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The map label for this gene is ygcA [C]

Identifier: 238923775

GI number: 238923775

Start: 1275441

End: 1276853

Strand: Direct

Name: ygcA [C]

Synonym: EUBREC_1397

Alternate gene names: 238923775

Gene position: 1275441-1276853 (Clockwise)

Preceding gene: 238923774

Following gene: 238923777

Centisome position: 36.97

GC content: 43.74

Gene sequence:

>1413_bases
ATGAAAAAAGGATTTAGAGGAACAGGAACCGTAGAAAGAGTAGACTTCCCAAACAAGGGAATAGCCGTTACAGATGATGG
CGACAGAGTAATTGTGAAAAATACAATTCCGGGACAGAAGGTGGAATTTGTTGTAAATAAAGTAAAGCATCAAAGAGCAG
AGGGCAGACTCATGGAGGTAATTGAGAAATCGCCTCTGGAGACAGAAGAGCCATGTCCTCACTTTGGAATGTGCGGGGGC
TGTACATATCAGACAGTGCCTTACGAAAAGCAGCTTGATATGAAGCTTACCCAGGTGAAAAAGCTCATTTCGGATGCTAT
CGGCACTGAAAAAGAGTCAGGATATGAGTTTATAGGGATACATGGAAGTCCGAAAAAGAGTGAATACAGAAACAAGATGG
AATTTTCCTTCGGTGATGAGTACAAGGATGGCCCTCTTGCGCTTGGCATGCACAAAAGAGGAAGCTTTTATGACCTTGTG
ACAGTATCAGACTGTCAGATTGTGGATGAGGATTTCAGGACAATATTAAAGGCAACACTTGATTATTTTTCAAAAAACAA
TATCCCATATTTCCACAGAGCAACACACAAGGGCTATCTGCGGCATCTGCTTGTCAGAAAGGCAACAAAAACCGGTGAAA
TCATAGTCGACCTTGTCACCACCACACAGACAGAGGGCTTCAACGAGGAGGAACTGCTCGCAGGCTTTAGATATGCACTT
TTGACCAGGCACTATGACGGCAGATTCAAGGGCGTTTTACACACAAAAAATGACAGCGTGGCAGATGTGGTCAAAAACGA
GGGCACAGAGGTGCTCTACGGAGATTCATATTTCTACGAGAAGCTCTTAGGTCTGAAATTCAAAATCACACCATTCTCAT
TTTTCCAGACCAACTCACTCGGAGCGGAGGTGCTCTATGAGACAGCGAGAGAGTTTATCCTGGGAGATAACAAGGATTCG
CTAAACGGTAAAACAGTCTACGACCTCTACAGTGGAACTGGCACCATCGCGCAGCTTATGGCACCGGTGTGTAAGGAAGT
AGTAGGTGTCGAAATAGTTGAGGAGGCAGTTTGCGCAGCAAAGGAAAATGCAGCTCTTAATGGTCTTGATAACTGTAAAT
TTATCGCAGGTGATGTCCTCAAGGTGCTTGATGAGATAGAGGAAAAACCGGATTATATAATTCTTGATCCACCACGAGAC
GGTATCCATCCGAAGGCTATTGGGAAAATCATAGAGTATGGTGTTGAGAATATGGTTTATATTTCATGTAAACCTACAAG
CCTGGCAAGGGATTTGCAGATATTTATGGACAGAGGGTATAGAGTGGAGAAGATATGCTGCGTGGATATGTTTCCGAATA
CTTATCACGTCGAGACAGTAGTATTGATGTCAAAGGTGAACCCAGGCAAGTAG

Upstream 100 bases:

>100_bases
GGCTACATATGTAGTCCTCATTTTTCTTTATGTGTGAAGCAAGGCATTTGCAGTCAGGCATACAAAGGAATAATAAAGTA
TAAAGAGAGATAAGAATTAC

Downstream 100 bases:

>100_bases
AAAAAACACTGTAAATAAAAGGCTTTTAAGAGAGCTATCGTTAATGAGTATGATTAGCTGCTGGAAAGCCTTTCTTTTTA
TGTGAAGTAATGACTTTGTG

Product: tRNA (uracil-5-) -methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKKGFRGTGTVERVDFPNKGIAVTDDGDRVIVKNTIPGQKVEFVVNKVKHQRAEGRLMEVIEKSPLETEEPCPHFGMCGG
CTYQTVPYEKQLDMKLTQVKKLISDAIGTEKESGYEFIGIHGSPKKSEYRNKMEFSFGDEYKDGPLALGMHKRGSFYDLV
TVSDCQIVDEDFRTILKATLDYFSKNNIPYFHRATHKGYLRHLLVRKATKTGEIIVDLVTTTQTEGFNEEELLAGFRYAL
LTRHYDGRFKGVLHTKNDSVADVVKNEGTEVLYGDSYFYEKLLGLKFKITPFSFFQTNSLGAEVLYETAREFILGDNKDS
LNGKTVYDLYSGTGTIAQLMAPVCKEVVGVEIVEEAVCAAKENAALNGLDNCKFIAGDVLKVLDEIEEKPDYIILDPPRD
GIHPKAIGKIIEYGVENMVYISCKPTSLARDLQIFMDRGYRVEKICCVDMFPNTYHVETVVLMSKVNPGK

Sequences:

>Translated_470_residues
MKKGFRGTGTVERVDFPNKGIAVTDDGDRVIVKNTIPGQKVEFVVNKVKHQRAEGRLMEVIEKSPLETEEPCPHFGMCGG
CTYQTVPYEKQLDMKLTQVKKLISDAIGTEKESGYEFIGIHGSPKKSEYRNKMEFSFGDEYKDGPLALGMHKRGSFYDLV
TVSDCQIVDEDFRTILKATLDYFSKNNIPYFHRATHKGYLRHLLVRKATKTGEIIVDLVTTTQTEGFNEEELLAGFRYAL
LTRHYDGRFKGVLHTKNDSVADVVKNEGTEVLYGDSYFYEKLLGLKFKITPFSFFQTNSLGAEVLYETAREFILGDNKDS
LNGKTVYDLYSGTGTIAQLMAPVCKEVVGVEIVEEAVCAAKENAALNGLDNCKFIAGDVLKVLDEIEEKPDYIILDPPRD
GIHPKAIGKIIEYGVENMVYISCKPTSLARDLQIFMDRGYRVEKICCVDMFPNTYHVETVVLMSKVNPGK
>Mature_470_residues
MKKGFRGTGTVERVDFPNKGIAVTDDGDRVIVKNTIPGQKVEFVVNKVKHQRAEGRLMEVIEKSPLETEEPCPHFGMCGG
CTYQTVPYEKQLDMKLTQVKKLISDAIGTEKESGYEFIGIHGSPKKSEYRNKMEFSFGDEYKDGPLALGMHKRGSFYDLV
TVSDCQIVDEDFRTILKATLDYFSKNNIPYFHRATHKGYLRHLLVRKATKTGEIIVDLVTTTQTEGFNEEELLAGFRYAL
LTRHYDGRFKGVLHTKNDSVADVVKNEGTEVLYGDSYFYEKLLGLKFKITPFSFFQTNSLGAEVLYETAREFILGDNKDS
LNGKTVYDLYSGTGTIAQLMAPVCKEVVGVEIVEEAVCAAKENAALNGLDNCKFIAGDVLKVLDEIEEKPDYIILDPPRD
GIHPKAIGKIIEYGVENMVYISCKPTSLARDLQIFMDRGYRVEKICCVDMFPNTYHVETVVLMSKVNPGK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=426, Percent_Identity=28.8732394366197, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI51173878, Length=426, Percent_Identity=28.8732394366197, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI269784680, Length=427, Percent_Identity=25.9953161592506, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI269784676, Length=427, Percent_Identity=25.9953161592506, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI20149688, Length=427, Percent_Identity=25.9953161592506, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI269784678, Length=216, Percent_Identity=32.8703703703704, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1789148, Length=466, Percent_Identity=27.0386266094421, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1787083, Length=391, Percent_Identity=26.3427109974425, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1790403, Length=235, Percent_Identity=25.1063829787234, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997438, Length=170, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322909, Length=403, Percent_Identity=25.0620347394541, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666579, Length=424, Percent_Identity=28.5377358490566, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 52866; Mature: 52866

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50926 TRAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGFRGTGTVERVDFPNKGIAVTDDGDRVIVKNTIPGQKVEFVVNKVKHQRAEGRLMEV
CCCCCCCCCCEEEECCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IEKSPLETEEPCPHFGMCGGCTYQTVPYEKQLDMKLTQVKKLISDAIGTEKESGYEFIGI
HHCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEE
HGSPKKSEYRNKMEFSFGDEYKDGPLALGMHKRGSFYDLVTVSDCQIVDEDFRTILKATL
CCCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHH
DYFSKNNIPYFHRATHKGYLRHLLVRKATKTGEIIVDLVTTTQTEGFNEEELLAGFRYAL
HHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHH
LTRHYDGRFKGVLHTKNDSVADVVKNEGTEVLYGDSYFYEKLLGLKFKITPFSFFQTNSL
HHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEECCHHHHHHHHCCEEEECCEEEEECCCC
GAEVLYETAREFILGDNKDSLNGKTVYDLYSGTGTIAQLMAPVCKEVVGVEIVEEAVCAA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KENAALNGLDNCKFIAGDVLKVLDEIEEKPDYIILDPPRDGIHPKAIGKIIEYGVENMVY
HCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEE
ISCKPTSLARDLQIFMDRGYRVEKICCVDMFPNTYHVETVVLMSKVNPGK
EEECCHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEEEEEECCCCCC
>Mature Secondary Structure
MKKGFRGTGTVERVDFPNKGIAVTDDGDRVIVKNTIPGQKVEFVVNKVKHQRAEGRLMEV
CCCCCCCCCCEEEECCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
IEKSPLETEEPCPHFGMCGGCTYQTVPYEKQLDMKLTQVKKLISDAIGTEKESGYEFIGI
HHCCCCCCCCCCCCCCCCCCCEEECCCCHHHHCHHHHHHHHHHHHHHCCCCCCCCEEEEE
HGSPKKSEYRNKMEFSFGDEYKDGPLALGMHKRGSFYDLVTVSDCQIVDEDFRTILKATL
CCCCCHHHHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHH
DYFSKNNIPYFHRATHKGYLRHLLVRKATKTGEIIVDLVTTTQTEGFNEEELLAGFRYAL
HHHHCCCCCCEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHH
LTRHYDGRFKGVLHTKNDSVADVVKNEGTEVLYGDSYFYEKLLGLKFKITPFSFFQTNSL
HHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEECCHHHHHHHHCCEEEECCEEEEECCCC
GAEVLYETAREFILGDNKDSLNGKTVYDLYSGTGTIAQLMAPVCKEVVGVEIVEEAVCAA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KENAALNGLDNCKFIAGDVLKVLDEIEEKPDYIILDPPRDGIHPKAIGKIIEYGVENMVY
HCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCEEE
ISCKPTSLARDLQIFMDRGYRVEKICCVDMFPNTYHVETVVLMSKVNPGK
EEECCHHHHHHHHHHHHCCCEEEEEEEEEECCCCEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]