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The map label for this gene is ribBA [H]

Identifier: 238921879

GI number: 238921879

Start: 85279

End: 86481

Strand: Reverse

Name: ribBA [H]

Synonym: EUBELI_20112

Alternate gene names: 238921879

Gene position: 86481-85279 (Counterclockwise)

Preceding gene: 238921880

Following gene: 238921878

Centisome position: 13.8

GC content: 43.39

Gene sequence:

>1203_bases
ATGTTTGAGTATAACACAGTAGAAGAGGCAGTTAAGGATTTACAGGATGGAAAGCTGATACTTGTCTCAGATGATGAAAG
CAGAGAGAATGAGGGAGACCTGATATGTGCCGCTGAATTTGCAACTACTGAAAATGTGAATTTCATGGCGACATATGGAA
AAGGACTTATATGCATGCCTATGAGTGGAGATTTGTGCAGAAAGCTGGGACTTACACAGATGGTTGCTGACAATACTGAT
AACCATGAAACTGCATTTACAGTGTCAATAGACCATGTTAAGACGACAACAGGAATATCGGCAGAGGAGAGAGGCTTTAC
TGCAAGAGCATGTGTGTCAGATGAGGCAAAGCCTGAGGATTTCAGAAGACCGGGACATATGTTTCCACTACGTTCAAAGC
CTAATGGAGTTCTTGAAAGAAACGGACATACAGAGGCAACAGTAGACCTTATGAGAATAGCAGGACTTAAGGAGTGCGGT
CTGTGCTGTGAGATAATGAAAGAGGACGGAACAATGATGAGAAAAGAAGACCTCATAGAAATGTCCGAAAAATTCAATCT
CAAATTCATAACAATTAAAGCGATTCAGGAATACAGAAAGAGACATGACAACCTGGTTGAGTGTGTGGCAGTTACAAGAA
TGCCTACAAAATACGGGGAATTCACAGCACACTGTTATGTCAATAAGTTAAATGGTGAGCATCATGTTGCATTGGTAAAG
GGCGACATTGGTGATGGCAGCAATCTTTTGTGCAGGGTACATTCAGAGTGCCTGACTGGAGACGCATTTGGCTCAATGAA
ATGTGACTGCGGTCAGCAGTTAGCGTCAGCAATGACACAGATTAACAATGAAGGCAGGGGTGTGCTTCTTTATATGAGAC
AGGAGGGCAGAGGAATCGGGCTTGTCAACAAGCTTAAGGCATACGCACTTCAGGATCAGGGAATGGATACACTTGAGGCT
AATCTGGCGCTTGGTCTGCCGGGAGACGCGCGCGAGTACTACATAGGAGCACAGATATTGAAAGACTTAGGTGCTAAGAG
CTTAAGGCTTCTTACGAACAATCCCGATAAGGTATACCAGCTTGCAGATTTTGGAATCGAAATCAGTGAGAGAGTGCCTA
TTGAGATAGATGCGACCAGCTTTGACAGGTTCTATCTTAAGACAAAGCAGACAAAGATGGGACACATTTTAAATGTGGTG
TAA

Upstream 100 bases:

>100_bases
CATCACATTTGAAAAGGAAAAGCCGAAAAGCGGGATAACGAAAGAGTTCCTGCTAAAGAATGGATTTTAAAATATCAAAG
GGAAAGGAAGGTAAAAGAAA

Downstream 100 bases:

>100_bases
AAAAATGAAATATTTATAAGGAGGAATTGATGATGAGAGTTTTAGAAGGTAAGTTAGTTGACAGTGGAATTAAGGTAGGT
ATTGTAGCAGCAAGATTTAA

Product: GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFEYNTVEEAVKDLQDGKLILVSDDESRENEGDLICAAEFATTENVNFMATYGKGLICMPMSGDLCRKLGLTQMVADNTD
NHETAFTVSIDHVKTTTGISAEERGFTARACVSDEAKPEDFRRPGHMFPLRSKPNGVLERNGHTEATVDLMRIAGLKECG
LCCEIMKEDGTMMRKEDLIEMSEKFNLKFITIKAIQEYRKRHDNLVECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVK
GDIGDGSNLLCRVHSECLTGDAFGSMKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIGLVNKLKAYALQDQGMDTLEA
NLALGLPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQLADFGIEISERVPIEIDATSFDRFYLKTKQTKMGHILNVV

