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The map label for this gene is yclK [H]

Identifier: 238922877

GI number: 238922877

Start: 422409

End: 423920

Strand: Direct

Name: yclK [H]

Synonym: EUBREC_0465

Alternate gene names: 238922877

Gene position: 422409-423920 (Clockwise)

Preceding gene: 238922876

Following gene: 238922878

Centisome position: 12.24

GC content: 42.53

Gene sequence:

>1512_bases
ATGGAGAATACTATGAAGATAAAAACAAAACTTGCTATATCATTCTGCATAATTATTTTTGTGCCTGTTGTGCTCACCAG
TATAGTGCTTGTGGGTTTCAATAAGATTCAGCTAAAGGCCATAAACAAGACATATGGCATGGAGGATGCGGGCATGCTCG
CGCTCACTGACACAGTACAGTTTCTGAACAAGGTGACAGGGCGCACATATGATGAGCTCGAGAAGACATCGCTCATAGAA
CCATCCAGGCTTCTTGATAGTGATTATCTGACTAAGATAAATAAGAAGCTGGAGAAGAAGTATTCATATCTCATAGTGAA
AAGTGAAGGAGAGCTCATTTTCAATGGTGGAATTGACAATGATGATATTTTGAGAAAGCTTCCGCGAATATCCAATAAGC
AGAGCAGCTCTGATGTGAGCAGCTATATGGACAGTGATGACAAGGTGCTCATAAAGCAGCTTAATTTTCGTGACAGTGAT
GGTGACGAGGCGAGTCTTTACATAGTGACATCAACTGCGTGCGTGATCCCTGAGGTCAGGACTGTTTTGATGGAGGGAGC
ATTTGCACTAGTATTGATACTTCTTACTACGGCTGCCATGCTTATAGTGTGGATATACAGGAGTATCATCACACCGATAG
AGAGGCTGCGTATTGCCGCTGAAAATATCAAGGATGGTAATCTGGACTTTGAGCTTGAGACGAGCCCGAGCGACGGAGAG
ATTGGCGAGCTGTGTACTGCGTTTGAGCAGATGCGTGCCCGCCTCAAGAAAAATGCCGAGGAAAAGGTGACGAATGAGTC
TGAAAACAGAGTGTTAATCAGTAATATCGCACATGATTTAAAGACTCCTATTACAGCGGTAAAGGGCTACGCCGAGGGCA
TACTTGACGGAGTGGCAAACACCCCTGAAAAGGTAGATAAATACGTCAGGACCATTTACAATAAGGCAAACGATATGGAT
AAGCTCATTAATGAGCTGACACTTTACTCGAAGATTGATACGAACAGGATTCCATATAATTTTGCGAAGATAAATGTCAC
AGATTATTTTAACGACTGTGTTGAGGAAATAGGACTCGATCTTGAGGCAAAAAATATCAGGCTTTCATATGAGAATCATG
TGGATAGCAACGTGCTTATCATTGCTGATCCGGAGCAGATTCGCCGTGTGATTAATAATATAGTCGGCAATTCGGTGAAG
TATATGAACAAGACACAAAGCTATATAGATATCAGGATAAATGATGTTGGTGACTTCATACAGGTTGAAATCGAGGACAA
TGGACGAGGAATCAACCAGAGAGATATGCCATATATTTTTGACAGATTTTACAGAGCGGATGCGTCGAGAAATTCGGCTA
CCGGAGGCAGCGGCATAGGACTTTCCATCGTAAAGAAGATTATAGAGGATCACGGCGGCAAGATATGGGCTACCAGCAAA
GAGGGTGATGGAACTACCATGTTTTTCGTAATCAGAAAGTATCAGGAAACACAGGATATGAACCGACAGTAA

Upstream 100 bases:

>100_bases
AAATATAGTAGATATTGTAGTATTAATAGGACATATCAAATTCAAATGCGAAAGGATATGTCCTTGTTGTATATATAAAG
TGGCTTATTAATTTATTCAA

Downstream 100 bases:

>100_bases
ACAAATAAACAGGATATTGACATAAAAAGTAAAGCTATAATTATAACAGTTAGATATTAGAATTTAAAATTAAGAGCTCC
CGATTGACAACGCAAATAGT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MENTMKIKTKLAISFCIIIFVPVVLTSIVLVGFNKIQLKAINKTYGMEDAGMLALTDTVQFLNKVTGRTYDELEKTSLIE
PSRLLDSDYLTKINKKLEKKYSYLIVKSEGELIFNGGIDNDDILRKLPRISNKQSSSDVSSYMDSDDKVLIKQLNFRDSD
GDEASLYIVTSTACVIPEVRTVLMEGAFALVLILLTTAAMLIVWIYRSIITPIERLRIAAENIKDGNLDFELETSPSDGE
IGELCTAFEQMRARLKKNAEEKVTNESENRVLISNIAHDLKTPITAVKGYAEGILDGVANTPEKVDKYVRTIYNKANDMD
KLINELTLYSKIDTNRIPYNFAKINVTDYFNDCVEEIGLDLEAKNIRLSYENHVDSNVLIIADPEQIRRVINNIVGNSVK
YMNKTQSYIDIRINDVGDFIQVEIEDNGRGINQRDMPYIFDRFYRADASRNSATGGSGIGLSIVKKIIEDHGGKIWATSK
EGDGTTMFFVIRKYQETQDMNRQ

Sequences:

>Translated_503_residues
MENTMKIKTKLAISFCIIIFVPVVLTSIVLVGFNKIQLKAINKTYGMEDAGMLALTDTVQFLNKVTGRTYDELEKTSLIE
PSRLLDSDYLTKINKKLEKKYSYLIVKSEGELIFNGGIDNDDILRKLPRISNKQSSSDVSSYMDSDDKVLIKQLNFRDSD
GDEASLYIVTSTACVIPEVRTVLMEGAFALVLILLTTAAMLIVWIYRSIITPIERLRIAAENIKDGNLDFELETSPSDGE
IGELCTAFEQMRARLKKNAEEKVTNESENRVLISNIAHDLKTPITAVKGYAEGILDGVANTPEKVDKYVRTIYNKANDMD
KLINELTLYSKIDTNRIPYNFAKINVTDYFNDCVEEIGLDLEAKNIRLSYENHVDSNVLIIADPEQIRRVINNIVGNSVK
YMNKTQSYIDIRINDVGDFIQVEIEDNGRGINQRDMPYIFDRFYRADASRNSATGGSGIGLSIVKKIIEDHGGKIWATSK
EGDGTTMFFVIRKYQETQDMNRQ
>Mature_503_residues
MENTMKIKTKLAISFCIIIFVPVVLTSIVLVGFNKIQLKAINKTYGMEDAGMLALTDTVQFLNKVTGRTYDELEKTSLIE
PSRLLDSDYLTKINKKLEKKYSYLIVKSEGELIFNGGIDNDDILRKLPRISNKQSSSDVSSYMDSDDKVLIKQLNFRDSD
GDEASLYIVTSTACVIPEVRTVLMEGAFALVLILLTTAAMLIVWIYRSIITPIERLRIAAENIKDGNLDFELETSPSDGE
IGELCTAFEQMRARLKKNAEEKVTNESENRVLISNIAHDLKTPITAVKGYAEGILDGVANTPEKVDKYVRTIYNKANDMD
KLINELTLYSKIDTNRIPYNFAKINVTDYFNDCVEEIGLDLEAKNIRLSYENHVDSNVLIIADPEQIRRVINNIVGNSVK
YMNKTQSYIDIRINDVGDFIQVEIEDNGRGINQRDMPYIFDRFYRADASRNSATGGSGIGLSIVKKIIEDHGGKIWATSK
EGDGTTMFFVIRKYQETQDMNRQ

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=26.1484098939929, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=30.4347826086957, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI48994928, Length=222, Percent_Identity=27.9279279279279, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786783, Length=312, Percent_Identity=28.2051282051282, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=29.4605809128631, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87081816, Length=341, Percent_Identity=24.3401759530792, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790346, Length=293, Percent_Identity=23.8907849829352, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788713, Length=223, Percent_Identity=24.2152466367713, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=23.5023041474654, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=23.1707317073171, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=302, Percent_Identity=23.1788079470199, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=26.7716535433071, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=298, Percent_Identity=26.1744966442953, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788549, Length=279, Percent_Identity=26.8817204301075, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790300, Length=292, Percent_Identity=25, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789808, Length=318, Percent_Identity=23.2704402515723, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=313, Percent_Identity=23.3226837060703, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=22.5589225589226, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789403, Length=474, Percent_Identity=22.5738396624473, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56821; Mature: 56821

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTMKIKTKLAISFCIIIFVPVVLTSIVLVGFNKIQLKAINKTYGMEDAGMLALTDTVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHCCCCCCCEEEHHHHHH
FLNKVTGRTYDELEKTSLIEPSRLLDSDYLTKINKKLEKKYSYLIVKSEGELIFNGGIDN
HHHHHHCCCHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHEEEEEEECCCCEEEECCCCC
DDILRKLPRISNKQSSSDVSSYMDSDDKVLIKQLNFRDSDGDEASLYIVTSTACVIPEVR
HHHHHHCCCCCCCCCHHHHHHHHCCCCCEEHHHCCCCCCCCCCEEEEEEECCHHHHHHHH
TVLMEGAFALVLILLTTAAMLIVWIYRSIITPIERLRIAAENIKDGNLDFELETSPSDGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
IGELCTAFEQMRARLKKNAEEKVTNESENRVLISNIAHDLKTPITAVKGYAEGILDGVAN
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPEKVDKYVRTIYNKANDMDKLINELTLYSKIDTNRIPYNFAKINVTDYFNDCVEEIGLD
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCC
LEAKNIRLSYENHVDSNVLIIADPEQIRRVINNIVGNSVKYMNKTQSYIDIRINDVGDFI
EEECEEEEEECCCCCCCEEEEECHHHHHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCEE
QVEIEDNGRGINQRDMPYIFDRFYRADASRNSATGGSGIGLSIVKKIIEDHGGKIWATSK
EEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECC
EGDGTTMFFVIRKYQETQDMNRQ
CCCCCEEEEEEHHHHHHHCCCCC
>Mature Secondary Structure
MENTMKIKTKLAISFCIIIFVPVVLTSIVLVGFNKIQLKAINKTYGMEDAGMLALTDTVQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECHHCCCCCCCEEEHHHHHH
FLNKVTGRTYDELEKTSLIEPSRLLDSDYLTKINKKLEKKYSYLIVKSEGELIFNGGIDN
HHHHHHCCCHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHEEEEEEECCCCEEEECCCCC
DDILRKLPRISNKQSSSDVSSYMDSDDKVLIKQLNFRDSDGDEASLYIVTSTACVIPEVR
HHHHHHCCCCCCCCCHHHHHHHHCCCCCEEHHHCCCCCCCCCCEEEEEEECCHHHHHHHH
TVLMEGAFALVLILLTTAAMLIVWIYRSIITPIERLRIAAENIKDGNLDFELETSPSDGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCH
IGELCTAFEQMRARLKKNAEEKVTNESENRVLISNIAHDLKTPITAVKGYAEGILDGVAN
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPEKVDKYVRTIYNKANDMDKLINELTLYSKIDTNRIPYNFAKINVTDYFNDCVEEIGLD
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHCCC
LEAKNIRLSYENHVDSNVLIIADPEQIRRVINNIVGNSVKYMNKTQSYIDIRINDVGDFI
EEECEEEEEECCCCCCCEEEEECHHHHHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCEE
QVEIEDNGRGINQRDMPYIFDRFYRADASRNSATGGSGIGLSIVKKIIEDHGGKIWATSK
EEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECC
EGDGTTMFFVIRKYQETQDMNRQ
CCCCCEEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]