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The map label for this gene is pth

Identifier: 238922869

GI number: 238922869

Start: 411003

End: 411563

Strand: Direct

Name: pth

Synonym: EUBREC_0457

Alternate gene names: 238922869

Gene position: 411003-411563 (Clockwise)

Preceding gene: 238922868

Following gene: 238922870

Centisome position: 11.91

GC content: 47.59

Gene sequence:

>561_bases
ATGTACGTTATAGTAGGACTTGGAAATCCTGATAAAAAATATGAGCACACAAGACACAATATCGGATTTGATGTGATAGA
TGCGCTTGCGGATAAATATAATATAAGTGTGACAGACAAAAAGCACAAGGCGCTCTGTGGAAGCGGAGTGATTGAGGGCA
TGAAGGTGCTGCTTGTGAAGCCGCAGACATACATGAACTTAAGCGGCGAGTCTGTTGCTGAGGTGATGAATTTTTATAAG
CTTGATCCGGATGAGGAAATGATTGTTATTTTTGATGATATTTCGCTTGAGCCGGGGCGTATCCGTATCCGCAAAAAGGG
CAGCGCCGGCGGTCACAACGGGATTAAGAGCATCATTGCAATGACCGGCACACAGGGCTTCAGCCGTATCAAGGTCGGTG
TTGGAGAGAAGCCGCAGGGCTGGGATCTTGCTGACCATGTGCTCGGGCGTTTCAGTTCTGAGGACAGGGCAAAGGTGGAG
GAAGCTATCGGTCATGCGATGGATGCAGCAGTTCTTATGATGCAGGGCGAGACGGATAAGGCTATGAACATATATAACTA
G

Upstream 100 bases:

>100_bases
GGCTTTGATTTTGAACGCTACAAGGGTGTGGCGGGAATTATCCAGCAGTATTTGTTTTATTTTGAATTGTAAATGATATG
AGAAAGAGAAAGGATAAACG

Downstream 100 bases:

>100_bases
CTGGAAATCGACAAGGTGATTTTGAACAGACAGAAATGGAGAATTGAAAGTGAAAGCATTTACAGAGCCACTCCTTTCCC
TTGCGGGCTTTGAGGAGATG

Product: aminoacyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MYVIVGLGNPDKKYEHTRHNIGFDVIDALADKYNISVTDKKHKALCGSGVIEGMKVLLVKPQTYMNLSGESVAEVMNFYK
LDPDEEMIVIFDDISLEPGRIRIRKKGSAGGHNGIKSIIAMTGTQGFSRIKVGVGEKPQGWDLADHVLGRFSSEDRAKVE
EAIGHAMDAAVLMMQGETDKAMNIYN

Sequences:

>Translated_186_residues
MYVIVGLGNPDKKYEHTRHNIGFDVIDALADKYNISVTDKKHKALCGSGVIEGMKVLLVKPQTYMNLSGESVAEVMNFYK
LDPDEEMIVIFDDISLEPGRIRIRKKGSAGGHNGIKSIIAMTGTQGFSRIKVGVGEKPQGWDLADHVLGRFSSEDRAKVE
EAIGHAMDAAVLMMQGETDKAMNIYN
>Mature_186_residues
MYVIVGLGNPDKKYEHTRHNIGFDVIDALADKYNISVTDKKHKALCGSGVIEGMKVLLVKPQTYMNLSGESVAEVMNFYK
LDPDEEMIVIFDDISLEPGRIRIRKKGSAGGHNGIKSIIAMTGTQGFSRIKVGVGEKPQGWDLADHVLGRFSSEDRAKVE
EAIGHAMDAAVLMMQGETDKAMNIYN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=30, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787455, Length=183, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321983, Length=143, Percent_Identity=28.6713286713287, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_EUBR3 (C4ZBV8)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002936382.1
- GeneID:   7966625
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_0457
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20458; Mature: 20458

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVIVGLGNPDKKYEHTRHNIGFDVIDALADKYNISVTDKKHKALCGSGVIEGMKVLLVK
CEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCEEEEECCHHHHHHCCHHHCCEEEEEEC
PQTYMNLSGESVAEVMNFYKLDPDEEMIVIFDDISLEPGRIRIRKKGSAGGHNGIKSIIA
CHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHH
MTGTQGFSRIKVGVGEKPQGWDLADHVLGRFSSEDRAKVEEAIGHAMDAAVLMMQGETDK
HHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
AMNIYN
CCCCCC
>Mature Secondary Structure
MYVIVGLGNPDKKYEHTRHNIGFDVIDALADKYNISVTDKKHKALCGSGVIEGMKVLLVK
CEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHCEEEEECCHHHHHHCCHHHCCEEEEEEC
PQTYMNLSGESVAEVMNFYKLDPDEEMIVIFDDISLEPGRIRIRKKGSAGGHNGIKSIIA
CHHHCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHH
MTGTQGFSRIKVGVGEKPQGWDLADHVLGRFSSEDRAKVEEAIGHAMDAAVLMMQGETDK
HHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEECCCCC
AMNIYN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA