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The map label for this gene is tdh [H]

Identifier: 239617330

GI number: 239617330

Start: 993128

End: 994117

Strand: Reverse

Name: tdh [H]

Synonym: Kole_0939

Alternate gene names: 239617330

Gene position: 994117-993128 (Counterclockwise)

Preceding gene: 239617331

Following gene: 239617329

Centisome position: 43.18

GC content: 42.93

Gene sequence:

>990_bases
ATGAAGGCACTCTTCTATTTAGGACCTAAGAAACTTGAGTTGAGGGATATTGAGGAACCAAAGAATGAAGACGGTGTAGT
CATCAAGGTTTTGGAAACAGGCATATGTGGGACCGATATTAAAACCTTTTTGCGAGGGCATCATCTTTTTAAACCGCCAA
CGATACTGGGGCACGAATGTTACGGAATTGTCGTGGAAAAACCTGCTTTTGTAGAACATCTCGAAGTCGGTGATTATGTT
GCGGTCGCTCCGTACGGTGAATGCGGTGTCTGTGAAAAATGCAGAAAAGGGCTTCCCGAGCTTTGTAAGAATAAGACATA
TCTTCCGAGCGGCTGTTTTGCACAGTACATAACAGTTCCTGCGAATCATAGTTTGAGGGGTCTTTTCAAGATAGAGAAAC
CGGGAAAACAGGTAGTACTGGCAGAGCCTCTTGCGTGCGTAATTGGTACGGTTAGAAAGTTTGGTGTTCCCGAACGTGTT
CTGATAGTTGGTGGAGGAGTTATGGGAACGCTTTTTGCCATTTATTTAAGCGTTAGGGGAACATCTGTCAGGATTTTAGA
ACCTTTCGAGTGGAGGGCTTCTTTTTTGAAAGATATGGGGCTTGATGTCATGGAACCTGATGCTCTTAAAGAAAAAGGCT
ACGATATGGTAGTGATTGCCGCAACCATAGATGAACCTTTCCAGTACATGGATTTGATGCAGGATGGCGGGAGTTTGCTA
CTATTCGGTGGTTACCCGAAGGATAAGAGGCTCACATTAAATCCATTCCATCTACATTACAGGGAAATAGTCGTTAGCGG
AAGCTTCGGATATAGCTTGCCCGATTTTGCTGAAGCACTTGAAGAACTTGGAATAGAAAATGAGCTTTATTCAAAGCTTG
TTACGCACAGTTACTCAGTATCTGAATACGACAAGGCTTTTGAAAAAGTTATGGACAAGGAGTGTATGAAAATCTCACTG
AGGATGTGGGAAAATGATGAAAAAGCGTAA

Upstream 100 bases:

>100_bases
GAATAATAACAGCTTCTAAGAAAGGGTATTTTAATGTGCTTGTAACAGATTCCATAACGGCTAATTTTGTCCTTGAGAAG
CTGAGAGAGGAGAGAGGGGA

Downstream 100 bases:

>100_bases
GCTTCGCGAAACCATAACCGCTTATGTGTGCCTTTCACCGACATTGGTACTTGCCACCATTTTCATGATAATTCCCATGA
TCGTGGTATTTTACGTCAGT

Product: Alcohol dehydrogenase GroES domain protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKALFYLGPKKLELRDIEEPKNEDGVVIKVLETGICGTDIKTFLRGHHLFKPPTILGHECYGIVVEKPAFVEHLEVGDYV
AVAPYGECGVCEKCRKGLPELCKNKTYLPSGCFAQYITVPANHSLRGLFKIEKPGKQVVLAEPLACVIGTVRKFGVPERV
LIVGGGVMGTLFAIYLSVRGTSVRILEPFEWRASFLKDMGLDVMEPDALKEKGYDMVVIAATIDEPFQYMDLMQDGGSLL
LFGGYPKDKRLTLNPFHLHYREIVVSGSFGYSLPDFAEALEELGIENELYSKLVTHSYSVSEYDKAFEKVMDKECMKISL
RMWENDEKA

Sequences:

>Translated_329_residues
MKALFYLGPKKLELRDIEEPKNEDGVVIKVLETGICGTDIKTFLRGHHLFKPPTILGHECYGIVVEKPAFVEHLEVGDYV
AVAPYGECGVCEKCRKGLPELCKNKTYLPSGCFAQYITVPANHSLRGLFKIEKPGKQVVLAEPLACVIGTVRKFGVPERV
LIVGGGVMGTLFAIYLSVRGTSVRILEPFEWRASFLKDMGLDVMEPDALKEKGYDMVVIAATIDEPFQYMDLMQDGGSLL
LFGGYPKDKRLTLNPFHLHYREIVVSGSFGYSLPDFAEALEELGIENELYSKLVTHSYSVSEYDKAFEKVMDKECMKISL
RMWENDEKA
>Mature_329_residues
MKALFYLGPKKLELRDIEEPKNEDGVVIKVLETGICGTDIKTFLRGHHLFKPPTILGHECYGIVVEKPAFVEHLEVGDYV
AVAPYGECGVCEKCRKGLPELCKNKTYLPSGCFAQYITVPANHSLRGLFKIEKPGKQVVLAEPLACVIGTVRKFGVPERV
LIVGGGVMGTLFAIYLSVRGTSVRILEPFEWRASFLKDMGLDVMEPDALKEKGYDMVVIAATIDEPFQYMDLMQDGGSLL
LFGGYPKDKRLTLNPFHLHYREIVVSGSFGYSLPDFAEALEELGIENELYSKLVTHSYSVSEYDKAFEKVMDKECMKISL
RMWENDEKA

Specific function: Threonine catabolism; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=363, Percent_Identity=25.8953168044077, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=349, Percent_Identity=26.3610315186246, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI226510992, Length=337, Percent_Identity=25.5192878338279, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787863, Length=355, Percent_Identity=27.0422535211268, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788073, Length=340, Percent_Identity=25, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=228, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788407, Length=323, Percent_Identity=25.6965944272446, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786825, Length=161, Percent_Identity=32.2981366459627, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=348, Percent_Identity=25.5747126436782, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=340, Percent_Identity=23.5294117647059, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71988145, Length=292, Percent_Identity=26.7123287671233, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319258, Length=385, Percent_Identity=24.1558441558442, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=389, Percent_Identity=24.4215938303342, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=340, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=307, Percent_Identity=26.3843648208469, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=343, Percent_Identity=23.6151603498542, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=343, Percent_Identity=23.6151603498542, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737897, Length=324, Percent_Identity=27.1604938271605, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137530, Length=321, Percent_Identity=25.5451713395639, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36879; Mature: 36879

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALFYLGPKKLELRDIEEPKNEDGVVIKVLETGICGTDIKTFLRGHHLFKPPTILGHEC
CCEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCEECCCE
YGIVVEKPAFVEHLEVGDYVAVAPYGECGVCEKCRKGLPELCKNKTYLPSGCFAQYITVP
EEEEEECCHHHHHHCCCCEEEECCCCCCCHHHHHHCCCHHHHCCCCCCCCCHHEEEEEEC
ANHSLRGLFKIEKPGKQVVLAEPLACVIGTVRKFGVPERVLIVGGGVMGTLFAIYLSVRG
CCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCC
TSVRILEPFEWRASFLKDMGLDVMEPDALKEKGYDMVVIAATIDEPFQYMDLMQDGGSLL
CEEEEECCHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCEE
LFGGYPKDKRLTLNPFHLHYREIVVSGSFGYSLPDFAEALEELGIENELYSKLVTHSYSV
EECCCCCCCEEEECHHHEEEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCH
SEYDKAFEKVMDKECMKISLRMWENDEKA
HHHHHHHHHHHHHHHHEEHEEECCCCCCC
>Mature Secondary Structure
MKALFYLGPKKLELRDIEEPKNEDGVVIKVLETGICGTDIKTFLRGHHLFKPPTILGHEC
CCEEEECCCCCEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCEECCCE
YGIVVEKPAFVEHLEVGDYVAVAPYGECGVCEKCRKGLPELCKNKTYLPSGCFAQYITVP
EEEEEECCHHHHHHCCCCEEEECCCCCCCHHHHHHCCCHHHHCCCCCCCCCHHEEEEEEC
ANHSLRGLFKIEKPGKQVVLAEPLACVIGTVRKFGVPERVLIVGGGVMGTLFAIYLSVRG
CCCCEEEEEEECCCCCEEEEECHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCC
TSVRILEPFEWRASFLKDMGLDVMEPDALKEKGYDMVVIAATIDEPFQYMDLMQDGGSLL
CEEEEECCHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCEE
LFGGYPKDKRLTLNPFHLHYREIVVSGSFGYSLPDFAEALEELGIENELYSKLVTHSYSV
EECCCCCCCEEEECHHHEEEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCH
SEYDKAFEKVMDKECMKISLRMWENDEKA
HHHHHHHHHHHHHHHHEEHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]