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The map label for this gene is proC [H]

Identifier: 238923558

GI number: 238923558

Start: 1090005

End: 1090805

Strand: Direct

Name: proC [H]

Synonym: EUBREC_1178

Alternate gene names: 238923558

Gene position: 1090005-1090805 (Clockwise)

Preceding gene: 238923557

Following gene: 238923559

Centisome position: 31.6

GC content: 47.69

Gene sequence:

>801_bases
ATGAGTAAGAAATTAGGCTTCATAGGTTGTGGAAACATGGGAAAGGCAATGATACACGGAGTGCTTGCATCAGGCAAGGC
ACAGGCAAGCGATATTCTTGCATCTGCAAAGACCGAAAGCTCCAGAGAAAAGAATGCAGCAGAGCTTGGAATCAGGCTGA
CAGCGGACAATAAGAGCGTAGCAGAGTTTGCAGATATTCTGTTTTTAGCAGTAAAGCCACAGTACTATGAGGAGGTTATA
GCAGAGATAAAGGACACTGTTAGTGACGATGAAATTATTGTTTCGATTGCACCGGGCAAGTCACTTTCGTGGTTTGACGA
GATGTTTGGAAGGAGCTTAAAGGTTATACGTACCATGCCAAATACACCTGCCATGGTTGGTGAGGGCATGATGGGAGTCT
GTGCAAATGAAAGAGTATCGCAGGAGGAGCTTGATACAGTGCTTGATTTGTGCTCGGGCTTTTCAAAGGCTGAGATGATA
GACGAGAAGCTCATGGATGTAGTGACAGCGGTCAGCGGAAGCTCACCGGCATATGTGTTTATGTTTATCGAGGCTATGGC
AGATGCAGCTGTAGCAGGCGGCATGCCAAGGAGCCAGGCATATACATTTGCAGCCCAGGCAGTGCTTGGAAGCGCAAAAA
TGGTTCTCGAGACAGGAAAGCATCCGGGCGAGCTCAAGGATATGGTGTGCTCACCTGCCGGAACCACTATCCAGGCTGTG
CGTGTGCTTGAGGAAAAGGGCATGAGAAGCAGTGTTTTTGAAGCTATGATGAAATGCCTTGATATCTCCCGCAAAATGTA
G

Upstream 100 bases:

>100_bases
GAATGAAGTGTGCTAAAATAGTTTGCAAAAATACTGACTGTTAAACATGATTGTGGATGCTTTGAATAGTCAGATATATT
GATTACGGCAGGAGGATAAT

Downstream 100 bases:

>100_bases
TAGAATTATTGCATTGAGTTAAAGGAGAAAAGCAATGAGTCAGGCAAAGGTTGATAAATATAAGAATGAAAAGGCAAATC
GTAAAAAGACAAATGCCAGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSKKLGFIGCGNMGKAMIHGVLASGKAQASDILASAKTESSREKNAAELGIRLTADNKSVAEFADILFLAVKPQYYEEVI
AEIKDTVSDDEIIVSIAPGKSLSWFDEMFGRSLKVIRTMPNTPAMVGEGMMGVCANERVSQEELDTVLDLCSGFSKAEMI
DEKLMDVVTAVSGSSPAYVFMFIEAMADAAVAGGMPRSQAYTFAAQAVLGSAKMVLETGKHPGELKDMVCSPAGTTIQAV
RVLEEKGMRSSVFEAMMKCLDISRKM

Sequences:

>Translated_266_residues
MSKKLGFIGCGNMGKAMIHGVLASGKAQASDILASAKTESSREKNAAELGIRLTADNKSVAEFADILFLAVKPQYYEEVI
AEIKDTVSDDEIIVSIAPGKSLSWFDEMFGRSLKVIRTMPNTPAMVGEGMMGVCANERVSQEELDTVLDLCSGFSKAEMI
DEKLMDVVTAVSGSSPAYVFMFIEAMADAAVAGGMPRSQAYTFAAQAVLGSAKMVLETGKHPGELKDMVCSPAGTTIQAV
RVLEEKGMRSSVFEAMMKCLDISRKM
>Mature_265_residues
SKKLGFIGCGNMGKAMIHGVLASGKAQASDILASAKTESSREKNAAELGIRLTADNKSVAEFADILFLAVKPQYYEEVIA
EIKDTVSDDEIIVSIAPGKSLSWFDEMFGRSLKVIRTMPNTPAMVGEGMMGVCANERVSQEELDTVLDLCSGFSKAEMID
EKLMDVVTAVSGSSPAYVFMFIEAMADAAVAGGMPRSQAYTFAAQAVLGSAKMVLETGKHPGELKDMVCSPAGTTIQAVR
VLEEKGMRSSVFEAMMKCLDISRKM

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=37.4531835205993, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI24797097, Length=260, Percent_Identity=38.8461538461538, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI24797095, Length=260, Percent_Identity=38.8461538461538, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI21361454, Length=256, Percent_Identity=39.0625, Blast_Score=169, Evalue=2e-42,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=54.1353383458647, Blast_Score=285, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=37.7862595419847, Blast_Score=176, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17540664, Length=270, Percent_Identity=37.037037037037, Blast_Score=157, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=30.0699300699301, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=40.4494382022472, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24648116, Length=267, Percent_Identity=40.4494382022472, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=44.4444444444444, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28481; Mature: 28350

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
7.1 %Met     (Translated Protein)
9.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
6.8 %Met     (Mature Protein)
8.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKLGFIGCGNMGKAMIHGVLASGKAQASDILASAKTESSREKNAAELGIRLTADNKSV
CCCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHCEEEECCCCHH
AEFADILFLAVKPQYYEEVIAEIKDTVSDDEIIVSIAPGKSLSWFDEMFGRSLKVIRTMP
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCEEHHHCCC
NTPAMVGEGMMGVCANERVSQEELDTVLDLCSGFSKAEMIDEKLMDVVTAVSGSSPAYVF
CCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
MFIEAMADAAVAGGMPRSQAYTFAAQAVLGSAKMVLETGKHPGELKDMVCSPAGTTIQAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
RVLEEKGMRSSVFEAMMKCLDISRKM
HHHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKLGFIGCGNMGKAMIHGVLASGKAQASDILASAKTESSREKNAAELGIRLTADNKSV
CCCCCEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHCEEEECCCCHH
AEFADILFLAVKPQYYEEVIAEIKDTVSDDEIIVSIAPGKSLSWFDEMFGRSLKVIRTMP
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCEEHHHCCC
NTPAMVGEGMMGVCANERVSQEELDTVLDLCSGFSKAEMIDEKLMDVVTAVSGSSPAYVF
CCCHHHCCCCHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
MFIEAMADAAVAGGMPRSQAYTFAAQAVLGSAKMVLETGKHPGELKDMVCSPAGTTIQAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHH
RVLEEKGMRSSVFEAMMKCLDISRKM
HHHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]