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The map label for this gene is degU [H]

Identifier: 238926042

GI number: 238926042

Start: 3439474

End: 3440118

Strand: Reverse

Name: degU [H]

Synonym: EUBREC_3701

Alternate gene names: 238926042

Gene position: 3440118-3439474 (Counterclockwise)

Preceding gene: 238926043

Following gene: 238926041

Centisome position: 99.72

GC content: 35.5

Gene sequence:

>645_bases
ATGGCTATTAACATTATGATTACAGATGATCATTCTATGATCAGAGAGGGACTTAAAAATCTGCTGGAGCTCGACGGTGA
TATCAAGGTTATTGCTGAGGCAGAGAATGGTGAGGATTGTCTTGATAAATTAAAGACTTTTAGACCTGATGTATTACTTT
TGGATATCAATATGCCAAAGATGAATGGTCTTGAGGTATTAAAAGCATTAAAGGACAGAAAGTCTAAGGTAAAGGTACTT
GTTCTTACTGTTCACAATGAGACTGAATATCTTATGAAGGCTGTAGATATCGGAATCAATGGATATGTATTGAAGGATTC
TGAGTCTGCTGAGCTTAAAAAGGCTATTTTCACTATTGCTGATGGTGAGACTTATATACAGCCTAGTCTTATTCCGGCTC
TTAATTCTAAGATGATTCAGAAAAATGAGGATGAGCTTAAGATAGATGCTCTTACTAAGAGAGAGATGGAAGTACTTAAA
GAAATGGCTGTTGGTAAGTTTAACAGAGATATTGCTAAGGAAATGAAGATTAGTGAGAGAACTGTTAAGAATCATATTTC
AAGTATTTTCAAGAAGCTTGAGGTTACTGATCGTACACAGGCTGCGGTATTTGCAATCCGTAACAACATTATTCAGATTA
TGTAG

Upstream 100 bases:

>100_bases
AAGAATTTATCTTCTTTCCGGTAAAATATCTATTTCATCAAAACCTGGTGAGGGCTGTATAGTTAGGGTAATTATACCTG
TAAATAAGGAGGATTAAATT

Downstream 100 bases:

>100_bases
TATATTTTACATTATTTATTTTACATTAAAGGAATGTTTCACGTGAAACATTCCTTTTTGATTATTTAATATAGTTTATT
GACAGTAATACGGAATCCGT

Product: two-component response regulator (extracellular proteinase response regulator)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MAINIMITDDHSMIREGLKNLLELDGDIKVIAEAENGEDCLDKLKTFRPDVLLLDINMPKMNGLEVLKALKDRKSKVKVL
VLTVHNETEYLMKAVDIGINGYVLKDSESAELKKAIFTIADGETYIQPSLIPALNSKMIQKNEDELKIDALTKREMEVLK
EMAVGKFNRDIAKEMKISERTVKNHISSIFKKLEVTDRTQAAVFAIRNNIIQIM

Sequences:

>Translated_214_residues
MAINIMITDDHSMIREGLKNLLELDGDIKVIAEAENGEDCLDKLKTFRPDVLLLDINMPKMNGLEVLKALKDRKSKVKVL
VLTVHNETEYLMKAVDIGINGYVLKDSESAELKKAIFTIADGETYIQPSLIPALNSKMIQKNEDELKIDALTKREMEVLK
EMAVGKFNRDIAKEMKISERTVKNHISSIFKKLEVTDRTQAAVFAIRNNIIQIM
>Mature_213_residues
AINIMITDDHSMIREGLKNLLELDGDIKVIAEAENGEDCLDKLKTFRPDVLLLDINMPKMNGLEVLKALKDRKSKVKVLV
LTVHNETEYLMKAVDIGINGYVLKDSESAELKKAIFTIADGETYIQPSLIPALNSKMIQKNEDELKIDALTKREMEVLKE
MAVGKFNRDIAKEMKISERTVKNHISSIFKKLEVTDRTQAAVFAIRNNIIQIM

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=211, Percent_Identity=36.4928909952607, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787473, Length=209, Percent_Identity=37.3205741626794, Blast_Score=124, Evalue=3e-30,
Organism=Escherichia coli, GI1788222, Length=208, Percent_Identity=29.3269230769231, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=31.7307692307692, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=31.5, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1786747, Length=190, Percent_Identity=28.4210526315789, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1788546, Length=197, Percent_Identity=27.4111675126904, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87082052, Length=130, Percent_Identity=32.3076923076923, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789937, Length=201, Percent_Identity=25.3731343283582, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=114, Percent_Identity=34.2105263157895, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=33.9285714285714, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787277, Length=141, Percent_Identity=31.9148936170213, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=101, Percent_Identity=35.6435643564356, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24245; Mature: 24114

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINIMITDDHSMIREGLKNLLELDGDIKVIAEAENGEDCLDKLKTFRPDVLLLDINMPK
CEEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCC
MNGLEVLKALKDRKSKVKVLVLTVHNETEYLMKAVDIGINGYVLKDSESAELKKAIFTIA
CCHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHCCCCCEEEECCCHHHHHHHHEEEE
DGETYIQPSLIPALNSKMIQKNEDELKIDALTKREMEVLKEMAVGKFNRDIAKEMKISER
CCCEEECCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVKNHISSIFKKLEVTDRTQAAVFAIRNNIIQIM
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEC
>Mature Secondary Structure 
AINIMITDDHSMIREGLKNLLELDGDIKVIAEAENGEDCLDKLKTFRPDVLLLDINMPK
EEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCC
MNGLEVLKALKDRKSKVKVLVLTVHNETEYLMKAVDIGINGYVLKDSESAELKKAIFTIA
CCHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHCCCCCEEEECCCHHHHHHHHEEEE
DGETYIQPSLIPALNSKMIQKNEDELKIDALTKREMEVLKEMAVGKFNRDIAKEMKISER
CCCEEECCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVKNHISSIFKKLEVTDRTQAAVFAIRNNIIQIM
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]