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The map label for this gene is obg [H]

Identifier: 238924058

GI number: 238924058

Start: 1577978

End: 1579291

Strand: Direct

Name: obg [H]

Synonym: EUBREC_1696

Alternate gene names: 238924058

Gene position: 1577978-1579291 (Clockwise)

Preceding gene: 238924057

Following gene: 238924059

Centisome position: 45.74

GC content: 47.18

Gene sequence:

>1314_bases
ATGCAGACATTCAGCATGAGGTGGAAAATTATGTTTGCAGATCGTGCAAAAATTATCATAAAATCAGGAAAAGGCGGAGA
TGGTCATGTATCATTCCGCCGTGAAAAATACGTGCCGAACGGTGGTCCGGACGGCGGTGACGGTGGAAAAGGCGGAGACG
TTATATTTCTCGTGGATAAGGGAATCAACACCCTGACAGATTATCGTCACAGAAGAAAGTTTGCAGCAGAGCCCGGACAG
GAGGGCGGCAAAAAGAACTGCCACGGAAAGAATGGTGAGGATCTTATACTTAAGGTGCCGGAGGGTACACTCATAAAGGA
TGCAGCAAGCGGAAAGGTCATAGCAGATATGTCCGGTGACAATACAAGGCAGGTGATCCTGCGCGGAGGAAAAGGCGGTC
AGGGCAACCAGCACTATGCCACATCCACCATGCAGGCTCCTAAATATGCACAGCCGGGACAGGATGCAATAGAAATTGAG
GTACAGCTTGAGCTAAAGGTGATAGCGGATGTAGGGCTTGTAGGCTTTCCAAACGTAGGAAAATCAACACTTCTGTCACG
AGTTACCAATGCACAGCCAAAGATTGCCAACTATCATTTCACCACATTACAGCCAAATCTTGGTGTGGTTGATATGGATG
AGGGCTTTGGATTTGTAATTGCTGATATCCCGGGACTTATCGAGGGAGCATCAGAGGGCATCGGACTCGGTCATGAGTTT
TTGCGTCATATAGAGCGTACCAAGGTCATGATACACATGGTTGATGCTGCCGGTACTGAAGGCCGTGATCCGGTTGCTGA
CATCAAGGCGATAAACAAGGAGCTTGAAGCATACAATCCACAGCTTCTCAAAAAGCCACAGGTCATTGCAGCCAACAAAA
TAGATGCCATAGCAGGAGATGAGAATGAGGTGATTTCGGCCTTAAGAGCCGAATTCGAGCCACAGGGCATAAAGGTATTC
CCGATATCCGCAGTAAGCGGTAAGGGCCTTAAGGAGCTTTTGTACGAGGTGAAGAACCTGCTTGCAAATTGTCCAAAAGA
GGTTACTGTATATGAGCCGGAGATTGATCCTGCACTTTCATTCTTTAAGGATGAGCCGTACGCGGTTGAGGTGGCAGCCG
ATGGTGCATATGAGATATCAGGTCCAAAGATTGAGAAAATGCTCGGATATACAAATATGGACTCGGAGAAGGGCTTTGCC
TTTTTCCAGAGATTCTTGCGTGAGCAGGGTATCATCAAGGAGCTTGAAAATATGGGCATCGAGGATGGAGATACTGTCCG
CATGTATGATTTCGAGTTTGATTATTACAAGTAA

Upstream 100 bases:

>100_bases
TATGTTGTAAATTAGCAGGAATATTGATTTATTTATTATTACTGTGTCTTATACAGATATAGCATAGTAATGATTTGTCA
TAAAGTATACTGAGTGTTTT

Downstream 100 bases:

>100_bases
GGAGAAAGAGTATATATGAATTTATCAAGTAAACAGCGTGCATATTTAAGCAGCCTTGCAAGCACAATTAACCCTATTTT
CAATATTGGAAAGGCATCGC

Product: GTP1/OBG subdomain containing protein

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MQTFSMRWKIMFADRAKIIIKSGKGGDGHVSFRREKYVPNGGPDGGDGGKGGDVIFLVDKGINTLTDYRHRRKFAAEPGQ
EGGKKNCHGKNGEDLILKVPEGTLIKDAASGKVIADMSGDNTRQVILRGGKGGQGNQHYATSTMQAPKYAQPGQDAIEIE
VQLELKVIADVGLVGFPNVGKSTLLSRVTNAQPKIANYHFTTLQPNLGVVDMDEGFGFVIADIPGLIEGASEGIGLGHEF
LRHIERTKVMIHMVDAAGTEGRDPVADIKAINKELEAYNPQLLKKPQVIAANKIDAIAGDENEVISALRAEFEPQGIKVF
PISAVSGKGLKELLYEVKNLLANCPKEVTVYEPEIDPALSFFKDEPYAVEVAADGAYEISGPKIEKMLGYTNMDSEKGFA
FFQRFLREQGIIKELENMGIEDGDTVRMYDFEFDYYK

Sequences:

>Translated_437_residues
MQTFSMRWKIMFADRAKIIIKSGKGGDGHVSFRREKYVPNGGPDGGDGGKGGDVIFLVDKGINTLTDYRHRRKFAAEPGQ
EGGKKNCHGKNGEDLILKVPEGTLIKDAASGKVIADMSGDNTRQVILRGGKGGQGNQHYATSTMQAPKYAQPGQDAIEIE
VQLELKVIADVGLVGFPNVGKSTLLSRVTNAQPKIANYHFTTLQPNLGVVDMDEGFGFVIADIPGLIEGASEGIGLGHEF
LRHIERTKVMIHMVDAAGTEGRDPVADIKAINKELEAYNPQLLKKPQVIAANKIDAIAGDENEVISALRAEFEPQGIKVF
PISAVSGKGLKELLYEVKNLLANCPKEVTVYEPEIDPALSFFKDEPYAVEVAADGAYEISGPKIEKMLGYTNMDSEKGFA
FFQRFLREQGIIKELENMGIEDGDTVRMYDFEFDYYK
>Mature_437_residues
MQTFSMRWKIMFADRAKIIIKSGKGGDGHVSFRREKYVPNGGPDGGDGGKGGDVIFLVDKGINTLTDYRHRRKFAAEPGQ
EGGKKNCHGKNGEDLILKVPEGTLIKDAASGKVIADMSGDNTRQVILRGGKGGQGNQHYATSTMQAPKYAQPGQDAIEIE
VQLELKVIADVGLVGFPNVGKSTLLSRVTNAQPKIANYHFTTLQPNLGVVDMDEGFGFVIADIPGLIEGASEGIGLGHEF
LRHIERTKVMIHMVDAAGTEGRDPVADIKAINKELEAYNPQLLKKPQVIAANKIDAIAGDENEVISALRAEFEPQGIKVF
PISAVSGKGLKELLYEVKNLLANCPKEVTVYEPEIDPALSFFKDEPYAVEVAADGAYEISGPKIEKMLGYTNMDSEKGFA
FFQRFLREQGIIKELENMGIEDGDTVRMYDFEFDYYK

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=329, Percent_Identity=40.7294832826748, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI111955139, Length=294, Percent_Identity=37.4149659863946, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI111955063, Length=238, Percent_Identity=36.1344537815126, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI58761500, Length=136, Percent_Identity=35.2941176470588, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=35.5371900826446, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4758796, Length=150, Percent_Identity=35.3333333333333, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789574, Length=334, Percent_Identity=46.1077844311377, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=38.28125, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790615, Length=131, Percent_Identity=28.2442748091603, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=327, Percent_Identity=38.2262996941896, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17552324, Length=326, Percent_Identity=32.5153374233129, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=34.5323741007194, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=38.9830508474576, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=38.135593220339, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=198, Percent_Identity=38.3838383838384, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=36.5079365079365, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI20129375, Length=328, Percent_Identity=39.0243902439024, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24585318, Length=361, Percent_Identity=34.0720221606648, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24640873, Length=138, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640877, Length=138, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640875, Length=138, Percent_Identity=34.7826086956522, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356473, Length=121, Percent_Identity=37.1900826446281, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=38.5826771653543, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 47808; Mature: 47808

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTFSMRWKIMFADRAKIIIKSGKGGDGHVSFRREKYVPNGGPDGGDGGKGGDVIFLVDK
CCCCEEEEEEEEECCEEEEEECCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCEEEEECC
GINTLTDYRHRRKFAAEPGQEGGKKNCHGKNGEDLILKVPEGTLIKDAASGKVIADMSGD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEECCCC
NTRQVILRGGKGGQGNQHYATSTMQAPKYAQPGQDAIEIEVQLELKVIADVGLVGFPNVG
CCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCC
KSTLLSRVTNAQPKIANYHFTTLQPNLGVVDMDEGFGFVIADIPGLIEGASEGIGLGHEF
HHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCCHHHH
LRHIERTKVMIHMVDAAGTEGRDPVADIKAINKELEAYNPQLLKKPQVIAANKIDAIAGD
HHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCEEECCCCCCCCCC
ENEVISALRAEFEPQGIKVFPISAVSGKGLKELLYEVKNLLANCPKEVTVYEPEIDPALS
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
FFKDEPYAVEVAADGAYEISGPKIEKMLGYTNMDSEKGFAFFQRFLREQGIIKELENMGI
HHCCCCEEEEEECCCEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCC
EDGDTVRMYDFEFDYYK
CCCCEEEEEEEECCCCC
>Mature Secondary Structure
MQTFSMRWKIMFADRAKIIIKSGKGGDGHVSFRREKYVPNGGPDGGDGGKGGDVIFLVDK
CCCCEEEEEEEEECCEEEEEECCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCEEEEECC
GINTLTDYRHRRKFAAEPGQEGGKKNCHGKNGEDLILKVPEGTLIKDAASGKVIADMSGD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEECCCC
NTRQVILRGGKGGQGNQHYATSTMQAPKYAQPGQDAIEIEVQLELKVIADVGLVGFPNVG
CCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCCCCCC
KSTLLSRVTNAQPKIANYHFTTLQPNLGVVDMDEGFGFVIADIPGLIEGASEGIGLGHEF
HHHHHHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCCHHHH
LRHIERTKVMIHMVDAAGTEGRDPVADIKAINKELEAYNPQLLKKPQVIAANKIDAIAGD
HHHHHHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCEEECCCCCCCCCC
ENEVISALRAEFEPQGIKVFPISAVSGKGLKELLYEVKNLLANCPKEVTVYEPEIDPALS
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHH
FFKDEPYAVEVAADGAYEISGPKIEKMLGYTNMDSEKGFAFFQRFLREQGIIKELENMGI
HHCCCCEEEEEECCCEEECCCCHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCC
EDGDTVRMYDFEFDYYK
CCCCEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA