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The map label for this gene is pgcA [H]

Identifier: 238924964

GI number: 238924964

Start: 2491559

End: 2493289

Strand: Reverse

Name: pgcA [H]

Synonym: EUBREC_2615

Alternate gene names: 238924964

Gene position: 2493289-2491559 (Counterclockwise)

Preceding gene: 238924965

Following gene: 238924963

Centisome position: 72.28

GC content: 45.41

Gene sequence:

>1731_bases
ATGGATTTTAGAGCGGAGTACGAGAAATGGTGTACAGACCCATATTTTGATGAGGCTACAAAGGCAGAGCTTAAGGCTAT
CGCGGGTGATGATAAGGAGATAGAGGACAGATTCTATCGCACACTTGAGTTTGGTACAGCAGGTCTTCGTGGTGTAATAG
GAGCCGGCACCAACAGGATGAATATATACACAGTCCGTCAGGCTACACAGGGATTGGCGAATTACATACTTTCACAGGGA
GAGGACGCAGTAAAGAGAGGTGTTGCAATCGCACATGACTCACGTAATATGCATGATGAGTTCACAGATGCCACAGCACT
CTGTCTTGCAGCTAACGGAATCAAGACATATGTATTCCCACAGCTCGCACCTGTTCCTGAGCTGTCATACGCAGTAAGGA
CACTCGGTACAATAGCCGGTGTTGTTATCACAGCAAGCCACAATCCTCGTGAGTACAATGGATACAAGGTATACTGGGAG
GATGGTGCACAGGTTACTCCACCTCATGATACAAGCATCATGGCTGAGGTGGCAAAGGTTACATCATTTGACCAGGTAAA
GACTATGGACAAAGCTGCTGCTATTGAGGCTGGTCTTTACAATGTCATCTCTGATGAGGTTGAGGAGGGATATTTCGGAG
AGCTCCGCAAGCTTTCTATCCATCCAGAGATTATCAAGGCTATGGCAAAGGATATCAAGATCGTTTACACACCACTCCAC
GGCACAGGTCTTCGCCCTGTACAGAGAGTACTTAAGGATATGGGCTTTGAGAATGTATACATTGAGCCAAGCCAGGCAGT
GCCTGATGGCAATTTCCCTACATGTCCTTATCCAAATCCTGAGAATCCTGATGCATGGAAGCTTGCACTTGAGCTGGCAA
AGGAAAAGGATGCTGATATCGTTTTAGCAACTGACCCTGATGCCGACAGACTCGGTGTATACTGCAAGGATACAAAGACA
GGTGAGTATGTGACATTTACAGGAAATATGTCAGCTATGCTTATCGGTGAGTATATTTTAAGCCAGAAGAGTGCCAATGG
TACTCTGCCTGAGAATCCTGCATTTGTTGAGTCAATTGTTTCTACAGATATGGGTAAGGCAATTGCGGCAGCATATGGCG
TAAAGCATATCGAGGTTTTAACAGGTTTCAAGTATATCGGAGAGCAGATGCTCAAATTTGAAAAAACCGGCTGCAACAAT
TATGTATTCGGTATGGAGGAGAGCTACGGATGTCTGCCGGGCACATATGCAAGGGACAAGGATGCTCCTGCAGCAGTTTG
TATGCTGTGTGAGGTGGCTGCCTTCTACAAGTCACAGGGCAAGACTCTCTGGGATGGCATGATTGACATGTACGAGAAGT
ATGGCTACTACAGAGAGGGCATTTCCACAATGACCTTAAAGGGCATTGATGGTGCTGCACAGATAAATGAGATTATGACA
AAGGCACGTGCCGCTGAGCCAAAGAAATTTGGTGATTATCAGGTGATTGCTATCCGTGATTACAAGAATGACACAAGAAA
AGATATGACAACAGGAAAGGTTGAGCCGACAGGTCTTCCTTCTTCTAATGTACTTTACTACGAACTTAACGATAACGCTT
GGTGCTGTGTACGCCCTTCTGGTACAGAGCCTAAGATTAAATTCTATTTCGGAGTTAAAGGAGTGTCTCTTGAAGATTCA
CAGGCTAAGCTTGATGCTTTGTCAGCTGAGGTTCTCGGACAGTTTGAATAA

Upstream 100 bases:

