Click here to switch to the map view.

The map label for this gene is adhB [H]

Identifier: 238922526

GI number: 238922526

Start: 95875

End: 97059

Strand: Direct

Name: adhB [H]

Synonym: EUBREC_0100

Alternate gene names: 238922526

Gene position: 95875-97059 (Clockwise)

Preceding gene: 238922525

Following gene: 238922527

Centisome position: 2.78

GC content: 47.93

Gene sequence:

>1185_bases
ATGGAAACATTTAATTTCTCGGAGCCACAGGACATCACAGTGGGAAAGGGCAGTCTCTCAAAGCTGCCGGAAATAGCTAA
AAAGCTTGGAGGAAAGCATGCGCTCATCATTTCAGGACCGCATCTTGAGAAGATGGGACTTGTAAAAAAGGCAGCTGATT
ATCTGGCATCAGTTGACATAAAAGCAGACACTTTTACAGATATAGAGGCAAATCCATCTGTCACAACAGTGGAGAAAGCC
ACAGCAAAATACCTGGAGTCAGGCGCAGACTTTATCGTGGCATTCGGAGGCGGCTCACCGATGGATGTGGCAAAAGCAGT
GGGCGTGGTTGCCAAATATGGCGGAAGCGTCACAGACTATGAGGGAGCACACAAGGTGCCGGGACCAATCGTACCGCTCA
TTGCGATACCAACCACCGCAGGAACCGGCTCAGAGGTGACAGCATTCTCTGTAATCACAGATCATAGCAGAAACTATAAG
CTCACAGTATTCAGCTACGAGATATTGCCAAAATATGCAATTCTCGATGCAGAACTCATCACAACAGCACCGGCAAGCGT
AGCGGCAGCCTGCGGAATTGATGCATTTATCCATGCCGAGGAGGCGTATGTATCCACAGCGGCATCGCCATTTTCTGATG
CACTGGCAGAAAAAGCGATGGCACTTATCGGTAAAAATATCCGCAGATTTGTAGCAAACAGAAACGATATCGAGGCTGCA
GAAGCTATGATGACAGGCTCACTTTTTGCAGGAATAGCATTCTCATTTGCAAGGCTCGGAAATGTGCATGCGATGAGTCA
TCCGGTCAGCGCATTTTTCGATGTGCCTCACGGAGTGGCAAATGCAGTGCTGCTTCCTGTAATCGCAGAGTACAATGCAC
TTGCAGATCATGGCAAGTATCTGACTATCTACAATGATATAAGACCGATTTCTGCGTATGCGGACGAATTTGAGCCGATG
ATGCTGGTAGATGCAATCAGGGAGCTTTGCACAGACATCGGAATCCCTGAGAATCTGACCATTGCAATCAACAATGCCAG
CAAAAACGGAACAGTCACAAAGGAAGAGATAGAAAGCAGGATAGAGCCGATGGCTGTCGATGCCATGAAGAGTGGCAACA
TTGCTGTAAATCCAAGGGCTTCACGCCAGTGCGATATCGAGATGCTGTATCGCAAGGCACTGTAA

Upstream 100 bases:

>100_bases
CCGGAGGCAGATGAGGTTGAACTGGATAAGGTTATCGATGCTGCAATAGACAGGGTACTTGCCAAGAAAGCAAGCTAGGA
ACAGAAAGGACAGATTATAT

Downstream 100 bases:

>100_bases
ACTTATAAAATACAAAAACGGAGATATGAGTATGGATTATCTGTCACACAATGTATCTGAAAATTTAAAAAGAATACGTC
AGTCAAAGGGCATGAGCTTA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
METFNFSEPQDITVGKGSLSKLPEIAKKLGGKHALIISGPHLEKMGLVKKAADYLASVDIKADTFTDIEANPSVTTVEKA
TAKYLESGADFIVAFGGGSPMDVAKAVGVVAKYGGSVTDYEGAHKVPGPIVPLIAIPTTAGTGSEVTAFSVITDHSRNYK
LTVFSYEILPKYAILDAELITTAPASVAAACGIDAFIHAEEAYVSTAASPFSDALAEKAMALIGKNIRRFVANRNDIEAA
EAMMTGSLFAGIAFSFARLGNVHAMSHPVSAFFDVPHGVANAVLLPVIAEYNALADHGKYLTIYNDIRPISAYADEFEPM
MLVDAIRELCTDIGIPENLTIAINNASKNGTVTKEEIESRIEPMAVDAMKSGNIAVNPRASRQCDIEMLYRKAL

Sequences:

>Translated_394_residues
METFNFSEPQDITVGKGSLSKLPEIAKKLGGKHALIISGPHLEKMGLVKKAADYLASVDIKADTFTDIEANPSVTTVEKA
TAKYLESGADFIVAFGGGSPMDVAKAVGVVAKYGGSVTDYEGAHKVPGPIVPLIAIPTTAGTGSEVTAFSVITDHSRNYK
LTVFSYEILPKYAILDAELITTAPASVAAACGIDAFIHAEEAYVSTAASPFSDALAEKAMALIGKNIRRFVANRNDIEAA
EAMMTGSLFAGIAFSFARLGNVHAMSHPVSAFFDVPHGVANAVLLPVIAEYNALADHGKYLTIYNDIRPISAYADEFEPM
MLVDAIRELCTDIGIPENLTIAINNASKNGTVTKEEIESRIEPMAVDAMKSGNIAVNPRASRQCDIEMLYRKAL
>Mature_394_residues
METFNFSEPQDITVGKGSLSKLPEIAKKLGGKHALIISGPHLEKMGLVKKAADYLASVDIKADTFTDIEANPSVTTVEKA
TAKYLESGADFIVAFGGGSPMDVAKAVGVVAKYGGSVTDYEGAHKVPGPIVPLIAIPTTAGTGSEVTAFSVITDHSRNYK
LTVFSYEILPKYAILDAELITTAPASVAAACGIDAFIHAEEAYVSTAASPFSDALAEKAMALIGKNIRRFVANRNDIEAA
EAMMTGSLFAGIAFSFARLGNVHAMSHPVSAFFDVPHGVANAVLLPVIAEYNALADHGKYLTIYNDIRPISAYADEFEPM
MLVDAIRELCTDIGIPENLTIAINNASKNGTVTKEEIESRIEPMAVDAMKSGNIAVNPRASRQCDIEMLYRKAL

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=306, Percent_Identity=29.7385620915033, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI48994951, Length=404, Percent_Identity=33.4158415841584, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI1789163, Length=383, Percent_Identity=35.2480417754569, Blast_Score=211, Evalue=6e-56,
Organism=Escherichia coli, GI87082107, Length=335, Percent_Identity=37.6119402985075, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1787493, Length=403, Percent_Identity=31.2655086848635, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1789386, Length=356, Percent_Identity=25.561797752809, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537053, Length=427, Percent_Identity=27.8688524590164, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321181, Length=327, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24657991, Length=426, Percent_Identity=23.4741784037559, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41880; Mature: 41880

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METFNFSEPQDITVGKGSLSKLPEIAKKLGGKHALIISGPHLEKMGLVKKAADYLASVDI
CCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHEECC
KADTFTDIEANPSVTTVEKATAKYLESGADFIVAFGGGSPMDVAKAVGVVAKYGGSVTDY
CCCCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCC
EGAHKVPGPIVPLIAIPTTAGTGSEVTAFSVITDHSRNYKLTVFSYEILPKYAILDAELI
CCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEEEECCCCCCEECHHHH
TTAPASVAAACGIDAFIHAEEAYVSTAASPFSDALAEKAMALIGKNIRRFVANRNDIEAA
HCCCHHHHHHHCCHHEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EAMMTGSLFAGIAFSFARLGNVHAMSHPVSAFFDVPHGVANAVLLPVIAEYNALADHGKY
HHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCE
LTIYNDIRPISAYADEFEPMMLVDAIRELCTDIGIPENLTIAINNASKNGTVTKEEIESR
EEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHH
IEPMAVDAMKSGNIAVNPRASRQCDIEMLYRKAL
CCCCEEHHHCCCCEEECCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
METFNFSEPQDITVGKGSLSKLPEIAKKLGGKHALIISGPHLEKMGLVKKAADYLASVDI
CCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHEECC
KADTFTDIEANPSVTTVEKATAKYLESGADFIVAFGGGSPMDVAKAVGVVAKYGGSVTDY
CCCCCCCCCCCCCEEHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCC
EGAHKVPGPIVPLIAIPTTAGTGSEVTAFSVITDHSRNYKLTVFSYEILPKYAILDAELI
CCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEEEEECCCCCCEECHHHH
TTAPASVAAACGIDAFIHAEEAYVSTAASPFSDALAEKAMALIGKNIRRFVANRNDIEAA
HCCCHHHHHHHCCHHEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EAMMTGSLFAGIAFSFARLGNVHAMSHPVSAFFDVPHGVANAVLLPVIAEYNALADHGKY
HHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCE
LTIYNDIRPISAYADEFEPMMLVDAIRELCTDIGIPENLTIAINNASKNGTVTKEEIESR
EEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHH
IEPMAVDAMKSGNIAVNPRASRQCDIEMLYRKAL
CCCCEEHHHCCCCEEECCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]