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The map label for this gene is hgdC [H]

Identifier: 238923515

GI number: 238923515

Start: 1050135

End: 1051871

Strand: Direct

Name: hgdC [H]

Synonym: EUBREC_1135

Alternate gene names: 238923515

Gene position: 1050135-1051871 (Clockwise)

Preceding gene: 238923514

Following gene: 238923517

Centisome position: 30.44

GC content: 43.52

Gene sequence:

>1737_bases
GTGGATATTTACTATAAAACAATTTCAGAAAGTGGAAAACAGATGATAAATTATGTTTGTAAATATGCTCCGGTAGAGCT
GTTTAAGGGCTTTGGACAGGACTGTGCTGTGCTTGAGGAGATGCCGGAGAATTTCGATAAATCAGATAAGATAGCTCATG
CGAATCTCTGCGGATTCGGCAAATCAGTCATACAGGCTGTGCTCGAAGGCAAGGTAGAGGAGCTTGTGCTCGTGAACTGC
TGTGATTCAATGCGCAGAGTCTATGATATCATAGAGAATACAAAGAAATGCAAATTCCTGTATATGCTTGATCTGCCTCA
TGAGGATAACGAGTGTGAGAACATAAAATTTGCACAGTCAATTCTGCGTTTGAAGAAAGCATATGAGAGATATTCGCACA
GGACATTCGACAGGGAGCTTTTTATAAAGTCATTTGCAAAACCTGAATCTGAGCGCAAGCCATACATAGGTCTTATGGGT
GTGCATGTGAGCAGTATTCTTGAGAAGACAATACGTGAAAATATGCAGATGGATGTGGAAAATATGACATGCACATCCGG
CAGAAATCTCATTATTTTACAGAAGGATCTTAGAAATATGGATGATGAGACTCTCTTTGTAGCATATGCAGAGAGTCTGC
TCGGACAGATGCCATGTGCCAGAATGAACAATAATACAAGAAGAAACCAGCTCTTTTTAGACCCAAGCCTTAAGGGCATC
ATATATCACACGATAAAGTTCTGCGATTACTATGGCTTTGAGTATGCAAGCATAAAGAATAATATTAAGGTGCCTCTTTT
AAAGCTTGAGACGGATTTTACAAGCCAGAGTGCCGGGCAGCTTCTGACAAGAATACAGGCATTTGCAGAGACAATAGAGG
GCTCAGATGACATGGACCCTACAAAAGGCATAAGCGAGGAGGCAAGAAGAAGGATGGAATCAGGAGTCTACTATGTAGCA
GGAATTGACAGCGGCTCAACAAGCACAGATGTGGTGATACTGGATCAGGATGGAAAAATTAAATCGACAATGATTATTCC
GACAGGTGGCGGAGCTATGATGAGTGCCGAAAAGAGTCTGGAGAAGGCTGTCGAAAAGGCCGGTATATCAAAGGATGATA
TTGTAAGGATTGTAACAACAGGATATGGACGTGCATACATCAACAGCGGCGATGACAGCATCACAGAGATTACATGCCAT
GCAAAAGGCGCGCATTATCTGAACTCCAACGTGCGCACAGTTATTGACATAGGTGGACAGGATATAAAGGCAATCAGTAT
AGATGAAAATGGTGCTGTGAAGAATTTCCTGATGAACGATAAATGTGCGGCAGGAACCGGACGTTTTCTGGAGATGATGG
CAAGGACACTCGGACTTTCACTCGAGGAGATGAGCACCATGGGACTTGAGTGGAAGGAAAACATTGTGATTTCAAGCATG
TGTACAGTTTTTGCAGAGTCTGAGGTAGTATCGCTGGTGGCACAGAACAAGGCTGTTTCTGATATTATCCACGGACTAAA
CATGTCTGTAGCTTCAAAGGTAGGCGCACTTGCAGCAAGGCTTGGGCAGGATAATCCGGGTGAGTATATGATGACAGGCG
GAGTGGCAAAGAACAAAGGCATCACAAATGCACTTGAAGAAAAGCTCGGCGCAAAGCTGTATATTTGCGATGAGGCACAG
CTTTGCGGAGCGCTTGGTGCAGCACTTTTTGCATATGAGAAGTGCAGGGAGGCTTAA

Upstream 100 bases:

>100_bases
CAGTGACGGACAGATTTCCACAAGGCTTCAGGCATTTGTGGAGATGCTTACAGAGCAGGAACGTAATTAGAAATAATACA
CCGGTTATTGTGTGCGGTGT

Downstream 100 bases:

>100_bases
TAGAGGAGCTATAGCAAACCACCAGTTGAACTGGTGGTTGCTGACTTTACTCCATGATTTTCCCATCAATACTTATTGTT
ACAACTTGCCATGGTATGAA

Product: putative R-2-hydroxyglutaryl-CoA dehydratase subunit/R-2-hydroxyglutaryl-CoA dehydratase activase, putative

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MDIYYKTISESGKQMINYVCKYAPVELFKGFGQDCAVLEEMPENFDKSDKIAHANLCGFGKSVIQAVLEGKVEELVLVNC
CDSMRRVYDIIENTKKCKFLYMLDLPHEDNECENIKFAQSILRLKKAYERYSHRTFDRELFIKSFAKPESERKPYIGLMG
VHVSSILEKTIRENMQMDVENMTCTSGRNLIILQKDLRNMDDETLFVAYAESLLGQMPCARMNNNTRRNQLFLDPSLKGI
IYHTIKFCDYYGFEYASIKNNIKVPLLKLETDFTSQSAGQLLTRIQAFAETIEGSDDMDPTKGISEEARRRMESGVYYVA
GIDSGSTSTDVVILDQDGKIKSTMIIPTGGGAMMSAEKSLEKAVEKAGISKDDIVRIVTTGYGRAYINSGDDSITEITCH
AKGAHYLNSNVRTVIDIGGQDIKAISIDENGAVKNFLMNDKCAAGTGRFLEMMARTLGLSLEEMSTMGLEWKENIVISSM
CTVFAESEVVSLVAQNKAVSDIIHGLNMSVASKVGALAARLGQDNPGEYMMTGGVAKNKGITNALEEKLGAKLYICDEAQ
LCGALGAALFAYEKCREA

Sequences:

>Translated_578_residues
MDIYYKTISESGKQMINYVCKYAPVELFKGFGQDCAVLEEMPENFDKSDKIAHANLCGFGKSVIQAVLEGKVEELVLVNC
CDSMRRVYDIIENTKKCKFLYMLDLPHEDNECENIKFAQSILRLKKAYERYSHRTFDRELFIKSFAKPESERKPYIGLMG
VHVSSILEKTIRENMQMDVENMTCTSGRNLIILQKDLRNMDDETLFVAYAESLLGQMPCARMNNNTRRNQLFLDPSLKGI
IYHTIKFCDYYGFEYASIKNNIKVPLLKLETDFTSQSAGQLLTRIQAFAETIEGSDDMDPTKGISEEARRRMESGVYYVA
GIDSGSTSTDVVILDQDGKIKSTMIIPTGGGAMMSAEKSLEKAVEKAGISKDDIVRIVTTGYGRAYINSGDDSITEITCH
AKGAHYLNSNVRTVIDIGGQDIKAISIDENGAVKNFLMNDKCAAGTGRFLEMMARTLGLSLEEMSTMGLEWKENIVISSM
CTVFAESEVVSLVAQNKAVSDIIHGLNMSVASKVGALAARLGQDNPGEYMMTGGVAKNKGITNALEEKLGAKLYICDEAQ
LCGALGAALFAYEKCREA
>Mature_578_residues
MDIYYKTISESGKQMINYVCKYAPVELFKGFGQDCAVLEEMPENFDKSDKIAHANLCGFGKSVIQAVLEGKVEELVLVNC
CDSMRRVYDIIENTKKCKFLYMLDLPHEDNECENIKFAQSILRLKKAYERYSHRTFDRELFIKSFAKPESERKPYIGLMG
VHVSSILEKTIRENMQMDVENMTCTSGRNLIILQKDLRNMDDETLFVAYAESLLGQMPCARMNNNTRRNQLFLDPSLKGI
IYHTIKFCDYYGFEYASIKNNIKVPLLKLETDFTSQSAGQLLTRIQAFAETIEGSDDMDPTKGISEEARRRMESGVYYVA
GIDSGSTSTDVVILDQDGKIKSTMIIPTGGGAMMSAEKSLEKAVEKAGISKDDIVRIVTTGYGRAYINSGDDSITEITCH
AKGAHYLNSNVRTVIDIGGQDIKAISIDENGAVKNFLMNDKCAAGTGRFLEMMARTLGLSLEEMSTMGLEWKENIVISSM
CTVFAESEVVSLVAQNKAVSDIIHGLNMSVASKVGALAARLGQDNPGEYMMTGGVAKNKGITNALEEKLGAKLYICDEAQ
LCGALGAALFAYEKCREA

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=258, Percent_Identity=40.6976744186046, Blast_Score=177, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 64095; Mature: 64095

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIYYKTISESGKQMINYVCKYAPVELFKGFGQDCAVLEEMPENFDKSDKIAHANLCGFG
CCEEHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECHHHHCC
KSVIQAVLEGKVEELVLVNCCDSMRRVYDIIENTKKCKFLYMLDLPHEDNECENIKFAQS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHH
ILRLKKAYERYSHRTFDRELFIKSFAKPESERKPYIGLMGVHVSSILEKTIRENMQMDVE
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCC
NMTCTSGRNLIILQKDLRNMDDETLFVAYAESLLGQMPCARMNNNTRRNQLFLDPSLKGI
CCEECCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCEEEECCCCCHH
IYHTIKFCDYYGFEYASIKNNIKVPLLKLETDFTSQSAGQLLTRIQAFAETIEGSDDMDP
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TKGISEEARRRMESGVYYVAGIDSGSTSTDVVILDQDGKIKSTMIIPTGGGAMMSAEKSL
CCCCHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHH
EKAVEKAGISKDDIVRIVTTGYGRAYINSGDDSITEITCHAKGAHYLNSNVRTVIDIGGQ
HHHHHHCCCCHHHEEEEEEECCCEEEEECCCCCEEEEEEECCCCHHHCCCCEEEEEECCC
DIKAISIDENGAVKNFLMNDKCAAGTGRFLEMMARTLGLSLEEMSTMGLEWKENIVISSM
CEEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCHHHCCHHHHH
CTVFAESEVVSLVAQNKAVSDIIHGLNMSVASKVGALAARLGQDNPGEYMMTGGVAKNKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
ITNALEEKLGAKLYICDEAQLCGALGAALFAYEKCREA
CHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIYYKTISESGKQMINYVCKYAPVELFKGFGQDCAVLEEMPENFDKSDKIAHANLCGFG
CCEEHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECHHHHCC
KSVIQAVLEGKVEELVLVNCCDSMRRVYDIIENTKKCKFLYMLDLPHEDNECENIKFAQS
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHH
ILRLKKAYERYSHRTFDRELFIKSFAKPESERKPYIGLMGVHVSSILEKTIRENMQMDVE
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCC
NMTCTSGRNLIILQKDLRNMDDETLFVAYAESLLGQMPCARMNNNTRRNQLFLDPSLKGI
CCEECCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCEEEECCCCCHH
IYHTIKFCDYYGFEYASIKNNIKVPLLKLETDFTSQSAGQLLTRIQAFAETIEGSDDMDP
HHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TKGISEEARRRMESGVYYVAGIDSGSTSTDVVILDQDGKIKSTMIIPTGGGAMMSAEKSL
CCCCHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHH
EKAVEKAGISKDDIVRIVTTGYGRAYINSGDDSITEITCHAKGAHYLNSNVRTVIDIGGQ
HHHHHHCCCCHHHEEEEEEECCCEEEEECCCCCEEEEEEECCCCHHHCCCCEEEEEECCC
DIKAISIDENGAVKNFLMNDKCAAGTGRFLEMMARTLGLSLEEMSTMGLEWKENIVISSM
CEEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCHHHCCHHHHH
CTVFAESEVVSLVAQNKAVSDIIHGLNMSVASKVGALAARLGQDNPGEYMMTGGVAKNKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
ITNALEEKLGAKLYICDEAQLCGALGAALFAYEKCREA
CHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]