMQIVNEIEGMPTIFESILATSNDLTRELAKEYFDYIHFMYIGRGYGYPSAL
EGALKLKEISYIHASAYQAGELKHGPIALLDRKFPVFAIVPDDSLKTKTLSNIMETRARDAKVVAICTEGDQAVARIVNS
RIEVPKVSEPLYPLVMSPYLQLFAYHVAVMRGHDPDKPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGIVGREFYLEQLMKGLKKLEYRGYDSSGVAYVENGELIIRKAVGRIAALEEKLGKENKNKIPIGIAHTRWATHGI
PSDVNAHPHIDCSGKLAVVHNGIIENHTELKARLQRKGHVFKSDTDTEVIAHLIEEHFNGSLLDAVRHALVDLEGAYAIA
VVHVDVPDRIVAARKGSPLVVGANGDGAYLASDVTPLLHYIRDVYFIEDGDVALLSAGEVKIFRTDGTRVSRPLTHINWT
EDAAEKGGYPHFMLKEIFEEPQVIRNAITGRVKNGKTIIAELESIADKLKTTRNVQVVACGTSYHAGLVFKRFLEEYAAL
NVEIDVASEFRYRKIKFDEDTIVVAISQSGETADTLEGIRIAKARGATIIAVTNVVGSTISRESHAVVYLNAGPEIGVAA
TKTYVSQLTVLLLIASYIAQLRGFGDKKLMQIVNEIEGMPTIFESILATSNDLTRELAKEYFDYIHFMYIGRGYGYPSAL
EGALKLKEISYIHASAYQAGELKHGPIALLDRKFPVFAIVPDDSLKTKTLSNIMETRARDAKVVAICTEGDQAVARIVNS
RIEVPKVSEPLYPLVMSPYLQLFAYHVAVMRGHDPDKPRNLAKSVTVE
>Mature_608_residues
MCGIVGIVGREFYLEQLMKGLKKLEYRGYDSSGVAYVENGELIIRKAVGRIAALEEKLGKENKNKIPIGIAHTRWATHGI
PSDVNAHPHIDCSGKLAVVHNGIIENHTELKARLQRKGHVFKSDTDTEVIAHLIEEHFNGSLLDAVRHALVDLEGAYAIA
VVHVDVPDRIVAARKGSPLVVGANGDGAYLASDVTPLLHYIRDVYFIEDGDVALLSAGEVKIFRTDGTRVSRPLTHINWT
EDAAEKGGYPHFMLKEIFEEPQVIRNAITGRVKNGKTIIAELESIADKLKTTRNVQVVACGTSYHAGLVFKRFLEEYAAL
NVEIDVASEFRYRKIKFDEDTIVVAISQSGETADTLEGIRIAKARGATIIAVTNVVGSTISRESHAVVYLNAGPEIGVAA
TKTYVSQLTVLLLIASYIAQLRGFGDKKLMQIVNEIEGMPTIFESILATSNDLTRELAKEYFDYIHFMYIGRGYGYPSAL
EGALKLKEISYIHASAYQAGELKHGPIALLDRKFPVFAIVPDDSLKTKTLSNIMETRARDAKVVAICTEGDQAVARIVNS
RIEVPKVSEPLYPLVMSPYLQLFAYHVAVMRGHDPDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=684, Percent_Identity=36.6959064327485, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI205277386, Length=683, Percent_Identity=36.896046852123, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI29570798, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=44.5350734094617, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI87082251, Length=316, Percent_Identity=20.253164556962, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=429, Percent_Identity=37.0629370629371, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=37.0629370629371, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=37.2960372960373, Blast_Score=288, Evalue=8e-78,
Organism=Saccharomyces cerevisiae, GI6322745, Length=449, Percent_Identity=37.4164810690423, Blast_Score=289, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=29.5081967213115, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=43.75, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=37.1345029239766, Blast_Score=445, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66942; Mature: 66942

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIVGREFYLEQLMKGLKKLEYRGYDSSGVAYVENGELIIRKAVGRIAALEEKLGK
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCC
ENKNKIPIGIAHTRWATHGIPSDVNAHPHIDCSGKLAVVHNGIIENHTELKARLQRKGHV
CCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCE
FKSDTDTEVIAHLIEEHFNGSLLDAVRHALVDLEGAYAIAVVHVDVPDRIVAARKGSPLV
ECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHEECCCCCEE
VGANGDGAYLASDVTPLLHYIRDVYFIEDGDVALLSAGEVKIFRTDGTRVSRPLTHINWT
EECCCCCCEEHHHHHHHHHHHHHEEEEECCCEEEEECCCEEEEECCCCCCCCCCCCCCCC
EDAAEKGGYPHFMLKEIFEEPQVIRNAITGRVKNGKTIIAELESIADKLKTTRNVQVVAC
HHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
GTSYHAGLVFKRFLEEYAALNVEIDVASEFRYRKIKFDEDTIVVAISQSGETADTLEGIR
CCCCHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEECCCEEEEEEECCCCCHHHHHCEE
IAKARGATIIAVTNVVGSTISRESHAVVYLNAGPEIGVAATKTYVSQLTVLLLIASYIAQ
EEECCCCEEEEEHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRGFGDKKLMQIVNEIEGMPTIFESILATSNDLTRELAKEYFDYIHFMYIGRGYGYPSAL
HHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHH
EGALKLKEISYIHASAYQAGELKHGPIALLDRKFPVFAIVPDDSLKTKTLSNIMETRARD
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCC
AKVVAICTEGDQAVARIVNSRIEVPKVSEPLYPLVMSPYLQLFAYHVAVMRGHDPDKPRN
CEEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGIVGREFYLEQLMKGLKKLEYRGYDSSGVAYVENGELIIRKAVGRIAALEEKLGK
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEHHHHHHHHHHHHHHCC
ENKNKIPIGIAHTRWATHGIPSDVNAHPHIDCSGKLAVVHNGIIENHTELKARLQRKGHV
CCCCCCCEEEEECCHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCE
FKSDTDTEVIAHLIEEHFNGSLLDAVRHALVDLEGAYAIAVVHVDVPDRIVAARKGSPLV
ECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHEECCCCCEE
VGANGDGAYLASDVTPLLHYIRDVYFIEDGDVALLSAGEVKIFRTDGTRVSRPLTHINWT
EECCCCCCEEHHHHHHHHHHHHHEEEEECCCEEEEECCCEEEEECCCCCCCCCCCCCCCC
EDAAEKGGYPHFMLKEIFEEPQVIRNAITGRVKNGKTIIAELESIADKLKTTRNVQVVAC
HHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEE
GTSYHAGLVFKRFLEEYAALNVEIDVASEFRYRKIKFDEDTIVVAISQSGETADTLEGIR
CCCCHHHHHHHHHHHHHHHEEEEEEECCCCCEEEEEECCCEEEEEEECCCCCHHHHHCEE
IAKARGATIIAVTNVVGSTISRESHAVVYLNAGPEIGVAATKTYVSQLTVLLLIASYIAQ
EEECCCCEEEEEHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRGFGDKKLMQIVNEIEGMPTIFESILATSNDLTRELAKEYFDYIHFMYIGRGYGYPSAL
HHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCHHHH
EGALKLKEISYIHASAYQAGELKHGPIALLDRKFPVFAIVPDDSLKTKTLSNIMETRARD
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHCCCC
AKVVAICTEGDQAVARIVNSRIEVPKVSEPLYPLVMSPYLQLFAYHVAVMRGHDPDKPRN
CEEEEEEECCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]