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The map label for this gene is mro [H]

Identifier: 238922763

GI number: 238922763

Start: 314089

End: 315132

Strand: Direct

Name: mro [H]

Synonym: EUBREC_0351

Alternate gene names: 238922763

Gene position: 314089-315132 (Clockwise)

Preceding gene: 238922761

Following gene: 238922764

Centisome position: 9.1

GC content: 42.24

Gene sequence:

>1044_bases
ATGAGTAAAAAAGCTTTCGGTACAACATCAAAAGGAGTGGAGGCATCGCTTTACGAAATCAGCAATGGCGGTGGATTGAG
AGTACTTTTGACAGACTATGGCGCTTCAGTTGTATCTATTTTTGTAAAGGACAAGGATGGCAATGAGAGAGATGTCATTT
TAGGATATGACAATGTAAAGTCATATGAGAAGGAGTACAGCTATTTTGGTGCTACTGTCGGCAGATATGCAAACAGGATA
TCCGATGCAAAGATTAATATTGATGGAGTGGAATATAAGCTTGAGGCTAATGACAATGAGAACAGTCTTCACAGTGGATC
AAATGGTTTTTCTAAGCGCTTTTGGACTGTTAAGGAGCAGAAGGCAGATGAGATTACCTTTGAGATAGAGGATGCAGATC
TGGAGCAGGGCTTCCCTGGAAATGCAGTCGTTGATGTGACATTTAAGGTAACAGAAGAAAATGCTCTCGCTATTATATAC
AATGCAAAGGCAGATAAGACAACTACCTTCAATATGACAAACCACAGCTATTTCAATCTGAACGGTCATGCATCAGGAAG
CGTATACACTCACACATTGCAGATAAATGCTGAGCATTACACACCTGTAAAGGATTCCAAGGCTATTCCTACAGGTGAGA
TTGCACCGGTTGAGGGTACACCATTTGATTTTACAGAGGCTAAGCCAATCGGAAGAGATATCGAGGCAAATGATACACAG
CTTCATTATGGAAGCGGATATGATCACAATTTTGCAATAGACAAGACCGCTCCGGGAGTAGAAAAGGTCGCAACAGCATA
CTCTCCTGAGAGTGGCATACAGATGGAGGTATACACCGACTGTGTCGGAATCCAGCTTTATACTGCCAACTTTATCGTGG
GACAGGAAGGCAAGGGCGGAGTCAAATACAATAACCGCGATGCATTCTGCCTCGAGACACAGTTCTATCCAAACTCAATA
AATGAGACCAACTTCAGTACACCTGTTACAAAGGCAGGTGATACATACCACACAGAGACCGATTACAAATTCTCTGTGAA
ATAA

Upstream 100 bases:

>100_bases
AACATAATGTAAAAAGCATAATGTATTAAAACAAAATGTAACAAACATAAAGTTACAAAAAATGCAACAAACATAATGTA
ACCAAAGGAGGATATGGGGC

Downstream 100 bases:

>100_bases
AATGCCAACATAAGAGAGATACAGAATAGTTAAAGCCCACCATATTGATGAAATTTATCATTAATATGGTGGGCTTTCTT
AAGCTTTGTTTAATCAAATA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSKKAFGTTSKGVEASLYEISNGGGLRVLLTDYGASVVSIFVKDKDGNERDVILGYDNVKSYEKEYSYFGATVGRYANRI
SDAKINIDGVEYKLEANDNENSLHSGSNGFSKRFWTVKEQKADEITFEIEDADLEQGFPGNAVVDVTFKVTEENALAIIY
NAKADKTTTFNMTNHSYFNLNGHASGSVYTHTLQINAEHYTPVKDSKAIPTGEIAPVEGTPFDFTEAKPIGRDIEANDTQ
LHYGSGYDHNFAIDKTAPGVEKVATAYSPESGIQMEVYTDCVGIQLYTANFIVGQEGKGGVKYNNRDAFCLETQFYPNSI
NETNFSTPVTKAGDTYHTETDYKFSVK

Sequences:

>Translated_347_residues
MSKKAFGTTSKGVEASLYEISNGGGLRVLLTDYGASVVSIFVKDKDGNERDVILGYDNVKSYEKEYSYFGATVGRYANRI
SDAKINIDGVEYKLEANDNENSLHSGSNGFSKRFWTVKEQKADEITFEIEDADLEQGFPGNAVVDVTFKVTEENALAIIY
NAKADKTTTFNMTNHSYFNLNGHASGSVYTHTLQINAEHYTPVKDSKAIPTGEIAPVEGTPFDFTEAKPIGRDIEANDTQ
LHYGSGYDHNFAIDKTAPGVEKVATAYSPESGIQMEVYTDCVGIQLYTANFIVGQEGKGGVKYNNRDAFCLETQFYPNSI
NETNFSTPVTKAGDTYHTETDYKFSVK
>Mature_346_residues
SKKAFGTTSKGVEASLYEISNGGGLRVLLTDYGASVVSIFVKDKDGNERDVILGYDNVKSYEKEYSYFGATVGRYANRIS
DAKINIDGVEYKLEANDNENSLHSGSNGFSKRFWTVKEQKADEITFEIEDADLEQGFPGNAVVDVTFKVTEENALAIIYN
AKADKTTTFNMTNHSYFNLNGHASGSVYTHTLQINAEHYTPVKDSKAIPTGEIAPVEGTPFDFTEAKPIGRDIEANDTQL
HYGSGYDHNFAIDKTAPGVEKVATAYSPESGIQMEVYTDCVGIQLYTANFIVGQEGKGGVKYNNRDAFCLETQFYPNSIN
ETNFSTPVTKAGDTYHTETDYKFSVK

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=345, Percent_Identity=38.2608695652174, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1786971, Length=335, Percent_Identity=35.8208955223881, Blast_Score=228, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17557428, Length=338, Percent_Identity=32.2485207100592, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115533334, Length=338, Percent_Identity=32.2485207100592, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319493, Length=374, Percent_Identity=29.6791443850267, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324399, Length=339, Percent_Identity=28.9085545722714, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322004, Length=357, Percent_Identity=26.6106442577031, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24659048, Length=341, Percent_Identity=40.7624633431085, Blast_Score=248, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24668282, Length=331, Percent_Identity=33.5347432024169, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24583720, Length=339, Percent_Identity=31.5634218289086, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24668278, Length=338, Percent_Identity=30.7692307692308, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24641876, Length=348, Percent_Identity=27.5862068965517, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 38249; Mature: 38118

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKAFGTTSKGVEASLYEISNGGGLRVLLTDYGASVVSIFVKDKDGNERDVILGYDNVK
CCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEECCCHH
SYEKEYSYFGATVGRYANRISDAKINIDGVEYKLEANDNENSLHSGSNGFSKRFWTVKEQ
HHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEEECC
KADEITFEIEDADLEQGFPGNAVVDVTFKVTEENALAIIYNAKADKTTTFNMTNHSYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCCEEEEE
NGHASGSVYTHTLQINAEHYTPVKDSKAIPTGEIAPVEGTPFDFTEAKPIGRDIEANDTQ
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCE
LHYGSGYDHNFAIDKTAPGVEKVATAYSPESGIQMEVYTDCVGIQLYTANFIVGQEGKGG
EEECCCCCCCEEECCCCCCHHHHHHHCCCCCCCEEEEEECEEEEEEEEEEEEEECCCCCC
VKYNNRDAFCLETQFYPNSINETNFSTPVTKAGDTYHTETDYKFSVK
CEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCEEEEEC
>Mature Secondary Structure 
SKKAFGTTSKGVEASLYEISNGGGLRVLLTDYGASVVSIFVKDKDGNERDVILGYDNVK
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCEEEEECCCHH
SYEKEYSYFGATVGRYANRISDAKINIDGVEYKLEANDNENSLHSGSNGFSKRFWTVKEQ
HHHHHHHHHHHHHHHHHHHCCCCEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEEECC
KADEITFEIEDADLEQGFPGNAVVDVTFKVTEENALAIIYNAKADKTTTFNMTNHSYFNL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEEECCCCCEEEEEECCCEEEEE
NGHASGSVYTHTLQINAEHYTPVKDSKAIPTGEIAPVEGTPFDFTEAKPIGRDIEANDTQ
CCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCE
LHYGSGYDHNFAIDKTAPGVEKVATAYSPESGIQMEVYTDCVGIQLYTANFIVGQEGKGG
EEECCCCCCCEEECCCCCCHHHHHHHCCCCCCCEEEEEECEEEEEEEEEEEEEECCCCCC
VKYNNRDAFCLETQFYPNSINETNFSTPVTKAGDTYHTETDYKFSVK
CEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]