Click here to switch to the map view.

The map label for this gene is ubiB [C]

Identifier: 238923076

GI number: 238923076

Start: 607657

End: 609216

Strand: Direct

Name: ubiB [C]

Synonym: EUBREC_0666

Alternate gene names: 238923076

Gene position: 607657-609216 (Clockwise)

Preceding gene: 238923075

Following gene: 238923078

Centisome position: 17.61

GC content: 46.15

Gene sequence:

>1560_bases
ATGGATGGCCGCCTGAAGGAGATGACAGCGGTACTGAAGAAGTACAAGCTCACGCATGGACTTACACCCGAAAAATTCAG
ACTTATATTGCAGGAGCTGGGACCTACCTATATTAAGCTTGGACAGATAATGTCGCTTCACTCGGATATTCTGCCAAAGG
AATATTGTGAGGAGCTTATGAAGCTATGCTCAGATGTGGAGCCGATGCCGTTTGAGCAGGTGGAGGCTGTCATAGATGCT
TCATTTGGCTATTCATGGAAGGATGTTTTTGCTTCAATAGATAAAAAGCCTCTTGGGGCAGCTTCTATAGCGCAGGTGCA
CAGGGCCACACTTAAAACCGGTGAGCAGGTGGTTGTGAAGGTGCAAAGGAAGGGCATTCACGAGGTGATGTCAAAGGATA
TGGCGCTGCTTCACAAGGCGGTTAAGCTTGTGCCACCCATCTCTATAAAGGGCATTGTGGATTTTGACATGGTGCTTGAT
GAAATGTGGGCTGTGGCACAGGAGGAGATGAATTTTCTGCTTGAGGCATCCAATATTGAGGAGTTTGCCGGCAATAACAG
GGATGTTGCATTTGTAGCCACACCAAAGCTTTACCGCAAGTATACCACATCACATGTGCTTGTCATGGAGTATATAAAGG
GCTTTAATATCGATGATAAGGAGGGGCTTTTAAAGGATGGCTATGATCTTGAGGAGATAGGCAGCAAGCTGATTGACAAC
TATATCAGGCAGGTGATAGAGGATGGCTTCTTCCATGCGGACCCGCATCCGGGCAATGTAAAGATAAGGGATGGCAAAAT
TGTCTGGATTGATATGGGCATGATGGGAAGGCTTTCTGAGCATGACAAAAAGGAACTGAGCAATGCTGTTTACGGCATCG
CCATGAACGATATCGGCATGATAGAGGATGCGGTGCTTGCAATTGGTGACTTTAAGGGTGAGCCTGACAGGGCAAAGCTG
TACAAGGATATCAAAATAATCATGAATAAATACGGCAGTCTGGATATGGGACAGGTCGATGTCGCAGAGTTTATTCAGGA
GCTTTTGGAGGTAATGAAGAACAACCGCATTGTTATGCCGCATGGTTTTACAATGCTTGCGAGGGGCATCACTCAGATAG
AGGGCGTGCTTGCGGATATTGCACCTGGCATCAACATGGTTGGGATTGCTTCTGCAAGGATTAAACAGGAGATGCTTAAG
AATTTTGATTTGAAGGGCGAGCTTAAAAAAGCCGGGAAGACAGCCTACAAATCAGCTCACCGCATGGCAGAACTGCCGGA
TAGGCTGGCGCAGATACTCGAGGAATATCAAAGAGGGCAGACAAGCATAAATTTTGACATGCATGCTTCTGATGAGCTTG
CGAGGCTTTTACACAGGCTGGTGAGAAATATCGTCATGGGCTTATGGGTTATGGCACTTCTAATCAGCTCAAGCATAGTG
TGTACCACAGATATGACACCTAAGATACTTGGCATACCGGCGCTTGGTGTTATGGGATATGTGTTTGCATGCATCATAGT
GCTTTATACGATTGTGAAGCATTTCATATCCAGACGATGA

Upstream 100 bases:

>100_bases
GATACTTCAGCCGATGGAAAAAGTGCTTCCGGTGGAGAATCACAGACAGTGGATATAAAAATAGAAGCTGAGGACGATAA
AGAGGAAAGCGTGAACTAGT

Downstream 100 bases:

>100_bases
TAAAAAAGCAGGATTCTGAAATTAATCAGAAATCCTGCTTTTTAATTACGTTATATTATTTCGATGATTTTTTACTCTTT
GCTTTTTTAGAATCCTCATC

Product: hypothetical protein kinase in ABC1 family

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MDGRLKEMTAVLKKYKLTHGLTPEKFRLILQELGPTYIKLGQIMSLHSDILPKEYCEELMKLCSDVEPMPFEQVEAVIDA
SFGYSWKDVFASIDKKPLGAASIAQVHRATLKTGEQVVVKVQRKGIHEVMSKDMALLHKAVKLVPPISIKGIVDFDMVLD
EMWAVAQEEMNFLLEASNIEEFAGNNRDVAFVATPKLYRKYTTSHVLVMEYIKGFNIDDKEGLLKDGYDLEEIGSKLIDN
YIRQVIEDGFFHADPHPGNVKIRDGKIVWIDMGMMGRLSEHDKKELSNAVYGIAMNDIGMIEDAVLAIGDFKGEPDRAKL
YKDIKIIMNKYGSLDMGQVDVAEFIQELLEVMKNNRIVMPHGFTMLARGITQIEGVLADIAPGINMVGIASARIKQEMLK
NFDLKGELKKAGKTAYKSAHRMAELPDRLAQILEEYQRGQTSINFDMHASDELARLLHRLVRNIVMGLWVMALLISSSIV
CTTDMTPKILGIPALGVMGYVFACIIVLYTIVKHFISRR

Sequences:

>Translated_519_residues
MDGRLKEMTAVLKKYKLTHGLTPEKFRLILQELGPTYIKLGQIMSLHSDILPKEYCEELMKLCSDVEPMPFEQVEAVIDA
SFGYSWKDVFASIDKKPLGAASIAQVHRATLKTGEQVVVKVQRKGIHEVMSKDMALLHKAVKLVPPISIKGIVDFDMVLD
EMWAVAQEEMNFLLEASNIEEFAGNNRDVAFVATPKLYRKYTTSHVLVMEYIKGFNIDDKEGLLKDGYDLEEIGSKLIDN
YIRQVIEDGFFHADPHPGNVKIRDGKIVWIDMGMMGRLSEHDKKELSNAVYGIAMNDIGMIEDAVLAIGDFKGEPDRAKL
YKDIKIIMNKYGSLDMGQVDVAEFIQELLEVMKNNRIVMPHGFTMLARGITQIEGVLADIAPGINMVGIASARIKQEMLK
NFDLKGELKKAGKTAYKSAHRMAELPDRLAQILEEYQRGQTSINFDMHASDELARLLHRLVRNIVMGLWVMALLISSSIV
CTTDMTPKILGIPALGVMGYVFACIIVLYTIVKHFISRR
>Mature_519_residues
MDGRLKEMTAVLKKYKLTHGLTPEKFRLILQELGPTYIKLGQIMSLHSDILPKEYCEELMKLCSDVEPMPFEQVEAVIDA
SFGYSWKDVFASIDKKPLGAASIAQVHRATLKTGEQVVVKVQRKGIHEVMSKDMALLHKAVKLVPPISIKGIVDFDMVLD
EMWAVAQEEMNFLLEASNIEEFAGNNRDVAFVATPKLYRKYTTSHVLVMEYIKGFNIDDKEGLLKDGYDLEEIGSKLIDN
YIRQVIEDGFFHADPHPGNVKIRDGKIVWIDMGMMGRLSEHDKKELSNAVYGIAMNDIGMIEDAVLAIGDFKGEPDRAKL
YKDIKIIMNKYGSLDMGQVDVAEFIQELLEVMKNNRIVMPHGFTMLARGITQIEGVLADIAPGINMVGIASARIKQEMLK
NFDLKGELKKAGKTAYKSAHRMAELPDRLAQILEEYQRGQTSINFDMHASDELARLLHRLVRNIVMGLWVMALLISSSIV
CTTDMTPKILGIPALGVMGYVFACIIVLYTIVKHFISRR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=280, Percent_Identity=30.3571428571429, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI41393593, Length=269, Percent_Identity=30.1115241635688, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI217035081, Length=228, Percent_Identity=30.7017543859649, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI34147522, Length=341, Percent_Identity=24.3401759530792, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI27363457, Length=337, Percent_Identity=23.7388724035608, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI217416386, Length=332, Percent_Identity=23.7951807228916, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI2367309, Length=446, Percent_Identity=26.0089686098655, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17559152, Length=290, Percent_Identity=32.4137931034483, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=250, Percent_Identity=28.4, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=323, Percent_Identity=28.1733746130031, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=248, Percent_Identity=29.8387096774194, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=256, Percent_Identity=25.390625, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI22024280, Length=281, Percent_Identity=32.0284697508897, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24662575, Length=313, Percent_Identity=29.7124600638978, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI18859849, Length=342, Percent_Identity=23.0994152046784, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 58401; Mature: 58401

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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EECCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA