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The map label for this gene is 238922868

Identifier: 238922868

GI number: 238922868

Start: 410171

End: 410974

Strand: Direct

Name: 238922868

Synonym: EUBREC_0456

Alternate gene names: NA

Gene position: 410171-410974 (Clockwise)

Preceding gene: 238922867

Following gene: 238922869

Centisome position: 11.89

GC content: 43.03

Gene sequence:

>804_bases
ATGTACAAGACGAAAATAGATAATCTGGATTTAAAACAGATTGCTGACAGTGGTCAGTGCTTTAGATGGAAGAATACAGG
AGAAAATGAATACACGGTAGTGGCATTTGACAGGGCGCTTCGGATTAAGCAGGATGGGAATGAGTTTGAGTTGGACTGTG
ATGAGGCAGACTGGAACAATATATGGAAAAGCTATCTGGATATGGATACGGATTATGCGGGGATTGCAAAGCTGATAGCA
GACGGAGATGACGCGCATCTGAAGGAGGCATATGCATATGGCAGTGGTGTGCGCATTTTAAGGCAGGATTTGTGGGAGAT
GATTGTTACTTTTATGATTTCCCAGAATAATAACATTAAGCGAATCACAAACAGTGTGGATTTACTTTGCAGGCGGTGCG
GACATAAAATAGACGGCAGTGCAGAGGGGGGAGAACTGTATACATTTCCCAAGCCTCTTGAGGTACCGGATGAGGTATTT
GATGACAGGAGCATGGGCTTTGGCTATAGGGCACCGTATCTGAAGGAAATATATGGGTATGGCGCTAATAATCCTGACTG
GCTTGATAATCTGCGCAAAATGAGCTATGATGAGGCGATGGAAAGCCTGCTTACTCGCAAAGGAATTGGCAAAAAGGTGG
CGAACTGCATATGTCTTTTTGGTTTACATCATGTGGATGCGTTTCCGATAGATACGCATGTAAAGCAGCTTTTGGACAAA
TATTATAGTGACGGCTTTGATTTTGAACGCTACAAGGGTGTGGCGGGAATTATCCAGCAGTATTTGTTTTATTTTGAATT
GTAA

Upstream 100 bases:

>100_bases
AATATATTTCACACAAACCGGTCTATCCGTGGTACAATAAGCCACAGAAAGACCGGCTTTTTAGAGTATAGCTACAATAA
AAGAGGATAGACAAACAGAT

Downstream 100 bases:

>100_bases
ATGATATGAGAAAGAGAAAGGATAAACGATGTACGTTATAGTAGGACTTGGAAATCCTGATAAAAAATATGAGCACACAA
GACACAATATCGGATTTGAT

Product: 8-oxoguanine DNA glycosylase domain protein

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MYKTKIDNLDLKQIADSGQCFRWKNTGENEYTVVAFDRALRIKQDGNEFELDCDEADWNNIWKSYLDMDTDYAGIAKLIA
DGDDAHLKEAYAYGSGVRILRQDLWEMIVTFMISQNNNIKRITNSVDLLCRRCGHKIDGSAEGGELYTFPKPLEVPDEVF
DDRSMGFGYRAPYLKEIYGYGANNPDWLDNLRKMSYDEAMESLLTRKGIGKKVANCICLFGLHHVDAFPIDTHVKQLLDK
YYSDGFDFERYKGVAGIIQQYLFYFEL

Sequences:

>Translated_267_residues
MYKTKIDNLDLKQIADSGQCFRWKNTGENEYTVVAFDRALRIKQDGNEFELDCDEADWNNIWKSYLDMDTDYAGIAKLIA
DGDDAHLKEAYAYGSGVRILRQDLWEMIVTFMISQNNNIKRITNSVDLLCRRCGHKIDGSAEGGELYTFPKPLEVPDEVF
DDRSMGFGYRAPYLKEIYGYGANNPDWLDNLRKMSYDEAMESLLTRKGIGKKVANCICLFGLHHVDAFPIDTHVKQLLDK
YYSDGFDFERYKGVAGIIQQYLFYFEL
>Mature_267_residues
MYKTKIDNLDLKQIADSGQCFRWKNTGENEYTVVAFDRALRIKQDGNEFELDCDEADWNNIWKSYLDMDTDYAGIAKLIA
DGDDAHLKEAYAYGSGVRILRQDLWEMIVTFMISQNNNIKRITNSVDLLCRRCGHKIDGSAEGGELYTFPKPLEVPDEVF
DDRSMGFGYRAPYLKEIYGYGANNPDWLDNLRKMSYDEAMESLLTRKGIGKKVANCICLFGLHHVDAFPIDTHVKQLLDK
YYSDGFDFERYKGVAGIIQQYLFYFEL

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI8670542, Length=267, Percent_Identity=30.3370786516854, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI8670534, Length=269, Percent_Identity=30.8550185873606, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI8670530, Length=273, Percent_Identity=31.1355311355311, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI8670540, Length=273, Percent_Identity=31.1355311355311, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4505495, Length=267, Percent_Identity=30.3370786516854, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI8670532, Length=273, Percent_Identity=31.1355311355311, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI8670536, Length=228, Percent_Identity=29.8245614035088, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323580, Length=159, Percent_Identity=34.5911949685535, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24640654, Length=256, Percent_Identity=31.640625, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 30849; Mature: 30849

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKTKIDNLDLKQIADSGQCFRWKNTGENEYTVVAFDRALRIKQDGNEFELDCDEADWNN
CCCCCCCCCCHHHHHCCCCEEEECCCCCCCEEEEEECCHHHCCCCCCEEEEECCCCCHHH
IWKSYLDMDTDYAGIAKLIADGDDAHLKEAYAYGSGVRILRQDLWEMIVTFMISQNNNIK
HHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHH
RITNSVDLLCRRCGHKIDGSAEGGELYTFPKPLEVPDEVFDDRSMGFGYRAPYLKEIYGY
HHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCC
GANNPDWLDNLRKMSYDEAMESLLTRKGIGKKVANCICLFGLHHVDAFPIDTHVKQLLDK
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YYSDGFDFERYKGVAGIIQQYLFYFEL
HHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MYKTKIDNLDLKQIADSGQCFRWKNTGENEYTVVAFDRALRIKQDGNEFELDCDEADWNN
CCCCCCCCCCHHHHHCCCCEEEECCCCCCCEEEEEECCHHHCCCCCCEEEEECCCCCHHH
IWKSYLDMDTDYAGIAKLIADGDDAHLKEAYAYGSGVRILRQDLWEMIVTFMISQNNNIK
HHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHH
RITNSVDLLCRRCGHKIDGSAEGGELYTFPKPLEVPDEVFDDRSMGFGYRAPYLKEIYGY
HHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHHHCC
GANNPDWLDNLRKMSYDEAMESLLTRKGIGKKVANCICLFGLHHVDAFPIDTHVKQLLDK
CCCCHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
YYSDGFDFERYKGVAGIIQQYLFYFEL
HHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]