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The map label for this gene is lon [H]

Identifier: 238923371

GI number: 238923371

Start: 885784

End: 888096

Strand: Direct

Name: lon [H]

Synonym: EUBREC_0991

Alternate gene names: 238923371

Gene position: 885784-888096 (Clockwise)

Preceding gene: 238923370

Following gene: 238923372

Centisome position: 25.68

GC content: 47.0

Gene sequence:

>2313_bases
GTGGAAGAACAGATTATGAATATGCCTGCAGTAGCGCTGAGAGGGCTTACTATTCTGCCGGGGATGATTGCCCATTTCGA
CATCAGCAGAGAGCGCTCCCTTCGTGCTGTTGAGGAGGCTATGGAGCAGGATCAAAAGATTTATCTTGTCACACAAAGGA
ATGTGGACAGTGAGGACCCGACTCAGGAAGACCTCTATCAGATGGGTATTGTTGCTGATATAAAGCAGGTTGTCAGATTA
CAGAATGATGTTGTGAGAATACTCGTAGATGGAATAAGCCGGGCAGCATTGCTTGGCTTTACCGGTAATGAGAAGTACCT
TGAGGCAGAAATCTGTTATTGTGATAGTAATGCAGACAGCCTGCCGGAGGATCTCAGGGAAGCCATGCTTCTCGGAGTCA
GAGAGGCTTTTCACAGATATGCGGCAGTCGTCGGCAAAATCAGCAAGGAGCTTATCAGACAGATAGATCAGTATGAGGAT
CTTGAAAAGCTCATTGATTATGTAACCAACAATCTGCCGGTGTCATATGAGCTTAAGCAGCAGGTGCTTGAGGCAGAGGA
TATCAATGACAGATATCAGGTTATAGTATCATTACTTCTCTCCCAGGTGGAGGTTATTTCCATAAAGAATGAGCTTCAGA
AAAAAGTAAAGGTTCGTGTGGACAAGCATCAGAAGGAGTATGTGCTTCGTGAACAGCTTGGTGTGATACGTGAGGAGCTG
GGCGAGAATGCTGACTCGGAGGCTGATGAATATGAGAAAAAGCTATCTGAGTTAGATGCGCCTGACTACGTAAAGGAAAA
GACGAAAAAAGAGATAAAGCGCTTTAGAAATATGAGCAGCAGCTCATCAGAGAGCACAGTTGAGAGAGGCTATATAGAGA
CAGTACTTGAGCTTCCGTGGAACAAGATGTCTGTGGACAACAAGGATCTTGACCATGCAGCACAGGTGCTGGATGATGAT
CACTACGGATTAAAGGATGTTAAGGAGAGAATACTTGAGTTTCTGGCAGTCAGAAATCTGACAAGCAAGGGAGAGAGTCC
TATAATTTGTCTTGTAGGTCCTCCGGGAACAGGAAAGACAAGCATAGCCCGTTCAATTGCGTCTGCACTGGAGAAGAAAT
ATGTGCGTATTTCTCTTGGTGGTGTGCGCGATGAGGCAGAAATCCGTGGACACAGAAAGACATATATCGGCGCTATGCCG
GGCCGTATAGTAAATGGCTTAAGACAGGCAGGCGTTTCAAATCCTCTCATGCTGTTGGATGAGATAGATAAGGTGTCAAG
TGACTACAAGGGTGACACATCAGCCGCTCTTCTCGAGGTGCTTGACAGTGAGCAGAACTGCAGATTCAGGGATCATTACA
TCGAGATGCCTGTGGATTTGTCGGAGGTGCTTTTTATTGCAACGGCAAATGAGGTTTCAGGTATTCCAAAGCCACTTCTT
GACAGGATGGAGCTTATCGAGGTGTCAAGCTACACTGAAAATGAGAAATTTCACATAGCAAAGGAACACCTGGTTGAGAA
GCAAAAGAGCAAAAACGGAATTAAAAAGGAACAGCTTACGATAACAGATGGTGCTTTAAAGGATATCATCAGGCTGTACA
CCAGAGAGGCCGGAGTCAGAAGCCTTGAGAGGACTATCGGCAAGCTGTGCCGCAAGGCTGCCAGGGAAATCTTCAAGGAC
AGCGAAGCTGCTGTAAAGGTTACAAAGACCAATCTTAAGACGTATCTGGGCAATCCGAAGTACAGTCCGGAGAAGAAAAA
TGATCACGCAGAGGTTGGAATCGTTAGAGGCCTGGCATGGACCAGCGTGGGCGGAGTTACACTCGAGGTTGAGGTGAATG
TGCTGCCGGGCAAGGGTGAGCTCGTGCTCACCGGTAAGCTTGGCGACGTGATGAAGGAGTCGGCACAGGCGGCACTTAGC
TATGTGCGCTCAATAAGCGAAGGATATGGCATTGATGCAGAGTTTTACACGAAGCATGATATCCATATACATATCCCGGA
GGGCGCAGTGCCAAAGGACGGACCATCTGCAGGCATCACTATGGCGACAGCCATGCTCTCAGCCATTACAGACAGAGCTG
TCAGGGCAGATGTAGCCATGACAGGCGAGATAACACTGCGCGGCAGGGTGCTTCCGATAGGAGGACTCAAGGAAAAGCTG
CTTGCAGCCAAAGTAATCGGAATAAAAACAGTATGTATTCCAAAGGATAATGAAAAGGACCTGGAGGAGATTTCAAAAGA
AATAACAGACGGCATGGAAATCGTGCCGGTGGAGAGATTTTCACAGGTGGAGAAGATAGCATTTGTAAAATAA

Upstream 100 bases:

>100_bases
GTAAGTACATGGCGGTATTTTACAAAAGATACAGCATCGGATAATATAAATTGCACAGCGGTTTGTTATGCATGGCTGTG
CAATAATACAGGAGATATAA

Downstream 100 bases:

>100_bases
GAATGAGGAAGAGATTATGGTAATTAAAAGTGTTAATTTAGAGACAGTTTGCGGAATTACAAGCACAATCCCTGACAATG
AGTATAATGAAGTGGCATTC

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MEEQIMNMPAVALRGLTILPGMIAHFDISRERSLRAVEEAMEQDQKIYLVTQRNVDSEDPTQEDLYQMGIVADIKQVVRL
QNDVVRILVDGISRAALLGFTGNEKYLEAEICYCDSNADSLPEDLREAMLLGVREAFHRYAAVVGKISKELIRQIDQYED
LEKLIDYVTNNLPVSYELKQQVLEAEDINDRYQVIVSLLLSQVEVISIKNELQKKVKVRVDKHQKEYVLREQLGVIREEL
GENADSEADEYEKKLSELDAPDYVKEKTKKEIKRFRNMSSSSSESTVERGYIETVLELPWNKMSVDNKDLDHAAQVLDDD
HYGLKDVKERILEFLAVRNLTSKGESPIICLVGPPGTGKTSIARSIASALEKKYVRISLGGVRDEAEIRGHRKTYIGAMP
GRIVNGLRQAGVSNPLMLLDEIDKVSSDYKGDTSAALLEVLDSEQNCRFRDHYIEMPVDLSEVLFIATANEVSGIPKPLL
DRMELIEVSSYTENEKFHIAKEHLVEKQKSKNGIKKEQLTITDGALKDIIRLYTREAGVRSLERTIGKLCRKAAREIFKD
SEAAVKVTKTNLKTYLGNPKYSPEKKNDHAEVGIVRGLAWTSVGGVTLEVEVNVLPGKGELVLTGKLGDVMKESAQAALS
YVRSISEGYGIDAEFYTKHDIHIHIPEGAVPKDGPSAGITMATAMLSAITDRAVRADVAMTGEITLRGRVLPIGGLKEKL
LAAKVIGIKTVCIPKDNEKDLEEISKEITDGMEIVPVERFSQVEKIAFVK

Sequences:

>Translated_770_residues
MEEQIMNMPAVALRGLTILPGMIAHFDISRERSLRAVEEAMEQDQKIYLVTQRNVDSEDPTQEDLYQMGIVADIKQVVRL
QNDVVRILVDGISRAALLGFTGNEKYLEAEICYCDSNADSLPEDLREAMLLGVREAFHRYAAVVGKISKELIRQIDQYED
LEKLIDYVTNNLPVSYELKQQVLEAEDINDRYQVIVSLLLSQVEVISIKNELQKKVKVRVDKHQKEYVLREQLGVIREEL
GENADSEADEYEKKLSELDAPDYVKEKTKKEIKRFRNMSSSSSESTVERGYIETVLELPWNKMSVDNKDLDHAAQVLDDD
HYGLKDVKERILEFLAVRNLTSKGESPIICLVGPPGTGKTSIARSIASALEKKYVRISLGGVRDEAEIRGHRKTYIGAMP
GRIVNGLRQAGVSNPLMLLDEIDKVSSDYKGDTSAALLEVLDSEQNCRFRDHYIEMPVDLSEVLFIATANEVSGIPKPLL
DRMELIEVSSYTENEKFHIAKEHLVEKQKSKNGIKKEQLTITDGALKDIIRLYTREAGVRSLERTIGKLCRKAAREIFKD
SEAAVKVTKTNLKTYLGNPKYSPEKKNDHAEVGIVRGLAWTSVGGVTLEVEVNVLPGKGELVLTGKLGDVMKESAQAALS
YVRSISEGYGIDAEFYTKHDIHIHIPEGAVPKDGPSAGITMATAMLSAITDRAVRADVAMTGEITLRGRVLPIGGLKEKL
LAAKVIGIKTVCIPKDNEKDLEEISKEITDGMEIVPVERFSQVEKIAFVK
>Mature_770_residues
MEEQIMNMPAVALRGLTILPGMIAHFDISRERSLRAVEEAMEQDQKIYLVTQRNVDSEDPTQEDLYQMGIVADIKQVVRL
QNDVVRILVDGISRAALLGFTGNEKYLEAEICYCDSNADSLPEDLREAMLLGVREAFHRYAAVVGKISKELIRQIDQYED
LEKLIDYVTNNLPVSYELKQQVLEAEDINDRYQVIVSLLLSQVEVISIKNELQKKVKVRVDKHQKEYVLREQLGVIREEL
GENADSEADEYEKKLSELDAPDYVKEKTKKEIKRFRNMSSSSSESTVERGYIETVLELPWNKMSVDNKDLDHAAQVLDDD
HYGLKDVKERILEFLAVRNLTSKGESPIICLVGPPGTGKTSIARSIASALEKKYVRISLGGVRDEAEIRGHRKTYIGAMP
GRIVNGLRQAGVSNPLMLLDEIDKVSSDYKGDTSAALLEVLDSEQNCRFRDHYIEMPVDLSEVLFIATANEVSGIPKPLL
DRMELIEVSSYTENEKFHIAKEHLVEKQKSKNGIKKEQLTITDGALKDIIRLYTREAGVRSLERTIGKLCRKAAREIFKD
SEAAVKVTKTNLKTYLGNPKYSPEKKNDHAEVGIVRGLAWTSVGGVTLEVEVNVLPGKGELVLTGKLGDVMKESAQAALS
YVRSISEGYGIDAEFYTKHDIHIHIPEGAVPKDGPSAGITMATAMLSAITDRAVRADVAMTGEITLRGRVLPIGGLKEKL
LAAKVIGIKTVCIPKDNEKDLEEISKEITDGMEIVPVERFSQVEKIAFVK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=606, Percent_Identity=43.0693069306931, Blast_Score=524, Evalue=1e-148,
Organism=Homo sapiens, GI31377667, Length=819, Percent_Identity=37.7289377289377, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1786643, Length=766, Percent_Identity=47.2584856396867, Blast_Score=717, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=635, Percent_Identity=40, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=536, Percent_Identity=39.9253731343284, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=652, Percent_Identity=39.8773006134969, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24666867, Length=604, Percent_Identity=44.0397350993377, Blast_Score=527, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221513036, Length=604, Percent_Identity=44.0397350993377, Blast_Score=527, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86058; Mature: 86058

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQIMNMPAVALRGLTILPGMIAHFDISRERSLRAVEEAMEQDQKIYLVTQRNVDSEDP
CCCHHHCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
TQEDLYQMGIVADIKQVVRLQNDVVRILVDGISRAALLGFTGNEKYLEAEICYCDSNADS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEEECCCCCC
LPEDLREAMLLGVREAFHRYAAVVGKISKELIRQIDQYEDLEKLIDYVTNNLPVSYELKQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QVLEAEDINDRYQVIVSLLLSQVEVISIKNELQKKVKVRVDKHQKEYVLREQLGVIREEL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GENADSEADEYEKKLSELDAPDYVKEKTKKEIKRFRNMSSSSSESTVERGYIETVLELPW
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
NKMSVDNKDLDHAAQVLDDDHYGLKDVKERILEFLAVRNLTSKGESPIICLVGPPGTGKT
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
SIARSIASALEKKYVRISLGGVRDEAEIRGHRKTYIGAMPGRIVNGLRQAGVSNPLMLLD
HHHHHHHHHHHHCEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCHHHHH
EIDKVSSDYKGDTSAALLEVLDSEQNCRFRDHYIEMPVDLSEVLFIATANEVSGIPKPLL
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHEECCCCHHHEEEEEECHHHCCCCHHHH
DRMELIEVSSYTENEKFHIAKEHLVEKQKSKNGIKKEQLTITDGALKDIIRLYTREAGVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEECHHHHHHHHHHHHHHHHHH
SLERTIGKLCRKAAREIFKDSEAAVKVTKTNLKTYLGNPKYSPEKKNDHAEVGIVRGLAW
HHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
TSVGGVTLEVEVNVLPGKGELVLTGKLGDVMKESAQAALSYVRSISEGYGIDAEFYTKHD
HCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECE
IHIHIPEGAVPKDGPSAGITMATAMLSAITDRAVRADVAMTGEITLRGRVLPIGGLKEKL
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEECEEEEEEEEEECCCHHHHH
LAAKVIGIKTVCIPKDNEKDLEEISKEITDGMEIVPVERFSQVEKIAFVK
HHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MEEQIMNMPAVALRGLTILPGMIAHFDISRERSLRAVEEAMEQDQKIYLVTQRNVDSEDP
CCCHHHCCCHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
TQEDLYQMGIVADIKQVVRLQNDVVRILVDGISRAALLGFTGNEKYLEAEICYCDSNADS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEEEECCCCCC
LPEDLREAMLLGVREAFHRYAAVVGKISKELIRQIDQYEDLEKLIDYVTNNLPVSYELKQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QVLEAEDINDRYQVIVSLLLSQVEVISIKNELQKKVKVRVDKHQKEYVLREQLGVIREEL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GENADSEADEYEKKLSELDAPDYVKEKTKKEIKRFRNMSSSSSESTVERGYIETVLELPW
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
NKMSVDNKDLDHAAQVLDDDHYGLKDVKERILEFLAVRNLTSKGESPIICLVGPPGTGKT
CCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHH
SIARSIASALEKKYVRISLGGVRDEAEIRGHRKTYIGAMPGRIVNGLRQAGVSNPLMLLD
HHHHHHHHHHHHCEEEEEECCCCCHHHHCCCHHHEECCCCHHHHHHHHHCCCCCCHHHHH
EIDKVSSDYKGDTSAALLEVLDSEQNCRFRDHYIEMPVDLSEVLFIATANEVSGIPKPLL
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHEECCCCHHHEEEEEECHHHCCCCHHHH
DRMELIEVSSYTENEKFHIAKEHLVEKQKSKNGIKKEQLTITDGALKDIIRLYTREAGVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEECHHHHHHHHHHHHHHHHHH
SLERTIGKLCRKAAREIFKDSEAAVKVTKTNLKTYLGNPKYSPEKKNDHAEVGIVRGLAW
HHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
TSVGGVTLEVEVNVLPGKGELVLTGKLGDVMKESAQAALSYVRSISEGYGIDAEFYTKHD
HCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECE
IHIHIPEGAVPKDGPSAGITMATAMLSAITDRAVRADVAMTGEITLRGRVLPIGGLKEKL
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEECEEEEEEEEEECCCHHHHH
LAAKVIGIKTVCIPKDNEKDLEEISKEITDGMEIVPVERFSQVEKIAFVK
HHHHHHCEEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA