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The map label for this gene is patB [H]

Identifier: 239616554

GI number: 239616554

Start: 163976

End: 165160

Strand: Reverse

Name: patB [H]

Synonym: Kole_0146

Alternate gene names: 239616554

Gene position: 165160-163976 (Counterclockwise)

Preceding gene: 239616555

Following gene: 239616552

Centisome position: 7.17

GC content: 42.7

Gene sequence:

>1185_bases
ATGGAAAAATACGATTTTGATAAGTTCATAGATCGCAGGGAGACAAACTCATACAAATGGGATTATTTAGATGAGGCCTT
TGGCACCCGGGATTTGATTCCCATGTGGGTAGCAGATATGGATTTTGAGGCTCCAAAACCAGTAATAGAAGCCATTAAAA
ATCGCGCGCAGCACGGGTGTTACGGTTATACAGCGAGACCCGATAGCTATTACGAGAGCATAATGAACTGGCTGGAAAAA
AGACACAGCTGGAAAGTAGAAAAAGAGTGGCTTTTGCATTCACCTGGTGTTGTTCCCGGGATAGTAATAGCGATATTGGC
ATTTACGAACCCGGGCGATAAGGTTATCATACAGACGCCTGTTTACCATCCTTTCTATTCAACTGTCCGTGAGAACGGAA
GGCAGCTCGTGAAAAATCCGTTGAAACTCGAAAACGGAAAATACTTTATGAATTTCGAAGATCTGGAGTCAAAGATAGAT
GAACGGGCGAGGATGTTGATACTATGTAATCCCCACAATCCCGGTGGCAGGGTCTGGACCGAAGGCGAGCTGTTGAAACT
CGGTGAGCTTTGTATTAAACACGATCTGATAATTTTATCCGACGAAATACATTCTGACATAATCATGCCCGGGTACAAAC
ATATTCCCATAGCATCAATTTCGCAGGAGCTTGCTGATCGAACCATCACCTATATAGCGCCAAGTAAAACCTTTAATCTC
GCCGGGCTTACAACTTCAACTGTTATCATTTCCAATCAACGTTTAAGAAGGATCTACAACAATATGCTTTCTTCTCTTGA
ACTCAATCTTGGAAACGTTTTCGGGATCGTTGCTACTGAAGCAGCGTACAGATACGGAGAGGAATGGCTGGAGCAACTTC
TGAAATACCTTAAAGGGAATTTAGAGTTTCTCAAAAAATTCATCTCTGAAAGATTGCCGGAAATTAAGGTTGTAGAGCCT
GAAGGGACTTACCTCGTTTGGCTTGATTTCAGAGGCCTGGGAATGGATCAGGAAGAACTCAGAAAGTTTATTATTGAAAA
AGCGAAGCTCGGCCTCAATGATGGAGTTACTTTTGGAGAAGAGGGTAAAGGATTTCAACGAATGAACATCGCCTGCCCGC
GTTCCATACTCAAAAAAGCTCTGGAACAGCTCGAAACAGCGGTTAAAAATCTAAAAGGAACTTAA

Upstream 100 bases:

>100_bases
TTGACTTACCACCCGGTCCGGTTGTGGTTTTGATTCTGTTTCTGGAATTTCTGCTTACATATGTATTTGCAATGAAAACA
AAGAATGAATAGGTGGGATT

Downstream 100 bases:

>100_bases
CGGGTCTCGATACCCTTAACTCCCTGAAAGAAGAAGCCTTTTATCATTAGTCTATCTATTCCTTTGAGGTATCCGTTCAG
ATACACATACAGTAATTTTG

Product: aminotransferase class I and II

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MEKYDFDKFIDRRETNSYKWDYLDEAFGTRDLIPMWVADMDFEAPKPVIEAIKNRAQHGCYGYTARPDSYYESIMNWLEK
RHSWKVEKEWLLHSPGVVPGIVIAILAFTNPGDKVIIQTPVYHPFYSTVRENGRQLVKNPLKLENGKYFMNFEDLESKID
ERARMLILCNPHNPGGRVWTEGELLKLGELCIKHDLIILSDEIHSDIIMPGYKHIPIASISQELADRTITYIAPSKTFNL
AGLTTSTVIISNQRLRRIYNNMLSSLELNLGNVFGIVATEAAYRYGEEWLEQLLKYLKGNLEFLKKFISERLPEIKVVEP
EGTYLVWLDFRGLGMDQEELRKFIIEKAKLGLNDGVTFGEEGKGFQRMNIACPRSILKKALEQLETAVKNLKGT

Sequences:

>Translated_394_residues
MEKYDFDKFIDRRETNSYKWDYLDEAFGTRDLIPMWVADMDFEAPKPVIEAIKNRAQHGCYGYTARPDSYYESIMNWLEK
RHSWKVEKEWLLHSPGVVPGIVIAILAFTNPGDKVIIQTPVYHPFYSTVRENGRQLVKNPLKLENGKYFMNFEDLESKID
ERARMLILCNPHNPGGRVWTEGELLKLGELCIKHDLIILSDEIHSDIIMPGYKHIPIASISQELADRTITYIAPSKTFNL
AGLTTSTVIISNQRLRRIYNNMLSSLELNLGNVFGIVATEAAYRYGEEWLEQLLKYLKGNLEFLKKFISERLPEIKVVEP
EGTYLVWLDFRGLGMDQEELRKFIIEKAKLGLNDGVTFGEEGKGFQRMNIACPRSILKKALEQLETAVKNLKGT
>Mature_394_residues
MEKYDFDKFIDRRETNSYKWDYLDEAFGTRDLIPMWVADMDFEAPKPVIEAIKNRAQHGCYGYTARPDSYYESIMNWLEK
RHSWKVEKEWLLHSPGVVPGIVIAILAFTNPGDKVIIQTPVYHPFYSTVRENGRQLVKNPLKLENGKYFMNFEDLESKID
ERARMLILCNPHNPGGRVWTEGELLKLGELCIKHDLIILSDEIHSDIIMPGYKHIPIASISQELADRTITYIAPSKTFNL
AGLTTSTVIISNQRLRRIYNNMLSSLELNLGNVFGIVATEAAYRYGEEWLEQLLKYLKGNLEFLKKFISERLPEIKVVEP
EGTYLVWLDFRGLGMDQEELRKFIIEKAKLGLNDGVTFGEEGKGFQRMNIACPRSILKKALEQLETAVKNLKGT

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=176, Percent_Identity=30.1136363636364, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI56713254, Length=160, Percent_Identity=31.875, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI95147551, Length=174, Percent_Identity=28.1609195402299, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI169881279, Length=174, Percent_Identity=28.1609195402299, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4507369, Length=310, Percent_Identity=23.8709677419355, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI169881281, Length=159, Percent_Identity=28.3018867924528, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=34.1836734693878, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1788627, Length=223, Percent_Identity=29.1479820627803, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786816, Length=314, Percent_Identity=20.0636942675159, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788722, Length=372, Percent_Identity=20.9677419354839, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=216, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71994476, Length=216, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17567369, Length=219, Percent_Identity=27.8538812785388, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322401, Length=288, Percent_Identity=25.6944444444444, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28573069, Length=280, Percent_Identity=27.5, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646114, Length=280, Percent_Identity=27.5, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573067, Length=280, Percent_Identity=27.5, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573065, Length=280, Percent_Identity=27.5, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859735, Length=177, Percent_Identity=25.4237288135593, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45435; Mature: 45435

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYDFDKFIDRRETNSYKWDYLDEAFGTRDLIPMWVADMDFEAPKPVIEAIKNRAQHGC
CCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCC
YGYTARPDSYYESIMNWLEKRHSWKVEKEWLLHSPGVVPGIVIAILAFTNPGDKVIIQTP
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECC
VYHPFYSTVRENGRQLVKNPLKLENGKYFMNFEDLESKIDERARMLILCNPHNPGGRVWT
CCCHHHHHHHHHHHHHHCCCCEECCCEEEECHHHHHHHHHHCCCEEEEECCCCCCCCEEC
EGELLKLGELCIKHDLIILSDEIHSDIIMPGYKHIPIASISQELADRTITYIAPSKTFNL
CCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCEEE
AGLTTSTVIISNQRLRRIYNNMLSSLELNLGNVFGIVATEAAYRYGEEWLEQLLKYLKGN
CCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCC
LEFLKKFISERLPEIKVVEPEGTYLVWLDFRGLGMDQEELRKFIIEKAKLGLNDGVTFGE
HHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
EGKGFQRMNIACPRSILKKALEQLETAVKNLKGT
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKYDFDKFIDRRETNSYKWDYLDEAFGTRDLIPMWVADMDFEAPKPVIEAIKNRAQHGC
CCCCCHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCC
YGYTARPDSYYESIMNWLEKRHSWKVEKEWLLHSPGVVPGIVIAILAFTNPGDKVIIQTP
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECC
VYHPFYSTVRENGRQLVKNPLKLENGKYFMNFEDLESKIDERARMLILCNPHNPGGRVWT
CCCHHHHHHHHHHHHHHCCCCEECCCEEEECHHHHHHHHHHCCCEEEEECCCCCCCCEEC
EGELLKLGELCIKHDLIILSDEIHSDIIMPGYKHIPIASISQELADRTITYIAPSKTFNL
CCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCEEE
AGLTTSTVIISNQRLRRIYNNMLSSLELNLGNVFGIVATEAAYRYGEEWLEQLLKYLKGN
CCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCC
LEFLKKFISERLPEIKVVEPEGTYLVWLDFRGLGMDQEELRKFIIEKAKLGLNDGVTFGE
HHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
EGKGFQRMNIACPRSILKKALEQLETAVKNLKGT
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]