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The map label for this gene is argH

Identifier: 238921683

GI number: 238921683

Start: 3724562

End: 3725944

Strand: Reverse

Name: argH

Synonym: NT01EI_3844

Alternate gene names: 238921683

Gene position: 3725944-3724562 (Counterclockwise)

Preceding gene: 238921684

Following gene: 238921680

Centisome position: 97.73

GC content: 60.45

Gene sequence:

>1383_bases
ATGGCACTTTGGGGCGGGCGTTTTTCTCTGGCAGCAGATCGGCGTTTTAAACAGTTTAATGACTCTCTGCGCTTTGACTA
TCGGCTGGCGGAGCAGGATATCATCGGATCCGTCGCCTGGTCCCGGGCGCTGGTGACCGTCGGTGTGTTGACGGTACAGG
AGCAGCAGCAGCTGGTGCAGGCGCTAACTGCGCTGTTGGAAGAGGTTCGCACCGATCCCCGGTCTATTCTGGACAGCGAT
GCGGAGGATATTCACAGCTGGGTGGAGCAGCAACTGATTGGGCGGGTTGGCGATCTGGGCAAGAAGCTGCATACCGGGCG
TAGCCGCAACGATCAGGTGGCGACCGATCTGAAACTCTGGTGTAAGGATCAGGGTGAGATGCTGCGTCAGGCGCTGATTG
CGTTGCAGCAGGTGCTGACGGCCTGTGCCCGCCAGAATCAGGATGCGGTGATGCCCGGTTATACCCATTTGCAGCGGGCG
CAGCCGATCACTTTTGCCCATTGGTGTATGGCTTATGTCGAGATGCTGGCCCGCGATGAGAGCCGTCTGGATGATGCCCT
GCGGCGTCTGAATACCAGCCCGCTGGGCAGTGGTGCATTGGCCGGTACCGCCTACCCTATCGATCGTGATCGGCTGGCCG
ACTGGCTGGGGTTCTCTGCCGCAACGCGTAACAGTCTGGATAGCGTATCCGATCGCGATCATGTCCTGGAGTTGCTGTCA
GCGGCCGCTATTGGCATGGTGCATCTGTCGCGCTTCGCTGAGGATCTGATCTTCTTTAACAGCGGTGAGGCCGGTTTTAT
CGAGCTGTCGGAGCGGGTAACCTCCGGATCGTCGCTGATGCCGCAGAAAAAGAACCCGGATGCGCTAGAGCTGATCCGCG
GTAAGTGTGGGCGGGTGCAGGGGGCGCTCAGCGGCATGCTTATGACGTTAAAAGGGCTTCCGCTGGCTTACAATAAGGAT
ATGCAGGAAGACAAAGAGGGGCTGTTTGATGCCCTGGATACCTGGCTGGACTGTTTACAGATGGCGACGCTGGCGTTGGA
CGGGCTGGCGGTGAAGCGCCCGCGCTGTGCCGAGGCGGCGCAGCAGGGGTACGCGAATGCCACGGAGCTGGCGGATTATT
TGGTGGCCAAAGGGATCCCGTTTAGGGAGGCACATCACATTGTCGGAGAGGCGGTCGTGGCGGCGCTGGCACAGGGCAAG
CCGCTGGAGGCGTTGCCGCTGGAGATGCTGCAGTCGTTCAGTCCAGTGATCGGCGCCGATATCTATCCACTGCTGGCGTT
GGACTCCTGTCTGGTAAAACGCAGCGCCCGCGGCGGCGTGGCGCCGCAGCAGGTCGCACAGGCGATCGATGATGCCCAGC
GGCGACTGGGTAACATTCTCTGA

Upstream 100 bases:

>100_bases
CGCTGAACAGCGCAAAGCAGTAGTACGCGCAGGGCAGAATGCGGGCCGCGCTGCGGCCGCGGCCCGCCGATCATTTTATT
TTGAGTACGGAGCAGTCACT

Downstream 100 bases:

>100_bases
TGCGCAGCGCGCCGGCGGGGTTAATCCCCCGGGCAGCGCAGGCAGCGCTCGATTTCGTCGCTGCCCAGACGCAGTTTGCT
TTGCAGATCGCGCAGGGCGG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MALWGGRFSLAADRRFKQFNDSLRFDYRLAEQDIIGSVAWSRALVTVGVLTVQEQQQLVQALTALLEEVRTDPRSILDSD
AEDIHSWVEQQLIGRVGDLGKKLHTGRSRNDQVATDLKLWCKDQGEMLRQALIALQQVLTACARQNQDAVMPGYTHLQRA
QPITFAHWCMAYVEMLARDESRLDDALRRLNTSPLGSGALAGTAYPIDRDRLADWLGFSAATRNSLDSVSDRDHVLELLS
AAAIGMVHLSRFAEDLIFFNSGEAGFIELSERVTSGSSLMPQKKNPDALELIRGKCGRVQGALSGMLMTLKGLPLAYNKD
MQEDKEGLFDALDTWLDCLQMATLALDGLAVKRPRCAEAAQQGYANATELADYLVAKGIPFREAHHIVGEAVVAALAQGK
PLEALPLEMLQSFSPVIGADIYPLLALDSCLVKRSARGGVAPQQVAQAIDDAQRRLGNIL

Sequences:

>Translated_460_residues
MALWGGRFSLAADRRFKQFNDSLRFDYRLAEQDIIGSVAWSRALVTVGVLTVQEQQQLVQALTALLEEVRTDPRSILDSD
AEDIHSWVEQQLIGRVGDLGKKLHTGRSRNDQVATDLKLWCKDQGEMLRQALIALQQVLTACARQNQDAVMPGYTHLQRA
QPITFAHWCMAYVEMLARDESRLDDALRRLNTSPLGSGALAGTAYPIDRDRLADWLGFSAATRNSLDSVSDRDHVLELLS
AAAIGMVHLSRFAEDLIFFNSGEAGFIELSERVTSGSSLMPQKKNPDALELIRGKCGRVQGALSGMLMTLKGLPLAYNKD
MQEDKEGLFDALDTWLDCLQMATLALDGLAVKRPRCAEAAQQGYANATELADYLVAKGIPFREAHHIVGEAVVAALAQGK
PLEALPLEMLQSFSPVIGADIYPLLALDSCLVKRSARGGVAPQQVAQAIDDAQRRLGNIL
>Mature_459_residues
ALWGGRFSLAADRRFKQFNDSLRFDYRLAEQDIIGSVAWSRALVTVGVLTVQEQQQLVQALTALLEEVRTDPRSILDSDA
EDIHSWVEQQLIGRVGDLGKKLHTGRSRNDQVATDLKLWCKDQGEMLRQALIALQQVLTACARQNQDAVMPGYTHLQRAQ
PITFAHWCMAYVEMLARDESRLDDALRRLNTSPLGSGALAGTAYPIDRDRLADWLGFSAATRNSLDSVSDRDHVLELLSA
AAIGMVHLSRFAEDLIFFNSGEAGFIELSERVTSGSSLMPQKKNPDALELIRGKCGRVQGALSGMLMTLKGLPLAYNKDM
QEDKEGLFDALDTWLDCLQMATLALDGLAVKRPRCAEAAQQGYANATELADYLVAKGIPFREAHHIVGEAVVAALAQGKP
LEALPLEMLQSFSPVIGADIYPLLALDSCLVKRSARGGVAPQQVAQAIDDAQRRLGNIL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=443, Percent_Identity=45.372460496614, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=443, Percent_Identity=45.372460496614, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI68303549, Length=443, Percent_Identity=43.1151241534989, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI68303547, Length=443, Percent_Identity=42.2121896162528, Blast_Score=322, Evalue=6e-88,
Organism=Escherichia coli, GI1790398, Length=457, Percent_Identity=81.4004376367615, Blast_Score=767, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=45.5337690631808, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI221473854, Length=450, Percent_Identity=42, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI78706858, Length=450, Percent_Identity=42, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_EDWI9 (C5BC57)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002935198.1
- ProteinModelPortal:   C5BC57
- GeneID:   7959885
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_3844
- OMA:   MAEDLIF
- ProtClustDB:   PRK04833
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50481; Mature: 50350

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFSLAADRRFKQFNDSLRFDYRLAEQDIIGSVAWSRALVTVGVLTVQEQQQLVQ
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTALLEEVRTDPRSILDSDAEDIHSWVEQQLIGRVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKDQGEMLRQALIALQQVLTACARQNQDAVMPGYTHLQRAQPITFAHWCMAYVEMLARDE
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCH
SRLDDALRRLNTSPLGSGALAGTAYPIDRDRLADWLGFSAATRNSLDSVSDRDHVLELLS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHH
AAAIGMVHLSRFAEDLIFFNSGEAGFIELSERVTSGSSLMPQKKNPDALELIRGKCGRVQ
HHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALSGMLMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLQMATLALDGLAVKRPRCAEAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QQGYANATELADYLVAKGIPFREAHHIVGEAVVAALAQGKPLEALPLEMLQSFSPVIGAD
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCH
IYPLLALDSCLVKRSARGGVAPQQVAQAIDDAQRRLGNIL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALWGGRFSLAADRRFKQFNDSLRFDYRLAEQDIIGSVAWSRALVTVGVLTVQEQQQLVQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALTALLEEVRTDPRSILDSDAEDIHSWVEQQLIGRVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CKDQGEMLRQALIALQQVLTACARQNQDAVMPGYTHLQRAQPITFAHWCMAYVEMLARDE
HCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCH
SRLDDALRRLNTSPLGSGALAGTAYPIDRDRLADWLGFSAATRNSLDSVSDRDHVLELLS
HHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHH
AAAIGMVHLSRFAEDLIFFNSGEAGFIELSERVTSGSSLMPQKKNPDALELIRGKCGRVQ
HHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALSGMLMTLKGLPLAYNKDMQEDKEGLFDALDTWLDCLQMATLALDGLAVKRPRCAEAA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QQGYANATELADYLVAKGIPFREAHHIVGEAVVAALAQGKPLEALPLEMLQSFSPVIGAD
HHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCH
IYPLLALDSCLVKRSARGGVAPQQVAQAIDDAQRRLGNIL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA