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The map label for this gene is yhdG [H]

Identifier: 238922525

GI number: 238922525

Start: 94329

End: 95852

Strand: Direct

Name: yhdG [H]

Synonym: EUBREC_0099

Alternate gene names: 238922525

Gene position: 94329-95852 (Clockwise)

Preceding gene: 238922524

Following gene: 238922526

Centisome position: 2.73

GC content: 46.78

Gene sequence:

>1524_bases
ATGGAACAGAAAAAATCAGAATTTAACAAAGTCCTGAATGCCTGGGACGTACTTGTAATTGCATTTGGAGCCATGATTGG
CTGGGGCTGGGTTGTCTCAACCGGAGGCTGGATTGAAAAGGGCGGAGTGCTCGGTGCCGCAATCGGCTTCGTTATCGGCG
GTATCATGATATTTTTCGTGGGAATGACCTACGCGGAGCTGACAGCAGCCATGCCTCAGTGCGGTGGCGAGCATGTATTC
AGCTACAAGGCAATGGGTTCGACAGGCTCATTCATATGTACGTGGATGATTATCCTTGGATATGTCAGTGTGGCATGCTT
TGAGGCGTGCGCTTTCCCAACAATCATCACATATCTGTGGCCGGGCTTTTTGAAGGGATATCTGTATACGGTAGCAGGCT
TTGATATCTATGCTTCATGGCTTATTGTGGCGATAGTTGTGGCATTTTTAATCATGATGATAAACATTATCGGCGCAAAG
ACAGCAGCGATTTTGCAGACTGTGCTCACATGTATTATTGGTGGCGCCGGAATTTTGTTGATAATTGCATCGGTAATCAA
TGGAACAGTTGATAACCTGGATGGACAGATGTTTGCAGGCAGCTCTGCAGGTCTGAACGTAAAGGCAATTATCGGAGTGG
CAGCTCTGTCACCATTTTACTTTATCGGATTTGACGTAATACCTCAGGCGGCTGAGGAAATCAATGTTCCGGCAAAGAAA
ATCGGCTCAATACTTATCTTATCAGTAGTTCTGGCAGTTGTGTTCTACGCACTTGTCATTGTTGCGGTAGGTCTTGTCAT
GGGCCCACAGGCAATTGTTGATTCAGAGCAGGCAACAGGACTTGTCACAGCAGATGCAATGGCTGCCGCATTCAACACAA
AGATAATGGCAAAGGTTATAATAGTCGGCGGAATGTGCGGTATCGTAACCTCATGGAACTCATTTATGCTCGGTGGCTCG
CGTGCCATGTACTCAATGGCAGAGTCATATATGATTCCGAAGTTTTTTGCAAAGCTTCATCCAAAGCACAAGACACCTAT
CAATGCACTGATTCTCATCGGATCTCTCACAATGCTTGCACCTTTTGCAGGCAGAAAGATGCTCGTATGGATCAGTGATG
CCGGAAACTTTGGCTGCTGTGTGGCATATTGCATGGTTGCTCTTTCATTTATTATTCTTCGCAAGAAGAAGCCGGATATG
CCAAGACCTTACAAGGTTCCCGCATACAAGTTCTTTGGAACGATGGCGGTCATCATGTCAGGCTTCATGGTTGCCATGTA
CTGTATACCGGGAAGCGGCGGAACACTTATCGTCCAGGAGTGGGGCATCGTGCTTGCATGGTGTGCGCTCGGCGTGGTAT
TCTTCGTCTTCTGTAAAAAGAAATACAAGGAGTCATTTGGTACACTTGTTGAGCTCATCTCAGATGAGGATGCTGCAACA
CTTATGCCGGAGGCAGATGAGGTTGAACTGGATAAGGTTATCGATGCTGCAATAGACAGGGTACTTGCCAAGAAAGCAAG
CTAG

Upstream 100 bases:

>100_bases
GCAGCCTGTTAGGAGTGGATGGCACAGCGGAGCTTATTGAGTCTCTGGCAAGAAAAGTGGTAGAGAATGAAAGTAAGACA
GAAGCTGGAGGTGACAAGTA

Downstream 100 bases:

>100_bases
GAACAGAAAGGACAGATTATATATGGAAACATTTAATTTCTCGGAGCCACAGGACATCACAGTGGGAAAGGGCAGTCTCT
CAAAGCTGCCGGAAATAGCT

Product: cationic amino acid transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MEQKKSEFNKVLNAWDVLVIAFGAMIGWGWVVSTGGWIEKGGVLGAAIGFVIGGIMIFFVGMTYAELTAAMPQCGGEHVF
SYKAMGSTGSFICTWMIILGYVSVACFEACAFPTIITYLWPGFLKGYLYTVAGFDIYASWLIVAIVVAFLIMMINIIGAK
TAAILQTVLTCIIGGAGILLIIASVINGTVDNLDGQMFAGSSAGLNVKAIIGVAALSPFYFIGFDVIPQAAEEINVPAKK
IGSILILSVVLAVVFYALVIVAVGLVMGPQAIVDSEQATGLVTADAMAAAFNTKIMAKVIIVGGMCGIVTSWNSFMLGGS
RAMYSMAESYMIPKFFAKLHPKHKTPINALILIGSLTMLAPFAGRKMLVWISDAGNFGCCVAYCMVALSFIILRKKKPDM
PRPYKVPAYKFFGTMAVIMSGFMVAMYCIPGSGGTLIVQEWGIVLAWCALGVVFFVFCKKKYKESFGTLVELISDEDAAT
LMPEADEVELDKVIDAAIDRVLAKKAS

Sequences:

>Translated_507_residues
MEQKKSEFNKVLNAWDVLVIAFGAMIGWGWVVSTGGWIEKGGVLGAAIGFVIGGIMIFFVGMTYAELTAAMPQCGGEHVF
SYKAMGSTGSFICTWMIILGYVSVACFEACAFPTIITYLWPGFLKGYLYTVAGFDIYASWLIVAIVVAFLIMMINIIGAK
TAAILQTVLTCIIGGAGILLIIASVINGTVDNLDGQMFAGSSAGLNVKAIIGVAALSPFYFIGFDVIPQAAEEINVPAKK
IGSILILSVVLAVVFYALVIVAVGLVMGPQAIVDSEQATGLVTADAMAAAFNTKIMAKVIIVGGMCGIVTSWNSFMLGGS
RAMYSMAESYMIPKFFAKLHPKHKTPINALILIGSLTMLAPFAGRKMLVWISDAGNFGCCVAYCMVALSFIILRKKKPDM
PRPYKVPAYKFFGTMAVIMSGFMVAMYCIPGSGGTLIVQEWGIVLAWCALGVVFFVFCKKKYKESFGTLVELISDEDAAT
LMPEADEVELDKVIDAAIDRVLAKKAS
>Mature_507_residues
MEQKKSEFNKVLNAWDVLVIAFGAMIGWGWVVSTGGWIEKGGVLGAAIGFVIGGIMIFFVGMTYAELTAAMPQCGGEHVF
SYKAMGSTGSFICTWMIILGYVSVACFEACAFPTIITYLWPGFLKGYLYTVAGFDIYASWLIVAIVVAFLIMMINIIGAK
TAAILQTVLTCIIGGAGILLIIASVINGTVDNLDGQMFAGSSAGLNVKAIIGVAALSPFYFIGFDVIPQAAEEINVPAKK
IGSILILSVVLAVVFYALVIVAVGLVMGPQAIVDSEQATGLVTADAMAAAFNTKIMAKVIIVGGMCGIVTSWNSFMLGGS
RAMYSMAESYMIPKFFAKLHPKHKTPINALILIGSLTMLAPFAGRKMLVWISDAGNFGCCVAYCMVALSFIILRKKKPDM
PRPYKVPAYKFFGTMAVIMSGFMVAMYCIPGSGGTLIVQEWGIVLAWCALGVVFFVFCKKKYKESFGTLVELISDEDAAT
LMPEADEVELDKVIDAAIDRVLAKKAS

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=430, Percent_Identity=24.4186046511628, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI258614005, Length=433, Percent_Identity=24.9422632794457, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI258614003, Length=433, Percent_Identity=24.9422632794457, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI258645169, Length=433, Percent_Identity=24.0184757505774, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI7657683, Length=470, Percent_Identity=23.8297872340426, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI33286428, Length=404, Percent_Identity=26.2376237623762, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI114326544, Length=428, Percent_Identity=24.2990654205607, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI114326550, Length=428, Percent_Identity=24.2990654205607, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI110347453, Length=399, Percent_Identity=23.0576441102757, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI186910308, Length=480, Percent_Identity=23.75, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI186910306, Length=480, Percent_Identity=23.75, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI186910304, Length=480, Percent_Identity=23.75, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI181337167, Length=405, Percent_Identity=24.1975308641975, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788480, Length=430, Percent_Identity=24.6511627906977, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082250, Length=448, Percent_Identity=24.3303571428571, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081708, Length=445, Percent_Identity=19.5505617977528, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082023, Length=359, Percent_Identity=25.0696378830084, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17533459, Length=407, Percent_Identity=27.5184275184275, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532491, Length=423, Percent_Identity=24.3498817966903, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=417, Percent_Identity=24.4604316546763, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32566699, Length=351, Percent_Identity=23.6467236467236, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=408, Percent_Identity=23.5294117647059, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321629, Length=465, Percent_Identity=23.010752688172, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221512776, Length=414, Percent_Identity=27.0531400966184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666159, Length=414, Percent_Identity=27.0531400966184, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667468, Length=413, Percent_Identity=25.181598062954, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281366235, Length=414, Percent_Identity=25.8454106280193, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI116007820, Length=414, Percent_Identity=25.8454106280193, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24668806, Length=476, Percent_Identity=24.3697478991597, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356285, Length=476, Percent_Identity=24.3697478991597, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24668802, Length=476, Percent_Identity=24.3697478991597, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI116007818, Length=412, Percent_Identity=26.6990291262136, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI85725152, Length=412, Percent_Identity=26.6990291262136, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24641995, Length=435, Percent_Identity=23.6781609195402, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641993, Length=435, Percent_Identity=23.6781609195402, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161077963, Length=400, Percent_Identity=24.5, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004758
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54197; Mature: 54197

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKKSEFNKVLNAWDVLVIAFGAMIGWGWVVSTGGWIEKGGVLGAAIGFVIGGIMIFFV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
GMTYAELTAAMPQCGGEHVFSYKAMGSTGSFICTWMIILGYVSVACFEACAFPTIITYLW
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PGFLKGYLYTVAGFDIYASWLIVAIVVAFLIMMINIIGAKTAAILQTVLTCIIGGAGILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
IIASVINGTVDNLDGQMFAGSSAGLNVKAIIGVAALSPFYFIGFDVIPQAAEEINVPAKK
HHHHHHCCCHHCCCCCEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHH
IGSILILSVVLAVVFYALVIVAVGLVMGPQAIVDSEQATGLVTADAMAAAFNTKIMAKVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
IVGGMCGIVTSWNSFMLGGSRAMYSMAESYMIPKFFAKLHPKHKTPINALILIGSLTMLA
HHCCHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
PFAGRKMLVWISDAGNFGCCVAYCMVALSFIILRKKKPDMPRPYKVPAYKFFGTMAVIMS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GFMVAMYCIPGSGGTLIVQEWGIVLAWCALGVVFFVFCKKKYKESFGTLVELISDEDAAT
HHHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LMPEADEVELDKVIDAAIDRVLAKKAS
CCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEQKKSEFNKVLNAWDVLVIAFGAMIGWGWVVSTGGWIEKGGVLGAAIGFVIGGIMIFFV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHH
GMTYAELTAAMPQCGGEHVFSYKAMGSTGSFICTWMIILGYVSVACFEACAFPTIITYLW
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PGFLKGYLYTVAGFDIYASWLIVAIVVAFLIMMINIIGAKTAAILQTVLTCIIGGAGILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
IIASVINGTVDNLDGQMFAGSSAGLNVKAIIGVAALSPFYFIGFDVIPQAAEEINVPAKK
HHHHHHCCCHHCCCCCEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHH
IGSILILSVVLAVVFYALVIVAVGLVMGPQAIVDSEQATGLVTADAMAAAFNTKIMAKVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHH
IVGGMCGIVTSWNSFMLGGSRAMYSMAESYMIPKFFAKLHPKHKTPINALILIGSLTMLA
HHCCHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
PFAGRKMLVWISDAGNFGCCVAYCMVALSFIILRKKKPDMPRPYKVPAYKFFGTMAVIMS
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
GFMVAMYCIPGSGGTLIVQEWGIVLAWCALGVVFFVFCKKKYKESFGTLVELISDEDAAT
HHHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LMPEADEVELDKVIDAAIDRVLAKKAS
CCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]