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The map label for this gene is vanR [H]

Identifier: 238925901

GI number: 238925901

Start: 3321101

End: 3321802

Strand: Reverse

Name: vanR [H]

Synonym: EUBREC_3559

Alternate gene names: 238925901

Gene position: 3321802-3321101 (Counterclockwise)

Preceding gene: 238925902

Following gene: 238925900

Centisome position: 96.29

GC content: 38.89

Gene sequence:

>702_bases
ATGAACAAGAAGATTTTAATTGTGGATGACGAAAAAGAAATCGTTGATCTGCTTGAAGTGTATTTGAGTAACGATGGTTA
TTCAGTATATAAATGTTATAATGGGTTAGAGGCGATGAAATGTATCAAACAGTCGCAGATTGATTTAGCGATACTTGATA
TTATGCTGCCGGATATTGATGGTTTTCGACTTTGCCAAAAAATTCGGGAAAAGTTTTACTTCCCTATTATTATGCTTACC
GCCAAAATTGAGGATAGCGACAAGATTATGGGGCTTACGATTGGTGCGGATGATTATATAACGAAACCGTTTAATCCTTT
AGAGGTTGTGGCAAGAGTAAAGACGCAATTAAGGCGTTATCAGAGCTATAACAGTCCTAATTTGAGCCAATCCGAAGAAA
AAGACGAGTATGACATCAGAGGTCTACTGATAAACAGAGTCAGCCACAAGTGCTACTTGTATGGCAAAGAAATAGCCTTG
ACTCCGTTGGAGTTTTCTATTCTGTGGTATCTGTGCGAACATCAGGGTAAAGTTGTCGCCTCGGAGGAATTATTTGAAGC
CGTGTGGAAAGAAAAGTATCTTCGCAACAGTAACAATACGGTAATGGCGCACATTGGGCGGCTTCGGGAAAAATTGAATG
AACCTTCAAAAAATCCGAAGTTCATTAAAACTGTTTGGGGGGTAGGGTATGAAATTGAATAA

Upstream 100 bases:

>100_bases
AAAATGTTACCCTTCCCGTGCTGTTGAATATATGCGAATACTTAGAGTGTGATTTTGGCGACATAATGGAAGCCGTACCC
GAAAATGAGGTGTAGGATCA

Downstream 100 bases:

>100_bases
AAAAGAAAAAAACTATCTGCTCTCTACCTTGTTCAAAGGGTATGTAATTCAATGTGCGATTTGCTCTGTGCTTATTTTTG
GCGGTACTTTTCTTTTAGGA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MNKKILIVDDEKEIVDLLEVYLSNDGYSVYKCYNGLEAMKCIKQSQIDLAILDIMLPDIDGFRLCQKIREKFYFPIIMLT
AKIEDSDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYQSYNSPNLSQSEEKDEYDIRGLLINRVSHKCYLYGKEIAL
TPLEFSILWYLCEHQGKVVASEELFEAVWKEKYLRNSNNTVMAHIGRLREKLNEPSKNPKFIKTVWGVGYEIE

Sequences:

>Translated_233_residues
MNKKILIVDDEKEIVDLLEVYLSNDGYSVYKCYNGLEAMKCIKQSQIDLAILDIMLPDIDGFRLCQKIREKFYFPIIMLT
AKIEDSDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYQSYNSPNLSQSEEKDEYDIRGLLINRVSHKCYLYGKEIAL
TPLEFSILWYLCEHQGKVVASEELFEAVWKEKYLRNSNNTVMAHIGRLREKLNEPSKNPKFIKTVWGVGYEIE
>Mature_233_residues
MNKKILIVDDEKEIVDLLEVYLSNDGYSVYKCYNGLEAMKCIKQSQIDLAILDIMLPDIDGFRLCQKIREKFYFPIIMLT
AKIEDSDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYQSYNSPNLSQSEEKDEYDIRGLLINRVSHKCYLYGKEIAL
TPLEFSILWYLCEHQGKVVASEELFEAVWKEKYLRNSNNTVMAHIGRLREKLNEPSKNPKFIKTVWGVGYEIE

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=39.2241379310345, Blast_Score=156, Evalue=9e-40,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=35.6521739130435, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=33.6206896551724, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=34.070796460177, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=35.9307359307359, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=32.1888412017167, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=34.6320346320346, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=32.034632034632, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=32.6086956521739, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=30.6034482758621, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=31.6017316017316, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1787375, Length=232, Percent_Identity=33.1896551724138, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.6943231441048, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790299, Length=123, Percent_Identity=30.0813008130081, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=103, Percent_Identity=31.0679611650485, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27167; Mature: 27167

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILIVDDEKEIVDLLEVYLSNDGYSVYKCYNGLEAMKCIKQSQIDLAILDIMLPDID
CCCCEEEEECHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCC
GFRLCQKIREKFYFPIIMLTAKIEDSDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRY
HHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
QSYNSPNLSQSEEKDEYDIRGLLINRVSHKCYLYGKEIALTPLEFSILWYLCEHQGKVVA
HCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECEEEECCHHHHHHHHHHHCCCCEEE
SEELFEAVWKEKYLRNSNNTVMAHIGRLREKLNEPSKNPKFIKTVWGVGYEIE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MNKKILIVDDEKEIVDLLEVYLSNDGYSVYKCYNGLEAMKCIKQSQIDLAILDIMLPDID
CCCCEEEEECHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCC
GFRLCQKIREKFYFPIIMLTAKIEDSDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRY
HHHHHHHHHHHHCCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
QSYNSPNLSQSEEKDEYDIRGLLINRVSHKCYLYGKEIALTPLEFSILWYLCEHQGKVVA
HCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEECEEEECCHHHHHHHHHHHCCCCEEE
SEELFEAVWKEKYLRNSNNTVMAHIGRLREKLNEPSKNPKFIKTVWGVGYEIE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]