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The map label for this gene is pleC [H]

Identifier: 239617406

GI number: 239617406

Start: 1076847

End: 1078463

Strand: Reverse

Name: pleC [H]

Synonym: Kole_1017

Alternate gene names: 239617406

Gene position: 1078463-1076847 (Counterclockwise)

Preceding gene: 239617409

Following gene: 239617405

Centisome position: 46.85

GC content: 37.85

Gene sequence:

>1617_bases
ATGAATAAGTTGTTGAACATCTTCAGATTGAGTCTACTTCTTTCTTTGCTGATCATATTATTCGCTATACTATTTGGGAT
ATACCTGCCAATGAAAAATGAACTTACAAAAGAAGTCCATGAGAGCTTCTCAAACAACGCCAAATTATCCGAGAAAACTG
TTGAGAGTTTCCTTGAACGCTGTATCGAGGGAGCAGAAAGCCTTTCCAGCCGTACTATGATCAGGAAGATGATAGTTGAA
TATCTCGGTGGTAACATCACCCTCAAGGAACTTCAAGAATACACTTCACCGAAATATCTCGATGGAGCTAGTACACTCCG
GAATTTGAAAAGTGCTACTCGAGTTGTCTCGGGAAACATCATTGCTTCTGTTGGAGATTCAAACATGGAAAAAGCAATAA
GTTGTGAAGACGTGTCAGAAACATCTTTAGATATAGAATTTGAGAATCAATCGATTGTTGTCAATGTATGTTCTCCAATA
CGCGAAGCCGACACAATTATAGGTTATGACTTTGTTTCTTTTGACATGACAAAACTCTTAGATGAAATCAATACAGGAAA
TATTGTATATGAGATCTATATCGCAACTAATTCAAAATACATTTCATCAAAAGGAAAAACATTTGACGTTCTCAAAGACG
ATACGTTGGGTTCAAATGAGAAAATAACATGGTATACTATGAAAATAGGAGATACGGATGCCTTTCTGGTTGCCAGCATA
CTTAATGATATTATCTACGCTCATATAAAAAAATTGGCCCTGCTCATTTCGATTATTATTGCTGCCACATTCCTCACCGT
TATTCTCCTAACGTATTTTGCTATTCTCACAAACGCAAGGAAGATGATAAAAACTATGGAACAAGATAATATAAAGATCA
AAGAGTTAGAACGTCTTAAATCCGAATTTCTTGCTACTATGAGTCATGAGTTGAGAACCCCTCTCAACTCTATTATTGGG
TTCGTTAGCATGATTTTGCAGGGCATTTCAGGAGACATCAACGAGGAGCAGAGGAAGCAACTCTCTATGGTTCACAGTTC
TTCAATACACCTCTTAAATCTGATAAACGATATCCTGGATATCTCCAAGATTGAAGCTGGTAAAATGAGTTTTTCTAAGG
ATAGATTCAATATTAAAGACGTTATTTCTGAAGTTGTACAAAATGTTTCGCCGTTGATTTCTAAAAAAGAAGTGAAGTTA
ATAACAGAAATACCTGACGAGATTCCAGAGGTCTACAGTGATAAAACGAGGGTTTTCCAGATTCTCCTGAATCTGGTCAG
TAACGCGATTAAATTCACGGAGAAGGGCGAGATAAGGATAAAATGCGAGGTAGATGGAGATAAACTGAAAATCAGCGTTT
CTGATACAGGAAAAGGGATAAAGGAAGAAGATATGGAAACATTATTTGAAGCATTTCGACAGATAAGTGGTTCGGCACGG
CGCAGGTACCAAGGTGCTGGGCTGGGGCTTTATCTTTCCAAAAAGCTTGTGACATTGTTGGGCGGTGAAATCTGGGTTGA
GAGCGAATACGGTAAAGGTTCTACATTTACATTCACCCTGCCGCTCAAATCTGTGGAGGAGAATAATCATGAAGAAAAAA
GTACTGGTGATAGATGA

Upstream 100 bases:

>100_bases
GTACGGGGAGATTGTCTTGTTCCCATACAAAATCATCCTTTGGATGACATTGTCATTATTTAAATGTTCTTCTTTTCGTT
TAATTGCCTGGAGGCGTTCT

Downstream 100 bases:

>100_bases
TAACGAACAGAATCTGTATTTAATAACCTTTCTTCTTGAAAGTAAAGGATATGAGGTCATTACAGCCATCGATGGGATCA
AAGGGATAAAAAAAGCTATA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MNKLLNIFRLSLLLSLLIILFAILFGIYLPMKNELTKEVHESFSNNAKLSEKTVESFLERCIEGAESLSSRTMIRKMIVE
YLGGNITLKELQEYTSPKYLDGASTLRNLKSATRVVSGNIIASVGDSNMEKAISCEDVSETSLDIEFENQSIVVNVCSPI
READTIIGYDFVSFDMTKLLDEINTGNIVYEIYIATNSKYISSKGKTFDVLKDDTLGSNEKITWYTMKIGDTDAFLVASI
LNDIIYAHIKKLALLISIIIAATFLTVILLTYFAILTNARKMIKTMEQDNIKIKELERLKSEFLATMSHELRTPLNSIIG
FVSMILQGISGDINEEQRKQLSMVHSSSIHLLNLINDILDISKIEAGKMSFSKDRFNIKDVISEVVQNVSPLISKKEVKL
ITEIPDEIPEVYSDKTRVFQILLNLVSNAIKFTEKGEIRIKCEVDGDKLKISVSDTGKGIKEEDMETLFEAFRQISGSAR
RRYQGAGLGLYLSKKLVTLLGGEIWVESEYGKGSTFTFTLPLKSVEENNHEEKSTGDR

Sequences:

>Translated_538_residues
MNKLLNIFRLSLLLSLLIILFAILFGIYLPMKNELTKEVHESFSNNAKLSEKTVESFLERCIEGAESLSSRTMIRKMIVE
YLGGNITLKELQEYTSPKYLDGASTLRNLKSATRVVSGNIIASVGDSNMEKAISCEDVSETSLDIEFENQSIVVNVCSPI
READTIIGYDFVSFDMTKLLDEINTGNIVYEIYIATNSKYISSKGKTFDVLKDDTLGSNEKITWYTMKIGDTDAFLVASI
LNDIIYAHIKKLALLISIIIAATFLTVILLTYFAILTNARKMIKTMEQDNIKIKELERLKSEFLATMSHELRTPLNSIIG
FVSMILQGISGDINEEQRKQLSMVHSSSIHLLNLINDILDISKIEAGKMSFSKDRFNIKDVISEVVQNVSPLISKKEVKL
ITEIPDEIPEVYSDKTRVFQILLNLVSNAIKFTEKGEIRIKCEVDGDKLKISVSDTGKGIKEEDMETLFEAFRQISGSAR
RRYQGAGLGLYLSKKLVTLLGGEIWVESEYGKGSTFTFTLPLKSVEENNHEEKSTGDR
>Mature_538_residues
MNKLLNIFRLSLLLSLLIILFAILFGIYLPMKNELTKEVHESFSNNAKLSEKTVESFLERCIEGAESLSSRTMIRKMIVE
YLGGNITLKELQEYTSPKYLDGASTLRNLKSATRVVSGNIIASVGDSNMEKAISCEDVSETSLDIEFENQSIVVNVCSPI
READTIIGYDFVSFDMTKLLDEINTGNIVYEIYIATNSKYISSKGKTFDVLKDDTLGSNEKITWYTMKIGDTDAFLVASI
LNDIIYAHIKKLALLISIIIAATFLTVILLTYFAILTNARKMIKTMEQDNIKIKELERLKSEFLATMSHELRTPLNSIIG
FVSMILQGISGDINEEQRKQLSMVHSSSIHLLNLINDILDISKIEAGKMSFSKDRFNIKDVISEVVQNVSPLISKKEVKL
ITEIPDEIPEVYSDKTRVFQILLNLVSNAIKFTEKGEIRIKCEVDGDKLKISVSDTGKGIKEEDMETLFEAFRQISGSAR
RRYQGAGLGLYLSKKLVTLLGGEIWVESEYGKGSTFTFTLPLKSVEENNHEEKSTGDR

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=41.5686274509804, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=36.8421052631579, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI48994928, Length=234, Percent_Identity=37.6068376068376, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081816, Length=227, Percent_Identity=36.5638766519824, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1788713, Length=256, Percent_Identity=33.984375, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=26.2357414448669, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790436, Length=272, Percent_Identity=29.7794117647059, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786600, Length=257, Percent_Identity=27.2373540856031, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=26.8398268398268, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788549, Length=243, Percent_Identity=28.3950617283951, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=24.5551601423488, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=25.9574468085106, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=27.3109243697479, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=244, Percent_Identity=27.4590163934426, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=223, Percent_Identity=21.9730941704036, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790861, Length=226, Percent_Identity=23.4513274336283, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=79, Percent_Identity=41.7721518987342, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60435; Mature: 60435

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00018 EF_HAND_1 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLLNIFRLSLLLSLLIILFAILFGIYLPMKNELTKEVHESFSNNAKLSEKTVESFLER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
CIEGAESLSSRTMIRKMIVEYLGGNITLKELQEYTSPKYLDGASTLRNLKSATRVVSGNI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCE
IASVGDSNMEKAISCEDVSETSLDIEFENQSIVVNVCSPIREADTIIGYDFVSFDMTKLL
EEECCCCCHHHCCCCCCCCCCCEEEEECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHH
DEINTGNIVYEIYIATNSKYISSKGKTFDVLKDDTLGSNEKITWYTMKIGDTDAFLVASI
HHCCCCCEEEEEEEEECCEEECCCCCEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHH
LNDIIYAHIKKLALLISIIIAATFLTVILLTYFAILTNARKMIKTMEQDNIKIKELERLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SEFLATMSHELRTPLNSIIGFVSMILQGISGDINEEQRKQLSMVHSSSIHLLNLINDILD
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
ISKIEAGKMSFSKDRFNIKDVISEVVQNVSPLISKKEVKLITEIPDEIPEVYSDKTRVFQ
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHCCHHHHHH
ILLNLVSNAIKFTEKGEIRIKCEVDGDKLKISVSDTGKGIKEEDMETLFEAFRQISGSAR
HHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHH
RRYQGAGLGLYLSKKLVTLLGGEIWVESEYGKGSTFTFTLPLKSVEENNHEEKSTGDR
HHHCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNKLLNIFRLSLLLSLLIILFAILFGIYLPMKNELTKEVHESFSNNAKLSEKTVESFLER
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
CIEGAESLSSRTMIRKMIVEYLGGNITLKELQEYTSPKYLDGASTLRNLKSATRVVSGNI
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCE
IASVGDSNMEKAISCEDVSETSLDIEFENQSIVVNVCSPIREADTIIGYDFVSFDMTKLL
EEECCCCCHHHCCCCCCCCCCCEEEEECCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHH
DEINTGNIVYEIYIATNSKYISSKGKTFDVLKDDTLGSNEKITWYTMKIGDTDAFLVASI
HHCCCCCEEEEEEEEECCEEECCCCCEEECCCCCCCCCCCEEEEEEEEECCCHHHHHHHH
LNDIIYAHIKKLALLISIIIAATFLTVILLTYFAILTNARKMIKTMEQDNIKIKELERLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
SEFLATMSHELRTPLNSIIGFVSMILQGISGDINEEQRKQLSMVHSSSIHLLNLINDILD
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
ISKIEAGKMSFSKDRFNIKDVISEVVQNVSPLISKKEVKLITEIPDEIPEVYSDKTRVFQ
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHCCHHHHHH
ILLNLVSNAIKFTEKGEIRIKCEVDGDKLKISVSDTGKGIKEEDMETLFEAFRQISGSAR
HHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHH
RRYQGAGLGLYLSKKLVTLLGGEIWVESEYGKGSTFTFTLPLKSVEENNHEEKSTGDR
HHHCCCCCHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEEHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]