>100_bases
ATTAAGGAACTAAAACTTTTCAAATGCACGTTAATGTGGTAAAATCGGTATAGTTAACATTAATAGGCTTATTACTAGCT
GACACAGGAGGTTAATATAA

Downstream 100 bases:

>100_bases
AGACTATGATGAAAATATACATTTGCCCGGATTGTGGCTGGATACGGATGGTTTCAAGAAGGAAAGAGGTTGAATGCTTC
AAGTGTGGCAGGCCGCAGAT

Product: putative phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MDFRAEYEKWCTDPYFDEATKAELKAIAGDDKEIEDRFYRTLEFGTAGLRGVIGAGTNRMNIYTVRQATQGLANYILSQG
EDAVKRGVAIAHDSRNMHDEFTDATALCLAANGIKTYVFPQLAPVPELSYAVRTLGTIAGVVITASHNPREYNGYKVYWE
DGAQVTPPHDTSIMAEVAKVTSFDQVKTMDKAAAIEAGLYNVISDEVEEGYFGELRKLSIHPEIIKAMAKDIKIVYTPLH
GTGLRPVQRVLKDMGFENVYIEPSQAVPDGNFPTCPYPNPENPDAWKLALELAKEKDADIVLATDPDADRLGVYCKDTKT
GEYVTFTGNMSAMLIGEYILSQKSANGTLPENPAFVESIVSTDMGKAIAAAYGVKHIEVLTGFKYIGEQMLKFEKTGCNN
YVFGMEESYGCLPGTYARDKDAPAAVCMLCEVAAFYKSQGKTLWDGMIDMYEKYGYYREGISTMTLKGIDGAAQINEIMT
KARAAEPKKFGDYQVIAIRDYKNDTRKDMTTGKVEPTGLPSSNVLYYELNDNAWCCVRPSGTEPKIKFYFGVKGVSLEDS
QAKLDALSAEVLGQFE

Sequences:

>Translated_576_residues
MDFRAEYEKWCTDPYFDEATKAELKAIAGDDKEIEDRFYRTLEFGTAGLRGVIGAGTNRMNIYTVRQATQGLANYILSQG
EDAVKRGVAIAHDSRNMHDEFTDATALCLAANGIKTYVFPQLAPVPELSYAVRTLGTIAGVVITASHNPREYNGYKVYWE
DGAQVTPPHDTSIMAEVAKVTSFDQVKTMDKAAAIEAGLYNVISDEVEEGYFGELRKLSIHPEIIKAMAKDIKIVYTPLH
GTGLRPVQRVLKDMGFENVYIEPSQAVPDGNFPTCPYPNPENPDAWKLALELAKEKDADIVLATDPDADRLGVYCKDTKT
GEYVTFTGNMSAMLIGEYILSQKSANGTLPENPAFVESIVSTDMGKAIAAAYGVKHIEVLTGFKYIGEQMLKFEKTGCNN
YVFGMEESYGCLPGTYARDKDAPAAVCMLCEVAAFYKSQGKTLWDGMIDMYEKYGYYREGISTMTLKGIDGAAQINEIMT
KARAAEPKKFGDYQVIAIRDYKNDTRKDMTTGKVEPTGLPSSNVLYYELNDNAWCCVRPSGTEPKIKFYFGVKGVSLEDS
QAKLDALSAEVLGQFE
>Mature_576_residues
MDFRAEYEKWCTDPYFDEATKAELKAIAGDDKEIEDRFYRTLEFGTAGLRGVIGAGTNRMNIYTVRQATQGLANYILSQG
EDAVKRGVAIAHDSRNMHDEFTDATALCLAANGIKTYVFPQLAPVPELSYAVRTLGTIAGVVITASHNPREYNGYKVYWE
DGAQVTPPHDTSIMAEVAKVTSFDQVKTMDKAAAIEAGLYNVISDEVEEGYFGELRKLSIHPEIIKAMAKDIKIVYTPLH
GTGLRPVQRVLKDMGFENVYIEPSQAVPDGNFPTCPYPNPENPDAWKLALELAKEKDADIVLATDPDADRLGVYCKDTKT
GEYVTFTGNMSAMLIGEYILSQKSANGTLPENPAFVESIVSTDMGKAIAAAYGVKHIEVLTGFKYIGEQMLKFEKTGCNN
YVFGMEESYGCLPGTYARDKDAPAAVCMLCEVAAFYKSQGKTLWDGMIDMYEKYGYYREGISTMTLKGIDGAAQINEIMT
KARAAEPKKFGDYQVIAIRDYKNDTRKDMTTGKVEPTGLPSSNVLYYELNDNAWCCVRPSGTEPKIKFYFGVKGVSLEDS
QAKLDALSAEVLGQFE

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=560, Percent_Identity=32.8571428571429, Blast_Score=269, Evalue=6e-72,
Organism=Homo sapiens, GI63055049, Length=562, Percent_Identity=31.8505338078292, Blast_Score=265, Evalue=7e-71,
Organism=Caenorhabditis elegans, GI71993870, Length=557, Percent_Identity=33.0341113105925, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71993878, Length=282, Percent_Identity=36.1702127659575, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323934, Length=582, Percent_Identity=33.1615120274914, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI20129809, Length=553, Percent_Identity=31.1030741410488, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24651977, Length=509, Percent_Identity=30.8447937131631, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24653722, Length=585, Percent_Identity=27.3504273504274, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63628; Mature: 63628

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRAEYEKWCTDPYFDEATKAELKAIAGDDKEIEDRFYRTLEFGTAGLRGVIGAGTNRM
CCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCE
NIYTVRQATQGLANYILSQGEDAVKRGVAIAHDSRNMHDEFTDATALCLAANGIKTYVFP
EEEEHHHHHHHHHHHHHHCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECC
QLAPVPELSYAVRTLGTIAGVVITASHNPREYNGYKVYWEDGAQVTPPHDTSIMAEVAKV
CCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEECCCCEECCCCCHHHHHHHHHH
TSFDQVKTMDKAAAIEAGLYNVISDEVEEGYFGELRKLSIHPEIIKAMAKDIKIVYTPLH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHCCCEEEEECCC
GTGLRPVQRVLKDMGFENVYIEPSQAVPDGNFPTCPYPNPENPDAWKLALELAKEKDADI
CCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VLATDPDADRLGVYCKDTKTGEYVTFTGNMSAMLIGEYILSQKSANGTLPENPAFVESIV
EEEECCCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
STDMGKAIAAAYGVKHIEVLTGFKYIGEQMLKFEKTGCNNYVFGMEESYGCLPGTYARDK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCC
DAPAAVCMLCEVAAFYKSQGKTLWDGMIDMYEKYGYYREGISTMTLKGIDGAAQINEIMT
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCEEEEECCCCHHHHHHHHH
KARAAEPKKFGDYQVIAIRDYKNDTRKDMTTGKVEPTGLPSSNVLYYELNDNAWCCVRPS
HHHCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCC
GTEPKIKFYFGVKGVSLEDSQAKLDALSAEVLGQFE
CCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDFRAEYEKWCTDPYFDEATKAELKAIAGDDKEIEDRFYRTLEFGTAGLRGVIGAGTNRM
CCCCCHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHCCCCCCCE
NIYTVRQATQGLANYILSQGEDAVKRGVAIAHDSRNMHDEFTDATALCLAANGIKTYVFP
EEEEHHHHHHHHHHHHHHCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEECC
QLAPVPELSYAVRTLGTIAGVVITASHNPREYNGYKVYWEDGAQVTPPHDTSIMAEVAKV
CCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEECCCCEECCCCCHHHHHHHHHH
TSFDQVKTMDKAAAIEAGLYNVISDEVEEGYFGELRKLSIHPEIIKAMAKDIKIVYTPLH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHCCCEEEEECCC
GTGLRPVQRVLKDMGFENVYIEPSQAVPDGNFPTCPYPNPENPDAWKLALELAKEKDADI
CCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCE
VLATDPDADRLGVYCKDTKTGEYVTFTGNMSAMLIGEYILSQKSANGTLPENPAFVESIV
EEEECCCCCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
STDMGKAIAAAYGVKHIEVLTGFKYIGEQMLKFEKTGCNNYVFGMEESYGCLPGTYARDK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCC
DAPAAVCMLCEVAAFYKSQGKTLWDGMIDMYEKYGYYREGISTMTLKGIDGAAQINEIMT
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCEEEEECCCCHHHHHHHHH
KARAAEPKKFGDYQVIAIRDYKNDTRKDMTTGKVEPTGLPSSNVLYYELNDNAWCCVRPS
HHHCCCCCCCCCEEEEEEECCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCCEEEEECCC
GTEPKIKFYFGVKGVSLEDSQAKLDALSAEVLGQFE
CCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]