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The map label for this gene is ypnP [H]

Identifier: 238922162

GI number: 238922162

Start: 355886

End: 357229

Strand: Reverse

Name: ypnP [H]

Synonym: EUBELI_20397

Alternate gene names: 238922162

Gene position: 357229-355886 (Counterclockwise)

Preceding gene: 238922163

Following gene: 238922161

Centisome position: 57.0

GC content: 38.62

Gene sequence:

>1344_bases
TTGAATAATTCAAAATCAGATTTTACACAGGGAAGAATATTAGGGAAGCTGATTCCTTTTATGATGCCAATACTTGGGGC
GTTAATATTACAGGCAGCATATGGTGCAGTTGACTTGCTTGTTGTTGGAAGATTTGGAACTACTGAAGGCCTTTCAGCAG
TATCGACAGGAAGCCAGGTACTTAATTTAGTTACATTTGTTATAACACAGTTTGCAATGGGGGTTACAGTGCTTATTGCA
AGATATATTGGTGAGAAAAGACCGGAGCAGATAGGCGCTCTGATAGGCGGAGCTATTGTTGTGTTTACAATGATTTCAGT
GGTGCTTTTCGTTGTTATGATTATTTTTTCAAGACAGATTGCAGTTATAATGCAGGCACCGAAAGAAGCAGTAGGTCTTA
CATCTGTATATGTAAAAATATGTGGCTCAGGAATATTCTTTATAGTTGCATATAATCTTCTTTCAGCAATATTCAGGGGA
CTTGGAGACAGCAAATCACCTCTTATATTCGTTGCAGTTGCATGTGTTATTAATATTGTGGGGGATCTTGTTCTTGTTGC
AGGGTTTAACATGAATGCTGCCGGAGCTGCTATTGCGACAGTCGCAGCACAGGCGGTAAGTGTTGTATTTGCACTTGTAT
TACTTTTTAAGAGAAAACTTCCGTTTAAGATAACTAAGAAAGATTTCTCAATTAACAGGCATTGCAGGAGAGCATTAAAG
GTCGGACTTCCACTTGCATTACAGGAATTTCTTACACAGATTTCATTCCTTGCTTTATGCGCATTCGTTAACAGACTGGG
ATTACAGGCATCGTCAGGATATGGTGTTGCATGTAAAATAGTTAATTTTGCAATGCTCATACCAAGCTCACTTATGCAGT
CAATGGCGTCATTTGTTTCACAGAATGTCGGTGCAGGCAATGAAAAGAGAGCAAAGAAGACGATGTTTGCCGGTATTGGT
GTTGGACTTGTGATAGGCTGTATAGTATTCCTGTTTGTGATGTTTAAGGGTGACCTTCTCACAGCAATATTTACAACTGA
TGAGGCTGTTATCCAGAATGGATATGATTACCTTAAGGGATTTGCATTAGAGACGATTGTTACTGCGATATTATTCAGTA
TGATTGGATATTTTAATGGTCATGACAAGACGGTATGGGTAATGATTCAGGGCCTTACACAGACACTGCTTGTCCGTCTG
CCATTTGCGTATTATATGAGTATACAGCCTGATGCGAGCCTTACTAAGATTGGTATGGCTGCTCCTGTAGCAACTATTTT
TGGAATTGTATTAAATGTGGTATTCTATATCTTGTGTAACAGAAAAGATAAGAAATATATATAA

Upstream 100 bases:

>100_bases
CTTAGCAAATATCTTACGGATATTAGTGATGAAGAGGCTGATTCTATGATCGAAACTATTAAAAAATTCTACAAGGTGAT
GAGCGAAAGGAAAGTTGACA

Downstream 100 bases:

>100_bases
TATTTGTAGAATATTTGCTACATTTCATCAGGCATGTTATAATAACTGACATTAATATAAAAGGAGATTTCTGAAAAAGA
AATAAGGTCAGATTATGTTG

Product: multidrug resistance protein, MATE family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MNNSKSDFTQGRILGKLIPFMMPILGALILQAAYGAVDLLVVGRFGTTEGLSAVSTGSQVLNLVTFVITQFAMGVTVLIA
RYIGEKRPEQIGALIGGAIVVFTMISVVLFVVMIIFSRQIAVIMQAPKEAVGLTSVYVKICGSGIFFIVAYNLLSAIFRG
LGDSKSPLIFVAVACVINIVGDLVLVAGFNMNAAGAAIATVAAQAVSVVFALVLLFKRKLPFKITKKDFSINRHCRRALK
VGLPLALQEFLTQISFLALCAFVNRLGLQASSGYGVACKIVNFAMLIPSSLMQSMASFVSQNVGAGNEKRAKKTMFAGIG
VGLVIGCIVFLFVMFKGDLLTAIFTTDEAVIQNGYDYLKGFALETIVTAILFSMIGYFNGHDKTVWVMIQGLTQTLLVRL
PFAYYMSIQPDASLTKIGMAAPVATIFGIVLNVVFYILCNRKDKKYI

Sequences:

>Translated_447_residues
MNNSKSDFTQGRILGKLIPFMMPILGALILQAAYGAVDLLVVGRFGTTEGLSAVSTGSQVLNLVTFVITQFAMGVTVLIA
RYIGEKRPEQIGALIGGAIVVFTMISVVLFVVMIIFSRQIAVIMQAPKEAVGLTSVYVKICGSGIFFIVAYNLLSAIFRG
LGDSKSPLIFVAVACVINIVGDLVLVAGFNMNAAGAAIATVAAQAVSVVFALVLLFKRKLPFKITKKDFSINRHCRRALK
VGLPLALQEFLTQISFLALCAFVNRLGLQASSGYGVACKIVNFAMLIPSSLMQSMASFVSQNVGAGNEKRAKKTMFAGIG
VGLVIGCIVFLFVMFKGDLLTAIFTTDEAVIQNGYDYLKGFALETIVTAILFSMIGYFNGHDKTVWVMIQGLTQTLLVRL
PFAYYMSIQPDASLTKIGMAAPVATIFGIVLNVVFYILCNRKDKKYI
>Mature_447_residues
MNNSKSDFTQGRILGKLIPFMMPILGALILQAAYGAVDLLVVGRFGTTEGLSAVSTGSQVLNLVTFVITQFAMGVTVLIA
RYIGEKRPEQIGALIGGAIVVFTMISVVLFVVMIIFSRQIAVIMQAPKEAVGLTSVYVKICGSGIFFIVAYNLLSAIFRG
LGDSKSPLIFVAVACVINIVGDLVLVAGFNMNAAGAAIATVAAQAVSVVFALVLLFKRKLPFKITKKDFSINRHCRRALK
VGLPLALQEFLTQISFLALCAFVNRLGLQASSGYGVACKIVNFAMLIPSSLMQSMASFVSQNVGAGNEKRAKKTMFAGIG
VGLVIGCIVFLFVMFKGDLLTAIFTTDEAVIQNGYDYLKGFALETIVTAILFSMIGYFNGHDKTVWVMIQGLTQTLLVRL
PFAYYMSIQPDASLTKIGMAAPVATIFGIVLNVVFYILCNRKDKKYI

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48116; Mature: 48116

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSKSDFTQGRILGKLIPFMMPILGALILQAAYGAVDLLVVGRFGTTEGLSAVSTGSQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEECCCCCCCCHHHHHHHHH
LNLVTFVITQFAMGVTVLIARYIGEKRPEQIGALIGGAIVVFTMISVVLFVVMIIFSRQI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIMQAPKEAVGLTSVYVKICGSGIFFIVAYNLLSAIFRGLGDSKSPLIFVAVACVINIV
HHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GDLVLVAGFNMNAAGAAIATVAAQAVSVVFALVLLFKRKLPFKITKKDFSINRHCRRALK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
VGLPLALQEFLTQISFLALCAFVNRLGLQASSGYGVACKIVNFAMLIPSSLMQSMASFVS
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QNVGAGNEKRAKKTMFAGIGVGLVIGCIVFLFVMFKGDLLTAIFTTDEAVIQNGYDYLKG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHHHHH
FALETIVTAILFSMIGYFNGHDKTVWVMIQGLTQTLLVRLPFAYYMSIQPDASLTKIGMA
HHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHH
APVATIFGIVLNVVFYILCNRKDKKYI
HHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNNSKSDFTQGRILGKLIPFMMPILGALILQAAYGAVDLLVVGRFGTTEGLSAVSTGSQV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEEEECCCCCCCCHHHHHHHHH
LNLVTFVITQFAMGVTVLIARYIGEKRPEQIGALIGGAIVVFTMISVVLFVVMIIFSRQI
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVIMQAPKEAVGLTSVYVKICGSGIFFIVAYNLLSAIFRGLGDSKSPLIFVAVACVINIV
HHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
GDLVLVAGFNMNAAGAAIATVAAQAVSVVFALVLLFKRKLPFKITKKDFSINRHCRRALK
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
VGLPLALQEFLTQISFLALCAFVNRLGLQASSGYGVACKIVNFAMLIPSSLMQSMASFVS
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QNVGAGNEKRAKKTMFAGIGVGLVIGCIVFLFVMFKGDLLTAIFTTDEAVIQNGYDYLKG
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCHHHHHH
FALETIVTAILFSMIGYFNGHDKTVWVMIQGLTQTLLVRLPFAYYMSIQPDASLTKIGMA
HHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHH
APVATIFGIVLNVVFYILCNRKDKKYI
HHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]