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The map label for this gene is serS [H]

Identifier: 238923500

GI number: 238923500

Start: 1033675

End: 1034964

Strand: Direct

Name: serS [H]

Synonym: EUBREC_1120

Alternate gene names: 238923500

Gene position: 1033675-1034964 (Clockwise)

Preceding gene: 238923499

Following gene: 238923501

Centisome position: 29.96

GC content: 45.19

Gene sequence:

>1290_bases
ATGATAGACTTAAAGTTTTTAAGAGAGAATCCGGATCTCGTAAAAGAAAATATTAAAAAGAAATTCCAGGACCACAAGCT
TCCGCTCGTTGATGAAGTAATCGAGTATGACAAGAAGGCCAGAGAGGCACAGCAGGAGGCTGATGATCTTCGTGCAAAGA
AGAATCAGGTTTCTAAGCAGATTGGTGCTCTTATGGCACAGGGCAAGAAGGAAGAGGCTGAGGCTGTAAAGGCTGAGGTA
GCACAGATTTCAAAGCGCCTCACAGAGCTTGAGCCGCTCGAGAAAGAGTATCAGGACAAGGTGCTTGAGGATATGATGAA
GATTCCAAACATCATCGATCCATCAGTTCCAATCGGAAAGGATGATACCTTCAACGTGGAGAACGAGAAGTTTGGTGAGC
CTGTTGTTCCTGATTTCGAGATTCCTTATCATACAGATATCATGGAGAGATTTGACGGAATAGACCTCGATGCAGCAGGA
AAGGTTGCAGGAAACGGTTTCTATTATCTGATGGGAGATATCGCACGTCTTCACTCAGCCATGACAGCATATGCGCGTGA
CTTCATGATTGGAAAGGGCTTTACATACTGTATCCCACCATTTATGATCCGTTCAAATGTCGTAACAGGCGTTATGAGCT
TTGAGGAGATGGATGCCATGATGTACAAGATTGAGGGAGAGGATCTCTACCTTATCGGCACATCTGAGCACTCAATGATC
GGTAAGTTCATCGATACAATAAACGATGAGTCAAAGCTTCCATACACACTCACAAGCTACTCACCTTGCTTCCGTAAGGA
AAAGGGTGCACACGGCATTGAGGAGAGAGGTGTTTACCGTATCCATCAGTTTGAGAAGCAGGAGATGATTGTTGTCTGCA
AGCCACAGGATTCAAAGGAATGGTATGAGAAGATGTGGAAGTACACAGTAGAGCTTTTCAGAAGTCTCGATGTGCCTGTC
CGTACTCTTGAGTGCTGTTCAGGAGACCTCGCAGATCTCAAGGTTAAATCATGCGACGTAGAGGCATGGTCACCAAGACA
GAAGAAGTACTTCGAGGTTGGAAGCTGCTCTAACTTAGGCGATGCACAGGCAAGACGTCTTAAGATTCGTGTAAAGGGCG
AGGATGGCAAGAAATACTTTGCACATACTCTTAACAACACAGTTGTTGCTCCACCACGTATGCTTATCGCATTCCTTGAG
AACAACCTGAATGCAGATGGCTCTGTAAATATCCCTAAGGCACTTCAGCCATACATGGGTGGTACAGAGAAGCTTATTCC
GAAGCACTAG

Upstream 100 bases:

>100_bases
GCTATCATCAAGACACTTACTGACAAGTATCCTCTTGCATTTTAAGGGTTTTCAGAGTAAAATGTTATAAGTTATAAAAA
CATAATACTTTGGAGGAATT

Downstream 100 bases:

>100_bases
TTTTTGAAATAAATTAGTTCATGTAAATAATTAATACATGTAAATATAACAGCCGTAGCTGCGATTGAAAAAGAAAATCG
TGGTTACGGCTGTTTTGTAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MIDLKFLRENPDLVKENIKKKFQDHKLPLVDEVIEYDKKAREAQQEADDLRAKKNQVSKQIGALMAQGKKEEAEAVKAEV
AQISKRLTELEPLEKEYQDKVLEDMMKIPNIIDPSVPIGKDDTFNVENEKFGEPVVPDFEIPYHTDIMERFDGIDLDAAG
KVAGNGFYYLMGDIARLHSAMTAYARDFMIGKGFTYCIPPFMIRSNVVTGVMSFEEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTINDESKLPYTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPQDSKEWYEKMWKYTVELFRSLDVPV
RTLECCSGDLADLKVKSCDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVKGEDGKKYFAHTLNNTVVAPPRMLIAFLE
NNLNADGSVNIPKALQPYMGGTEKLIPKH

Sequences:

>Translated_429_residues
MIDLKFLRENPDLVKENIKKKFQDHKLPLVDEVIEYDKKAREAQQEADDLRAKKNQVSKQIGALMAQGKKEEAEAVKAEV
AQISKRLTELEPLEKEYQDKVLEDMMKIPNIIDPSVPIGKDDTFNVENEKFGEPVVPDFEIPYHTDIMERFDGIDLDAAG
KVAGNGFYYLMGDIARLHSAMTAYARDFMIGKGFTYCIPPFMIRSNVVTGVMSFEEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTINDESKLPYTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPQDSKEWYEKMWKYTVELFRSLDVPV
RTLECCSGDLADLKVKSCDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVKGEDGKKYFAHTLNNTVVAPPRMLIAFLE
NNLNADGSVNIPKALQPYMGGTEKLIPKH
>Mature_429_residues
MIDLKFLRENPDLVKENIKKKFQDHKLPLVDEVIEYDKKAREAQQEADDLRAKKNQVSKQIGALMAQGKKEEAEAVKAEV
AQISKRLTELEPLEKEYQDKVLEDMMKIPNIIDPSVPIGKDDTFNVENEKFGEPVVPDFEIPYHTDIMERFDGIDLDAAG
KVAGNGFYYLMGDIARLHSAMTAYARDFMIGKGFTYCIPPFMIRSNVVTGVMSFEEMDAMMYKIEGEDLYLIGTSEHSMI
GKFIDTINDESKLPYTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPQDSKEWYEKMWKYTVELFRSLDVPV
RTLECCSGDLADLKVKSCDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVKGEDGKKYFAHTLNNTVVAPPRMLIAFLE
NNLNADGSVNIPKALQPYMGGTEKLIPKH

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=473, Percent_Identity=32.1353065539112, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI8923421, Length=409, Percent_Identity=32.0293398533007, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI225579074, Length=411, Percent_Identity=31.1435523114355, Blast_Score=191, Evalue=2e-48,
Organism=Escherichia coli, GI1787120, Length=436, Percent_Identity=33.256880733945, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17539260, Length=454, Percent_Identity=32.8193832599119, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=315, Percent_Identity=30.7936507936508, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=437, Percent_Identity=32.9519450800915, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6321799, Length=408, Percent_Identity=30.1470588235294, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=31.9057815845824, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI17737985, Length=354, Percent_Identity=31.3559322033898, Blast_Score=161, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48992; Mature: 48992

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLKFLRENPDLVKENIKKKFQDHKLPLVDEVIEYDKKAREAQQEADDLRAKKNQVSKQ
CCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALMAQGKKEEAEAVKAEVAQISKRLTELEPLEKEYQDKVLEDMMKIPNIIDPSVPIGK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DDTFNVENEKFGEPVVPDFEIPYHTDIMERFDGIDLDAAGKVAGNGFYYLMGDIARLHSA
CCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
MTAYARDFMIGKGFTYCIPPFMIRSNVVTGVMSFEEMDAMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCCHHHH
GKFIDTINDESKLPYTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPQDSKE
HHHHHHCCCCCCCCEEECCCCHHHHHCCCCCCHHHCCCHHHHHCCCCCEEEEECCCCHHH
WYEKMWKYTVELFRSLDVPVRTLECCSGDLADLKVKSCDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCEEEECCCCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVKGEDGKKYFAHTLNNTVVAPPRMLIAFLENNLNADGSVNIPKALQPYMG
CCCCEEEEEEEECCCCHHHHHHHHCCCEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHCC
GTEKLIPKH
CCCCCCCCC
>Mature Secondary Structure
MIDLKFLRENPDLVKENIKKKFQDHKLPLVDEVIEYDKKAREAQQEADDLRAKKNQVSKQ
CCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGALMAQGKKEEAEAVKAEVAQISKRLTELEPLEKEYQDKVLEDMMKIPNIIDPSVPIGK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DDTFNVENEKFGEPVVPDFEIPYHTDIMERFDGIDLDAAGKVAGNGFYYLMGDIARLHSA
CCCCCCCCHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHH
MTAYARDFMIGKGFTYCIPPFMIRSNVVTGVMSFEEMDAMMYKIEGEDLYLIGTSEHSMI
HHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEEECCCHHHH
GKFIDTINDESKLPYTLTSYSPCFRKEKGAHGIEERGVYRIHQFEKQEMIVVCKPQDSKE
HHHHHHCCCCCCCCEEECCCCHHHHHCCCCCCHHHCCCHHHHHCCCCCEEEEECCCCHHH
WYEKMWKYTVELFRSLDVPVRTLECCSGDLADLKVKSCDVEAWSPRQKKYFEVGSCSNLG
HHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCEEEECCCCCCCCCHHHEEECCCCCCCC
DAQARRLKIRVKGEDGKKYFAHTLNNTVVAPPRMLIAFLENNLNADGSVNIPKALQPYMG
CCCCEEEEEEEECCCCHHHHHHHHCCCEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHCC
GTEKLIPKH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA