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The map label for this gene is phoR [H]

Identifier: 238922449

GI number: 238922449

Start: 25420

End: 26793

Strand: Direct

Name: phoR [H]

Synonym: EUBREC_0023

Alternate gene names: 238922449

Gene position: 25420-26793 (Clockwise)

Preceding gene: 238922448

Following gene: 238922450

Centisome position: 0.74

GC content: 39.45

Gene sequence:

>1374_bases
ATGAAGCAGTATACGATAGGAAAAAAAGCAGCGGTCATAGTCTTACATCAGCTATGCATGATACTTATGGTAACAGGAGT
GTTTGCCACAGGCTATGCATTCAGGCACGATGCGCATGAAAATATTGATATATATACACTAATATCGCTGGCGGGCCTGG
TAGGCAGCTTTGTGAGCCTGGCATATATGGCAAACGTGGCAGGCAGAAAATCAGAGGATGATTACACAATATACTATTTA
CCGATTGACAAGGTATACTCTGATGTGATGCTAGTGATATTTACACTGCTCATGGTATTTATGGGAAAAGTGATTTCAGG
CGTAAAAAACCAGCATTTTGACTATGCATCACTCATTATGACGGCCGGCACATTTACTTTTTTGTTTGATATGGCTTTTA
TTATTTTATACCAGAGCATTGTAAGGAAGATAAAAGGCAATATACTTTGCACACACAGCCTGATGTACAAGGGCTATGAG
CTTTTGAAAAGAGTTATTGAGAAAAAGGATATCCATACACAAAAAACCAAAGAGATAATGCGCATACAGGAGGCTCTTGA
AGCTATCTCGGAAGGAGCGCTTGACACTACACTTAATGTCAATGAGTTTCATGGGCAGCAGAAAAAGGTGGCGGAGGCTG
TCAACCATATACGCCAGGGTCTTATGAGCTCGGTAAATGAGAGCCTTAAAAATGAAAAACTAAAGGCAGACTTAATAACA
AACGTATCACACGATATAAAGACACCTCTGACTTCAATAGTCAACTATGTTGACCTGCTTAAGAGGGAAAATCTGGAAAA
TGAAAATGCCAAATACTATATACATGTGCTGGAGGAAAAGTCACAGCGTTTAAAGCAGCTTACAGAGGATTTGGTAGAGA
CATCAAAGATTACCTCGGGAAATGTGAAGCTCAATATGCAAAAGCTTGATCTGGTTGAGCTTTTATACCAGACCGGAGGT
GAATTCAATGAGCGCTTTGAGTCGAGAAATCTCACAATAGTTACAAAAATTCCATCAGAACAGATATTTATCTATGCGGA
TGGGCGTCAGCTTTACCGCTCTATTGAAAATCTGTATACTAATGCCGCAAAGTATGCACTGGAAAATACCAGAGTGTATG
TAGAGCTTGAAAAGGCAGATACAAAGGCAGTTTTTACAATAAAGAATGTGTCTAAGAACGAGCTTGACATAGTAAGCAAC
GGAAATGTAGACCTGACAGAGCGTTTTGTGAGGGGAGAGAGGTCGAGAACTACTGAAGGAAGTGGACTTGGACTTTCGAT
TGCAAAGAATCTGACCCATTTGATGGGAGGAAAATTCGAAATTAAGGTAGATGGTGATTTATTTATTGCCACAATTACCT
ATAATATTATATAA

Upstream 100 bases:

>100_bases
TGCACATCAGACATATCAGGGAAAAAATAGAGATAAATCCTAAGGAGCCACGCTATCTGAAGGTGGTCTGGGGAGTAGGC
TATAAGATAGAGGACAACAA

Downstream 100 bases:

>100_bases
TAGTAAATAAAAGAATTTTGAAATACACATACGGAGGTAGAATAAGTGAAATTATATGAAAATGGTGCTTACCTTTTAAA
CGGTAAGGAAGTAATAATTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKQYTIGKKAAVIVLHQLCMILMVTGVFATGYAFRHDAHENIDIYTLISLAGLVGSFVSLAYMANVAGRKSEDDYTIYYL
PIDKVYSDVMLVIFTLLMVFMGKVISGVKNQHFDYASLIMTAGTFTFLFDMAFIILYQSIVRKIKGNILCTHSLMYKGYE
LLKRVIEKKDIHTQKTKEIMRIQEALEAISEGALDTTLNVNEFHGQQKKVAEAVNHIRQGLMSSVNESLKNEKLKADLIT
NVSHDIKTPLTSIVNYVDLLKRENLENENAKYYIHVLEEKSQRLKQLTEDLVETSKITSGNVKLNMQKLDLVELLYQTGG
EFNERFESRNLTIVTKIPSEQIFIYADGRQLYRSIENLYTNAAKYALENTRVYVELEKADTKAVFTIKNVSKNELDIVSN
GNVDLTERFVRGERSRTTEGSGLGLSIAKNLTHLMGGKFEIKVDGDLFIATITYNII

Sequences:

>Translated_457_residues
MKQYTIGKKAAVIVLHQLCMILMVTGVFATGYAFRHDAHENIDIYTLISLAGLVGSFVSLAYMANVAGRKSEDDYTIYYL
PIDKVYSDVMLVIFTLLMVFMGKVISGVKNQHFDYASLIMTAGTFTFLFDMAFIILYQSIVRKIKGNILCTHSLMYKGYE
LLKRVIEKKDIHTQKTKEIMRIQEALEAISEGALDTTLNVNEFHGQQKKVAEAVNHIRQGLMSSVNESLKNEKLKADLIT
NVSHDIKTPLTSIVNYVDLLKRENLENENAKYYIHVLEEKSQRLKQLTEDLVETSKITSGNVKLNMQKLDLVELLYQTGG
EFNERFESRNLTIVTKIPSEQIFIYADGRQLYRSIENLYTNAAKYALENTRVYVELEKADTKAVFTIKNVSKNELDIVSN
GNVDLTERFVRGERSRTTEGSGLGLSIAKNLTHLMGGKFEIKVDGDLFIATITYNII
>Mature_457_residues
MKQYTIGKKAAVIVLHQLCMILMVTGVFATGYAFRHDAHENIDIYTLISLAGLVGSFVSLAYMANVAGRKSEDDYTIYYL
PIDKVYSDVMLVIFTLLMVFMGKVISGVKNQHFDYASLIMTAGTFTFLFDMAFIILYQSIVRKIKGNILCTHSLMYKGYE
LLKRVIEKKDIHTQKTKEIMRIQEALEAISEGALDTTLNVNEFHGQQKKVAEAVNHIRQGLMSSVNESLKNEKLKADLIT
NVSHDIKTPLTSIVNYVDLLKRENLENENAKYYIHVLEEKSQRLKQLTEDLVETSKITSGNVKLNMQKLDLVELLYQTGG
EFNERFESRNLTIVTKIPSEQIFIYADGRQLYRSIENLYTNAAKYALENTRVYVELEKADTKAVFTIKNVSKNELDIVSN
GNVDLTERFVRGERSRTTEGSGLGLSIAKNLTHLMGGKFEIKVDGDLFIATITYNII

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=201, Percent_Identity=29.8507462686567, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1788393, Length=215, Percent_Identity=27.4418604651163, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788713, Length=237, Percent_Identity=25.7383966244726, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=24.8868778280543, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51836; Mature: 51836

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQYTIGKKAAVIVLHQLCMILMVTGVFATGYAFRHDAHENIDIYTLISLAGLVGSFVSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AYMANVAGRKSEDDYTIYYLPIDKVYSDVMLVIFTLLMVFMGKVISGVKNQHFDYASLIM
HHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TAGTFTFLFDMAFIILYQSIVRKIKGNILCTHSLMYKGYELLKRVIEKKDIHTQKTKEIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RIQEALEAISEGALDTTLNVNEFHGQQKKVAEAVNHIRQGLMSSVNESLKNEKLKADLIT
HHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVSHDIKTPLTSIVNYVDLLKRENLENENAKYYIHVLEEKSQRLKQLTEDLVETSKITSG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
NVKLNMQKLDLVELLYQTGGEFNERFESRNLTIVTKIPSEQIFIYADGRQLYRSIENLYT
CEEEEHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHH
NAAKYALENTRVYVELEKADTKAVFTIKNVSKNELDIVSNGNVDLTERFVRGERSRTTEG
HHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCCCCC
SGLGLSIAKNLTHLMGGKFEIKVDGDLFIATITYNII
CCCCHHHHHHHHHHHCCEEEEEECCCEEEEEEEEECC
>Mature Secondary Structure
MKQYTIGKKAAVIVLHQLCMILMVTGVFATGYAFRHDAHENIDIYTLISLAGLVGSFVSL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
AYMANVAGRKSEDDYTIYYLPIDKVYSDVMLVIFTLLMVFMGKVISGVKNQHFDYASLIM
HHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
TAGTFTFLFDMAFIILYQSIVRKIKGNILCTHSLMYKGYELLKRVIEKKDIHTQKTKEIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RIQEALEAISEGALDTTLNVNEFHGQQKKVAEAVNHIRQGLMSSVNESLKNEKLKADLIT
HHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NVSHDIKTPLTSIVNYVDLLKRENLENENAKYYIHVLEEKSQRLKQLTEDLVETSKITSG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
NVKLNMQKLDLVELLYQTGGEFNERFESRNLTIVTKIPSEQIFIYADGRQLYRSIENLYT
CEEEEHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCEEEEEECHHHHHHHHHHHHH
NAAKYALENTRVYVELEKADTKAVFTIKNVSKNELDIVSNGNVDLTERFVRGERSRTTEG
HHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCCEEEEECCCCHHHHHHHCCCCCCCCCC
SGLGLSIAKNLTHLMGGKFEIKVDGDLFIATITYNII
CCCCHHHHHHHHHHHCCEEEEEECCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2556368 [H]