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The map label for this gene is cysK [H]

Identifier: 238922742

GI number: 238922742

Start: 292123

End: 293055

Strand: Direct

Name: cysK [H]

Synonym: EUBREC_0318

Alternate gene names: 238922742

Gene position: 292123-293055 (Clockwise)

Preceding gene: 238922741

Following gene: 238922743

Centisome position: 8.47

GC content: 46.62

Gene sequence:

>933_bases
ATGTCAAACATTTATCAGGGAACATTAGGACTTATTGGAAATACACCGCTCGTAGAGCTTACACACGTAGAGAAGGCATA
CGGACTTGAGGCAAGACTTCTTGCAAAGCTTGAGTACTTCAACCCGGCAGGATCAGTAAAGGATAGAATCGCAAAAGAGA
TGATCGAGCAGGCAGAGAGAGACGGAAAGCTCAAGCCGGGCTCAACAATTATCGAGCCAACATCAGGAAATACAGGAATC
GGACTTGCAGCAATCGCAGCAGCAAAGGGATATAAGATTATCATCGTTCTTCCTGAGACAATGTCCATCGAGAGAAGAAA
CATCATCAAGGCATATGGCGCAGAGCTCGTGCTTTCAGACGGTACAAAGGGTATGAAGGGAGCCATCGCCAAGGCAGAGG
AGCTTCATGAGCAGATTCCTGATAGCTTCATTCCGGAGCAGTTTGAGAACCCTGCAAACCCGGAGGCACACAGAAAGACA
ACAGGTCCTGAGATCTGGAACGATACAGACGGACAGGTAGATGCATTCGTAGCCGGAGTCGGAACAGGCGGAACAATCAC
AGGAACAGGTGAGTACTTAAAGAGCAAGAACCCTGATGTAAAGATTGTCGCTGTAGAGCCTGAGACATCAGCAGTGCTTT
CAACAGGAAAAGCCGGAGCACACAAGATTCAGGGAATCGGAGCAGGCTTCGTACCAAACACATTAAATACAGAGGTATAT
GATGAGATTATCCCTGTATCAAATGAGGCATCATTTGAGTACGGAAAGATTATCGCAAAAGAGGAGGGTGTACTTGTAGG
TATTTCTTCAGGAGCAGCTCTCTATGCAGCAATCGAGGTAGCCAAGAGACCGGAGTTCAAGGGCAAGACAGTAGTAGCAC
TTCTTCCTGACAGCGGAGACAGATATTACTCAACTGATCTTTTCAAAGATTAA

Upstream 100 bases:

>100_bases
GGTATATTTATATCAACAATTAATTCATACAAATACAGTATGAATATAGGAGATTAAAACAAAGCATTAACATTACAATG
ACATCAAGGAGGACACAAAC

Downstream 100 bases:

>100_bases
TAAAGTATATTATGATAGCGAATAAGACACCCCTGCGGTGTCTTTTTGCATATAATTCAATTGATTCTTTAAATACCATA
AACTTTTCCTTTGTTTTTGG

Product: cysteine synthase K/M/A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSNIYQGTLGLIGNTPLVELTHVEKAYGLEARLLAKLEYFNPAGSVKDRIAKEMIEQAERDGKLKPGSTIIEPTSGNTGI
GLAAIAAAKGYKIIIVLPETMSIERRNIIKAYGAELVLSDGTKGMKGAIAKAEELHEQIPDSFIPEQFENPANPEAHRKT
TGPEIWNDTDGQVDAFVAGVGTGGTITGTGEYLKSKNPDVKIVAVEPETSAVLSTGKAGAHKIQGIGAGFVPNTLNTEVY
DEIIPVSNEASFEYGKIIAKEEGVLVGISSGAALYAAIEVAKRPEFKGKTVVALLPDSGDRYYSTDLFKD

Sequences:

>Translated_310_residues
MSNIYQGTLGLIGNTPLVELTHVEKAYGLEARLLAKLEYFNPAGSVKDRIAKEMIEQAERDGKLKPGSTIIEPTSGNTGI
GLAAIAAAKGYKIIIVLPETMSIERRNIIKAYGAELVLSDGTKGMKGAIAKAEELHEQIPDSFIPEQFENPANPEAHRKT
TGPEIWNDTDGQVDAFVAGVGTGGTITGTGEYLKSKNPDVKIVAVEPETSAVLSTGKAGAHKIQGIGAGFVPNTLNTEVY
DEIIPVSNEASFEYGKIIAKEEGVLVGISSGAALYAAIEVAKRPEFKGKTVVALLPDSGDRYYSTDLFKD
>Mature_309_residues
SNIYQGTLGLIGNTPLVELTHVEKAYGLEARLLAKLEYFNPAGSVKDRIAKEMIEQAERDGKLKPGSTIIEPTSGNTGIG
LAAIAAAKGYKIIIVLPETMSIERRNIIKAYGAELVLSDGTKGMKGAIAKAEELHEQIPDSFIPEQFENPANPEAHRKTT
GPEIWNDTDGQVDAFVAGVGTGGTITGTGEYLKSKNPDVKIVAVEPETSAVLSTGKAGAHKIQGIGAGFVPNTLNTEVYD
EIIPVSNEASFEYGKIIAKEEGVLVGISSGAALYAAIEVAKRPEFKGKTVVALLPDSGDRYYSTDLFKD

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=43.0379746835443, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=43.0379746835443, Blast_Score=254, Evalue=7e-68,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=43.0379746835443, Blast_Score=254, Evalue=7e-68,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=52.3510971786834, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=42.9530201342282, Blast_Score=224, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17562970, Length=300, Percent_Identity=50, Blast_Score=311, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=53.8709677419355, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=50.8305647840532, Blast_Score=306, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI32566674, Length=292, Percent_Identity=50.3424657534247, Blast_Score=301, Evalue=3e-82,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=48.3221476510067, Blast_Score=272, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI32566672, Length=214, Percent_Identity=47.6635514018692, Blast_Score=220, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=40.1253918495298, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI25147552, Length=317, Percent_Identity=38.801261829653, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17561716, Length=118, Percent_Identity=38.9830508474576, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=338, Percent_Identity=26.9230769230769, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321594, Length=321, Percent_Identity=41.7445482866044, Blast_Score=226, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=35.3474320241692, Blast_Score=138, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24643623, Length=317, Percent_Identity=40.3785488958991, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI20129101, Length=317, Percent_Identity=40.3785488958991, Blast_Score=208, Evalue=3e-54,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32951; Mature: 32820

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIYQGTLGLIGNTPLVELTHVEKAYGLEARLLAKLEYFNPAGSVKDRIAKEMIEQAER
CCCCCCCHHHCCCCCCEEEEEEHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DGKLKPGSTIIEPTSGNTGIGLAAIAAAKGYKIIIVLPETMSIERRNIIKAYGAELVLSD
CCCCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEC
GTKGMKGAIAKAEELHEQIPDSFIPEQFENPANPEAHRKTTGPEIWNDTDGQVDAFVAGV
CCCCHHHHHHHHHHHHHHCCHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
GTGGTITGTGEYLKSKNPDVKIVAVEPETSAVLSTGKAGAHKIQGIGAGFVPNTLNTEVY
CCCCEEECCHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCEEEECCCCCCCCCCCHHHH
DEIIPVSNEASFEYGKIIAKEEGVLVGISSGAALYAAIEVAKRPEFKGKTVVALLPDSGD
HHHCCCCCCCCCHHHEEEEECCCEEEEECCCCEEEHHHHHHHCCCCCCCEEEEEECCCCC
RYYSTDLFKD
CEEECCCCCC
>Mature Secondary Structure 
SNIYQGTLGLIGNTPLVELTHVEKAYGLEARLLAKLEYFNPAGSVKDRIAKEMIEQAER
CCCCCCHHHCCCCCCEEEEEEHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
DGKLKPGSTIIEPTSGNTGIGLAAIAAAKGYKIIIVLPETMSIERRNIIKAYGAELVLSD
CCCCCCCCEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCEEEEEC
GTKGMKGAIAKAEELHEQIPDSFIPEQFENPANPEAHRKTTGPEIWNDTDGQVDAFVAGV
CCCCHHHHHHHHHHHHHHCCHHCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
GTGGTITGTGEYLKSKNPDVKIVAVEPETSAVLSTGKAGAHKIQGIGAGFVPNTLNTEVY
CCCCEEECCHHHHHCCCCCEEEEEECCCCHHHHCCCCCCCCEEEECCCCCCCCCCCHHHH
DEIIPVSNEASFEYGKIIAKEEGVLVGISSGAALYAAIEVAKRPEFKGKTVVALLPDSGD
HHHCCCCCCCCCHHHEEEEECCCEEEEECCCCEEEHHHHHHHCCCCCCCEEEEEECCCCC
RYYSTDLFKD
CEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA