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The map label for this gene is lexA [C]

Identifier: 238925885

GI number: 238925885

Start: 3309095

End: 3309826

Strand: Direct

Name: lexA [C]

Synonym: EUBREC_3543

Alternate gene names: 238925885

Gene position: 3309095-3309826 (Clockwise)

Preceding gene: 238925883

Following gene: 238925886

Centisome position: 95.92

GC content: 37.57

Gene sequence:

>732_bases
ATGCGTGATTTCGGGGAAATATTAGCAGAAAATAGAAAAAAGAAAGGATACTCTCAATCAGATCTGGTAAACCTGCTTTC
TCAGGAAGGTATTCAGGTCACTACAAAAGCACTCTCCAAATGGGAGAACAATGCACGAGAACCCGCTTTACATGTTTTCC
TGACACTTTGCCAGTTACTTGATATCGAAGATATATATGAATCCTTCTTTGGAGAAAATCCATATAACATTATGAGTGGA
TTGAATGAAGAAGGCAGAAATAAATTGATTGAATTTGCTGATATTTTGAAAGCTTCTAAAAAGTTTTCTCCACTGTCTGC
AAAGATTATCCCATTCCATCATCCTGTAGAAATTACCTGGGAACCAGTTTCTGCTGGTACTGGAAATTACCTGGAAGATT
CTGTAAAAGAAACCTATGACGTAGGACATCTTGCTCCTGAGCAGACTGACTTTGGTGTGCGGATCTCTGGTGATAGTATG
GAGCCACTTTATCATACAGACGATGTTGCATGGATTCAGAAAAAAGATTCTCTTGCTAATGGTGAAATTGGAATCTTCTA
TCTCAACGGCAATACTTACATCAAGGAATTACACGATGAGCCAGATGGTGTTTATCTGATCTCTTTAAATCAAAAATATC
GTCCTATCCAAGTTTTGGAATCTGACTCTTTTAAGATTTTTGGAAAAGTAATCGGGAAATGCAAAGGTGCAGAAATTCCA
GGATTTCATTAG

Upstream 100 bases:

>100_bases
TCTTGGTTGTATTTTCTCCATTTTGGAGATTATTGTTGATTTTATTTCTAACATACGGTATAATGCATATAGAAAATTCA
AATAGAAATGAGGCGAACAA

Downstream 100 bases:

>100_bases
ATTTCAACAGCAGGTTCATGATCCTACTGATAACAATAAGCAAAGGAAGTGATTGAATGGCAATCAATAATACATTAAAA
GATATTCGTGAAGAACGGAA

Product: putative prophage repressor

Products: Hydrolyzed repressor LexA [C]

Alternate protein names: Transcriptional Regulator; Repressor; Prophage Repressor; Phage Repressor-Like Protein; Peptidase; Transcriptional Regulator Cro/CI Family; Repressor-Like Protein; XRE Family Transcriptional Regulator; Phage Repressor; Prophage; Helix-Turn-Helix Domain-Containing Protein; Transcriptional Regulator XRE Family; LexA Repressor; SOS-Response Transcriptional Repressor

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MRDFGEILAENRKKKGYSQSDLVNLLSQEGIQVTTKALSKWENNAREPALHVFLTLCQLLDIEDIYESFFGENPYNIMSG
LNEEGRNKLIEFADILKASKKFSPLSAKIIPFHHPVEITWEPVSAGTGNYLEDSVKETYDVGHLAPEQTDFGVRISGDSM
EPLYHTDDVAWIQKKDSLANGEIGIFYLNGNTYIKELHDEPDGVYLISLNQKYRPIQVLESDSFKIFGKVIGKCKGAEIP
GFH

Sequences:

>Translated_243_residues
MRDFGEILAENRKKKGYSQSDLVNLLSQEGIQVTTKALSKWENNAREPALHVFLTLCQLLDIEDIYESFFGENPYNIMSG
LNEEGRNKLIEFADILKASKKFSPLSAKIIPFHHPVEITWEPVSAGTGNYLEDSVKETYDVGHLAPEQTDFGVRISGDSM
EPLYHTDDVAWIQKKDSLANGEIGIFYLNGNTYIKELHDEPDGVYLISLNQKYRPIQVLESDSFKIFGKVIGKCKGAEIP
GFH
>Mature_243_residues
MRDFGEILAENRKKKGYSQSDLVNLLSQEGIQVTTKALSKWENNAREPALHVFLTLCQLLDIEDIYESFFGENPYNIMSG
LNEEGRNKLIEFADILKASKKFSPLSAKIIPFHHPVEITWEPVSAGTGNYLEDSVKETYDVGHLAPEQTDFGVRISGDSM
EPLYHTDDVAWIQKKDSLANGEIGIFYLNGNTYIKELHDEPDGVYLISLNQKYRPIQVLESDSFKIFGKVIGKCKGAEIP
GFH

Specific function: Represses A Number Of Genes Involved In The Response To DNA Damage (Sos Response), Including Reca And Lexa. Binds To The 16 Bp Palindromic Sequence 5'-CTGT-At(4)-ACAG-3'. In The Presence Of Single-Stranded DNA, Reca Interacts With Lexa Causing An Autocata

COG id: COG2932

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.4.21.88 [C]

Molecular weight: Translated: 27433; Mature: 27433

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDFGEILAENRKKKGYSQSDLVNLLSQEGIQVTTKALSKWENNAREPALHVFLTLCQLL
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DIEDIYESFFGENPYNIMSGLNEEGRNKLIEFADILKASKKFSPLSAKIIPFHHPVEITW
CHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEE
EPVSAGTGNYLEDSVKETYDVGHLAPEQTDFGVRISGDSMEPLYHTDDVAWIQKKDSLAN
ECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEECCCHHHHCCCCCCCC
GEIGIFYLNGNTYIKELHDEPDGVYLISLNQKYRPIQVLESDSFKIFGKVIGKCKGAEIP
CCEEEEEECCCCEEEHHCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCC
GFH
CCC
>Mature Secondary Structure
MRDFGEILAENRKKKGYSQSDLVNLLSQEGIQVTTKALSKWENNAREPALHVFLTLCQLL
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DIEDIYESFFGENPYNIMSGLNEEGRNKLIEFADILKASKKFSPLSAKIIPFHHPVEITW
CHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEE
EPVSAGTGNYLEDSVKETYDVGHLAPEQTDFGVRISGDSMEPLYHTDDVAWIQKKDSLAN
ECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEECCCHHHHCCCCCCCC
GEIGIFYLNGNTYIKELHDEPDGVYLISLNQKYRPIQVLESDSFKIFGKVIGKCKGAEIP
CCEEEEEECCCCEEEHHCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHCCCCCCC
GFH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: RecA protein; Single-stranded DNA [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Repressor LexA; H2O [C]

Specific reaction: Repressor LexA + H2O = hydrolyzed repressor LexA [C]

General reaction: Hydrolysis of peptide bonds (serine endopeptidase) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA