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The map label for this gene is moaA [H]

Identifier: 239617100

GI number: 239617100

Start: 756866

End: 757816

Strand: Direct

Name: moaA [H]

Synonym: Kole_0702

Alternate gene names: 239617100

Gene position: 756866-757816 (Clockwise)

Preceding gene: 239617099

Following gene: 239617101

Centisome position: 32.88

GC content: 40.48

Gene sequence:

>951_bases
ATGAAGGAAGAGCTGAAGGATAAAATTGGAAGGAATATTGATTATCTCCGATTTTCAATCACGGACCGGTGCAATTTCAG
GTGCTTCTACTGCATGCCTGAAAACACCTCTTTTTTACCAGAATCAGAGCTATTAACCCTTGATGATATCCGCTTTGCTG
TACAGATATTCAAAGAAATTGGTTTTAAGAGATTGAGGCTTACCGGTGGAGAGCCAACACTACGAAGTGATCTCCTTGAA
ATTGTTTCGATCGTTTCAGAAACTTTTGGGAGCTGTGCTATGACTACAAACGGTTCAAGGTTGAAGGAACTTGCTCTTGA
ACTCTATTCCGCGGGTTTGAGGGAGGTGAATGTAAGCCTCGACTCAATCGATAGTGAAACTTTCTTCCGGATAACCCGTG
GCGGGAATCTCAAAGAAGTTCTGAAGGGAATCGATGAAGCCATTTCTGTTGGCATAAAGGTCAAACTCAATACTGTGATA
ACACAGATGAACTTCCATGAGATTCCGGAACTGGTACAGTACGCTGAAAAGCTTGGAGTACCTATAAGGTTCATTGAAGA
GATGCCAATAGGGAAAAACAACAACCGTCATTTCATTCCATATAAAAAAGTTTTGGAATTACTACACGAAAACGATTTTA
TCCAAATAGAAACTCGAATAGGTTATGGCCCTGCCAGGTATTATAAAACCTCACGAGGAACAATTGTAGGCTTTATCACT
GCTATTACCCATAACTTTTGTAACGGATGCAACAAGCTCCGGCTTTCCGCCGATGGAAAACTGTTTCCATGTTTGGCCTA
TGATTATCATGTTTCTTTGAAAGGCGCAATAAAAAGCCGAAGATCCGATGAAGTTAAGAAAAATATTTATAATGCTATTA
GCTTAAAACCTTTAAGACACGAACTGCTCAACAGAACTCAGAGCAATGGCATGAACCGGATGGGAGGATAA

Upstream 100 bases:

>100_bases
AAGCAGCAAATCTGCAGTCTCTGGTTCTTGTCGGATTCTCTCTCATGACCCTGATGCTTATTAAAAAACTTATGGAAAGA
AGAGATTAGATGGTGAAAAT

Downstream 100 bases:

>100_bases
CTATGAAACTAAGTCACATGGACGACAAGGGCAATGCAAAGATGGTGGATGTCTCTGCCAAAGAAAATACAAAAAGAACA
GCCAAAGCTTATGGAAGAAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MKEELKDKIGRNIDYLRFSITDRCNFRCFYCMPENTSFLPESELLTLDDIRFAVQIFKEIGFKRLRLTGGEPTLRSDLLE
IVSIVSETFGSCAMTTNGSRLKELALELYSAGLREVNVSLDSIDSETFFRITRGGNLKEVLKGIDEAISVGIKVKLNTVI
TQMNFHEIPELVQYAEKLGVPIRFIEEMPIGKNNNRHFIPYKKVLELLHENDFIQIETRIGYGPARYYKTSRGTIVGFIT
AITHNFCNGCNKLRLSADGKLFPCLAYDYHVSLKGAIKSRRSDEVKKNIYNAISLKPLRHELLNRTQSNGMNRMGG

Sequences:

>Translated_316_residues
MKEELKDKIGRNIDYLRFSITDRCNFRCFYCMPENTSFLPESELLTLDDIRFAVQIFKEIGFKRLRLTGGEPTLRSDLLE
IVSIVSETFGSCAMTTNGSRLKELALELYSAGLREVNVSLDSIDSETFFRITRGGNLKEVLKGIDEAISVGIKVKLNTVI
TQMNFHEIPELVQYAEKLGVPIRFIEEMPIGKNNNRHFIPYKKVLELLHENDFIQIETRIGYGPARYYKTSRGTIVGFIT
AITHNFCNGCNKLRLSADGKLFPCLAYDYHVSLKGAIKSRRSDEVKKNIYNAISLKPLRHELLNRTQSNGMNRMGG
>Mature_316_residues
MKEELKDKIGRNIDYLRFSITDRCNFRCFYCMPENTSFLPESELLTLDDIRFAVQIFKEIGFKRLRLTGGEPTLRSDLLE
IVSIVSETFGSCAMTTNGSRLKELALELYSAGLREVNVSLDSIDSETFFRITRGGNLKEVLKGIDEAISVGIKVKLNTVI
TQMNFHEIPELVQYAEKLGVPIRFIEEMPIGKNNNRHFIPYKKVLELLHENDFIQIETRIGYGPARYYKTSRGTIVGFIT
AITHNFCNGCNKLRLSADGKLFPCLAYDYHVSLKGAIKSRRSDEVKKNIYNAISLKPLRHELLNRTQSNGMNRMGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=308, Percent_Identity=35.0649350649351, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI22027536, Length=308, Percent_Identity=35.0649350649351, Blast_Score=167, Evalue=2e-41,
Organism=Escherichia coli, GI1786999, Length=284, Percent_Identity=35.9154929577465, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566331, Length=314, Percent_Identity=37.2611464968153, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=304, Percent_Identity=37.171052631579, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17561210, Length=305, Percent_Identity=38.0327868852459, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI28574488, Length=314, Percent_Identity=37.2611464968153, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI28574490, Length=288, Percent_Identity=38.1944444444444, Blast_Score=181, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36038; Mature: 36038

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEELKDKIGRNIDYLRFSITDRCNFRCFYCMPENTSFLPESELLTLDDIRFAVQIFKEI
CCHHHHHHHCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHC
GFKRLRLTGGEPTLRSDLLEIVSIVSETFGSCAMTTNGSRLKELALELYSAGLREVNVSL
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCHHEEECCH
DSIDSETFFRITRGGNLKEVLKGIDEAISVGIKVKLNTVITQMNFHEIPELVQYAEKLGV
HCCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEHHHHHHCCHHHHHHHHHHHHHHCC
PIRFIEEMPIGKNNNRHFIPYKKVLELLHENDFIQIETRIGYGPARYYKTSRGTIVGFIT
CEEEHHHCCCCCCCCEEECCHHHHHHHHCCCCEEEEEEECCCCHHHHEECCCCCHHHHHH
AITHNFCNGCNKLRLSADGKLFPCLAYDYHVSLKGAIKSRRSDEVKKNIYNAISLKPLRH
HHHHHHHCCCCEEEECCCCCEEEEEEEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCHHHH
ELLNRTQSNGMNRMGG
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKEELKDKIGRNIDYLRFSITDRCNFRCFYCMPENTSFLPESELLTLDDIRFAVQIFKEI
CCHHHHHHHCCCEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHC
GFKRLRLTGGEPTLRSDLLEIVSIVSETFGSCAMTTNGSRLKELALELYSAGLREVNVSL
CCEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCHHEEECCH
DSIDSETFFRITRGGNLKEVLKGIDEAISVGIKVKLNTVITQMNFHEIPELVQYAEKLGV
HCCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEHHHHHHCCHHHHHHHHHHHHHHCC
PIRFIEEMPIGKNNNRHFIPYKKVLELLHENDFIQIETRIGYGPARYYKTSRGTIVGFIT
CEEEHHHCCCCCCCCEEECCHHHHHHHHCCCCEEEEEEECCCCHHHHEECCCCCHHHHHH
AITHNFCNGCNKLRLSADGKLFPCLAYDYHVSLKGAIKSRRSDEVKKNIYNAISLKPLRH
HHHHHHHCCCCEEEECCCCCEEEEEEEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCHHHH
ELLNRTQSNGMNRMGG
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA