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The map label for this gene is vanR [H]

Identifier: 238925846

GI number: 238925846

Start: 3279672

End: 3280418

Strand: Direct

Name: vanR [H]

Synonym: EUBREC_3504

Alternate gene names: 238925846

Gene position: 3279672-3280418 (Clockwise)

Preceding gene: 238925845

Following gene: 238925847

Centisome position: 95.07

GC content: 40.03

Gene sequence:

>747_bases
ATGTTGTATTTGCTATACTTAATTGGAAATATGAGCAAAGGAGTTGAAAATATGTCTGAAAAGATATTGATTATAGATGA
CGAGCAAGATATAGCGGATCTGTTGGAGGTCTACTTGAAAAACGAAAATTACGTCGTTTATAAATTTTACTGTGCAACGG
ATGCCATGTCGTGTATTGAAAGCGGCGACATTGATCTTGCCATTCTGGATATTATGCTCCCGGATATGAACGGCTTTTCA
CTTTGCCAGCTTATCCGAAAGAAATACACTTATCCAATCATAATGCTAACGGCTAAAATTGAGGAAACGGATAAAATAAC
GGGGCTGACATTGGGAGCGGACGATTATGTGACAAAACCCTTTCGCCCACTTGAAGTAGTTGCCAGAGTGAAAGCGCAGT
TAAGACGTTACAAGAAATATTCACCCGGTATCATCACAGAGAAAATTCCATCGGAACTTTCCTATAACAAATTGTGCTTG
AATGTGCAGACCCATGAATGTCTGTTAGACGGGGAACTTGTTTCTCTAACCCCGACAGAATTTTCTATTCTCCACGTCCT
TTTGTCAAGTGCTGGAAATGTTGTAAGCATTGAGGAACTGTTTCATGCGGTTTGGAAAGATGAATACTACTCTAAAAACA
GCAGCACAATTACTGTGCATATCCGGCATCTGCGCGAGAAACTGAACGATACTTCCGATACTCCGCAGTATATTAAAACG
ATTTGGGGTGTCGGCTACAAAATTTAA

Upstream 100 bases:

>100_bases
TAAAAAACTGATATGTAAATTACGTTAGCATTTTGAGTTGCCTAAATTCGAAAGTTAGGAAAATCTTAATAATTTCTCAG
GCAATCCATTGTGAATTTAG

Downstream 100 bases:

>100_bases
GCGAAAGGAGAACGCTATGAAGAGAAAATCAAATTGTTTGGTAACTATTTTATTCTTAATTTATCTGGCACTTCTGGTTT
GGATCATACTGTTCAAACTA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLYLLYLIGNMSKGVENMSEKILIIDDEQDIADLLEVYLKNENYVVYKFYCATDAMSCIESGDIDLAILDIMLPDMNGFS
LCQLIRKKYTYPIIMLTAKIEETDKITGLTLGADDYVTKPFRPLEVVARVKAQLRRYKKYSPGIITEKIPSELSYNKLCL
NVQTHECLLDGELVSLTPTEFSILHVLLSSAGNVVSIEELFHAVWKDEYYSKNSSTITVHIRHLREKLNDTSDTPQYIKT
IWGVGYKI

Sequences:

>Translated_248_residues
MLYLLYLIGNMSKGVENMSEKILIIDDEQDIADLLEVYLKNENYVVYKFYCATDAMSCIESGDIDLAILDIMLPDMNGFS
LCQLIRKKYTYPIIMLTAKIEETDKITGLTLGADDYVTKPFRPLEVVARVKAQLRRYKKYSPGIITEKIPSELSYNKLCL
NVQTHECLLDGELVSLTPTEFSILHVLLSSAGNVVSIEELFHAVWKDEYYSKNSSTITVHIRHLREKLNDTSDTPQYIKT
IWGVGYKI
>Mature_248_residues
MLYLLYLIGNMSKGVENMSEKILIIDDEQDIADLLEVYLKNENYVVYKFYCATDAMSCIESGDIDLAILDIMLPDMNGFS
LCQLIRKKYTYPIIMLTAKIEETDKITGLTLGADDYVTKPFRPLEVVARVKAQLRRYKKYSPGIITEKIPSELSYNKLCL
NVQTHECLLDGELVSLTPTEFSILHVLLSSAGNVVSIEELFHAVWKDEYYSKNSSTITVHIRHLREKLNDTSDTPQYIKT
IWGVGYKI

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.5638766519824, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=35.1931330472103, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=36.9565217391304, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=32.9059829059829, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=36.2445414847162, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=36.7256637168142, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=32.0175438596491, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=33.6206896551724, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=33.4801762114537, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=33.6283185840708, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=33.0434782608696, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=215, Percent_Identity=33.0232558139535, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=31.5789473684211, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.9475982532751, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28356; Mature: 28356

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLLYLIGNMSKGVENMSEKILIIDDEQDIADLLEVYLKNENYVVYKFYCATDAMSCIE
CEEEEEECCCHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHH
SGDIDLAILDIMLPDMNGFSLCQLIRKKYTYPIIMLTAKIEETDKITGLTLGADDYVTKP
CCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEEECCCCCCCCC
FRPLEVVARVKAQLRRYKKYSPGIITEKIPSELSYNKLCLNVQTHECLLDGELVSLTPTE
CHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEEEHHHEEECCCEEEECCCH
FSILHVLLSSAGNVVSIEELFHAVWKDEYYSKNSSTITVHIRHLREKLNDTSDTPQYIKT
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCHHHHHH
IWGVGYKI
HHCCCCCC
>Mature Secondary Structure
MLYLLYLIGNMSKGVENMSEKILIIDDEQDIADLLEVYLKNENYVVYKFYCATDAMSCIE
CEEEEEECCCHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHH
SGDIDLAILDIMLPDMNGFSLCQLIRKKYTYPIIMLTAKIEETDKITGLTLGADDYVTKP
CCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEEEECCCCCCCCC
FRPLEVVARVKAQLRRYKKYSPGIITEKIPSELSYNKLCLNVQTHECLLDGELVSLTPTE
CHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCEEEEEEEHHHEEECCCEEEECCCH
FSILHVLLSSAGNVVSIEELFHAVWKDEYYSKNSSTITVHIRHLREKLNDTSDTPQYIKT
HHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCHHHHHH
IWGVGYKI
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]