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The map label for this gene is tabA [H]

Identifier: 238923829

GI number: 238923829

Start: 1335143

End: 1336411

Strand: Direct

Name: tabA [H]

Synonym: EUBREC_1457

Alternate gene names: 238923829

Gene position: 1335143-1336411 (Clockwise)

Preceding gene: 238923827

Following gene: 238923831

Centisome position: 38.7

GC content: 43.66

Gene sequence:

>1269_bases
ATGAAAAAGACACCATTTGTGACAAAACAACAGGTAGAGGAGATTGTTAAACAATTTCCTACACCATTTCATTTATATGA
CGAGGCTGGCATCCGTGCCAACGCGCAGGCTGTAAAGGATGCATTTGCATGGAATCCGGGTTTTAGAGAGTATTTTGCTG
TAAAGGCTACCCCAAACCCATATCTGCTCAAGATTTTAAAGGATTATGACATGGGCTGTGACTGCTCATCATACACAGAG
CTTATGCTTGCAAAGTCATGCGGCTTCGACGGAGAGCATATCATGTTTTCATCAAATGATACACCGGCAGAGGAATTTGC
ATATGCAGACAAGCTTGGTGCTATCATCAATCTCGATGATTTCACACATATTGATTTTTTGGAGGAAACAATCGGACATA
TTCCGGAGACAATAAGCTGCAGATATAATCCGGGTGGAGTGTTCACACTGTCAAACGGTATTATGGACAATCCGGGAGAC
TCCAAGTATGGAATGACAAAGGAACAGCTTTTTGAGGCATTCAAAATTCTTAAGTCAAAAGGCGCTAAATACTTTGGCGT
GCATGCATTCCTGGCAAGCAATACAGTAACCAACGAGTATTATCCACAGCTTGCAAAGGAGCTTTTTGAGCTGGTTGTTG
AGCTTAAAAATGAGACCGGCTGCGATATTAGATTTGTAAATCTTTCAGGTGGAGTTGGCGTGGCTTATAAGCCGGATCAG
ACACCAAACGATATATCAGTTATCGGCGCCGGTGTACATAAGGTGTACGATGAGGTTTTGGTACCGGCAGGAATGGGCGA
TGTGGCTATTTACACAGAGATGGGACGTTTTATGATGGCTCCGTATGGCTGTCTTGTGACAAAGGCTATCCATGAGAAGC
ATATCTACAAGGAGTATATAGGAGTAGATGCGTGTGCGGCAAACCTTATGAGACCGGCTATTTACGGCTCATACCATCAT
ATCACAGTGCTCGGCAAGGAGGATGCACCTTGTGACCATACATATGATGTGGTAGGCTCACTCTGTGAGAACTGTGACAA
GTTTGCAATTGACAGACAGCTTCCGAAGATTGATATGGGAGACTATCTGGTAATCCATGATACAGGAGCACACGGCTTTT
CAATGGGCTACAATTACAACGGACGACTTCGCTCAGCAGAGATATTGCTCGAAAGCAATGGAGAGGCAAAACTCATCAGA
AGAGCAGAAACTCCGGCAGACTACTTTGCAACCTTTGACTGCTTTGATGATATTAAAATAACAGAGTAA

Upstream 100 bases:

>100_bases
CCTAATGAGAAATTATACCATAAAAATTCTTGAAAATATACCCATTTTGTTGTAGCATATGTTTTAGTACACTTTACTAT
GTAAAAGTTAGGAGATAAAC

Downstream 100 bases:

>100_bases
TCTGCTAGCGCACCTTGCAGAGCACGTGTCCGAATTTTATCCATTTGCTCATATCATCAACATTATCGCTGTCGACATAA
AAGGTCTCACCGTAATTGTT

Product: diaminopimelate decarboxylase

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKKTPFVTKQQVEEIVKQFPTPFHLYDEAGIRANAQAVKDAFAWNPGFREYFAVKATPNPYLLKILKDYDMGCDCSSYTE
LMLAKSCGFDGEHIMFSSNDTPAEEFAYADKLGAIINLDDFTHIDFLEETIGHIPETISCRYNPGGVFTLSNGIMDNPGD
SKYGMTKEQLFEAFKILKSKGAKYFGVHAFLASNTVTNEYYPQLAKELFELVVELKNETGCDIRFVNLSGGVGVAYKPDQ
TPNDISVIGAGVHKVYDEVLVPAGMGDVAIYTEMGRFMMAPYGCLVTKAIHEKHIYKEYIGVDACAANLMRPAIYGSYHH
ITVLGKEDAPCDHTYDVVGSLCENCDKFAIDRQLPKIDMGDYLVIHDTGAHGFSMGYNYNGRLRSAEILLESNGEAKLIR
RAETPADYFATFDCFDDIKITE

Sequences:

>Translated_422_residues
MKKTPFVTKQQVEEIVKQFPTPFHLYDEAGIRANAQAVKDAFAWNPGFREYFAVKATPNPYLLKILKDYDMGCDCSSYTE
LMLAKSCGFDGEHIMFSSNDTPAEEFAYADKLGAIINLDDFTHIDFLEETIGHIPETISCRYNPGGVFTLSNGIMDNPGD
SKYGMTKEQLFEAFKILKSKGAKYFGVHAFLASNTVTNEYYPQLAKELFELVVELKNETGCDIRFVNLSGGVGVAYKPDQ
TPNDISVIGAGVHKVYDEVLVPAGMGDVAIYTEMGRFMMAPYGCLVTKAIHEKHIYKEYIGVDACAANLMRPAIYGSYHH
ITVLGKEDAPCDHTYDVVGSLCENCDKFAIDRQLPKIDMGDYLVIHDTGAHGFSMGYNYNGRLRSAEILLESNGEAKLIR
RAETPADYFATFDCFDDIKITE
>Mature_422_residues
MKKTPFVTKQQVEEIVKQFPTPFHLYDEAGIRANAQAVKDAFAWNPGFREYFAVKATPNPYLLKILKDYDMGCDCSSYTE
LMLAKSCGFDGEHIMFSSNDTPAEEFAYADKLGAIINLDDFTHIDFLEETIGHIPETISCRYNPGGVFTLSNGIMDNPGD
SKYGMTKEQLFEAFKILKSKGAKYFGVHAFLASNTVTNEYYPQLAKELFELVVELKNETGCDIRFVNLSGGVGVAYKPDQ
TPNDISVIGAGVHKVYDEVLVPAGMGDVAIYTEMGRFMMAPYGCLVTKAIHEKHIYKEYIGVDACAANLMRPAIYGSYHH
ITVLGKEDAPCDHTYDVVGSLCENCDKFAIDRQLPKIDMGDYLVIHDTGAHGFSMGYNYNGRLRSAEILLESNGEAKLIR
RAETPADYFATFDCFDDIKITE

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=421, Percent_Identity=28.5035629453682, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 47052; Mature: 47052

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTPFVTKQQVEEIVKQFPTPFHLYDEAGIRANAQAVKDAFAWNPGFREYFAVKATPNP
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCHHEEEEECCCCH
YLLKILKDYDMGCDCSSYTELMLAKSCGFDGEHIMFSSNDTPAEEFAYADKLGAIINLDD
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCEEECCC
FTHIDFLEETIGHIPETISCRYNPGGVFTLSNGIMDNPGDSKYGMTKEQLFEAFKILKSK
CHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GAKYFGVHAFLASNTVTNEYYPQLAKELFELVVELKNETGCDIRFVNLSGGVGVAYKPDQ
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCC
TPNDISVIGAGVHKVYDEVLVPAGMGDVAIYTEMGRFMMAPYGCLVTKAIHEKHIYKEYI
CCCCCEEEEHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GVDACAANLMRPAIYGSYHHITVLGKEDAPCDHTYDVVGSLCENCDKFAIDRQLPKIDMG
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DYLVIHDTGAHGFSMGYNYNGRLRSAEILLESNGEAKLIRRAETPADYFATFDCFDDIKI
CEEEEECCCCCCEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCHHHEEEEECCCCCEE
TE
CC
>Mature Secondary Structure
MKKTPFVTKQQVEEIVKQFPTPFHLYDEAGIRANAQAVKDAFAWNPGFREYFAVKATPNP
CCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCHHEEEEECCCCH
YLLKILKDYDMGCDCSSYTELMLAKSCGFDGEHIMFSSNDTPAEEFAYADKLGAIINLDD
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCEEECCC
FTHIDFLEETIGHIPETISCRYNPGGVFTLSNGIMDNPGDSKYGMTKEQLFEAFKILKSK
CHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GAKYFGVHAFLASNTVTNEYYPQLAKELFELVVELKNETGCDIRFVNLSGGVGVAYKPDQ
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCCC
TPNDISVIGAGVHKVYDEVLVPAGMGDVAIYTEMGRFMMAPYGCLVTKAIHEKHIYKEYI
CCCCCEEEEHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GVDACAANLMRPAIYGSYHHITVLGKEDAPCDHTYDVVGSLCENCDKFAIDRQLPKIDMG
CHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DYLVIHDTGAHGFSMGYNYNGRLRSAEILLESNGEAKLIRRAETPADYFATFDCFDDIKI
CEEEEECCCCCCEECCCCCCCCEEEEEEEEECCCCEEEEEECCCCHHHEEEEECCCCCEE
TE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]