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The map label for this gene is sthA [H]

Identifier: 238921679

GI number: 238921679

Start: 3719791

End: 3721224

Strand: Direct

Name: sthA [H]

Synonym: NT01EI_3841

Alternate gene names: 238921679

Gene position: 3719791-3721224 (Clockwise)

Preceding gene: 238921678

Following gene: 238921681

Centisome position: 97.57

GC content: 53.49

Gene sequence:

>1434_bases
TTGTGGTTTTGTATAAAAAAGGCCTGCTCTAACATGCAACAGCATTTCCATTTTGACGCCATCGTTATTGGTTCAGGTCC
CGGGGGTGAGGGTGCCGCCATGGGACTGGTTAAACAGGGGGCTCAAGTTGCCGTAATCGAACGGCAATTCAGCGTCGGTG
GAGGGTGTACCCACTGGGGAACCATCCCATCGAAGGCCCTCCGTCACGCTGTCAGCCGCATTATCGAATTTAACCAAAAC
CCACTCTACAGTGATAATACCCGCCTCATCGGCGCGACCTTTCCCGATATCCTGCGTCACGCCGACAGCGTAATAAATCA
ACAAACCCGAATGCGTCAGGGATTCTATGAGCGCAATCACTGCCAACTGTTTTACGGCGAGGCCCGTTTTGTCGATCCCC
ATACGCTAAGCGTGACCTATCCGGATGGCAGCAGCGATACCCTAACGGCAGATAACATTGTTATCGCCTGCGGCTCCCGC
CCCTATCACCCACAGGACGTCGACTTTAGCCATCCCCGGATTTATGACAGCGACTCTATCCTTAATCTGCACCATGAGCC
CAGCCACATCATCATCTATGGGGCCGGTGTTATCGGCTGTGAGTATGCCTCTATCTTCCGCGGCCTAAACGTTAAGGTCG
ATCTGATTAATACTCGCGATAGGCTGCTCTCTTTCCTAGATCAAGAGATGTCGGACTCGCTCTCTTACCACTTCTGGAAT
AACGGCGTAGTGATCCGCCACAACGAAGAGTTTGAGCAAATTGAGGGAGTTGAGGACGGCGTTATCGTGCACCTACGCTC
AGGTAAAAAGGTCAAGGCCGATTGCCTGCTGTTTGCCAACGGCCGCACGGGAAATACCGATGGCCTATGCCTTGAAACGG
TAGGTCTGGAGGCAGACAAACGCGGTCAGCTGAAGGTAAACGCACACTACCAGACTGAAGTGCCACATATTTATGCCGTC
GGAGACGTCATCGGCTACCCCAGCCTAGCCTCTGCCGCATATGACCAAGGGCGTATCGCCGCACAGGTCATCACCCGTGG
AGAAACCCATACACACCTTATCGAAGATATTCCAACCGGAATCTACACCATCCCGGAGATAAGCTCCGTCGGAAAAACCG
AACAGGAACTGACCGCGATGAAAATTCCGTATGAAGTGGGTCGCTCGCAGTTCAAGCATCTGGCCCGGGCGCAGATTGCC
GGAATGAACGTCGGAGGATTAAAGATCCTGTTCCACCGCGAAACCAAGCAAATCCTGGGGATCCACTGCTTTGGCGAACG
CGCCGCAGAGATCATTCACATCGGACAGGCGATCATGGAGCAGAAGGGGGAGGGCAATACCATCGAATACTTCGTCAATA
CCACCTTCAACTACCCCACGATGGCAGAAGCCTACCGCGTGGCGGCGCTTAACGGCCTAAACCGCCTGTTTTAA

Upstream 100 bases:

>100_bases
TAAATGGCATTATATTACGTAATTATCTGTCGATTATAACTATTTCCCATATAAATAATGAGGATGATTGGGCCGCACGG
GATTTCATGTTAATCTATAG

Downstream 100 bases:

>100_bases
CGTCTCTCGCTGGATCATTACCTGCTGCATATGCTCGCGGATAGCCTCCGCGAGCTGCTCGTAGCGTGCGCGCAGCGGCG
AACCGGGACGATAGACCAGA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MWFCIKKACSNMQQHFHFDAIVIGSGPGGEGAAMGLVKQGAQVAVIERQFSVGGGCTHWGTIPSKALRHAVSRIIEFNQN
PLYSDNTRLIGATFPDILRHADSVINQQTRMRQGFYERNHCQLFYGEARFVDPHTLSVTYPDGSSDTLTADNIVIACGSR
PYHPQDVDFSHPRIYDSDSILNLHHEPSHIIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLSFLDQEMSDSLSYHFWN
NGVVIRHNEEFEQIEGVEDGVIVHLRSGKKVKADCLLFANGRTGNTDGLCLETVGLEADKRGQLKVNAHYQTEVPHIYAV
GDVIGYPSLASAAYDQGRIAAQVITRGETHTHLIEDIPTGIYTIPEISSVGKTEQELTAMKIPYEVGRSQFKHLARAQIA
GMNVGGLKILFHRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_477_residues
MWFCIKKACSNMQQHFHFDAIVIGSGPGGEGAAMGLVKQGAQVAVIERQFSVGGGCTHWGTIPSKALRHAVSRIIEFNQN
PLYSDNTRLIGATFPDILRHADSVINQQTRMRQGFYERNHCQLFYGEARFVDPHTLSVTYPDGSSDTLTADNIVIACGSR
PYHPQDVDFSHPRIYDSDSILNLHHEPSHIIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLSFLDQEMSDSLSYHFWN
NGVVIRHNEEFEQIEGVEDGVIVHLRSGKKVKADCLLFANGRTGNTDGLCLETVGLEADKRGQLKVNAHYQTEVPHIYAV
GDVIGYPSLASAAYDQGRIAAQVITRGETHTHLIEDIPTGIYTIPEISSVGKTEQELTAMKIPYEVGRSQFKHLARAQIA
GMNVGGLKILFHRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_477_residues
MWFCIKKACSNMQQHFHFDAIVIGSGPGGEGAAMGLVKQGAQVAVIERQFSVGGGCTHWGTIPSKALRHAVSRIIEFNQN
PLYSDNTRLIGATFPDILRHADSVINQQTRMRQGFYERNHCQLFYGEARFVDPHTLSVTYPDGSSDTLTADNIVIACGSR
PYHPQDVDFSHPRIYDSDSILNLHHEPSHIIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLSFLDQEMSDSLSYHFWN
NGVVIRHNEEFEQIEGVEDGVIVHLRSGKKVKADCLLFANGRTGNTDGLCLETVGLEADKRGQLKVNAHYQTEVPHIYAV
GDVIGYPSLASAAYDQGRIAAQVITRGETHTHLIEDIPTGIYTIPEISSVGKTEQELTAMKIPYEVGRSQFKHLARAQIA
GMNVGGLKILFHRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=476, Percent_Identity=29.8319327731092, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=26.7818574514039, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=26.8980477223427, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI33519430, Length=443, Percent_Identity=25.5079006772009, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI33519428, Length=443, Percent_Identity=25.5079006772009, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI33519426, Length=443, Percent_Identity=25.5079006772009, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI148277065, Length=443, Percent_Identity=25.5079006772009, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI148277071, Length=443, Percent_Identity=25.5079006772009, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=25.1700680272109, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI291045268, Length=313, Percent_Identity=26.517571884984, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=83.0472103004292, Blast_Score=825, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=30.1927194860814, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=27.1551724137931, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=28.175519630485, Blast_Score=142, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=29.8924731182796, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=25.9493670886076, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI71983429, Length=350, Percent_Identity=26.2857142857143, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983419, Length=350, Percent_Identity=26.2857142857143, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=268, Percent_Identity=27.6119402985075, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321091, Length=481, Percent_Identity=28.0665280665281, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=27.9661016949153, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=25.974025974026, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=31.4775160599572, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24640553, Length=494, Percent_Identity=28.5425101214575, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24640549, Length=488, Percent_Identity=28.6885245901639, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24640551, Length=484, Percent_Identity=28.7190082644628, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI17737741, Length=499, Percent_Identity=26.4529058116232, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52962; Mature: 52962

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFCIKKACSNMQQHFHFDAIVIGSGPGGEGAAMGLVKQGAQVAVIERQFSVGGGCTHWG
CEEEHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCCC
TIPSKALRHAVSRIIEFNQNPLYSDNTRLIGATFPDILRHADSVINQQTRMRQGFYERNH
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCC
CQLFYGEARFVDPHTLSVTYPDGSSDTLTADNIVIACGSRPYHPQDVDFSHPRIYDSDSI
EEEEECCEEEECCEEEEEECCCCCCCCEEECCEEEEECCCCCCCCCCCCCCCEEECCCCE
LNLHHEPSHIIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLSFLDQEMSDSLSYHFWN
EEEECCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEC
NGVVIRHNEEFEQIEGVEDGVIVHLRSGKKVKADCLLFANGRTGNTDGLCLETVGLEADK
CCEEEEECCHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCEEEEEECCCCCC
RGQLKVNAHYQTEVPHIYAVGDVIGYPSLASAAYDQGRIAAQVITRGETHTHLIEDIPTG
CCCEEEEEEEECCCCEEEEECCHHCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCC
IYTIPEISSVGKTEQELTAMKIPYEVGRSQFKHLARAQIAGMNVGGLKILFHRETKQILG
EEECCCCHHCCCCHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEE
IHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
EEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MWFCIKKACSNMQQHFHFDAIVIGSGPGGEGAAMGLVKQGAQVAVIERQFSVGGGCTHWG
CEEEHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCCC
TIPSKALRHAVSRIIEFNQNPLYSDNTRLIGATFPDILRHADSVINQQTRMRQGFYERNH
CCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCC
CQLFYGEARFVDPHTLSVTYPDGSSDTLTADNIVIACGSRPYHPQDVDFSHPRIYDSDSI
EEEEECCEEEECCEEEEEECCCCCCCCEEECCEEEEECCCCCCCCCCCCCCCEEECCCCE
LNLHHEPSHIIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLSFLDQEMSDSLSYHFWN
EEEECCCCEEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEC
NGVVIRHNEEFEQIEGVEDGVIVHLRSGKKVKADCLLFANGRTGNTDGLCLETVGLEADK
CCEEEEECCHHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCEEEEEECCCCCC
RGQLKVNAHYQTEVPHIYAVGDVIGYPSLASAAYDQGRIAAQVITRGETHTHLIEDIPTG
CCCEEEEEEEECCCCEEEEECCHHCCCCHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCC
IYTIPEISSVGKTEQELTAMKIPYEVGRSQFKHLARAQIAGMNVGGLKILFHRETKQILG
EEECCCCHHCCCCHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEE
IHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
EEEECHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA