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The map label for this gene is vanR [H]

Identifier: 238922448

GI number: 238922448

Start: 24731

End: 25423

Strand: Direct

Name: vanR [H]

Synonym: EUBREC_0022

Alternate gene names: 238922448

Gene position: 24731-25423 (Clockwise)

Preceding gene: 238922447

Following gene: 238922449

Centisome position: 0.72

GC content: 42.57

Gene sequence:

>693_bases
ATGACAATATTAGTTTGTGATGACGACAAGGAAATAGTTGAGGCAATTGAGATTTACCTGATGCAGGAGGGCTACGACGT
GGAGAAGGCTTACGACGGCATACAGGCGGTTGAAATTATGAAGAATAAAAAAATAGACCTCATGATAATAGATGTCATGA
TGCCAAAGCTCGACGGAATAAGAGCCACTTTGCAGATACGAAAGGAAAGCAGGGTGCCGATAATCATTCTATCGGCAAAG
ACAGAGGATGCTGACAAGATTTTAGGCCTCAATGTGGGAGCTGATGATTATGTCACAAAGCCTTTTAATCCGCTTGAGCT
TGTGGCAAGGGTAAAGTCACAGCTTCGCAGATATACCACTCTGTCAAGCAATGATGCAGCCGGAGACAAGGTTTATGAAG
CCGGAGGTCTTTTGGTAAATGATGATTTAAAAAAGGTGACTGTGGATGGTGAGGAGGTAAAGCTCACACCGATTGAATAC
AATATACTGCTTTTACTCCTTAAAAATAAGGGAAAGGTCTACTCAATAAACGAAATATATGAGAGCATATGGAACGAGGA
GGCGATAGGCGCCGACAATACAGTTGCTGTGCACATCAGACATATCAGGGAAAAAATAGAGATAAATCCTAAGGAGCCAC
GCTATCTGAAGGTGGTCTGGGGAGTAGGCTATAAGATAGAGGACAACAAATGA

Upstream 100 bases:

>100_bases
TAAGCAGATTTTAAGAAAAACAAAGTGGATAATCTGATAAAATATAGCTGACTAACGGCAGGAGAAGGTTTCTGTTCAAA
ATTCATAGAAGGAGGATAAT

Downstream 100 bases:

>100_bases
AGCAGTATACGATAGGAAAAAAAGCAGCGGTCATAGTCTTACATCAGCTATGCATGATACTTATGGTAACAGGAGTGTTT
GCCACAGGCTATGCATTCAG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MTILVCDDDKEIVEAIEIYLMQEGYDVEKAYDGIQAVEIMKNKKIDLMIIDVMMPKLDGIRATLQIRKESRVPIIILSAK
TEDADKILGLNVGADDYVTKPFNPLELVARVKSQLRRYTTLSSNDAAGDKVYEAGGLLVNDDLKKVTVDGEEVKLTPIEY
NILLLLLKNKGKVYSINEIYESIWNEEAIGADNTVAVHIRHIREKIEINPKEPRYLKVVWGVGYKIEDNK

Sequences:

>Translated_230_residues
MTILVCDDDKEIVEAIEIYLMQEGYDVEKAYDGIQAVEIMKNKKIDLMIIDVMMPKLDGIRATLQIRKESRVPIIILSAK
TEDADKILGLNVGADDYVTKPFNPLELVARVKSQLRRYTTLSSNDAAGDKVYEAGGLLVNDDLKKVTVDGEEVKLTPIEY
NILLLLLKNKGKVYSINEIYESIWNEEAIGADNTVAVHIRHIREKIEINPKEPRYLKVVWGVGYKIEDNK
>Mature_229_residues
TILVCDDDKEIVEAIEIYLMQEGYDVEKAYDGIQAVEIMKNKKIDLMIIDVMMPKLDGIRATLQIRKESRVPIIILSAKT
EDADKILGLNVGADDYVTKPFNPLELVARVKSQLRRYTTLSSNDAAGDKVYEAGGLLVNDDLKKVTVDGEEVKLTPIEYN
ILLLLLKNKGKVYSINEIYESIWNEEAIGADNTVAVHIRHIREKIEINPKEPRYLKVVWGVGYKIEDNK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=32.5892857142857, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.4821428571429, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=32.0175438596491, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=33.0396475770925, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=33.0357142857143, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=32.5991189427313, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1790860, Length=211, Percent_Identity=32.7014218009479, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=32.3144104803493, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787229, Length=206, Percent_Identity=33.495145631068, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=30.5309734513274, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=30.2631578947368, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=32.034632034632, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=29.2576419213974, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=27.5109170305677, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=32.0754716981132, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=118, Percent_Identity=33.0508474576271, Blast_Score=61, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=101, Percent_Identity=30.6930693069307, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26081; Mature: 25949

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILVCDDDKEIVEAIEIYLMQEGYDVEKAYDGIQAVEIMKNKKIDLMIIDVMMPKLDGI
CEEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHCCCEEEEEEEEECCCCCCC
RATLQIRKESRVPIIILSAKTEDADKILGLNVGADDYVTKPFNPLELVARVKSQLRRYTT
EEEEEEECCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHC
LSSNDAAGDKVYEAGGLLVNDDLKKVTVDGEEVKLTPIEYNILLLLLKNKGKVYSINEIY
CCCCCCCCCEEEECCCEEEECCCEEEEECCCEEEEEEEEEEEEEEEEECCCCEEEHHHHH
ESIWNEEAIGADNTVAVHIRHIREKIEINPKEPRYLKVVWGVGYKIEDNK
HHHCCCCCCCCCCEEEEEEEHHHHHHCCCCCCCCEEEEEEECCEEEECCC
>Mature Secondary Structure 
TILVCDDDKEIVEAIEIYLMQEGYDVEKAYDGIQAVEIMKNKKIDLMIIDVMMPKLDGI
EEEEECCCHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHCCCEEEEEEEEECCCCCCC
RATLQIRKESRVPIIILSAKTEDADKILGLNVGADDYVTKPFNPLELVARVKSQLRRYTT
EEEEEEECCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHC
LSSNDAAGDKVYEAGGLLVNDDLKKVTVDGEEVKLTPIEYNILLLLLKNKGKVYSINEIY
CCCCCCCCCEEEECCCEEEECCCEEEEECCCEEEEEEEEEEEEEEEEECCCCEEEHHHHH
ESIWNEEAIGADNTVAVHIRHIREKIEINPKEPRYLKVVWGVGYKIEDNK
HHHCCCCCCCCCCEEEEEEEHHHHHHCCCCCCCCEEEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]