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The map label for this gene is dltA [H]

Identifier: 238925015

GI number: 238925015

Start: 2541998

End: 2543644

Strand: Reverse

Name: dltA [H]

Synonym: EUBREC_2666

Alternate gene names: 238925015

Gene position: 2543644-2541998 (Counterclockwise)

Preceding gene: 238925017

Following gene: 238925014

Centisome position: 73.74

GC content: 48.27

Gene sequence:

>1647_bases
ATGAAAAACGTACTGGAGTGGCTTGAGGCCACAGTAGAAAAATACCCTGGCAAGCCTGCATTTTCGGATACTGAATGCAG
CATTACGTTTGCGCAGGTGTATGATATAGCAAGAAATACAGGAGCATATCTGATAGAACAGCTTGGAGTGGACAGAACAC
CTGTTGCAGTATTTGCCGGAAGGAAAATGGTGACACCGGCATACTTCCTGGGAGTGGTATATGCAGGCAGACCGTATGCG
CCGATTGACGCATCGCTTCCTGACAAGAGAATTGAGAAAATTCTTGAAAATCTGTGCCCAAGGGCTATTGTTGCAAACAG
GGAAAGTCTTGAGCATGTGGAGAGCATAGTGGATGAGCTAGTAAAGGCAGAAGGCTTCGATAGACCGCAGATATTTATTG
CTGAGGATATATCGCGCTTCGAGCAGGTGGCGTGTGCTGATAGTAATTGTAAAATCGGTGAATCAGCAGGAGACGCTGTG
ACGGATAGTGAGAACGATACAGATGGTGGTGTTGTGGCAGGCTGTGCAGGAAAAACAGATGACAGCTTACTGGAGAAGCT
CGCAGCAGTCCGCAGGCAGATGTCCATGACAGACCCGCTGTATATCATCTACACGTCAGGCTCCACCGGCAATCCAAAGG
GAGTCATGACATCGCATCTGTCACTTATGACGTACATCAACGCTTACTGTGATGTAATGCATATAGAGGAAAGTGATGTG
CTGGGCAATCAGTCGCCGCTTGACTATATTGCGGCAATCAGGGACATTTATCTGCCGCTAAAGACCGGCTGCAGCACAGC
TATTATCCCGAAAGAGTACTTTATGGAGCCAAATGCCCTGTTTGATTACATGAATGATAAGAAGGTCAGCAGTGTCGGCT
GGAGTGTTTCGGCATTTACCATCCTCACATCGCTTGGAGCATTTGAGGAAGTAGGGCTTAAGAGTCTTAGAAAAATCTGC
TTCTCAGGCTCAGTGATGCCGTGCAGGGTGCTCAGAAAATGGCAGGAAAATCTGCCTGAAGCACATTTTGTGAACCAGTA
TGGACCGACAGAGGCCACAGCATCATGCACATACTATAGCGTGGATCATACAGTGGAAGAGGACGAGGTGCTTCCTATAG
GAAAAGCCTATGACAATTACAGGGTTTTCCTGATAGATGAGCATGGAAATGAGCCGGCTGTCGGAGAACAGGGCGAGATA
TGCGTATGTGGACCAATCCTGGCGCTGGGTTATTATAATGATCCGGAGAGGACAGCTGCGGCATTTACACTCAATCCACT
CAACAAGGCTTATCCTGAGCGGATGTACCGCACAGGGGATTACGGAAGGCTCGATGAGGACGACATACTTCATTTCTGTG
GACGTATGGACCGCCAGATAAAGCACATGGGACACCGTGTGGAGCTTGATGAGGTGGAGCATGCCGCCAATGTGGTAGAG
GGAGTCGCAGAAAGCTGCGTTATATATAATAAAGCAAAAGAGGTGCTGATACTTTTCTACACAGGTGACTGTGACAGGAG
AAGCCTCGCGCTGGCGCTGAGGGACGAGCTCCCGGGCTTTATGGTGCCAAGGAAAATCAAGAAGCTGGAGCAGCTTCCTA
AGCTTCCAAACGGAAAATATGATATGAAAAAACTGGAGGAAATGTAA

Upstream 100 bases:

>100_bases
TCTTAAGAATTCTTAATTCGATAGCACATGACATTTTTTTCGGATGTTATGTGCTATAATTTTTTCGGCAACGTTTATTA
ATGCATGAAAGAGGACTAAG

Downstream 100 bases:

>100_bases
AATGAGAGACACAATTTTAGAGATTTTAGAGGAATTAAGACCGGATGTGGATTTTGAGAAGGAGACAAAGCTGATCGATG
ACAAGATTCTTGAGTCATTT

Product: putative amino acid activating enzyme

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MKNVLEWLEATVEKYPGKPAFSDTECSITFAQVYDIARNTGAYLIEQLGVDRTPVAVFAGRKMVTPAYFLGVVYAGRPYA
PIDASLPDKRIEKILENLCPRAIVANRESLEHVESIVDELVKAEGFDRPQIFIAEDISRFEQVACADSNCKIGESAGDAV
TDSENDTDGGVVAGCAGKTDDSLLEKLAAVRRQMSMTDPLYIIYTSGSTGNPKGVMTSHLSLMTYINAYCDVMHIEESDV
LGNQSPLDYIAAIRDIYLPLKTGCSTAIIPKEYFMEPNALFDYMNDKKVSSVGWSVSAFTILTSLGAFEEVGLKSLRKIC
FSGSVMPCRVLRKWQENLPEAHFVNQYGPTEATASCTYYSVDHTVEEDEVLPIGKAYDNYRVFLIDEHGNEPAVGEQGEI
CVCGPILALGYYNDPERTAAAFTLNPLNKAYPERMYRTGDYGRLDEDDILHFCGRMDRQIKHMGHRVELDEVEHAANVVE
GVAESCVIYNKAKEVLILFYTGDCDRRSLALALRDELPGFMVPRKIKKLEQLPKLPNGKYDMKKLEEM

Sequences:

>Translated_548_residues
MKNVLEWLEATVEKYPGKPAFSDTECSITFAQVYDIARNTGAYLIEQLGVDRTPVAVFAGRKMVTPAYFLGVVYAGRPYA
PIDASLPDKRIEKILENLCPRAIVANRESLEHVESIVDELVKAEGFDRPQIFIAEDISRFEQVACADSNCKIGESAGDAV
TDSENDTDGGVVAGCAGKTDDSLLEKLAAVRRQMSMTDPLYIIYTSGSTGNPKGVMTSHLSLMTYINAYCDVMHIEESDV
LGNQSPLDYIAAIRDIYLPLKTGCSTAIIPKEYFMEPNALFDYMNDKKVSSVGWSVSAFTILTSLGAFEEVGLKSLRKIC
FSGSVMPCRVLRKWQENLPEAHFVNQYGPTEATASCTYYSVDHTVEEDEVLPIGKAYDNYRVFLIDEHGNEPAVGEQGEI
CVCGPILALGYYNDPERTAAAFTLNPLNKAYPERMYRTGDYGRLDEDDILHFCGRMDRQIKHMGHRVELDEVEHAANVVE
GVAESCVIYNKAKEVLILFYTGDCDRRSLALALRDELPGFMVPRKIKKLEQLPKLPNGKYDMKKLEEM
>Mature_548_residues
MKNVLEWLEATVEKYPGKPAFSDTECSITFAQVYDIARNTGAYLIEQLGVDRTPVAVFAGRKMVTPAYFLGVVYAGRPYA
PIDASLPDKRIEKILENLCPRAIVANRESLEHVESIVDELVKAEGFDRPQIFIAEDISRFEQVACADSNCKIGESAGDAV
TDSENDTDGGVVAGCAGKTDDSLLEKLAAVRRQMSMTDPLYIIYTSGSTGNPKGVMTSHLSLMTYINAYCDVMHIEESDV
LGNQSPLDYIAAIRDIYLPLKTGCSTAIIPKEYFMEPNALFDYMNDKKVSSVGWSVSAFTILTSLGAFEEVGLKSLRKIC
FSGSVMPCRVLRKWQENLPEAHFVNQYGPTEATASCTYYSVDHTVEEDEVLPIGKAYDNYRVFLIDEHGNEPAVGEQGEI
CVCGPILALGYYNDPERTAAAFTLNPLNKAYPERMYRTGDYGRLDEDDILHFCGRMDRQIKHMGHRVELDEVEHAANVVE
GVAESCVIYNKAKEVLILFYTGDCDRRSLALALRDELPGFMVPRKIKKLEQLPKLPNGKYDMKKLEEM

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=511, Percent_Identity=23.091976516634, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI115511026, Length=372, Percent_Identity=26.8817204301075, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI38505220, Length=370, Percent_Identity=24.8648648648649, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI122937307, Length=365, Percent_Identity=26.5753424657534, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI42544132, Length=371, Percent_Identity=23.989218328841, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI157311624, Length=374, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI157311622, Length=374, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI58082049, Length=370, Percent_Identity=25.1351351351351, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI156151445, Length=387, Percent_Identity=21.9638242894057, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786801, Length=555, Percent_Identity=25.2252252252252, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788107, Length=582, Percent_Identity=22.1649484536082, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI145693145, Length=354, Percent_Identity=23.4463276836158, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789201, Length=377, Percent_Identity=25.9946949602122, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32564422, Length=348, Percent_Identity=24.7126436781609, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI32564420, Length=348, Percent_Identity=24.7126436781609, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17560308, Length=306, Percent_Identity=22.8758169934641, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17556356, Length=210, Percent_Identity=29.0476190476191, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=291, Percent_Identity=27.4914089347079, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994703, Length=376, Percent_Identity=22.0744680851064, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994694, Length=376, Percent_Identity=22.0744680851064, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994690, Length=376, Percent_Identity=22.0744680851064, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=394, Percent_Identity=26.1421319796954, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983001, Length=394, Percent_Identity=26.1421319796954, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=596, Percent_Identity=23.8255033557047, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24648676, Length=378, Percent_Identity=30.4232804232804, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI20130357, Length=288, Percent_Identity=25.6944444444444, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281365686, Length=307, Percent_Identity=25.0814332247557, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24581924, Length=381, Percent_Identity=23.3595800524934, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24656500, Length=297, Percent_Identity=26.9360269360269, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356947, Length=294, Percent_Identity=26.8707482993197, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648257, Length=381, Percent_Identity=25.4593175853018, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922652, Length=296, Percent_Identity=25.6756756756757, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076582, Length=296, Percent_Identity=24.3243243243243, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 61046; Mature: 61046

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVLEWLEATVEKYPGKPAFSDTECSITFAQVYDIARNTGAYLIEQLGVDRTPVAVFAG
CCHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHCHHHHHHHHHCCCCCCEEEECC
RKMVTPAYFLGVVYAGRPYAPIDASLPDKRIEKILENLCPRAIVANRESLEHVESIVDEL
CCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHH
VKAEGFDRPQIFIAEDISRFEQVACADSNCKIGESAGDAVTDSENDTDGGVVAGCAGKTD
HHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCH
DSLLEKLAAVRRQMSMTDPLYIIYTSGSTGNPKGVMTSHLSLMTYINAYCDVMHIEESDV
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCHHC
LGNQSPLDYIAAIRDIYLPLKTGCSTAIIPKEYFMEPNALFDYMNDKKVSSVGWSVSAFT
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCHHHHHHCCCCHHHHCCCCHHHHH
ILTSLGAFEEVGLKSLRKICFSGSVMPCRVLRKWQENLPEAHFVNQYGPTEATASCTYYS
HHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEE
VDHTVEEDEVLPIGKAYDNYRVFLIDEHGNEPAVGEQGEICVCGPILALGYYNDPERTAA
ECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEECHHHHCCCCCCCCCCEE
AFTLNPLNKAYPERMYRTGDYGRLDEDDILHFCGRMDRQIKHMGHRVELDEVEHAANVVE
EEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVAESCVIYNKAKEVLILFYTGDCDRRSLALALRDELPGFMVPRKIKKLEQLPKLPNGKY
HHHHHHHHEECCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCC
DMKKLEEM
HHHHHHCC
>Mature Secondary Structure
MKNVLEWLEATVEKYPGKPAFSDTECSITFAQVYDIARNTGAYLIEQLGVDRTPVAVFAG
CCHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHCHHHHHHHHHCCCCCCEEEECC
RKMVTPAYFLGVVYAGRPYAPIDASLPDKRIEKILENLCPRAIVANRESLEHVESIVDEL
CCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHH
VKAEGFDRPQIFIAEDISRFEQVACADSNCKIGESAGDAVTDSENDTDGGVVAGCAGKTD
HHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCH
DSLLEKLAAVRRQMSMTDPLYIIYTSGSTGNPKGVMTSHLSLMTYINAYCDVMHIEESDV
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCHHC
LGNQSPLDYIAAIRDIYLPLKTGCSTAIIPKEYFMEPNALFDYMNDKKVSSVGWSVSAFT
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCHHHHHHCCCCHHHHCCCCHHHHH
ILTSLGAFEEVGLKSLRKICFSGSVMPCRVLRKWQENLPEAHFVNQYGPTEATASCTYYS
HHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEE
VDHTVEEDEVLPIGKAYDNYRVFLIDEHGNEPAVGEQGEICVCGPILALGYYNDPERTAA
ECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEECHHHHCCCCCCCCCCEE
AFTLNPLNKAYPERMYRTGDYGRLDEDDILHFCGRMDRQIKHMGHRVELDEVEHAANVVE
EEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GVAESCVIYNKAKEVLILFYTGDCDRRSLALALRDELPGFMVPRKIKKLEQLPKLPNGKY
HHHHHHHHEECCCEEEEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCC
DMKKLEEM
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377; 7797557 [H]