Sequences:

>Translated_400_residues
MFEYNTVEEAVKDLQDGKLILVSDDESRENEGDLICAAEFATTENVNFMATYGKGLICMPMSGDLCRKLGLTQMVADNTD
NHETAFTVSIDHVKTTTGISAEERGFTARACVSDEAKPEDFRRPGHMFPLRSKPNGVLERNGHTEATVDLMRIAGLKECG
LCCEIMKEDGTMMRKEDLIEMSEKFNLKFITIKAIQEYRKRHDNLVECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVK
GDIGDGSNLLCRVHSECLTGDAFGSMKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIGLVNKLKAYALQDQGMDTLEA
NLALGLPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQLADFGIEISERVPIEIDATSFDRFYLKTKQTKMGHILNVV
>Mature_400_residues
MFEYNTVEEAVKDLQDGKLILVSDDESRENEGDLICAAEFATTENVNFMATYGKGLICMPMSGDLCRKLGLTQMVADNTD
NHETAFTVSIDHVKTTTGISAEERGFTARACVSDEAKPEDFRRPGHMFPLRSKPNGVLERNGHTEATVDLMRIAGLKECG
LCCEIMKEDGTMMRKEDLIEMSEKFNLKFITIKAIQEYRKRHDNLVECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVK
GDIGDGSNLLCRVHSECLTGDAFGSMKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIGLVNKLKAYALQDQGMDTLEA
NLALGLPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQLADFGIEISERVPIEIDATSFDRFYLKTKQTKMGHILNVV

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=190, Percent_Identity=54.2105263157895, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789420, Length=201, Percent_Identity=44.7761194029851, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=38.1642512077295, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=44.8275862068966, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44496; Mature: 44496

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEYNTVEEAVKDLQDGKLILVSDDESRENEGDLICAAEFATTENVNFMATYGKGLICMP
CCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEECCCCEEEEC
MSGDLCRKLGLTQMVADNTDNHETAFTVSIDHVKTTTGISAEERGFTARACVSDEAKPED
CCCHHHHHCCCHHHHHCCCCCCCEEEEEEECCEEECCCCCHHHCCCEEEEECCCCCCCHH
FRRPGHMFPLRSKPNGVLERNGHTEATVDLMRIAGLKECGLCCEIMKEDGTMMRKEDLIE
HCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
MSEKFNLKFITIKAIQEYRKRHDNLVECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVK
HHHHCCEEEEEHHHHHHHHHHCCHHEEHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEEE
GDIGDGSNLLCRVHSECLTGDAFGSMKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIG
ECCCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
LVNKLKAYALQDQGMDTLEANLALGLPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQ
HHHHHHHHHHHCCCCCEEECCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHEEE
LADFGIEISERVPIEIDATSFDRFYLKTKQTKMGHILNVV
HHHCCEEECCCCCEEEECCCCCEEEEEECCCHHCHHEECC
>Mature Secondary Structure
MFEYNTVEEAVKDLQDGKLILVSDDESRENEGDLICAAEFATTENVNFMATYGKGLICMP
CCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEECCCCEEEEC
MSGDLCRKLGLTQMVADNTDNHETAFTVSIDHVKTTTGISAEERGFTARACVSDEAKPED
CCCHHHHHCCCHHHHHCCCCCCCEEEEEEECCEEECCCCCHHHCCCEEEEECCCCCCCHH
FRRPGHMFPLRSKPNGVLERNGHTEATVDLMRIAGLKECGLCCEIMKEDGTMMRKEDLIE
HCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHH
MSEKFNLKFITIKAIQEYRKRHDNLVECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVK
HHHHCCEEEEEHHHHHHHHHHCCHHEEHHHHHCCCCCCCCEEEEEEEEECCCCEEEEEEE
GDIGDGSNLLCRVHSECLTGDAFGSMKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIG
ECCCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
LVNKLKAYALQDQGMDTLEANLALGLPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQ
HHHHHHHHHHHCCCCCEEECCEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHEEE
LADFGIEISERVPIEIDATSFDRFYLKTKQTKMGHILNVV
HHHCCEEECCCCCEEEECCCCCEEEEEECCCHHCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA