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The map label for this gene is map [H]

Identifier: 238922967

GI number: 238922967

Start: 513546

End: 514421

Strand: Direct

Name: map [H]

Synonym: EUBREC_0556

Alternate gene names: 238922967

Gene position: 513546-514421 (Clockwise)

Preceding gene: 238922966

Following gene: 238922969

Centisome position: 14.89

GC content: 46.8

Gene sequence:

>876_bases
ATGTCAACAAAAATTGGAAGAAATGACCCTTGCTGGTGTGGCAGCGGAAAGAAATATAAGACCTGTCATGCGGCATTTGA
TATGAAGCTTGAAAAGCTTGCTGAGGCACATCATAAGATACCGAGCCATTCAATCATTAAGACACCTGACCAGATAGCGG
GAATCAAGGAGAGCGCCAAGATAAATGTCGCAGTGCTCGACTACATAGGAGAGCATATCCATGAGGGTATGAACACAGCA
GAGATTGATAAAATAGTCTATGATATGACCACCAGCATGGGCGGCATCCCTGCACCGCTCAACTATGAGGGTTATCCTTA
CAGCGTATGTACATCAGTAAATGAGCAGGTTTGTCACGGATTTCCTTCAAAGGACGTCATCTTAAAGGATGGTGACATCA
TAAATGTAGACTGTTCTACAATTTTAAACGGATATTTTTCGGATTCATCAAGAATGTACTGTATCGGAAATGTAAGCCCG
GAGAAGAAAAAGCTCGTTGAAGTCACAAAGGAGTGTGTGGAGCTTGGACTCAAAGAGGTAAAGCCGTGGGGCTTCCTCGG
AGATATGGGACAGGCGGTGCACGACCATGCATTTGCAAACGGTTACACAGTAGTGCGTGAAATCGGTGGACACGGAGTGG
GACTTGAATTTCACGAGGATCCATGGGTAGGCTACAACACCAAGCGCGGCACCGACATGGTCATGGCACCCGGCATGATA
TTTACCATCGAGCCAATGGTCAACATGGGCAAGGCCGATATCTACGTAGATGACAAGAACAACTGGGAAGTATACACCGA
TGACGGACTTCCATCAGCCCAGTGGGAAATCATGGTACTCGTCACAGAGGATGGCCATGAGGTACTGAGCTGGTAA

Upstream 100 bases:

>100_bases
TGAGAAGCTGCTGGAGAAAAATAACTATAAAATAAAAGAAAAAGTGTGGAAAAGAGTCGATATGGGAAACGTTACTCTTG
ATCACTAGAAAGAAGATTTT

Downstream 100 bases:

>100_bases
ACTGTTAAATACCCTAAATTTACCGGAGAGTATGCAGTGTGTTCCGAAGAAAAATATAAACTGCCACGGCGTTCCATAAA
ATGTGGATGCGACAATTCAT

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSTKIGRNDPCWCGSGKKYKTCHAAFDMKLEKLAEAHHKIPSHSIIKTPDQIAGIKESAKINVAVLDYIGEHIHEGMNTA
EIDKIVYDMTTSMGGIPAPLNYEGYPYSVCTSVNEQVCHGFPSKDVILKDGDIINVDCSTILNGYFSDSSRMYCIGNVSP
EKKKLVEVTKECVELGLKEVKPWGFLGDMGQAVHDHAFANGYTVVREIGGHGVGLEFHEDPWVGYNTKRGTDMVMAPGMI
FTIEPMVNMGKADIYVDDKNNWEVYTDDGLPSAQWEIMVLVTEDGHEVLSW

Sequences:

>Translated_291_residues
MSTKIGRNDPCWCGSGKKYKTCHAAFDMKLEKLAEAHHKIPSHSIIKTPDQIAGIKESAKINVAVLDYIGEHIHEGMNTA
EIDKIVYDMTTSMGGIPAPLNYEGYPYSVCTSVNEQVCHGFPSKDVILKDGDIINVDCSTILNGYFSDSSRMYCIGNVSP
EKKKLVEVTKECVELGLKEVKPWGFLGDMGQAVHDHAFANGYTVVREIGGHGVGLEFHEDPWVGYNTKRGTDMVMAPGMI
FTIEPMVNMGKADIYVDDKNNWEVYTDDGLPSAQWEIMVLVTEDGHEVLSW
>Mature_290_residues
STKIGRNDPCWCGSGKKYKTCHAAFDMKLEKLAEAHHKIPSHSIIKTPDQIAGIKESAKINVAVLDYIGEHIHEGMNTAE
IDKIVYDMTTSMGGIPAPLNYEGYPYSVCTSVNEQVCHGFPSKDVILKDGDIINVDCSTILNGYFSDSSRMYCIGNVSPE
KKKLVEVTKECVELGLKEVKPWGFLGDMGQAVHDHAFANGYTVVREIGGHGVGLEFHEDPWVGYNTKRGTDMVMAPGMIF
TIEPMVNMGKADIYVDDKNNWEVYTDDGLPSAQWEIMVLVTEDGHEVLSW

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=262, Percent_Identity=37.0229007633588, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI40385867, Length=245, Percent_Identity=36.3265306122449, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=41.2955465587045, Blast_Score=199, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71996291, Length=254, Percent_Identity=37.7952755905512, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323273, Length=244, Percent_Identity=43.0327868852459, Blast_Score=192, Evalue=4e-50,
Organism=Drosophila melanogaster, GI21355531, Length=243, Percent_Identity=37.8600823045267, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=35.6275303643725, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027 [H]

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32257; Mature: 32126

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKIGRNDPCWCGSGKKYKTCHAAFDMKLEKLAEAHHKIPSHSIIKTPDQIAGIKESAK
CCCCCCCCCCCEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHCCCCCCE
INVAVLDYIGEHIHEGMNTAEIDKIVYDMTTSMGGIPAPLNYEGYPYSVCTSVNEQVCHG
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHCC
FPSKDVILKDGDIINVDCSTILNGYFSDSSRMYCIGNVSPEKKKLVEVTKECVELGLKEV
CCCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHC
KPWGFLGDMGQAVHDHAFANGYTVVREIGGHGVGLEFHEDPWVGYNTKRGTDMVMAPGMI
CCCCCHHHHHHHHHHHHHCCCCCEEEHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCEE
FTIEPMVNMGKADIYVDDKNNWEVYTDDGLPSAQWEIMVLVTEDGHEVLSW
EEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEEEECCCHHHHCC
>Mature Secondary Structure 
STKIGRNDPCWCGSGKKYKTCHAAFDMKLEKLAEAHHKIPSHSIIKTPDQIAGIKESAK
CCCCCCCCCCEECCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHCCCCCCE
INVAVLDYIGEHIHEGMNTAEIDKIVYDMTTSMGGIPAPLNYEGYPYSVCTSVNEQVCHG
EEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCHHHHCC
FPSKDVILKDGDIINVDCSTILNGYFSDSSRMYCIGNVSPEKKKLVEVTKECVELGLKEV
CCCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHC
KPWGFLGDMGQAVHDHAFANGYTVVREIGGHGVGLEFHEDPWVGYNTKRGTDMVMAPGMI
CCCCCHHHHHHHHHHHHHCCCCCEEEHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCEE
FTIEPMVNMGKADIYVDDKNNWEVYTDDGLPSAQWEIMVLVTEDGHEVLSW
EEECCCCCCCCEEEEEECCCCEEEEECCCCCCCCEEEEEEEECCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]