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The map label for this gene is xpt

Identifier: 238924125

GI number: 238924125

Start: 1640268

End: 1640846

Strand: Direct

Name: xpt

Synonym: EUBREC_1763

Alternate gene names: 238924125

Gene position: 1640268-1640846 (Clockwise)

Preceding gene: 238924124

Following gene: 238924179

Centisome position: 47.55

GC content: 41.28

Gene sequence:

>579_bases
ATGAAAGAACTGCAAGATCGAATTCTCAAGGATGGCCAGGTTATTGGCACAAACATCTTAAAGGTCAACAAATTTATCAA
CCATCAGGTAGATCCGGTGCTTATGGAGCACATCGGTGAGGATTTCGCAAATCACTTTGCCGATAAGGGAATCACAAAGG
TTGTCACAATAGAGAGCTCAGGAATTGCTCCTGCACTTATGGCAGCAGCCAAGATGAATGTACCGCTTGTTATTTTAAAG
AAGCAGCCTTCAAAGACATTACATAATGATTTATATCAGACACAGGTTACTTCATTTACAACAGAGAAGAGCTATGAGCT
TACACTCTCACGCGATGTTATCTCAGAGGATGACAATATTCTTTTGATTGATGATTTCATGGCTGACGGAGAGGCTGCTA
CAGGTGCCATCAGACTTCTTCGTATGGCTCACGCTACAGTTGCCGGTATAGGAATCCTTATTGAGAAGTCATTCCAGCCT
GGCAGAAGAAAAATCAACGAGCAGGGCTATGAGGTTTACTCACTTGCACGTATCAAGTACATGGATGAGTATCAGATAGA
TTTTATTGAAGAAAATTAA

Upstream 100 bases:

>100_bases
TCGATCATATGGTTGAAGAAATTTATTCTAAAATTTATAGTGATATTGTCGAAGAATAGTGCTATAATAATAACAATTTA
TTTTTTATGAGGTGAACAAA

Downstream 100 bases:

>100_bases
AATAAGATTTAATATTTAAGATCAATACATATTATACGCAAAATCCACTACTCTATTTACAGATTTATGAGTCTGTCAAT
GAGTAGTGGATTTTTATTAT

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKELQDRILKDGQVIGTNILKVNKFINHQVDPVLMEHIGEDFANHFADKGITKVVTIESSGIAPALMAAAKMNVPLVILK
KQPSKTLHNDLYQTQVTSFTTEKSYELTLSRDVISEDDNILLIDDFMADGEAATGAIRLLRMAHATVAGIGILIEKSFQP
GRRKINEQGYEVYSLARIKYMDEYQIDFIEEN

Sequences:

>Translated_192_residues
MKELQDRILKDGQVIGTNILKVNKFINHQVDPVLMEHIGEDFANHFADKGITKVVTIESSGIAPALMAAAKMNVPLVILK
KQPSKTLHNDLYQTQVTSFTTEKSYELTLSRDVISEDDNILLIDDFMADGEAATGAIRLLRMAHATVAGIGILIEKSFQP
GRRKINEQGYEVYSLARIKYMDEYQIDFIEEN
>Mature_192_residues
MKELQDRILKDGQVIGTNILKVNKFINHQVDPVLMEHIGEDFANHFADKGITKVVTIESSGIAPALMAAAKMNVPLVILK
KQPSKTLHNDLYQTQVTSFTTEKSYELTLSRDVISEDDNILLIDDFMADGEAATGAIRLLRMAHATVAGIGILIEKSFQP
GRRKINEQGYEVYSLARIKYMDEYQIDFIEEN

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_EUBR3 (C4ZA66)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002937641.1
- ProteinModelPortal:   C4ZA66
- GeneID:   7965319
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_1763
- ProtClustDB:   PRK09219
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 21570; Mature: 21570

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 20-20 BINDING 27-27 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELQDRILKDGQVIGTNILKVNKFINHQVDPVLMEHIGEDFANHFADKGITKVVTIESS
CCHHHHHHHCCCEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GIAPALMAAAKMNVPLVILKKQPSKTLHNDLYQTQVTSFTTEKSYELTLSRDVISEDDNI
CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHEECCCCEEEEEECHHHCCCCCE
LLIDDFMADGEAATGAIRLLRMAHATVAGIGILIEKSFQPGRRKINEQGYEVYSLARIKY
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHCCCEEEEHHHEEE
MDEYQIDFIEEN
CCCCEEEEEECC
>Mature Secondary Structure
MKELQDRILKDGQVIGTNILKVNKFINHQVDPVLMEHIGEDFANHFADKGITKVVTIESS
CCHHHHHHHCCCEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
GIAPALMAAAKMNVPLVILKKQPSKTLHNDLYQTQVTSFTTEKSYELTLSRDVISEDDNI
CCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHEECCCCEEEEEECHHHCCCCCE
LLIDDFMADGEAATGAIRLLRMAHATVAGIGILIEKSFQPGRRKINEQGYEVYSLARIKY
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHCCCEEEEHHHEEE
MDEYQIDFIEEN
CCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA