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The map label for this gene is pgi [H]

Identifier: 238922653

GI number: 238922653

Start: 211989

End: 213614

Strand: Direct

Name: pgi [H]

Synonym: EUBREC_0228

Alternate gene names: 238922653

Gene position: 211989-213614 (Clockwise)

Preceding gene: 238922652

Following gene: 238922654

Centisome position: 6.15

GC content: 46.31

Gene sequence:

>1626_bases
ATGCGATTGGTGAAAATAAGATTAAATGATAAGGAGGAAATCGCAATGATTACCTGGAACAACTTGGATACCCTGGAATC
CTTCAAGGAGCTTTCTAAAGTGGGACGTGTTGACATAAAAGAGGCCATGTCAGGAGACAATGGCGCTAAGCGTGTCAAGG
AGTACAACATCCCAATGGCAGAAGGATTCACTTACAACTTCGCTGCAAAGCAGGTGGACGCAGATGTGCTTGAGGCACTT
GCAAAGCTTGCAAAGGAGGCACAGCTTACAGAGAAATTTGAGGCACTTTACAATGGTGCTGTTATCAATACAGGTGAGAA
CCGTCTCGTTCTTCACCAGCTTACCCGTGGACAGCTCGGAGATGCTGTAGTGGCAGACGGAGTTGACAAGCGTAAATTCT
ACGTAGAGCAGCAGGAGAGAATCGCTGAGTTCGCAAACAAGGTTCACTCAGGCGAGATTACAAACGCAGCAGGAGAGAAG
TTTACAACAGTTGTTCAGATAGGAATCGGCGGAAGCGATTTAGGACCTCGTGCTATGTACTTAGCACTTGAGAACTGGGC
AAAGAAAAACAATACATTCAAGATGGAAGCCAAATTCATCAGCAATGTTGACCCTGATGATGCGGCAAGCGTACTTGCAT
CAGTTGACGTAGCTCACTCTATTTTCATATTAGTATCAAAATCAGGTACAACACTTGAGACTCTTACAAATGAGTCATTC
GTAAAGGATGCATTAAAGAACGCAGGACTTGATGCTTCTAAGCACATGATTGCCGTAACAAGCGAGACATCACCACTTGC
AAAGAGTGATGATTACCTTGCAGCCTTCTTCATGGACGATTACATCGGAGGACGTTACTCATCAACATCAGCAGTTGGTG
GAGCAGTTCTCTCACTTGCATTCGGTCCTGAAGTATTTGCACAGTTCCTCGACGGAGCAGCAGCAGAGGATAAGCTTTCA
AAGAATGCAAACATCATGGAGAATCCTGAGATGCTTGACGCACTCATCGGTGTTTACGAGAGAAACGTACTCGGATATCC
TAGCACAGCAGTGCTTCCATACTCACAGGCACTCAGCCGTTTCCCTGCACATTTACAGCAGGCTGATATGGAGTCAAACG
GCAAGTCGGTTAACCGTTTCGGTGAGCCTGTAGATTATGTGACAGGACCGGTTATCTTTGGTGAGCCTGGAACAAACGGA
CAGCACTCATTCTATCAGCTCCTTCATCAGGGAACAGATATTGTGCCACTCCAGTTCATCGGCTTCAAGAACAACCAGCT
TGACACAGATGTAGTCATCCAGGACAGCACAAGCCAGCAGAAGCTCTGCGCAAACGTAGCAGCTCAGATTGTTGCATTTG
CATGTGGTAAGGCAGACGACAACAAGAACAAGAACTTCGAGGGTGGACGTCCTTCAAGCATCATCATCGGAGACCAGGTA
AATCCTGCATCTCTTGGTGCACTCCTTGCACACTTTGAGAACAAGATTATGTTCCAGGGCTTCTTATGGAATGTAAACAG
CTTCGACCAGGAAGGTGTTCAGCTTGGAAAGCTGCTTGCAAAGAAGGTTCTTGCACATGAGACAGACGGAGCACTTAAGG
AGCTCAGCGATATGCTTAATATTTAG

Upstream 100 bases:

>100_bases
CATATTCGCACACGAACAAAACAAAATACAAATTTTATCGAAAAACTTACTTATAAAGTTTCTCAGCTCTTGAACTTAAA
AATGATTGATAGTATAATTT

Downstream 100 bases:

>100_bases
CACATCGTTTTGCAGAGGTGAAGATACAGAAATATAAAAACGAGCCGCAATCCTGATACCAACAGGATTGCGGCTCGTTT
TGTTCTGCCATAAATCATCC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MRLVKIRLNDKEEIAMITWNNLDTLESFKELSKVGRVDIKEAMSGDNGAKRVKEYNIPMAEGFTYNFAAKQVDADVLEAL
AKLAKEAQLTEKFEALYNGAVINTGENRLVLHQLTRGQLGDAVVADGVDKRKFYVEQQERIAEFANKVHSGEITNAAGEK
FTTVVQIGIGGSDLGPRAMYLALENWAKKNNTFKMEAKFISNVDPDDAASVLASVDVAHSIFILVSKSGTTLETLTNESF
VKDALKNAGLDASKHMIAVTSETSPLAKSDDYLAAFFMDDYIGGRYSSTSAVGGAVLSLAFGPEVFAQFLDGAAAEDKLS
KNANIMENPEMLDALIGVYERNVLGYPSTAVLPYSQALSRFPAHLQQADMESNGKSVNRFGEPVDYVTGPVIFGEPGTNG
QHSFYQLLHQGTDIVPLQFIGFKNNQLDTDVVIQDSTSQQKLCANVAAQIVAFACGKADDNKNKNFEGGRPSSIIIGDQV
NPASLGALLAHFENKIMFQGFLWNVNSFDQEGVQLGKLLAKKVLAHETDGALKELSDMLNI

Sequences:

>Translated_541_residues
MRLVKIRLNDKEEIAMITWNNLDTLESFKELSKVGRVDIKEAMSGDNGAKRVKEYNIPMAEGFTYNFAAKQVDADVLEAL
AKLAKEAQLTEKFEALYNGAVINTGENRLVLHQLTRGQLGDAVVADGVDKRKFYVEQQERIAEFANKVHSGEITNAAGEK
FTTVVQIGIGGSDLGPRAMYLALENWAKKNNTFKMEAKFISNVDPDDAASVLASVDVAHSIFILVSKSGTTLETLTNESF
VKDALKNAGLDASKHMIAVTSETSPLAKSDDYLAAFFMDDYIGGRYSSTSAVGGAVLSLAFGPEVFAQFLDGAAAEDKLS
KNANIMENPEMLDALIGVYERNVLGYPSTAVLPYSQALSRFPAHLQQADMESNGKSVNRFGEPVDYVTGPVIFGEPGTNG
QHSFYQLLHQGTDIVPLQFIGFKNNQLDTDVVIQDSTSQQKLCANVAAQIVAFACGKADDNKNKNFEGGRPSSIIIGDQV
NPASLGALLAHFENKIMFQGFLWNVNSFDQEGVQLGKLLAKKVLAHETDGALKELSDMLNI
>Mature_541_residues
MRLVKIRLNDKEEIAMITWNNLDTLESFKELSKVGRVDIKEAMSGDNGAKRVKEYNIPMAEGFTYNFAAKQVDADVLEAL
AKLAKEAQLTEKFEALYNGAVINTGENRLVLHQLTRGQLGDAVVADGVDKRKFYVEQQERIAEFANKVHSGEITNAAGEK
FTTVVQIGIGGSDLGPRAMYLALENWAKKNNTFKMEAKFISNVDPDDAASVLASVDVAHSIFILVSKSGTTLETLTNESF
VKDALKNAGLDASKHMIAVTSETSPLAKSDDYLAAFFMDDYIGGRYSSTSAVGGAVLSLAFGPEVFAQFLDGAAAEDKLS
KNANIMENPEMLDALIGVYERNVLGYPSTAVLPYSQALSRFPAHLQQADMESNGKSVNRFGEPVDYVTGPVIFGEPGTNG
QHSFYQLLHQGTDIVPLQFIGFKNNQLDTDVVIQDSTSQQKLCANVAAQIVAFACGKADDNKNKNFEGGRPSSIIIGDQV
NPASLGALLAHFENKIMFQGFLWNVNSFDQEGVQLGKLLAKKVLAHETDGALKELSDMLNI

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=489, Percent_Identity=36.8098159509202, Blast_Score=302, Evalue=5e-82,
Organism=Homo sapiens, GI296080693, Length=489, Percent_Identity=34.9693251533742, Blast_Score=262, Evalue=6e-70,
Organism=Escherichia coli, GI1790457, Length=536, Percent_Identity=37.3134328358209, Blast_Score=303, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI71996708, Length=484, Percent_Identity=37.603305785124, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71996703, Length=484, Percent_Identity=37.603305785124, Blast_Score=299, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6319673, Length=483, Percent_Identity=37.888198757764, Blast_Score=300, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24651916, Length=519, Percent_Identity=36.6088631984586, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI24651914, Length=519, Percent_Identity=36.6088631984586, Blast_Score=305, Evalue=6e-83,
Organism=Drosophila melanogaster, GI17737445, Length=519, Percent_Identity=36.6088631984586, Blast_Score=305, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 58835; Mature: 58835

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVKIRLNDKEEIAMITWNNLDTLESFKELSKVGRVDIKEAMSGDNGAKRVKEYNIPMA
CEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHCCCCHH
EGFTYNFAAKQVDADVLEALAKLAKEAQLTEKFEALYNGAVINTGENRLVLHQLTRGQLG
CCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEHHCCCCC
DAVVADGVDKRKFYVEQQERIAEFANKVHSGEITNAAGEKFTTVVQIGIGGSDLGPRAMY
CHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHH
LALENWAKKNNTFKMEAKFISNVDPDDAASVLASVDVAHSIFILVSKSGTTLETLTNESF
HHHHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCHHHHCCHHH
VKDALKNAGLDASKHMIAVTSETSPLAKSDDYLAAFFMDDYIGGRYSSTSAVGGAVLSLA
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHH
FGPEVFAQFLDGAAAEDKLSKNANIMENPEMLDALIGVYERNVLGYPSTAVLPYSQALSR
CCHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHH
FPAHLQQADMESNGKSVNRFGEPVDYVTGPVIFGEPGTNGQHSFYQLLHQGTDIVPLQFI
HHHHHHHHHHCCCCCHHHHCCCCHHHHCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEE
GFKNNQLDTDVVIQDSTSQQKLCANVAAQIVAFACGKADDNKNKNFEGGRPSSIIIGDQV
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCC
NPASLGALLAHFENKIMFQGFLWNVNSFDQEGVQLGKLLAKKVLAHETDGALKELSDMLN
CHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
I
C
>Mature Secondary Structure
MRLVKIRLNDKEEIAMITWNNLDTLESFKELSKVGRVDIKEAMSGDNGAKRVKEYNIPMA
CEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHCCCCHH
EGFTYNFAAKQVDADVLEALAKLAKEAQLTEKFEALYNGAVINTGENRLVLHQLTRGQLG
CCCEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEHHCCCCC
DAVVADGVDKRKFYVEQQERIAEFANKVHSGEITNAAGEKFTTVVQIGIGGSDLGPRAMY
CHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCHHHH
LALENWAKKNNTFKMEAKFISNVDPDDAASVLASVDVAHSIFILVSKSGTTLETLTNESF
HHHHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHHHHHEEEEEEEECCCCCHHHHCCHHH
VKDALKNAGLDASKHMIAVTSETSPLAKSDDYLAAFFMDDYIGGRYSSTSAVGGAVLSLA
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHH
FGPEVFAQFLDGAAAEDKLSKNANIMENPEMLDALIGVYERNVLGYPSTAVLPYSQALSR
CCHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHH
FPAHLQQADMESNGKSVNRFGEPVDYVTGPVIFGEPGTNGQHSFYQLLHQGTDIVPLQFI
HHHHHHHHHHCCCCCHHHHCCCCHHHHCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEE
GFKNNQLDTDVVIQDSTSQQKLCANVAAQIVAFACGKADDNKNKNFEGGRPSSIIIGDQV
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCC
NPASLGALLAHFENKIMFQGFLWNVNSFDQEGVQLGKLLAKKVLAHETDGALKELSDMLN
CHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA