Click here to switch to the map view.

The map label for this gene is uidB [H]

Identifier: 238921287

GI number: 238921287

Start: 3315516

End: 3316880

Strand: Reverse

Name: uidB [H]

Synonym: NT01EI_3430

Alternate gene names: 238921287

Gene position: 3316880-3315516 (Counterclockwise)

Preceding gene: 238921288

Following gene: 238921286

Centisome position: 87.0

GC content: 56.85

Gene sequence:

>1365_bases
ATGAGTCAGTCACTGAGCTGGAGGGCGGTGATTGGCTATGGCTGTGGCGATATGGCCAATAACTTTGCCTTTGCCATGGG
GGCGCTGTTTCTGCTGAGCTATTACACCGATGTGGCCGGTGTCGGCGCGGCGGCGGCGGGGGCCATGCTGCTGTCGGTGC
GGATACTGGATGCCTTTATCGATGTGATCGCCGGGCGGGTGGTGGATAAGACCGATACCCGCTGGGGGAAATTCCGTCCC
TATCTGGTGTTCGGTGCCCTGCCACTGATGCTGTGCAGCATACTGGTGTTTTCCGTGCCTGCCGACTGGTCGCACGACGG
TAAGGTGCTCTATGCCTACGCAACCTATATTGCCCTGAATATTTGCTACAGCTTCGTCAATATTCCCTATGGTTCGCTGG
CGACGGTGATGACACAGGATCCCGCGTCCCGGGCCAAGCTGGGGATGGCCCGCTCCATCGGCGCCGGACTGACCTTTGTG
CTGATAGGGTTTGTGATTTCGCCGCGTCTGAGCTCCTCGACGCCGACCGAGTTACAGACCCTGTATACCCAGCTGACGCT
GGTACTGGCGGTGGTCGGGATCGCACTGTATCTGTTCTGCTTTGCCAGCACCCGCGAGATTGTCCAGCGCCAGGTGGCCC
AGCCATCGTTTAGGGAAAGCCTGGGCACCCTGCGTCAGAACCGGCCTCTGTTTATGCTGTGCATCTGTGCGCTGTGTACT
CTGGGAGCCTCTTTCTCCGTCAGTGCGAGCACCATCTTTTATGCCCGTTACATCTTAAATGATGTGTCGCTTTTGGCGTT
GTTTGTGGCCATTCAGACGCTGTTTGGCATGTTGCTGGCGGCGCCCTCGGTGCCGTTTCTGGTGCGCAGGCTGGGTAAGC
GGAATACCTTTCTGGCCGGACTGCTGTTGGCCGCGTTGGGGTACCTCCTGATGTTCTTCATGGCCTCGCTGCCGGGAGTG
TTGATCTCCCTTGTGGTGACCACGCTGGGGCTGAGTATCTCGATGACGGTGATGTGGGCGCTGGAGGCGGATACCGTCGA
ATATGGCGAATGGTGTACCGGTGTGCGTATTGAGGGACTCACCTATTCGCTGTTCTCCTTTACCCGAAAATGTGGGCAGG
CTATCGGCGGCTCAATCCCCGCCTTTATTCTGGGTTACAGCGGTTATGTCGCCAATAGTGCTACCCAGAGCCCCAGTGCC
CTGCTCAGTATTAAGCTGTGTATGACGCTGATCCCGGCTGTTTTGATTCTGGCCGGATTTCTGATCATGCTTTTCTACCC
GCTGACCGATGCACGCTTTGCGGGAATTATCGATGAGATTAAACAAAGAAAAATACAGTCTGGGGATGACGCAGTAACAC
CGTAA

Upstream 100 bases:

>100_bases
CCCGCGACAGAAAGCCCAAGGCGGCGGCTTTTACCCTCAAGGCGCGCTGGACGGCGGTGCAATACGGTATGAAACCCGCG
GGTGACAAAGGGGGAGCGCA

Downstream 100 bases:

>100_bases
AAATAACGTAGGGCACGCTTTCGCGGTATGACTTATCGGCAGGCTGTTTTCTGCAAAATAGCCTGCCATCACCGCAATAA
ATACGCCACTTTATATTATT

Product: glucuronide transporter

Products: Proton [Cytoplasm]; Glucuronides [Cytoplasm] [C]

Alternate protein names: Glucuronide permease [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSQSLSWRAVIGYGCGDMANNFAFAMGALFLLSYYTDVAGVGAAAAGAMLLSVRILDAFIDVIAGRVVDKTDTRWGKFRP
YLVFGALPLMLCSILVFSVPADWSHDGKVLYAYATYIALNICYSFVNIPYGSLATVMTQDPASRAKLGMARSIGAGLTFV
LIGFVISPRLSSSTPTELQTLYTQLTLVLAVVGIALYLFCFASTREIVQRQVAQPSFRESLGTLRQNRPLFMLCICALCT
LGASFSVSASTIFYARYILNDVSLLALFVAIQTLFGMLLAAPSVPFLVRRLGKRNTFLAGLLLAALGYLLMFFMASLPGV
LISLVVTTLGLSISMTVMWALEADTVEYGEWCTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGYSGYVANSATQSPSA
LLSIKLCMTLIPAVLILAGFLIMLFYPLTDARFAGIIDEIKQRKIQSGDDAVTP

Sequences:

>Translated_454_residues
MSQSLSWRAVIGYGCGDMANNFAFAMGALFLLSYYTDVAGVGAAAAGAMLLSVRILDAFIDVIAGRVVDKTDTRWGKFRP
YLVFGALPLMLCSILVFSVPADWSHDGKVLYAYATYIALNICYSFVNIPYGSLATVMTQDPASRAKLGMARSIGAGLTFV
LIGFVISPRLSSSTPTELQTLYTQLTLVLAVVGIALYLFCFASTREIVQRQVAQPSFRESLGTLRQNRPLFMLCICALCT
LGASFSVSASTIFYARYILNDVSLLALFVAIQTLFGMLLAAPSVPFLVRRLGKRNTFLAGLLLAALGYLLMFFMASLPGV
LISLVVTTLGLSISMTVMWALEADTVEYGEWCTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGYSGYVANSATQSPSA
LLSIKLCMTLIPAVLILAGFLIMLFYPLTDARFAGIIDEIKQRKIQSGDDAVTP
>Mature_453_residues
SQSLSWRAVIGYGCGDMANNFAFAMGALFLLSYYTDVAGVGAAAAGAMLLSVRILDAFIDVIAGRVVDKTDTRWGKFRPY
LVFGALPLMLCSILVFSVPADWSHDGKVLYAYATYIALNICYSFVNIPYGSLATVMTQDPASRAKLGMARSIGAGLTFVL
IGFVISPRLSSSTPTELQTLYTQLTLVLAVVGIALYLFCFASTREIVQRQVAQPSFRESLGTLRQNRPLFMLCICALCTL
GASFSVSASTIFYARYILNDVSLLALFVAIQTLFGMLLAAPSVPFLVRRLGKRNTFLAGLLLAALGYLLMFFMASLPGVL
ISLVVTTLGLSISMTVMWALEADTVEYGEWCTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGYSGYVANSATQSPSAL
LSIKLCMTLIPAVLILAGFLIMLFYPLTDARFAGIIDEIKQRKIQSGDDAVTP

Specific function: Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by uidC (gusC, AC Q47706) [H]

COG id: COG2211

COG function: function code G; Na+/melibiose symporter and related transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:galactoside symporter (TC 2.A.2) family [H]

Homologues:

Organism=Homo sapiens, GI122937339, Length=463, Percent_Identity=22.8941684665227, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787902, Length=446, Percent_Identity=62.1076233183856, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI48994989, Length=460, Percent_Identity=33.0434782608696, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI145693206, Length=457, Percent_Identity=33.2603938730853, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1786466, Length=467, Percent_Identity=32.3340471092077, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI87082306, Length=459, Percent_Identity=31.8082788671024, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1790561, Length=451, Percent_Identity=27.9379157427938, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001927
- InterPro:   IPR018043 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48997; Mature: 48865

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00872 NA_GALACTOSIDE_SYMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SQSLSWRAVIGYGCGDMANNFAFAMGALFLLSYYTDVAGVGAAAAGAMLLSVRILDAFI
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
DVIAGRVVDKTDTRWGKFRPYLVFGALPLMLCSILVFSVPADWSHDGKVLYAYATYIALN
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHH
ICYSFVNIPYGSLATVMTQDPASRAKLGMARSIGAGLTFVLIGFVISPRLSSSTPTELQT
HHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHH
LYTQLTLVLAVVGIALYLFCFASTREIVQRQVAQPSFRESLGTLRQNRPLFMLCICALCT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHH
LGASFSVSASTIFYARYILNDVSLLALFVAIQTLFGMLLAAPSVPFLVRRLGKRNTFLAG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHH
LLLAALGYLLMFFMASLPGVLISLVVTTLGLSISMTVMWALEADTVEYGEWCTGVRIEGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHEEEEEECCCHHHCCCCCCCEECCC
TYSLFSFTRKCGQAIGGSIPAFILGYSGYVANSATQSPSALLSIKLCMTLIPAVLILAGF
HHHHHHHHHHHHHHHCCCCCHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LIMLFYPLTDARFAGIIDEIKQRKIQSGDDAVTP
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; Glucuronides [Periplasm] [C]

Specific reaction: Proton [Periplasm] + Glucuronides [Periplasm] = Proton [Cytoplasm] + Glucuronides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3534890 [H]