Click here to switch to the map view.

The map label for this gene is rnc [H]

Identifier: 238923872

GI number: 238923872

Start: 1379238

End: 1379951

Strand: Direct

Name: rnc [H]

Synonym: EUBREC_1500

Alternate gene names: 238923872

Gene position: 1379238-1379951 (Clockwise)

Preceding gene: 238923871

Following gene: 238923873

Centisome position: 39.98

GC content: 43.84

Gene sequence:

>714_bases
ATGGATAGATATAGAAATAGAGGAAAAATTATGGCAGATTTAAATGAATTTCAAAGCAAAATAGGCTATACGTTCAAGAA
CCGACATCTGCTTGAGCAGGCGCTGACACACAGCTCGTATGCCAATGAAAAGCACATGAAAAAGCATTCTGATAACGAAC
GTCTGGAGTTTTTGGGCGATGCTGTTTTGGAAATAGTTTCAAGTGAGTTTTTGTTTATCAATTATCCGCAAAAGCCTGAG
GGTGAGCTTACCAAGCTGCGCGCAAGCATTGTTTGTGAGCCGACTCTTGCACTTTGTACAAAGCCACTTGACCTTGGAAA
GTACTTACGTCTTGGCAGGGGCGAGGATCATACAGGAGGAAGAAAGAGAAAATCGATTCTTTCTGATGCACTTGAGGCAG
TGATTGGAGCAATTTATTTAGATGGTGGTTTTACTAATGCAAAGGAGTTTGTGCTTAGGTTTATCATGACTGATATTGAG
AATAAGCAGCTCTTTTATGATAGCAAGACTATCCTTCAGGAGCTTATACAGGGCAGACACGAGCAGCTTTCTTATGAACT
TATTGATGAGAGCGGTCCGGACCATGACAAGCAGTTTACAGTTGCGGTGCTTGTGGACGGCGAGCGTGTCAGCGAGGGAG
AAGGCCACACAAAGAAGGCGGCGGAGCAGCAGGCTGCATATCAGGCACTTCTTTTGTACAGAAACAGGGAATAG

Upstream 100 bases:

>100_bases
TTGAGCAGATTAAAAAAGCTGTAAGCGAGCAGTAGTATGTTTAACTAATGAAAAGCCCTTTATTATGAGGGCTTTTCGTT
ATACTCACAGAACATGTAAA

Downstream 100 bases:

>100_bases
GAGTTTTTAATGTATTTAAAGAGTTTGGAAGTACAGGGCTTTAAGTCCTTTGCCAACAAAATTGTTTTTGAGTTCCACAA
CGGCATCACAGGTATTGTAG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MDRYRNRGKIMADLNEFQSKIGYTFKNRHLLEQALTHSSYANEKHMKKHSDNERLEFLGDAVLEIVSSEFLFINYPQKPE
GELTKLRASIVCEPTLALCTKPLDLGKYLRLGRGEDHTGGRKRKSILSDALEAVIGAIYLDGGFTNAKEFVLRFIMTDIE
NKQLFYDSKTILQELIQGRHEQLSYELIDESGPDHDKQFTVAVLVDGERVSEGEGHTKKAAEQQAAYQALLLYRNRE

Sequences:

>Translated_237_residues
MDRYRNRGKIMADLNEFQSKIGYTFKNRHLLEQALTHSSYANEKHMKKHSDNERLEFLGDAVLEIVSSEFLFINYPQKPE
GELTKLRASIVCEPTLALCTKPLDLGKYLRLGRGEDHTGGRKRKSILSDALEAVIGAIYLDGGFTNAKEFVLRFIMTDIE
NKQLFYDSKTILQELIQGRHEQLSYELIDESGPDHDKQFTVAVLVDGERVSEGEGHTKKAAEQQAAYQALLLYRNRE
>Mature_237_residues
MDRYRNRGKIMADLNEFQSKIGYTFKNRHLLEQALTHSSYANEKHMKKHSDNERLEFLGDAVLEIVSSEFLFINYPQKPE
GELTKLRASIVCEPTLALCTKPLDLGKYLRLGRGEDHTGGRKRKSILSDALEAVIGAIYLDGGFTNAKEFVLRFIMTDIE
NKQLFYDSKTILQELIQGRHEQLSYELIDESGPDHDKQFTVAVLVDGERVSEGEGHTKKAAEQQAAYQALLLYRNRE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=244, Percent_Identity=31.1475409836066, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI155030234, Length=244, Percent_Identity=31.1475409836066, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788920, Length=200, Percent_Identity=41.5, Blast_Score=144, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=29.3103448275862, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=29.3103448275862, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17137682, Length=240, Percent_Identity=31.25, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27099; Mature: 27099

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRYRNRGKIMADLNEFQSKIGYTFKNRHLLEQALTHSSYANEKHMKKHSDNERLEFLGD
CCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHH
AVLEIVSSEFLFINYPQKPEGELTKLRASIVCEPTLALCTKPLDLGKYLRLGRGEDHTGG
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHCCCCCCCCCC
RKRKSILSDALEAVIGAIYLDGGFTNAKEFVLRFIMTDIENKQLFYDSKTILQELIQGRH
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCHH
EQLSYELIDESGPDHDKQFTVAVLVDGERVSEGEGHTKKAAEQQAAYQALLLYRNRE
HHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDRYRNRGKIMADLNEFQSKIGYTFKNRHLLEQALTHSSYANEKHMKKHSDNERLEFLGD
CCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHH
AVLEIVSSEFLFINYPQKPEGELTKLRASIVCEPTLALCTKPLDLGKYLRLGRGEDHTGG
HHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCHHHHHCCCCHHHHHHHCCCCCCCCCC
RKRKSILSDALEAVIGAIYLDGGFTNAKEFVLRFIMTDIENKQLFYDSKTILQELIQGRH
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHCHH
EQLSYELIDESGPDHDKQFTVAVLVDGERVSEGEGHTKKAAEQQAAYQALLLYRNRE
HHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA