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The map label for this gene is ilvD [H]

Identifier: 238921968

GI number: 238921968

Start: 165457

End: 167208

Strand: Reverse

Name: ilvD [H]

Synonym: EUBELI_20203

Alternate gene names: 238921968

Gene position: 167208-165457 (Counterclockwise)

Preceding gene: 238921969

Following gene: 238921967

Centisome position: 26.68

GC content: 41.38

Gene sequence:

>1752_bases
ATGTGTTTAGTAAGTCAGGAAATGAGAAAATTAGCCCCAGAATTAGATCCTTTGAGAATTGGCACAGGCTGGAAGAAGGA
AGACCTTGGAAAAGTACAGGTCATGGTAGAAAGTACATATGGTGACAGTCATCCGGGAAGCGGACATCTTAACATACTTG
TGGAAGAGGTTCGAAAGGGTGTTGCTGAAGAAGGCGGATTCGGAGCAAGGTACTATTGTACAGATATATGCGATGGTGAA
AGTCAGGGAACTGACGGTATCAATTATAGTCTTGCAAGCAGGGAAATGATAGCTAATATGATAGAGATACATGCAAATGC
AACACCATTTGATGCAGGTGTATATCTTTCAAGCTGTGATAAAGGAGTTCCTGGTAATCTGATGGGACTTGCAAGAGTTA
ATATTCCATCTGTATTTGTTCCAGGCGGTACAATGAATGCAGGTCCGGAAATGCTTACACTTGAGCAGCTTGGAATGTAC
AGTGCACAGTATGAAAGAGGCGAGATTGACGAAGAGAAGCTTGACTGGGCAAAATGTAATGCATGCCCTAGCTGTGGTGC
ATGTTCATTTATCGGAACAGCATCAACATTGCAGATAATGGCAGAGGCACTTGGATTAGCACTGCCTGGAAGTGCTCTTA
TGCCAGCTACAAGTCCTGACCTGTTAGCCTATGCAAGAGAAGCAGGAAGACAGTCAGTAAGGCTTGCAAAGATGAAGAAT
ATGAAACCATCAGATATAGTAACTATGGATAGCTTTGAAAATGCAATTCTTGTACATGCAGCAATATCAGGAAGTACTAA
CTGTCTGCTTCATATTCCTGCAATTGCACATGAATTCGGAATTGAGATTACAGGAGATACATTTGACAGATTACATCGTG
GTGCACATTATCTTCTTGATGTACGTCCAGCAGGAAGATGGCCAGCAGAAGTATTCTATTATGCAGGCGGTGTTCCAGCA
ATTATGGAAGAAATTAAGGAACATCTCCATCTTGATGTAATGACTGTTACAGGAAAGACTCTTGGTGAGAATCTTGAAGA
ACTTAAGTCAAATGGATTCTATGAAAGATGTAATAAGTGGCTTGATGATTTCAACAAGCGCTACAATGTAAATGTTACCA
AGGAAGATATAATCAGACCATACGATAAGCCTATTGGAGAGAATGGAAGCATTGCTGTTCTTAAAGGTAATCTTGCCCCA
GAGGGAGCAGTAATTAAGCATACAGCCTGCCCTAAGGAAATGTTTAAGGCAGTACTTAATGCAAGACCATTCGATAGCGA
AGAGGCATGTCTTGATGCAGTAATTCATCATAAGGTTCAGAAGGGTGATGCTGTATTTATAAGATATGAGGGACCTAAAG
GAAGTGGAATGCCTGAGATGTTCTATACATCAGAGGCAATAAGCAGTGATAAGGAGCTGGGTAAGAGTATAGCACTTATT
ACAGACGGAAGGTTCTCGGGAGCATCTACCGGTCCGGTAATTGGACACTGCAGCCCGGAAGCGGTAGATGGAGGTCCTAT
TGCACTCGTTGAAGAAGGAGATCTTATTGAAATCGATGTTGAGGAAAGAAAGCTTAACATAGTAGGTGTTGCAGGAAAGA
GAATGACACCTGAAGAGATAGATAAGATCCTTATGGAAAGAAGAAAACAGTGGAAACCTAAAGAACGTAAATATAAGAAG
GGCGTATTAAGATTATTCAGTGAACTTGCAGCAAGCCCAATGAAGGGTGCTTATCTGGAATACGATAAATAA

Upstream 100 bases:

>100_bases
CAATGTAGAGATGTGTGTGGATGATACTGAGAAAGACAAGGTGTACGAAAAATTAGAACAGATGAATTTATTAAGATAAG
AAGAAAGGCAGGTAATTATT

Downstream 100 bases:

>100_bases
GAATAGTAAGGGTACAAGGGTGGGAAGATTAGGTTCTTCCCACCCTTTTTAACCAACGTATTTTTATGAATGTATTGTGA
TATAATTGTGATTATCTTAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MCLVSQEMRKLAPELDPLRIGTGWKKEDLGKVQVMVESTYGDSHPGSGHLNILVEEVRKGVAEEGGFGARYYCTDICDGE
SQGTDGINYSLASREMIANMIEIHANATPFDAGVYLSSCDKGVPGNLMGLARVNIPSVFVPGGTMNAGPEMLTLEQLGMY
SAQYERGEIDEEKLDWAKCNACPSCGACSFIGTASTLQIMAEALGLALPGSALMPATSPDLLAYAREAGRQSVRLAKMKN
MKPSDIVTMDSFENAILVHAAISGSTNCLLHIPAIAHEFGIEITGDTFDRLHRGAHYLLDVRPAGRWPAEVFYYAGGVPA
IMEEIKEHLHLDVMTVTGKTLGENLEELKSNGFYERCNKWLDDFNKRYNVNVTKEDIIRPYDKPIGENGSIAVLKGNLAP
EGAVIKHTACPKEMFKAVLNARPFDSEEACLDAVIHHKVQKGDAVFIRYEGPKGSGMPEMFYTSEAISSDKELGKSIALI
TDGRFSGASTGPVIGHCSPEAVDGGPIALVEEGDLIEIDVEERKLNIVGVAGKRMTPEEIDKILMERRKQWKPKERKYKK
GVLRLFSELAASPMKGAYLEYDK

Sequences:

>Translated_583_residues
MCLVSQEMRKLAPELDPLRIGTGWKKEDLGKVQVMVESTYGDSHPGSGHLNILVEEVRKGVAEEGGFGARYYCTDICDGE
SQGTDGINYSLASREMIANMIEIHANATPFDAGVYLSSCDKGVPGNLMGLARVNIPSVFVPGGTMNAGPEMLTLEQLGMY
SAQYERGEIDEEKLDWAKCNACPSCGACSFIGTASTLQIMAEALGLALPGSALMPATSPDLLAYAREAGRQSVRLAKMKN
MKPSDIVTMDSFENAILVHAAISGSTNCLLHIPAIAHEFGIEITGDTFDRLHRGAHYLLDVRPAGRWPAEVFYYAGGVPA
IMEEIKEHLHLDVMTVTGKTLGENLEELKSNGFYERCNKWLDDFNKRYNVNVTKEDIIRPYDKPIGENGSIAVLKGNLAP
EGAVIKHTACPKEMFKAVLNARPFDSEEACLDAVIHHKVQKGDAVFIRYEGPKGSGMPEMFYTSEAISSDKELGKSIALI
TDGRFSGASTGPVIGHCSPEAVDGGPIALVEEGDLIEIDVEERKLNIVGVAGKRMTPEEIDKILMERRKQWKPKERKYKK
GVLRLFSELAASPMKGAYLEYDK
>Mature_583_residues
MCLVSQEMRKLAPELDPLRIGTGWKKEDLGKVQVMVESTYGDSHPGSGHLNILVEEVRKGVAEEGGFGARYYCTDICDGE
SQGTDGINYSLASREMIANMIEIHANATPFDAGVYLSSCDKGVPGNLMGLARVNIPSVFVPGGTMNAGPEMLTLEQLGMY
SAQYERGEIDEEKLDWAKCNACPSCGACSFIGTASTLQIMAEALGLALPGSALMPATSPDLLAYAREAGRQSVRLAKMKN
MKPSDIVTMDSFENAILVHAAISGSTNCLLHIPAIAHEFGIEITGDTFDRLHRGAHYLLDVRPAGRWPAEVFYYAGGVPA
IMEEIKEHLHLDVMTVTGKTLGENLEELKSNGFYERCNKWLDDFNKRYNVNVTKEDIIRPYDKPIGENGSIAVLKGNLAP
EGAVIKHTACPKEMFKAVLNARPFDSEEACLDAVIHHKVQKGDAVFIRYEGPKGSGMPEMFYTSEAISSDKELGKSIALI
TDGRFSGASTGPVIGHCSPEAVDGGPIALVEEGDLIEIDVEERKLNIVGVAGKRMTPEEIDKILMERRKQWKPKERKYKK
GVLRLFSELAASPMKGAYLEYDK

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=609, Percent_Identity=34.8111658456486, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1786464, Length=601, Percent_Identity=33.9434276206323, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI2367371, Length=565, Percent_Identity=36.1061946902655, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788157, Length=529, Percent_Identity=32.5141776937618, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6322476, Length=575, Percent_Identity=35.304347826087, Blast_Score=304, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 63664; Mature: 63664

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLVSQEMRKLAPELDPLRIGTGWKKEDLGKVQVMVESTYGDSHPGSGHLNILVEEVRKG
CCCCHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
VAEEGGFGARYYCTDICDGESQGTDGINYSLASREMIANMIEIHANATPFDAGVYLSSCD
HHHCCCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
KGVPGNLMGLARVNIPSVFVPGGTMNAGPEMLTLEQLGMYSAQYERGEIDEEKLDWAKCN
CCCCCCEEEEEEECCCEEEECCCCCCCCCCEEEHHHHCCHHHCCCCCCCCHHHCCHHHCC
ACPSCGACSFIGTASTLQIMAEALGLALPGSALMPATSPDLLAYAREAGRQSVRLAKMKN
CCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCC
MKPSDIVTMDSFENAILVHAAISGSTNCLLHIPAIAHEFGIEITGDTFDRLHRGAHYLLD
CCCCCEEEECCCCCEEEEEEEECCCCCEEEECCHHHHHHCCEECCCHHHHHHCCCEEEEE
VRPAGRWPAEVFYYAGGVPAIMEEIKEHLHLDVMTVTGKTLGENLEELKSNGFYERCNKW
ECCCCCCCHHEEEECCCHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCHHHHHHHH
LDDFNKRYNVNVTKEDIIRPYDKPIGENGSIAVLKGNLAPEGAVIKHTACPKEMFKAVLN
HHHHCCEEECCCCHHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHC
ARPFDSEEACLDAVIHHKVQKGDAVFIRYEGPKGSGMPEMFYTSEAISSDKELGKSIALI
CCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCHHHHCCHHHHCCEEEEE
TDGRFSGASTGPVIGHCSPEAVDGGPIALVEEGDLIEIDVEERKLNIVGVAGKRMTPEEI
ECCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCHHHH
DKILMERRKQWKPKERKYKKGVLRLFSELAASPMKGAYLEYDK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MCLVSQEMRKLAPELDPLRIGTGWKKEDLGKVQVMVESTYGDSHPGSGHLNILVEEVRKG
CCCCHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHH
VAEEGGFGARYYCTDICDGESQGTDGINYSLASREMIANMIEIHANATPFDAGVYLSSCD
HHHCCCCCCEEEEEECCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
KGVPGNLMGLARVNIPSVFVPGGTMNAGPEMLTLEQLGMYSAQYERGEIDEEKLDWAKCN
CCCCCCEEEEEEECCCEEEECCCCCCCCCCEEEHHHHCCHHHCCCCCCCCHHHCCHHHCC
ACPSCGACSFIGTASTLQIMAEALGLALPGSALMPATSPDLLAYAREAGRQSVRLAKMKN
CCCCCCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCC
MKPSDIVTMDSFENAILVHAAISGSTNCLLHIPAIAHEFGIEITGDTFDRLHRGAHYLLD
CCCCCEEEECCCCCEEEEEEEECCCCCEEEECCHHHHHHCCEECCCHHHHHHCCCEEEEE
VRPAGRWPAEVFYYAGGVPAIMEEIKEHLHLDVMTVTGKTLGENLEELKSNGFYERCNKW
ECCCCCCCHHEEEECCCHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCHHHHHHHH
LDDFNKRYNVNVTKEDIIRPYDKPIGENGSIAVLKGNLAPEGAVIKHTACPKEMFKAVLN
HHHHCCEEECCCCHHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCHHHHHHHHHC
ARPFDSEEACLDAVIHHKVQKGDAVFIRYEGPKGSGMPEMFYTSEAISSDKELGKSIALI
CCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHCCHHHHCCHHHHCCEEEEE
TDGRFSGASTGPVIGHCSPEAVDGGPIALVEEGDLIEIDVEERKLNIVGVAGKRMTPEEI
ECCCCCCCCCCCEEECCCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCHHHH
DKILMERRKQWKPKERKYKKGVLRLFSELAASPMKGAYLEYDK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA