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The map label for this gene is gmr [H]

Identifier: 238923521

GI number: 238923521

Start: 1055376

End: 1056752

Strand: Direct

Name: gmr [H]

Synonym: EUBREC_1141

Alternate gene names: 238923521

Gene position: 1055376-1056752 (Clockwise)

Preceding gene: 238923519

Following gene: 238923523

Centisome position: 30.59

GC content: 40.16

Gene sequence:

>1377_bases
ATGGACAAGAATTACGAGCTTGAAAAAAGAGTACTTACAATGGTATCCAGACAGTTTGAGTGTATTTATCAGATTAATCT
TGATGAAATGGCTGTTACTTGTGTTTATGATGTCAAGGATGAGGCTGGTGAGGAAAAAGTATTGTCTCTTGATGGCTGGT
TGGATATGTTGAATAAGTTTTGTTATTGCGAAGATAAAGAGAATCTGGGCAGATTTTTAGCGGTAGATTCTCTTTTTCAG
TGTATAAAAGCTCAGGAAGAAAGCGATAAGCCGTACAATCTGCGCAGAGATTACCGATTTATGAAGCGTGATGGGGTTAA
GTGGATATGCGTTACACTTATGCCGGAGATTGTATGTAATGAGATTACAGTGACATTTCGTGATGTGTCTCACCGCTATG
AGTATGATGAAATCATACAAAAGAAAAATTCTGAGCTTAGAAAACTTTTGCAGACAGCAGAGCAGTACAGGGATGCACTT
CTATCAGAGTCGGTTGTTCTGTATCAGGTTAATTTTAGCAGGGACAGCTTAGATAGTGATTTATTTCAGAAGAACAAGGA
TGGTAATGGAGTCATAAAAGTCTTAAATACCGTGGACATGTACAAGTCGGATTCTTACAACGAATACTGCACCCGCTGGC
AGAGCCGCGTGTCAAAAGATACCATAGATGAATACAGAAGATATGCAACATCTGACAGTCTGGTGGAGGAATACAGAGCA
GGCAGGACTCTTTTAAGTCAGGATTACCGGACACTGGATTCCTTTGGTGTTGAGATGTGGATTAACAAGACAATCTATCT
GGCTCAGGACAAGATGACTGGTGATGTCATAGGCATAGTAAGCCTTCGTGATGTCACAGACCGCTATCGTCAGGAGTTCA
TGAGAGAAGCCTTGGAAAAACAGGCATCAACTGATTTGCTCACAGGCTTATACAATCATGTGACCGGAGAAGTGCTTATA
AAGAGCAAGATTGATAACGAAAAATACATGGATGCGGCATTTATTATTTTTGATATCGATTTCTTTAAAAAGATTAATGA
TACCAGAGGTCATTATTTTGGAGACTGCGTCCTGCAAAAGGTCGCAGAAATTCTAAAGGGCTGTATCAGAGAGAACCAGG
ATGTGGCTTCAAGATATGGCGGTGACGAATTTGTGATATTTATTACCTACAAGCAGGAGGATGACATCTATGATATCGTA
GACAGAATATTTAAAGCTATTTCTACTCAATATGACGGGTGTCAGATTAGCATAAGCATGGGAATCTTTCTTGCTAGTGC
CTGTGAGGAGGGTTACTATGAGATGTACAAGAAGGCTGACAGGGCTTTGTACAGGGCGAAGGAAGCCGGAAAGGGCAGAT
ATATATTTTCAAATTAA

Upstream 100 bases:

>100_bases
ATTAATTTCGACAAAGACTTTGTCATCTTCGCAAAGAGTGGTATAATATCCTTGATATGGCAGATTGTATATACAAGATG
CAGATGAATGGGGATAAGAA

Downstream 100 bases:

>100_bases
AGATTTTATAGGCAGTATGGTGGGGAGTGCTGACTATTCCGCTTTTAAAGAACTATAAGCAGGTAAATTATGTGAAAAAA
GAGCAGGGCCTTGTCTAGCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MDKNYELEKRVLTMVSRQFECIYQINLDEMAVTCVYDVKDEAGEEKVLSLDGWLDMLNKFCYCEDKENLGRFLAVDSLFQ
CIKAQEESDKPYNLRRDYRFMKRDGVKWICVTLMPEIVCNEITVTFRDVSHRYEYDEIIQKKNSELRKLLQTAEQYRDAL
LSESVVLYQVNFSRDSLDSDLFQKNKDGNGVIKVLNTVDMYKSDSYNEYCTRWQSRVSKDTIDEYRRYATSDSLVEEYRA
GRTLLSQDYRTLDSFGVEMWINKTIYLAQDKMTGDVIGIVSLRDVTDRYRQEFMREALEKQASTDLLTGLYNHVTGEVLI
KSKIDNEKYMDAAFIIFDIDFFKKINDTRGHYFGDCVLQKVAEILKGCIRENQDVASRYGGDEFVIFITYKQEDDIYDIV
DRIFKAISTQYDGCQISISMGIFLASACEEGYYEMYKKADRALYRAKEAGKGRYIFSN

Sequences:

>Translated_458_residues
MDKNYELEKRVLTMVSRQFECIYQINLDEMAVTCVYDVKDEAGEEKVLSLDGWLDMLNKFCYCEDKENLGRFLAVDSLFQ
CIKAQEESDKPYNLRRDYRFMKRDGVKWICVTLMPEIVCNEITVTFRDVSHRYEYDEIIQKKNSELRKLLQTAEQYRDAL
LSESVVLYQVNFSRDSLDSDLFQKNKDGNGVIKVLNTVDMYKSDSYNEYCTRWQSRVSKDTIDEYRRYATSDSLVEEYRA
GRTLLSQDYRTLDSFGVEMWINKTIYLAQDKMTGDVIGIVSLRDVTDRYRQEFMREALEKQASTDLLTGLYNHVTGEVLI
KSKIDNEKYMDAAFIIFDIDFFKKINDTRGHYFGDCVLQKVAEILKGCIRENQDVASRYGGDEFVIFITYKQEDDIYDIV
DRIFKAISTQYDGCQISISMGIFLASACEEGYYEMYKKADRALYRAKEAGKGRYIFSN
>Mature_458_residues
MDKNYELEKRVLTMVSRQFECIYQINLDEMAVTCVYDVKDEAGEEKVLSLDGWLDMLNKFCYCEDKENLGRFLAVDSLFQ
CIKAQEESDKPYNLRRDYRFMKRDGVKWICVTLMPEIVCNEITVTFRDVSHRYEYDEIIQKKNSELRKLLQTAEQYRDAL
LSESVVLYQVNFSRDSLDSDLFQKNKDGNGVIKVLNTVDMYKSDSYNEYCTRWQSRVSKDTIDEYRRYATSDSLVEEYRA
GRTLLSQDYRTLDSFGVEMWINKTIYLAQDKMTGDVIGIVSLRDVTDRYRQEFMREALEKQASTDLLTGLYNHVTGEVLI
KSKIDNEKYMDAAFIIFDIDFFKKINDTRGHYFGDCVLQKVAEILKGCIRENQDVASRYGGDEFVIFITYKQEDDIYDIV
DRIFKAISTQYDGCQISISMGIFLASACEEGYYEMYKKADRALYRAKEAGKGRYIFSN

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=220, Percent_Identity=29.0909090909091, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786584, Length=209, Percent_Identity=29.1866028708134, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081881, Length=200, Percent_Identity=31, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082007, Length=176, Percent_Identity=32.3863636363636, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693134, Length=170, Percent_Identity=32.9411764705882, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788381, Length=188, Percent_Identity=30.8510638297872, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787816, Length=166, Percent_Identity=30.7228915662651, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787262, Length=163, Percent_Identity=31.2883435582822, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787056, Length=118, Percent_Identity=34.7457627118644, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081974, Length=152, Percent_Identity=32.2368421052632, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 53706; Mature: 53706

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNYELEKRVLTMVSRQFECIYQINLDEMAVTCVYDVKDEAGEEKVLSLDGWLDMLNKF
CCCCCHHHHHHHHHHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHH
CYCEDKENLGRFLAVDSLFQCIKAQEESDKPYNLRRDYRFMKRDGVKWICVTLMPEIVCN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHH
EITVTFRDVSHRYEYDEIIQKKNSELRKLLQTAEQYRDALLSESVVLYQVNFSRDSLDSD
HHEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
LFQKNKDGNGVIKVLNTVDMYKSDSYNEYCTRWQSRVSKDTIDEYRRYATSDSLVEEYRA
HHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GRTLLSQDYRTLDSFGVEMWINKTIYLAQDKMTGDVIGIVSLRDVTDRYRQEFMREALEK
CHHHHHHHHHHHHHCCHHEEECCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
QASTDLLTGLYNHVTGEVLIKSKIDNEKYMDAAFIIFDIDFFKKINDTRGHYFGDCVLQK
HHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHEEEEEEHHHHHHHCCCCCCHHHHHHHHH
VAEILKGCIRENQDVASRYGGDEFVIFITYKQEDDIYDIVDRIFKAISTQYDGCQISISM
HHHHHHHHHHCCHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEHH
GIFLASACEEGYYEMYKKADRALYRAKEAGKGRYIFSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MDKNYELEKRVLTMVSRQFECIYQINLDEMAVTCVYDVKDEAGEEKVLSLDGWLDMLNKF
CCCCCHHHHHHHHHHHHHHHEEEEECCCCEEEEEEEECCCCCCCCCEEEHHHHHHHHHHH
CYCEDKENLGRFLAVDSLFQCIKAQEESDKPYNLRRDYRFMKRDGVKWICVTLMPEIVCN
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHH
EITVTFRDVSHRYEYDEIIQKKNSELRKLLQTAEQYRDALLSESVVLYQVNFSRDSLDSD
HHEEEEEHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHH
LFQKNKDGNGVIKVLNTVDMYKSDSYNEYCTRWQSRVSKDTIDEYRRYATSDSLVEEYRA
HHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
GRTLLSQDYRTLDSFGVEMWINKTIYLAQDKMTGDVIGIVSLRDVTDRYRQEFMREALEK
CHHHHHHHHHHHHHCCHHEEECCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
QASTDLLTGLYNHVTGEVLIKSKIDNEKYMDAAFIIFDIDFFKKINDTRGHYFGDCVLQK
HHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHEEEEEEHHHHHHHCCCCCCHHHHHHHHH
VAEILKGCIRENQDVASRYGGDEFVIFITYKQEDDIYDIVDRIFKAISTQYDGCQISISM
HHHHHHHHHHCCHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEHH
GIFLASACEEGYYEMYKKADRALYRAKEAGKGRYIFSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]