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The map label for this gene is ygcA [C]

Identifier: 239617809

GI number: 239617809

Start: 1530952

End: 1532274

Strand: Direct

Name: ygcA [C]

Synonym: Kole_1435

Alternate gene names: 239617809

Gene position: 1530952-1532274 (Clockwise)

Preceding gene: 239617808

Following gene: 239617811

Centisome position: 66.5

GC content: 40.74

Gene sequence:

>1323_bases
ATGAAGCAATTTACAGTTGAGAAGCTGATTTCTGACGGATACAGTTTTGCCAGAGATGAAAATGGAAAGGTTGTGCTGTT
AACAGAGGGGCTTCCGGGAGAGACCGTTGAAGCTGTTAAGCTGAAAGGAAAGGAAAGTGTAGAATTCTGGAAGACAGTCA
GAGTGGTTCAGTCCTCACCGGATAGAAAAATTAAAGGATGCAAGGGTTTTCCCGACTGTGGGGGTTGCGACTGGGGAGGT
CTTCAATATAGTAACCAGCTTCTCTGGAAAAAGAGAATAGTTCAGGAACAATTTCGAAGGGTCGGTAAATTCTATGAACT
ACCGGATTTTGAGATGATACCATCTAAAAAAACCAACCATTACAGGAACAGGATGGAATATGTGGCTTACCAGAAAGGTA
AAAAGATCGGGTTTGGGATGTATAAAAGGTTTAGTAATGAAGTTGTGGATGTAGAGGATTGCGATCTGGGTTATGAGGGA
TTTGGGAAGGTTAGAAGGACGTTTGAGGAAATCCTTTCCAGATTTGGTGTAAAGCCTTACAATAGAGAATCAAAGAGAGG
TTTTTTGAAGCATCTGGTTCTCAGGGGTAACCGTAATGGTGATATTGTTGCTTTGCTAATAACGAAAAGGGAATCTTTTC
CCGAAATAGATAAAATAAGTCGGGAAGTCAAAGAGCAATTGCCTGAAGTTACTTCACTGGTACATGTATTTAATTCCCGT
GATGATGTTGTGCTTCGTGGACCCTACCGTGTTATATATGGAGAAGGGATTATCACGGAAACCCTCGGGGATGCTGTGTT
TCAGGTTCCACCGGTTTCTTTTTTTCAAGCGAATGTTTTTGTTATGGAGGAACTTTTGAAGTACGTTCAACAGGAATTAA
ATCCATCGCCATCGGAGACCTTTCTGGACCTTTATAGCGGAATAGGAACTTTCGCATTTTACTTTGCAAGGATGTTTAAG
AAAGTCGTAGCAGTGGAGGGAATAAAAATCTCTTCCAGAGCCATGCTTTCAAATGCAAGGATAAATATGATAAGTAATCT
TGAGGCTGTTAACATGGATACCAGAGATTTTCTTGAAAAGAATGAAGAAAAATTTGATAAAGTGATCCTCGATCCTCCAA
GAGCTGGTATCGGTAAAGATATCGAACTGATTGGGAAAGCTTTACCAAAGAGAATTGTTTACATCTCCTGTAATCCAACT
ACTCTTGCCAGAGATTCCAGATACTTGAGCAACAAAGGCTTTTCTCTCAAGGCTCTGAGAGCGTTCGATATGTTTCCAGA
TACTCACCACGTTGAGGTTGTAGCAATCTTCAATCGAGTTTGA

Upstream 100 bases:

>100_bases
TATGTTCAGGCTTACACTTTGTAAAGCTGTTAAGAATGTTCTTAGTGATGGGCTGAGCCTTATCGGGGTTTCGGCGCCTG
AAAGTATGTAGGTGGCTTGT

Downstream 100 bases:

>100_bases
TACTTGAAAGTATTTTTGACAGTGGCTCAAGGATTTTACCGTTGGTGAAGAGCATTTCATTTGTCTGGTGGACTTCTACG
TCTTCACCATACCAGTTTGT

Product: RNA methyltransferase, TrmA family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKQFTVEKLISDGYSFARDENGKVVLLTEGLPGETVEAVKLKGKESVEFWKTVRVVQSSPDRKIKGCKGFPDCGGCDWGG
LQYSNQLLWKKRIVQEQFRRVGKFYELPDFEMIPSKKTNHYRNRMEYVAYQKGKKIGFGMYKRFSNEVVDVEDCDLGYEG
FGKVRRTFEEILSRFGVKPYNRESKRGFLKHLVLRGNRNGDIVALLITKRESFPEIDKISREVKEQLPEVTSLVHVFNSR
DDVVLRGPYRVIYGEGIITETLGDAVFQVPPVSFFQANVFVMEELLKYVQQELNPSPSETFLDLYSGIGTFAFYFARMFK
KVVAVEGIKISSRAMLSNARINMISNLEAVNMDTRDFLEKNEEKFDKVILDPPRAGIGKDIELIGKALPKRIVYISCNPT
TLARDSRYLSNKGFSLKALRAFDMFPDTHHVEVVAIFNRV

Sequences:

>Translated_440_residues
MKQFTVEKLISDGYSFARDENGKVVLLTEGLPGETVEAVKLKGKESVEFWKTVRVVQSSPDRKIKGCKGFPDCGGCDWGG
LQYSNQLLWKKRIVQEQFRRVGKFYELPDFEMIPSKKTNHYRNRMEYVAYQKGKKIGFGMYKRFSNEVVDVEDCDLGYEG
FGKVRRTFEEILSRFGVKPYNRESKRGFLKHLVLRGNRNGDIVALLITKRESFPEIDKISREVKEQLPEVTSLVHVFNSR
DDVVLRGPYRVIYGEGIITETLGDAVFQVPPVSFFQANVFVMEELLKYVQQELNPSPSETFLDLYSGIGTFAFYFARMFK
KVVAVEGIKISSRAMLSNARINMISNLEAVNMDTRDFLEKNEEKFDKVILDPPRAGIGKDIELIGKALPKRIVYISCNPT
TLARDSRYLSNKGFSLKALRAFDMFPDTHHVEVVAIFNRV
>Mature_440_residues
MKQFTVEKLISDGYSFARDENGKVVLLTEGLPGETVEAVKLKGKESVEFWKTVRVVQSSPDRKIKGCKGFPDCGGCDWGG
LQYSNQLLWKKRIVQEQFRRVGKFYELPDFEMIPSKKTNHYRNRMEYVAYQKGKKIGFGMYKRFSNEVVDVEDCDLGYEG
FGKVRRTFEEILSRFGVKPYNRESKRGFLKHLVLRGNRNGDIVALLITKRESFPEIDKISREVKEQLPEVTSLVHVFNSR
DDVVLRGPYRVIYGEGIITETLGDAVFQVPPVSFFQANVFVMEELLKYVQQELNPSPSETFLDLYSGIGTFAFYFARMFK
KVVAVEGIKISSRAMLSNARINMISNLEAVNMDTRDFLEKNEEKFDKVILDPPRAGIGKDIELIGKALPKRIVYISCNPT
TLARDSRYLSNKGFSLKALRAFDMFPDTHHVEVVAIFNRV

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=368, Percent_Identity=26.9021739130435, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI51173878, Length=368, Percent_Identity=26.9021739130435, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI269784680, Length=364, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI269784676, Length=364, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI20149688, Length=364, Percent_Identity=23.0769230769231, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1789148, Length=439, Percent_Identity=28.4738041002278, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787083, Length=325, Percent_Identity=27.3846153846154, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790403, Length=176, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666579, Length=372, Percent_Identity=27.4193548387097, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 50446; Mature: 50446

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFTVEKLISDGYSFARDENGKVVLLTEGLPGETVEAVKLKGKESVEFWKTVRVVQSSP
CCCHHHHHHHHCCHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCC
DRKIKGCKGFPDCGGCDWGGLQYSNQLLWKKRIVQEQFRRVGKFYELPDFEMIPSKKTNH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
YRNRMEYVAYQKGKKIGFGMYKRFSNEVVDVEDCDLGYEGFGKVRRTFEEILSRFGVKPY
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NRESKRGFLKHLVLRGNRNGDIVALLITKRESFPEIDKISREVKEQLPEVTSLVHVFNSR
CCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DDVVLRGPYRVIYGEGIITETLGDAVFQVPPVSFFQANVFVMEELLKYVQQELNPSPSET
CCEEEECCEEEEECCCCHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FLDLYSGIGTFAFYFARMFKKVVAVEGIKISSRAMLSNARINMISNLEAVNMDTRDFLEK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHCCCCHHHHCCHHCCCCHHHHHHC
NEEKFDKVILDPPRAGIGKDIELIGKALPKRIVYISCNPTTLARDSRYLSNKGFSLKALR
CHHHHHHEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCEECCCCHHHHCCCCEEEEHH
AFDMFPDTHHVEVVAIFNRV
HHHCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKQFTVEKLISDGYSFARDENGKVVLLTEGLPGETVEAVKLKGKESVEFWKTVRVVQSSP
CCCHHHHHHHHCCHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCC
DRKIKGCKGFPDCGGCDWGGLQYSNQLLWKKRIVQEQFRRVGKFYELPDFEMIPSKKTNH
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
YRNRMEYVAYQKGKKIGFGMYKRFSNEVVDVEDCDLGYEGFGKVRRTFEEILSRFGVKPY
HHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
NRESKRGFLKHLVLRGNRNGDIVALLITKRESFPEIDKISREVKEQLPEVTSLVHVFNSR
CCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
DDVVLRGPYRVIYGEGIITETLGDAVFQVPPVSFFQANVFVMEELLKYVQQELNPSPSET
CCEEEECCEEEEECCCCHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
FLDLYSGIGTFAFYFARMFKKVVAVEGIKISSRAMLSNARINMISNLEAVNMDTRDFLEK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHCCCCHHHHCCHHCCCCHHHHHHC
NEEKFDKVILDPPRAGIGKDIELIGKALPKRIVYISCNPTTLARDSRYLSNKGFSLKALR
CHHHHHHEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCEECCCCHHHHCCCCEEEEHH
AFDMFPDTHHVEVVAIFNRV
HHHCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]