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The map label for this gene is hemN [H]

Identifier: 238921707

GI number: 238921707

Start: 3748068

End: 3749441

Strand: Reverse

Name: hemN [H]

Synonym: NT01EI_3868

Alternate gene names: 238921707

Gene position: 3749441-3748068 (Counterclockwise)

Preceding gene: 238921708

Following gene: 238921701

Centisome position: 98.35

GC content: 55.82

Gene sequence:

>1374_bases
ATGTCAGAACAGACTATCGTCTGGGATTTGGCCCTGATCCAGAAATATAACTATTCCGGGCCGCGCTATACCTCGTACCC
CACCGCGCTGGAGTTTAATGAACTCTTTGATGAGGCGGCCTTTCTGCGCGCCGTAGCCCGCTATCCCGAGCGGGCGCTTT
CCCTTTACGTGCATATCCCGTTCTGCCATAAGCTGTGCTACTTCTGCGGCTGTAATAAGATTGTGACCCGTCAGTCCCAC
AAGGCCGACGAGTATTTGGATAAGCTGGCGCTGGAGATCGCTGCTCGCGCGCCGCTGTTTGCAGGGCGGACGGTGAGCCA
GCTGCATTGGGGCGGCGGTACGCCGACCTTTCTCAATAAGGCGCAGATTAGCCGCCTGATGATGCTGCTGCGTCGCCATT
TTACCTTTGCGCCTCAGGCGGAGATTTCGATAGAGATCGATCCGCGGGAGATTGCGCTGGATGTGCTGGATCACCTTCGT
CAAGAAGGGTTTAACCGCCTGAGCATGGGGGTTCAGGACTTCAATAAGACCGTACAGACGTTGGTCAACCGCGAGCAGGA
TGAGGCGTTTATCTTTTCTCTGCTGCACCACGCGCGGGAAATCGGCTTTACCTCAACCAATATCGACCTGATTTATGGTC
TGCCCCGCCAGACGCCGGAGAGCTTCGGTTTTACGCTGCAAAAGGTGATTGAGCTGAATCCCGATCGACTCAGCATTTTT
AACTATGCACACATGCCCAAGCTGTTTGCTGCTCAGCGTAAGATTAAGGATGCCGATCTACCCAGCGCAGACCATAAGCT
GGCTATTCTGCAGCAGAGTATCGCGACGCTGACCAGCGTGGGATACCAGTTTATCGGAATGGATCACTTCGCCCACCGTG
ACGATGAGCTGGCGGTGGCCCAGCGCGCCGGTAAACTGCATCGCAACTTTCAGGGATATACCACGCAGGGCGACAGTGAT
TTGCTGGGGTTGGGCGTATCGGCGATTAGCATGATCGGGGATAGCTATGCCCAAAATCGCAAGGTGCTGAAGGAGTACTA
TGCCGCGGTTGAGGCGCAGGGCAACGCGCTGTGGCGCGGGCTGGCCATGAGCCGGGATGACTGCATTCGCCGCGATGTGA
TTAAGGGGCTTATCTGTAATTTCCGCCTGGATTTCGCGCCGATAGAGCAGCAGTACGGCATTCGCTTTGTGGATTATTTC
GTCGAGGATCTGGTGCTGTTGCGTCCGCTGGCGCAGGATGGGTTGGTCGAGCTGGGTGAGACGGCGATTAACGTCACGCC
GCGCGGTCGTTTGCTGATCCGGAATATCTGCATGTGCTTTGATGTGTATCTGCGTCATCAGGCCCGAATGAAGCAGTTTT
CGCGCGTCATCTGA

Upstream 100 bases:

>100_bases
GCGCAAAGCGCGCTGGCAACGGGCCGCCATGCGTTACGGCAGGCCGTCGGCTTCTCCACTGCGCACAGTCAGGAGAAAAC
AGAATAAGGAGTGAGCATCC

Downstream 100 bases:

>100_bases
CGCCAGCCTAAAACGACAATCCCCGGCACGCCGGGGATTGTCGTTTTAGGCTTAGCGGTTCAGACGCTCCAGAACAGCAG
CGCCAGCAGCTGGGGCGACA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSEQTIVWDLALIQKYNYSGPRYTSYPTALEFNELFDEAAFLRAVARYPERALSLYVHIPFCHKLCYFCGCNKIVTRQSH
KADEYLDKLALEIAARAPLFAGRTVSQLHWGGGTPTFLNKAQISRLMMLLRRHFTFAPQAEISIEIDPREIALDVLDHLR
QEGFNRLSMGVQDFNKTVQTLVNREQDEAFIFSLLHHAREIGFTSTNIDLIYGLPRQTPESFGFTLQKVIELNPDRLSIF
NYAHMPKLFAAQRKIKDADLPSADHKLAILQQSIATLTSVGYQFIGMDHFAHRDDELAVAQRAGKLHRNFQGYTTQGDSD
LLGLGVSAISMIGDSYAQNRKVLKEYYAAVEAQGNALWRGLAMSRDDCIRRDVIKGLICNFRLDFAPIEQQYGIRFVDYF
VEDLVLLRPLAQDGLVELGETAINVTPRGRLLIRNICMCFDVYLRHQARMKQFSRVI

Sequences:

>Translated_457_residues
MSEQTIVWDLALIQKYNYSGPRYTSYPTALEFNELFDEAAFLRAVARYPERALSLYVHIPFCHKLCYFCGCNKIVTRQSH
KADEYLDKLALEIAARAPLFAGRTVSQLHWGGGTPTFLNKAQISRLMMLLRRHFTFAPQAEISIEIDPREIALDVLDHLR
QEGFNRLSMGVQDFNKTVQTLVNREQDEAFIFSLLHHAREIGFTSTNIDLIYGLPRQTPESFGFTLQKVIELNPDRLSIF
NYAHMPKLFAAQRKIKDADLPSADHKLAILQQSIATLTSVGYQFIGMDHFAHRDDELAVAQRAGKLHRNFQGYTTQGDSD
LLGLGVSAISMIGDSYAQNRKVLKEYYAAVEAQGNALWRGLAMSRDDCIRRDVIKGLICNFRLDFAPIEQQYGIRFVDYF
VEDLVLLRPLAQDGLVELGETAINVTPRGRLLIRNICMCFDVYLRHQARMKQFSRVI
>Mature_456_residues
SEQTIVWDLALIQKYNYSGPRYTSYPTALEFNELFDEAAFLRAVARYPERALSLYVHIPFCHKLCYFCGCNKIVTRQSHK
ADEYLDKLALEIAARAPLFAGRTVSQLHWGGGTPTFLNKAQISRLMMLLRRHFTFAPQAEISIEIDPREIALDVLDHLRQ
EGFNRLSMGVQDFNKTVQTLVNREQDEAFIFSLLHHAREIGFTSTNIDLIYGLPRQTPESFGFTLQKVIELNPDRLSIFN
YAHMPKLFAAQRKIKDADLPSADHKLAILQQSIATLTSVGYQFIGMDHFAHRDDELAVAQRAGKLHRNFQGYTTQGDSDL
LGLGVSAISMIGDSYAQNRKVLKEYYAAVEAQGNALWRGLAMSRDDCIRRDVIKGLICNFRLDFAPIEQQYGIRFVDYFV
EDLVLLRPLAQDGLVELGETAINVTPRGRLLIRNICMCFDVYLRHQARMKQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=245, Percent_Identity=26.530612244898, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082341, Length=457, Percent_Identity=79.8687089715536, Blast_Score=769, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=232, Percent_Identity=31.4655172413793, Blast_Score=115, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52215; Mature: 52084

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQTIVWDLALIQKYNYSGPRYTSYPTALEFNELFDEAAFLRAVARYPERALSLYVHIP
CCCCEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHEEEEEECH
FCHKLCYFCGCNKIVTRQSHKADEYLDKLALEIAARAPLFAGRTVSQLHWGGGTPTFLNK
HHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCCCHHHHH
AQISRLMMLLRRHFTFAPQAEISIEIDPREIALDVLDHLRQEGFNRLSMGVQDFNKTVQT
HHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LVNREQDEAFIFSLLHHAREIGFTSTNIDLIYGLPRQTPESFGFTLQKVIELNPDRLSIF
HHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEHH
NYAHMPKLFAAQRKIKDADLPSADHKLAILQQSIATLTSVGYQFIGMDHFAHRDDELAVA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHHCCCCHHHHH
QRAGKLHRNFQGYTTQGDSDLLGLGVSAISMIGDSYAQNRKVLKEYYAAVEAQGNALWRG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LAMSRDDCIRRDVIKGLICNFRLDFAPIEQQYGIRFVDYFVEDLVLLRPLAQDGLVELGE
HCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TAINVTPRGRLLIRNICMCFDVYLRHQARMKQFSRVI
HHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEQTIVWDLALIQKYNYSGPRYTSYPTALEFNELFDEAAFLRAVARYPERALSLYVHIP
CCCEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHEEEEEECH
FCHKLCYFCGCNKIVTRQSHKADEYLDKLALEIAARAPLFAGRTVSQLHWGGGTPTFLNK
HHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCCCHHHHH
AQISRLMMLLRRHFTFAPQAEISIEIDPREIALDVLDHLRQEGFNRLSMGVQDFNKTVQT
HHHHHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LVNREQDEAFIFSLLHHAREIGFTSTNIDLIYGLPRQTPESFGFTLQKVIELNPDRLSIF
HHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCEEHH
NYAHMPKLFAAQRKIKDADLPSADHKLAILQQSIATLTSVGYQFIGMDHFAHRDDELAVA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHHCCCCHHHHH
QRAGKLHRNFQGYTTQGDSDLLGLGVSAISMIGDSYAQNRKVLKEYYAAVEAQGNALWRG
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LAMSRDDCIRRDVIKGLICNFRLDFAPIEQQYGIRFVDYFVEDLVLLRPLAQDGLVELGE
HCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCC
TAINVTPRGRLLIRNICMCFDVYLRHQARMKQFSRVI
HHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]