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The map label for this gene is cbh [H]

Identifier: 238925181

GI number: 238925181

Start: 2716971

End: 2717978

Strand: Reverse

Name: cbh [H]

Synonym: EUBREC_2835

Alternate gene names: 238925181

Gene position: 2717978-2716971 (Counterclockwise)

Preceding gene: 238925182

Following gene: 238925180

Centisome position: 78.79

GC content: 45.24

Gene sequence:

>1008_bases
ATGTGTACAGCAGCAGTTTATAAAACAAAGGATTTCTATTTTGGAAGAACACTCGACTACGAATTTTCATATGGAGATGA
GATTGCGGTAACACCGCGAAACTATGTGTTTAATTTCAGGCATTCGGGAAAGCTTGAAAACCATTATGCAATCATTGGAA
TGGCACATGTGGCAGGTGACTATCCTCTTTACTATGATGCTATAAATGAAAAGGGGCTCGGTATGGCAGGACTGAATTTC
GTGGGAAATGCAGCGTATGCGGCAGCAGACGAAAACAGCTCATGCGAGAATGGCACATGCGGCATTGCAAAGACAAAGGT
GGCACAGTTTGAGTTTATACCGTGGATACTGTCACTATGCGCTACGGTAGCGGATGCAAAGGAAAAATTAAATCGTATTT
TACTGGTAGATACACCATTTAGCAGTCAGCTTCCGGTTGCACAGCTTCACTGGATTATAGCCGACAAAAATGAGTGCATT
GTGGTGGAGTCGATGGCAGACGGTATGCATGTTTACGACAATCCGGTAGGTGTGCTCACAAACAATCCGCCATTCCCATA
TCAGATGGCTGCACTCAATAATTACAGAGGCTTATCTACAAAGCAGCCTGAAAATACATTTGCACCGGGAGTGGAGCTTA
GTGCATACAGCCGCGGAATGGGAGGACTGGGACTGCCGGGTGATTTATCATCGCAGTCACGCTTTGTACGTGTGGCATTC
ACAAAGCAAAACTCCAAATCGGATGACAGTGAGAATGCAAGTGTGAGCCAGTTCTTCCACATATTAGGCTCTGTGGACCA
GCAGAGAGGTCTGTGCGAGGTGACAGAGGGCAAATATGAGATTACGCTCTACACCTCATGCTGCAACTGCGACAAGGGAA
TCTACTATTACACCACATATGACAATAGCCAGATCACAGCGGTAGACATGAACAGGGAGAATCTTGATGAGAAGCTGCTT
ATCAGATATCCTGTTATTACGGAGGGAAAGATTTGTTGGCAGAATTAG

Upstream 100 bases:

>100_bases
AGGGGCGTGTGGCTTGAAATAATTGCAAATATGATGTATAGTACTCTACAATTTAAGGGATACTGATTAAGTATGGCAGC
ATAACAAGGAGGTCATAATT

Downstream 100 bases:

>100_bases
AGAATCTGTTTGCGTTGCAGGATAAAAATTACAGGGAATTTCATGCGAGGCTTATGCCCAATATTGAAAAAGAACGCATA
ATAGGAATAAGAGTCCCGGT

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MCTAAVYKTKDFYFGRTLDYEFSYGDEIAVTPRNYVFNFRHSGKLENHYAIIGMAHVAGDYPLYYDAINEKGLGMAGLNF
VGNAAYAAADENSSCENGTCGIAKTKVAQFEFIPWILSLCATVADAKEKLNRILLVDTPFSSQLPVAQLHWIIADKNECI
VVESMADGMHVYDNPVGVLTNNPPFPYQMAALNNYRGLSTKQPENTFAPGVELSAYSRGMGGLGLPGDLSSQSRFVRVAF
TKQNSKSDDSENASVSQFFHILGSVDQQRGLCEVTEGKYEITLYTSCCNCDKGIYYYTTYDNSQITAVDMNRENLDEKLL
IRYPVITEGKICWQN

Sequences:

>Translated_335_residues
MCTAAVYKTKDFYFGRTLDYEFSYGDEIAVTPRNYVFNFRHSGKLENHYAIIGMAHVAGDYPLYYDAINEKGLGMAGLNF
VGNAAYAAADENSSCENGTCGIAKTKVAQFEFIPWILSLCATVADAKEKLNRILLVDTPFSSQLPVAQLHWIIADKNECI
VVESMADGMHVYDNPVGVLTNNPPFPYQMAALNNYRGLSTKQPENTFAPGVELSAYSRGMGGLGLPGDLSSQSRFVRVAF
TKQNSKSDDSENASVSQFFHILGSVDQQRGLCEVTEGKYEITLYTSCCNCDKGIYYYTTYDNSQITAVDMNRENLDEKLL
IRYPVITEGKICWQN
>Mature_335_residues
MCTAAVYKTKDFYFGRTLDYEFSYGDEIAVTPRNYVFNFRHSGKLENHYAIIGMAHVAGDYPLYYDAINEKGLGMAGLNF
VGNAAYAAADENSSCENGTCGIAKTKVAQFEFIPWILSLCATVADAKEKLNRILLVDTPFSSQLPVAQLHWIIADKNECI
VVESMADGMHVYDNPVGVLTNNPPFPYQMAALNNYRGLSTKQPENTFAPGVELSAYSRGMGGLGLPGDLSSQSRFVRVAF
TKQNSKSDDSENASVSQFFHILGSVDQQRGLCEVTEGKYEITLYTSCCNCDKGIYYYTTYDNSQITAVDMNRENLDEKLL
IRYPVITEGKICWQN

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 37248; Mature: 37248

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTAAVYKTKDFYFGRTLDYEFSYGDEIAVTPRNYVFNFRHSGKLENHYAIIGMAHVAGD
CCCCEEEECCCEEECEEEEEEECCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEHHCCC
YPLYYDAINEKGLGMAGLNFVGNAAYAAADENSSCENGTCGIAKTKVAQFEFIPWILSLC
CCEEEECCCCCCCCEECCHHCCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHH
ATVADAKEKLNRILLVDTPFSSQLPVAQLHWIIADKNECIVVESMADGMHVYDNPVGVLT
HHHHHHHHHCCEEEEEECCCCCCCCHHHEEEEEECCCCEEEEEECCCCEEEECCCEEEEE
NNPPFPYQMAALNNYRGLSTKQPENTFAPGVELSAYSRGMGGLGLPGDLSSQSRFVRVAF
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEEEEEE
TKQNSKSDDSENASVSQFFHILGSVDQQRGLCEVTEGKYEITLYTSCCNCDKGIYYYTTY
EECCCCCCCCCCCHHHHHHHHHCCCHHHCCCEEEECCEEEEEEEEEECCCCCCEEEEEEE
DNSQITAVDMNRENLDEKLLIRYPVITEGKICWQN
CCCEEEEEECCCCCCCCEEEEEECCEECCEEEECC
>Mature Secondary Structure
MCTAAVYKTKDFYFGRTLDYEFSYGDEIAVTPRNYVFNFRHSGKLENHYAIIGMAHVAGD
CCCCEEEECCCEEECEEEEEEECCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEHHCCC
YPLYYDAINEKGLGMAGLNFVGNAAYAAADENSSCENGTCGIAKTKVAQFEFIPWILSLC
CCEEEECCCCCCCCEECCHHCCCCEEEECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHH
ATVADAKEKLNRILLVDTPFSSQLPVAQLHWIIADKNECIVVESMADGMHVYDNPVGVLT
HHHHHHHHHCCEEEEEECCCCCCCCHHHEEEEEECCCCEEEEEECCCCEEEECCCEEEEE
NNPPFPYQMAALNNYRGLSTKQPENTFAPGVELSAYSRGMGGLGLPGDLSSQSRFVRVAF
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEEEEEE
TKQNSKSDDSENASVSQFFHILGSVDQQRGLCEVTEGKYEITLYTSCCNCDKGIYYYTTY
EECCCCCCCCCCCHHHHHHHHHCCCHHHCCCEEEECCEEEEEEEEEECCCCCCEEEEEEE
DNSQITAVDMNRENLDEKLLIRYPVITEGKICWQN
CCCEEEEEECCCCCCCCEEEEEECCEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476424; 12566566 [H]