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The map label for this gene is Hgd [H]

Identifier: 238924944

GI number: 238924944

Start: 2469689

End: 2470552

Strand: Reverse

Name: Hgd [H]

Synonym: EUBREC_2595

Alternate gene names: 238924944

Gene position: 2470552-2469689 (Counterclockwise)

Preceding gene: 238924945

Following gene: 238924943

Centisome position: 71.62

GC content: 41.55

Gene sequence:

>864_bases
ATGAAAATTGGATTTGTAGGACTCGGAATCATGGGGGAGTCCATGAGTGAGAATATAGTGAAGAAGCATGATGATGAGGT
ATATGTATTTGATTTCGTAAAGGAGAAGGTAGAGCTATTGGAGAGCAAGGGTGCAATCGGCTGCAGCAGTTCGCTTAAGC
TGGCAGAAAAATCAGACGTAATTATATCAATGGTTCCAAAGTCAGAGCATTCGATGGCTGTTTATAAGGAGGTTTTACCG
GCACTTGATGATACAAAGCTCTGTATTGATATGAGCACGATAGATCCATCTGTTTCTGTGGAGATTTCTGAAATGGTAAA
GAAGACGGGCGCAGAGTTTGTGGACGCACCGGTTGTGAAATCGAAGCCTGCTGCTATTGCAGGAAAGCTCGGAATATATG
TCGGTGGAGATGAAAAAGCATGTGAGAAGGCTATGCCGATTCTTTCCTATATGGGAGAAAATATCATCAGGATGGGTGGA
AACGGAAAAGGTCTGGTCATGAAAATCTGCCATAACGCGCTTGTATCACAGATTCAAAATGGTGTAAATGAGACACTGAC
ACTTGCAAGGGCATATGGAATAGATATAGAAAGCTATACTACAGCTATCTCATATGGCGGTGGACAGAACTTTTATCTGG
ATTCCAAAAATGTGCCAATCAAAAATGAGGATTACACCACTGCCTTTTCGATTGAAAACATGTACAAGGATGTGAATATC
TGCATGAATATGGCAAAGGAGAGTGGATTAAAGCTTCAAGGAGAAAACGCTGCAAAGCAGGTATATGACAAGGCAATGGA
ACTTGGCTTTGGAAAAGAAGATTTCTGCGCTACTATAAAGGCTGTCAAGGCAATGCAAAGATAA

Upstream 100 bases:

>100_bases
GTATCAAACATGCATATACCAGACAGGGACTTGAGACATTCCAGAATGCATGGGATAATACAGTTACAGAATAGATGAAA
CAGGGAGGTGTTTGTAGGCA

Downstream 100 bases:

>100_bases
GTGGGGGAAATATGTTAAAACATTTGAATGAAAAAAATTCTGTGACTATATACAGTGTCACTGATCCATGTTTTGAAACC
TACGGAAGGGTGATTTCAAA

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MKIGFVGLGIMGESMSENIVKKHDDEVYVFDFVKEKVELLESKGAIGCSSSLKLAEKSDVIISMVPKSEHSMAVYKEVLP
ALDDTKLCIDMSTIDPSVSVEISEMVKKTGAEFVDAPVVKSKPAAIAGKLGIYVGGDEKACEKAMPILSYMGENIIRMGG
NGKGLVMKICHNALVSQIQNGVNETLTLARAYGIDIESYTTAISYGGGQNFYLDSKNVPIKNEDYTTAFSIENMYKDVNI
CMNMAKESGLKLQGENAAKQVYDKAMELGFGKEDFCATIKAVKAMQR

Sequences:

>Translated_287_residues
MKIGFVGLGIMGESMSENIVKKHDDEVYVFDFVKEKVELLESKGAIGCSSSLKLAEKSDVIISMVPKSEHSMAVYKEVLP
ALDDTKLCIDMSTIDPSVSVEISEMVKKTGAEFVDAPVVKSKPAAIAGKLGIYVGGDEKACEKAMPILSYMGENIIRMGG
NGKGLVMKICHNALVSQIQNGVNETLTLARAYGIDIESYTTAISYGGGQNFYLDSKNVPIKNEDYTTAFSIENMYKDVNI
CMNMAKESGLKLQGENAAKQVYDKAMELGFGKEDFCATIKAVKAMQR
>Mature_287_residues
MKIGFVGLGIMGESMSENIVKKHDDEVYVFDFVKEKVELLESKGAIGCSSSLKLAEKSDVIISMVPKSEHSMAVYKEVLP
ALDDTKLCIDMSTIDPSVSVEISEMVKKTGAEFVDAPVVKSKPAAIAGKLGIYVGGDEKACEKAMPILSYMGENIIRMGG
NGKGLVMKICHNALVSQIQNGVNETLTLARAYGIDIESYTTAISYGGGQNFYLDSKNVPIKNEDYTTAFSIENMYKDVNI
CMNMAKESGLKLQGENAAKQVYDKAMELGFGKEDFCATIKAVKAMQR

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=31.1643835616438, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI40556376, Length=283, Percent_Identity=25.0883392226148, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI145693186, Length=280, Percent_Identity=31.7857142857143, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790315, Length=285, Percent_Identity=28.4210526315789, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1786719, Length=293, Percent_Identity=30.0341296928328, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=24.9122807017544, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557316, Length=270, Percent_Identity=30.3703703703704, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24655230, Length=281, Percent_Identity=31.3167259786477, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922568, Length=281, Percent_Identity=31.3167259786477, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=23.2142857142857, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 31183; Mature: 31183

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFVGLGIMGESMSENIVKKHDDEVYVFDFVKEKVELLESKGAIGCSSSLKLAEKSDV
CEEEEEEECCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
IISMVPKSEHSMAVYKEVLPALDDTKLCIDMSTIDPSVSVEISEMVKKTGAEFVDAPVVK
EEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEHHHHHHHHCCHHHCCCCCC
SKPAAIAGKLGIYVGGDEKACEKAMPILSYMGENIIRMGGNGKGLVMKICHNALVSQIQN
CCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
GVNETLTLARAYGIDIESYTTAISYGGGQNFYLDSKNVPIKNEDYTTAFSIENMYKDVNI
CHHHHHHHHHHHCCCHHHHHEEEECCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHHH
CMNMAKESGLKLQGENAAKQVYDKAMELGFGKEDFCATIKAVKAMQR
HHHHHHHCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGFVGLGIMGESMSENIVKKHDDEVYVFDFVKEKVELLESKGAIGCSSSLKLAEKSDV
CEEEEEEECCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
IISMVPKSEHSMAVYKEVLPALDDTKLCIDMSTIDPSVSVEISEMVKKTGAEFVDAPVVK
EEEECCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEEHHHHHHHHCCHHHCCCCCC
SKPAAIAGKLGIYVGGDEKACEKAMPILSYMGENIIRMGGNGKGLVMKICHNALVSQIQN
CCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
GVNETLTLARAYGIDIESYTTAISYGGGQNFYLDSKNVPIKNEDYTTAFSIENMYKDVNI
CHHHHHHHHHHHCCCHHHHHEEEECCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHHH
CMNMAKESGLKLQGENAAKQVYDKAMELGFGKEDFCATIKAVKAMQR
HHHHHHHCCCEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA