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The map label for this gene is add [H]

Identifier: 238922720

GI number: 238922720

Start: 275935

End: 276972

Strand: Direct

Name: add [H]

Synonym: EUBREC_0295

Alternate gene names: 238922720

Gene position: 275935-276972 (Clockwise)

Preceding gene: 238922719

Following gene: 238922721

Centisome position: 8.0

GC content: 49.61

Gene sequence:

>1038_bases
GTGAACATTAGCCGCCTCAACAGGAAGTGGGAAACCGGAAATGGGGGAAATATGGAGAGAGAAGAGAATATAAGAGACAA
TATAATAAAGCTGCCGAAAATAGAGCTTCACTGCCATCTGGATGGCTCATTAAGCCGTGAATTTGTCGAGAAAAGGCTTG
GCAGGACAGTGCAGGAGGCAGAGCTTAGCGTGTCGGATGACTGCACAAGTCTTGCACAGTATCTGGAGAAATTTGACTTG
CCGGGGCAGTGCATCCAGGATGAAAAGGGGCTTGAGGGAGCCGCCTATGATGTGCTTAAGGGCATGCACCGGGAAAACGT
CGTATACGCGGAAATCCGTTTTGCACCGCTGCTTTCAGAGAATGAGCGCATGAGCTGTGAGCGCGTGATAGAGGCTGCAC
TTAAGGGACTTGAGAGAGGTAAAAAGGATTTTGGCATAGAATATGGGCTTATTGTGTGCGCCATGAGGCATCACGGCGAG
GAACAAAACAGACGCATGCTGCACACCGCAAGGGAATTTTTAGGCGCGGGTGTGTGCGCGGCAGACCTCGCAGGTGCTGA
GGTGCCTTATCCTATGTCCGGCTTCATGGAGCTTTTCAAATATGCAAAGCAGCTCGGGCTGCCTTTTACAATCCATGCGG
GAGAGTGTGGAAATGCACAGAATATTATAGATGCAGTGGAGGCCGGCGCAGCCAGGATAGGCCATGGAATAGCCATGAGA
GGTCACGATGATCTGGAAAGGCAGCTTTCGGCAAAGGGCATAGGCATCGAGCTTTGTCCAATAAGCAATCTACAGACAAA
GGCGGTGGCATCTGCAGATGAATATCCCATCAGGGAGTTTTTGGATGCGGGATTAAAGGTCACAATAAACACAGACAACC
GCACCGTAAGCAACACAACTTTATCTAAAGAGCTTGAGTTCATAGAAAAAACATATGGCATACGCGATGAGGAGCTGCCG
CTTATGATGAAAAATGCACTGGACGTGGCATTTGCGGATGATGCCGTGAAGGAGCGGATTTTCAGACAGCTGGTATAG

Upstream 100 bases:

>100_bases
CGCAGGGGTTCGGACCTGCGAACCTTGAGTAGAGCGACCTGTAGCTGTACCTTTAAGGGGCTGCATAATGGTCTGTAATA
GTTGTTGATTATATGGTCGT

Downstream 100 bases:

>100_bases
TGCCGTGAGACTTATGGAGATTTAACAGCTCCCCGCTGTGCAAATTTACGGACCGGAAAATGGAGGTATGACACTATGAA
GAAATACAACAGAATTTTTG

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNISRLNRKWETGNGGNMEREENIRDNIIKLPKIELHCHLDGSLSREFVEKRLGRTVQEAELSVSDDCTSLAQYLEKFDL
PGQCIQDEKGLEGAAYDVLKGMHRENVVYAEIRFAPLLSENERMSCERVIEAALKGLERGKKDFGIEYGLIVCAMRHHGE
EQNRRMLHTAREFLGAGVCAADLAGAEVPYPMSGFMELFKYAKQLGLPFTIHAGECGNAQNIIDAVEAGAARIGHGIAMR
GHDDLERQLSAKGIGIELCPISNLQTKAVASADEYPIREFLDAGLKVTINTDNRTVSNTTLSKELEFIEKTYGIRDEELP
LMMKNALDVAFADDAVKERIFRQLV

Sequences:

>Translated_345_residues
MNISRLNRKWETGNGGNMEREENIRDNIIKLPKIELHCHLDGSLSREFVEKRLGRTVQEAELSVSDDCTSLAQYLEKFDL
PGQCIQDEKGLEGAAYDVLKGMHRENVVYAEIRFAPLLSENERMSCERVIEAALKGLERGKKDFGIEYGLIVCAMRHHGE
EQNRRMLHTAREFLGAGVCAADLAGAEVPYPMSGFMELFKYAKQLGLPFTIHAGECGNAQNIIDAVEAGAARIGHGIAMR
GHDDLERQLSAKGIGIELCPISNLQTKAVASADEYPIREFLDAGLKVTINTDNRTVSNTTLSKELEFIEKTYGIRDEELP
LMMKNALDVAFADDAVKERIFRQLV
>Mature_345_residues
MNISRLNRKWETGNGGNMEREENIRDNIIKLPKIELHCHLDGSLSREFVEKRLGRTVQEAELSVSDDCTSLAQYLEKFDL
PGQCIQDEKGLEGAAYDVLKGMHRENVVYAEIRFAPLLSENERMSCERVIEAALKGLERGKKDFGIEYGLIVCAMRHHGE
EQNRRMLHTAREFLGAGVCAADLAGAEVPYPMSGFMELFKYAKQLGLPFTIHAGECGNAQNIIDAVEAGAARIGHGIAMR
GHDDLERQLSAKGIGIELCPISNLQTKAVASADEYPIREFLDAGLKVTINTDNRTVSNTTLSKELEFIEKTYGIRDEELP
LMMKNALDVAFADDAVKERIFRQLV

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=326, Percent_Identity=27.6073619631902, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI226693318, Length=328, Percent_Identity=22.5609756097561, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI61175224, Length=222, Percent_Identity=26.1261261261261, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787910, Length=330, Percent_Identity=30, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17538512, Length=341, Percent_Identity=28.1524926686217, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI32565969, Length=341, Percent_Identity=28.1524926686217, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115537133, Length=322, Percent_Identity=26.3975155279503, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324188, Length=324, Percent_Identity=27.4691358024691, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24645260, Length=318, Percent_Identity=26.4150943396226, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 38517; Mature: 38517

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISRLNRKWETGNGGNMEREENIRDNIIKLPKIELHCHLDGSLSREFVEKRLGRTVQEA
CCHHHHCCCCCCCCCCCCCHHHHHHHHHEECCCEEEEEECCCHHHHHHHHHHHCCHHHHH
ELSVSDDCTSLAQYLEKFDLPGQCIQDEKGLEGAAYDVLKGMHRENVVYAEIRFAPLLSE
HCCCCCCHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCC
NERMSCERVIEAALKGLERGKKDFGIEYGLIVCAMRHHGEEQNRRMLHTAREFLGAGVCA
CCCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHH
ADLAGAEVPYPMSGFMELFKYAKQLGLPFTIHAGECGNAQNIIDAVEAGAARIGHGIAMR
HHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEC
GHDDLERQLSAKGIGIELCPISNLQTKAVASADEYPIREFLDAGLKVTINTDNRTVSNTT
CCHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCCCHHHHHCCCCEEEEECCCCEECCHH
LSKELEFIEKTYGIRDEELPLMMKNALDVAFADDAVKERIFRQLV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNISRLNRKWETGNGGNMEREENIRDNIIKLPKIELHCHLDGSLSREFVEKRLGRTVQEA
CCHHHHCCCCCCCCCCCCCHHHHHHHHHEECCCEEEEEECCCHHHHHHHHHHHCCHHHHH
ELSVSDDCTSLAQYLEKFDLPGQCIQDEKGLEGAAYDVLKGMHRENVVYAEIRFAPLLSE
HCCCCCCHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHCCEEEEEEEECCCCCC
NERMSCERVIEAALKGLERGKKDFGIEYGLIVCAMRHHGEEQNRRMLHTAREFLGAGVCA
CCCCCHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHH
ADLAGAEVPYPMSGFMELFKYAKQLGLPFTIHAGECGNAQNIIDAVEAGAARIGHGIAMR
HHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEC
GHDDLERQLSAKGIGIELCPISNLQTKAVASADEYPIREFLDAGLKVTINTDNRTVSNTT
CCHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCCCHHHHHCCCCEEEEECCCCEECCHH
LSKELEFIEKTYGIRDEELPLMMKNALDVAFADDAVKERIFRQLV
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]