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The map label for this gene is pepD [H]

Identifier: 238921817

GI number: 238921817

Start: 28603

End: 30048

Strand: Reverse

Name: pepD [H]

Synonym: EUBELI_20050

Alternate gene names: 238921817

Gene position: 30048-28603 (Counterclockwise)

Preceding gene: 238921818

Following gene: 238921816

Centisome position: 4.79

GC content: 37.48

Gene sequence:

>1446_bases
ATGAGAGTATTATCTGAATTAGAACCTAAAAATGTATTTTCTTTTTTTGAGGATATATGTAATATCCCACATCCATCATA
TAAGGAAGAAAAAATCAGCAATTATCTTGTTGATTTCGCTAAGGAAAGAAAGCTTGAATATTATCAGGATTCACTTAACA
ATGTAATCATAATAAAGGAAGCCTCAAAGGGTTATGAGGATGCAGCACCTATAATACTTCAGGGACATATGGATATGGTA
TGCGAGAAGACACCTGATTGTGATAAGAATATGGATGAGGATGGACTGGATCTTGAGGTAAATGGTGATTTCATATCTGC
TAAGGGAACAACGCTTGGTGGTGATGATGGAATAGCTGTTGCCTATGCACTTGCAATACTTGATGACGACAGTATCGCAC
ATCCACGTCTTGAGTTCGTGTGTACAGTATCTGAGGAAGTAGGCATGGAAGGTGCTTCTTCCATAGATGTATCTATGTTA
AAGGGCAAAAAGCTTCTTAATATGGATAGTGAAGAAGAAGGAATCATGCTTGCAAGCTGTGCAGGTGGCTGCAGTAGCAG
AGTTACACTAAAGCTTGATAAAAATAAGGTTACTGGAACAAAGCTTAGTATTACTTTATCAGGACTGACAGGAGGTCATT
CAGGTGTTGAAATAGATAAAGGCAGAGGTAATGCGAATGTTCTTATGTCAAGAATATTAAGGGATGTTATCACAGACAAT
AATGTATATCTTGCAGCGTTTAACGGTGGAAGAAAGGATAACGCTATTCCAAGAGAATGTATGGCTGAGATTATTGTAGC
AGCAGACAAGACAGCAGAGGTTAAAGCAGCTATTGAGAATGCAGCAAAAGAGATAAAAGAAGAGTTTGCTACATCTGATG
CAGACTTAAAGTGTGTTGTAGATATATCAGAGGGTTGCAGCACAGAGGCAGTAACATATGAAGATAGCACAAGGGCAGTT
TCACTTATACAGGCATTACCTAACGGAATAATGAGAATGAGCCAGGATATAGATAATCTTGTGGAAACTTCGCTTAATCT
TGGTGTGATTTCACTAGATGAATCAGGTATATGTCTTAGATTCTCACTTAGAAGTTCTGTAGGGGCTGCTTTAAAGAATC
TTAAGAGCCAGATCAAATTCATTAGTGAAGCATTCAGGGCAAATGCTGAATTTACAGGTGAATATCCAGCATGGGAATAT
AAGAAGGATTCTAAGCTGCGTGATGACATGGTAAGGATATTTGAACAGATGTATGGTAAAAAGCCAACTATCGAGGCTAT
TCATGCAGGTGTTGAATGTGGTATACTTGCAGGCAAAATAGAAGGACTTGACTGCATATCAATGGGACCTGATATTTTTG
ATATTCATACAACTGAGGAACACTTAAGCATATCTTCAACTAAGAGAATGTATGAATATATACTTAACGTAATAGCTTGT
AAATAA

Upstream 100 bases:

>100_bases
AAGAATCAGTTTATTGTATATATGAACAAGATAAATAAGCAGATAAACAAATGAATAAAATAAATTTGTAGATTATAAAT
ATTTTAAAGGAGACAGTGTT

Downstream 100 bases:

>100_bases
TAATACAATAATGAAGCACATTGAAGCAGGGTGAGTCTATGTATAAAATATTAATAGTTGAGGATGACAGGATTATAGCT
GATAATGTATGTGAACAGTT

Product: aminoacylhistidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRVLSELEPKNVFSFFEDICNIPHPSYKEEKISNYLVDFAKERKLEYYQDSLNNVIIIKEASKGYEDAAPIILQGHMDMV
CEKTPDCDKNMDEDGLDLEVNGDFISAKGTTLGGDDGIAVAYALAILDDDSIAHPRLEFVCTVSEEVGMEGASSIDVSML
KGKKLLNMDSEEEGIMLASCAGGCSSRVTLKLDKNKVTGTKLSITLSGLTGGHSGVEIDKGRGNANVLMSRILRDVITDN
NVYLAAFNGGRKDNAIPRECMAEIIVAADKTAEVKAAIENAAKEIKEEFATSDADLKCVVDISEGCSTEAVTYEDSTRAV
SLIQALPNGIMRMSQDIDNLVETSLNLGVISLDESGICLRFSLRSSVGAALKNLKSQIKFISEAFRANAEFTGEYPAWEY
KKDSKLRDDMVRIFEQMYGKKPTIEAIHAGVECGILAGKIEGLDCISMGPDIFDIHTTEEHLSISSTKRMYEYILNVIAC
K

Sequences:

>Translated_481_residues
MRVLSELEPKNVFSFFEDICNIPHPSYKEEKISNYLVDFAKERKLEYYQDSLNNVIIIKEASKGYEDAAPIILQGHMDMV
CEKTPDCDKNMDEDGLDLEVNGDFISAKGTTLGGDDGIAVAYALAILDDDSIAHPRLEFVCTVSEEVGMEGASSIDVSML
KGKKLLNMDSEEEGIMLASCAGGCSSRVTLKLDKNKVTGTKLSITLSGLTGGHSGVEIDKGRGNANVLMSRILRDVITDN
NVYLAAFNGGRKDNAIPRECMAEIIVAADKTAEVKAAIENAAKEIKEEFATSDADLKCVVDISEGCSTEAVTYEDSTRAV
SLIQALPNGIMRMSQDIDNLVETSLNLGVISLDESGICLRFSLRSSVGAALKNLKSQIKFISEAFRANAEFTGEYPAWEY
KKDSKLRDDMVRIFEQMYGKKPTIEAIHAGVECGILAGKIEGLDCISMGPDIFDIHTTEEHLSISSTKRMYEYILNVIAC
K
>Mature_481_residues
MRVLSELEPKNVFSFFEDICNIPHPSYKEEKISNYLVDFAKERKLEYYQDSLNNVIIIKEASKGYEDAAPIILQGHMDMV
CEKTPDCDKNMDEDGLDLEVNGDFISAKGTTLGGDDGIAVAYALAILDDDSIAHPRLEFVCTVSEEVGMEGASSIDVSML
KGKKLLNMDSEEEGIMLASCAGGCSSRVTLKLDKNKVTGTKLSITLSGLTGGHSGVEIDKGRGNANVLMSRILRDVITDN
NVYLAAFNGGRKDNAIPRECMAEIIVAADKTAEVKAAIENAAKEIKEEFATSDADLKCVVDISEGCSTEAVTYEDSTRAV
SLIQALPNGIMRMSQDIDNLVETSLNLGVISLDESGICLRFSLRSSVGAALKNLKSQIKFISEAFRANAEFTGEYPAWEY
KKDSKLRDDMVRIFEQMYGKKPTIEAIHAGVECGILAGKIEGLDCISMGPDIFDIHTTEEHLSISSTKRMYEYILNVIAC
K

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=480, Percent_Identity=35.4166666666667, Blast_Score=324, Evalue=7e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52598; Mature: 52598

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLSELEPKNVFSFFEDICNIPHPSYKEEKISNYLVDFAKERKLEYYQDSLNNVIIIKE
CCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
ASKGYEDAAPIILQGHMDMVCEKTPDCDKNMDEDGLDLEVNGDFISAKGTTLGGDDGIAV
CCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCEE
AYALAILDDDSIAHPRLEFVCTVSEEVGMEGASSIDVSMLKGKKLLNMDSEEEGIMLASC
EEEEEEECCCCCCCCCEEEEEEEHHHHCCCCCCCCCHHHHCCCHHCCCCCCCCCEEEEEC
AGGCSSRVTLKLDKNKVTGTKLSITLSGLTGGHSGVEIDKGRGNANVLMSRILRDVITDN
CCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCC
NVYLAAFNGGRKDNAIPRECMAEIIVAADKTAEVKAAIENAAKEIKEEFATSDADLKCVV
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
DISEGCSTEAVTYEDSTRAVSLIQALPNGIMRMSQDIDNLVETSLNLGVISLDESGICLR
EECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEE
FSLRSSVGAALKNLKSQIKFISEAFRANAEFTGEYPAWEYKKDSKLRDDMVRIFEQMYGK
EEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
KPTIEAIHAGVECGILAGKIEGLDCISMGPDIFDIHTTEEHLSISSTKRMYEYILNVIAC
CCCHHHHHCCCCEEEEEECCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MRVLSELEPKNVFSFFEDICNIPHPSYKEEKISNYLVDFAKERKLEYYQDSLNNVIIIKE
CCCHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
ASKGYEDAAPIILQGHMDMVCEKTPDCDKNMDEDGLDLEVNGDFISAKGTTLGGDDGIAV
CCCCCCCCCCEEEECCHHHHHCCCCCCCCCCCCCCCEEEECCCEEEECCCCCCCCCCCEE
AYALAILDDDSIAHPRLEFVCTVSEEVGMEGASSIDVSMLKGKKLLNMDSEEEGIMLASC
EEEEEEECCCCCCCCCEEEEEEEHHHHCCCCCCCCCHHHHCCCHHCCCCCCCCCEEEEEC
AGGCSSRVTLKLDKNKVTGTKLSITLSGLTGGHSGVEIDKGRGNANVLMSRILRDVITDN
CCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCC
NVYLAAFNGGRKDNAIPRECMAEIIVAADKTAEVKAAIENAAKEIKEEFATSDADLKCVV
CEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
DISEGCSTEAVTYEDSTRAVSLIQALPNGIMRMSQDIDNLVETSLNLGVISLDESGICLR
EECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEE
FSLRSSVGAALKNLKSQIKFISEAFRANAEFTGEYPAWEYKKDSKLRDDMVRIFEQMYGK
EEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
KPTIEAIHAGVECGILAGKIEGLDCISMGPDIFDIHTTEEHLSISSTKRMYEYILNVIAC
CCCHHHHHCCCCEEEEEECCCCCEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]