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The map label for this gene is cadA [H]

Identifier: 238921270

GI number: 238921270

Start: 3300913

End: 3303048

Strand: Direct

Name: cadA [H]

Synonym: NT01EI_3413

Alternate gene names: 238921270

Gene position: 3300913-3303048 (Clockwise)

Preceding gene: 238921269

Following gene: 238921271

Centisome position: 86.59

GC content: 58.05

Gene sequence:

>2136_bases
ATGAAAGACATTCTGTTCCTGTGTAACCCCTCGCCGACCTTCAAGCGCATCCCGCTGGAGGAGCTGTACGCCCAGCTGCG
CAATCGGGGTTTTAACATCATCGAAAGCACCTCGGTAGACGATCTGCTGGATCTGGTACGCAATAACGCCCAGCTGGCCG
GGGTGGTCTTCGACTGGGACACCTACAGTCTGGATCTGTGCCAGCACATCACGGCGCTGAACGAGATGCTGCCGCTGTAT
GCCTTCACCAACACCCACTCCACGCTGGATGTCAGCCTGGGCGACCTGCGCATGAATATTCAGTTCTTTGAGTATACGCT
GGGCGGCGCTGCCGACATCGCCGACAAGATCCGCCAGGGAACCGATGGCTATATCGATGCCATTATGCCGCCGCTGACCA
AGGCGCTGTTCAACTATGTCAAAGAGGGGAAATACACCTTCTGTACCCCGGGCCACATGGGCGGTACCGCATTCCAGAAA
AGCCCGGTTGGCAGCCTGTTCTATGACTTCTTTGGCGCCAACACCATGAAGTCCGACATCTCCATTTCCGTCTCCGAGCT
GGGCTCCCTGCTGGACCACTCAGGCCCGCACAAAGAGGCGGAAGAGTATATCGCCCGTACCTTCAACGCCGATCGCAGCT
ACATGGTGACCAACGGCACCTCCACCGCCAACAAGATCGTCGGCATGTACTCCGCCCCGGCCGGCAGCACCATCCTGATC
GACCGCAACTGTCACAAGTCGCTCACCCACCTGATGATGATGAGCGACGTTATCCCGATCTACCTGCGGCCGACCCGCAA
CGCCTACGGTATTCTGGGCGGCATTCCGCAGAGCGAGTTCACCCACGACACCATCGCCAAACGGGTGAAGGATACCCCAA
ACGCCACCTGGCCGGTACACGCCGTGGTGACCAACTCCACCTATGACGGCCTGTTCTACAACGCGGAGTACATCAAGAAA
ACCCTGGATGTAAAATCCATCCACTTTGACTCCGCCTGGGTGCCCTACACCAACTTCAGCCCGATCTATAAAGGCCTGTG
TGGCATGAGCGGTGGTCGTGTAGAAGGCAAGGTTATCTACGAAACCCAGTCCACCCACAAACTGCTGGCGGCCTTCTCGC
AGGCGTCCATGATCCACGTGAAAGGCGACTTCAACCAGGAAACCTTCAACGAAGCCTACATGATGCACACCTCCACCTCA
CCGCACTACGGCATCGTGGCCTCCATCGAAACCGCGGCGGCGATGATGAAGGGCCACGCCGGTAAACGCCTGATCGATGA
CTCTATCGCGCGGGCCATCCGCTTCCGTAAGGAGATCAAGCGCCTGCGCAGCGAATCCGACAGCTGGTTCTTCGACGTCT
GGCAGCCGGATAATATTGACCAGGTCGCCTGCTGGAAACTGGATCCGCAAGCGTCCTGGCACGGCTTCAAGGGCATCGAT
GACAACCACATGTACCTCGACCCGGTCAAGGTCACCCTGCTGACCCCGGGGATGAAGGAAGATGGCACCATGGCAGACAC
CGGTATCCCGGCCTCCATCGTGGCCAAATACCTGGATGAGCATGGCATCATCGTTGAGAAGACCGGTCCGTACAACCTGC
TGTTCCTGTTCAGCATCGGTATCGACAAGACCAAGGCCATGAGTCTGCTGCGTGGTCTGACTGACTTCAAACGTGCCTAT
GACCTGAACCTGCGCGTTAAGAACATGCTGCCCTCACTGTACCGTGAAGATCCGGAGTTCTATGAAAACATGCGTATCCA
GGAACTGGCCCAGGGCATCCACGCGCTGATCCAGCATCACAACCTGCCGGATCTGATGTACCGTGCCTTCGAAGTTCTGC
CGACCATGGTGATGAACCCGCACAACGCCTTCCAACAGGAGCTGCGCGGCCAGGCCGAAGAGGTCTACCTCGACGAGATG
ATCGGCAAGGTCAACGCCAACATGATCCTGCCGTACCCGCCGGGAGTTCCGCTGGTAATGCCGGGTGAAATGCTGACCGA
AGAAAGCCGTCCGGTGCTGGAGTTTCTGCAGATGCTGTGCGAAATCGGCGCCCACTATCCGGGCTTCGAAACCGACATCC
ACGGCGCCTATCGTCAGGCCGACGGGCGCTATACGGTGAAAGTGCTCAGGCAGTAG

Upstream 100 bases:

>100_bases
GGTGACCTTTGCCGGCTGGAGTTGCTATGGCCTGTTCGTGCGGGACAACAACACCTGCCCGAAAGACAAAATTCAACATG
TTTAACCCGGAGAACGTGAA

Downstream 100 bases:

>100_bases
CGTCTTTTGTGCGGGGCGCCACGGTGCCCCGCAGTAACCTTCTGCATTTTCCTGCCTGAAGACGGCTGCGCGTAGGAGGC
GCCGCAGCGGCGCCGGGGGA

Product: Orn/Lys/Arg decarboxylase family

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 711; Mature: 711

Protein sequence:

>711_residues
MKDILFLCNPSPTFKRIPLEELYAQLRNRGFNIIESTSVDDLLDLVRNNAQLAGVVFDWDTYSLDLCQHITALNEMLPLY
AFTNTHSTLDVSLGDLRMNIQFFEYTLGGAADIADKIRQGTDGYIDAIMPPLTKALFNYVKEGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGANTMKSDISISVSELGSLLDHSGPHKEAEEYIARTFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
DRNCHKSLTHLMMMSDVIPIYLRPTRNAYGILGGIPQSEFTHDTIAKRVKDTPNATWPVHAVVTNSTYDGLFYNAEYIKK
TLDVKSIHFDSAWVPYTNFSPIYKGLCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDFNQETFNEAYMMHTSTS
PHYGIVASIETAAAMMKGHAGKRLIDDSIARAIRFRKEIKRLRSESDSWFFDVWQPDNIDQVACWKLDPQASWHGFKGID
DNHMYLDPVKVTLLTPGMKEDGTMADTGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKAMSLLRGLTDFKRAY
DLNLRVKNMLPSLYREDPEFYENMRIQELAQGIHALIQHHNLPDLMYRAFEVLPTMVMNPHNAFQQELRGQAEEVYLDEM
IGKVNANMILPYPPGVPLVMPGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLRQ

Sequences:

>Translated_711_residues
MKDILFLCNPSPTFKRIPLEELYAQLRNRGFNIIESTSVDDLLDLVRNNAQLAGVVFDWDTYSLDLCQHITALNEMLPLY
AFTNTHSTLDVSLGDLRMNIQFFEYTLGGAADIADKIRQGTDGYIDAIMPPLTKALFNYVKEGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGANTMKSDISISVSELGSLLDHSGPHKEAEEYIARTFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
DRNCHKSLTHLMMMSDVIPIYLRPTRNAYGILGGIPQSEFTHDTIAKRVKDTPNATWPVHAVVTNSTYDGLFYNAEYIKK
TLDVKSIHFDSAWVPYTNFSPIYKGLCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDFNQETFNEAYMMHTSTS
PHYGIVASIETAAAMMKGHAGKRLIDDSIARAIRFRKEIKRLRSESDSWFFDVWQPDNIDQVACWKLDPQASWHGFKGID
DNHMYLDPVKVTLLTPGMKEDGTMADTGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKAMSLLRGLTDFKRAY
DLNLRVKNMLPSLYREDPEFYENMRIQELAQGIHALIQHHNLPDLMYRAFEVLPTMVMNPHNAFQQELRGQAEEVYLDEM
IGKVNANMILPYPPGVPLVMPGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLRQ
>Mature_711_residues
MKDILFLCNPSPTFKRIPLEELYAQLRNRGFNIIESTSVDDLLDLVRNNAQLAGVVFDWDTYSLDLCQHITALNEMLPLY
AFTNTHSTLDVSLGDLRMNIQFFEYTLGGAADIADKIRQGTDGYIDAIMPPLTKALFNYVKEGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGANTMKSDISISVSELGSLLDHSGPHKEAEEYIARTFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
DRNCHKSLTHLMMMSDVIPIYLRPTRNAYGILGGIPQSEFTHDTIAKRVKDTPNATWPVHAVVTNSTYDGLFYNAEYIKK
TLDVKSIHFDSAWVPYTNFSPIYKGLCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDFNQETFNEAYMMHTSTS
PHYGIVASIETAAAMMKGHAGKRLIDDSIARAIRFRKEIKRLRSESDSWFFDVWQPDNIDQVACWKLDPQASWHGFKGID
DNHMYLDPVKVTLLTPGMKEDGTMADTGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKAMSLLRGLTDFKRAY
DLNLRVKNMLPSLYREDPEFYENMRIQELAQGIHALIQHHNLPDLMYRAFEVLPTMVMNPHNAFQQELRGQAEEVYLDEM
IGKVNANMILPYPPGVPLVMPGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLRQ

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=698, Percent_Identity=83.5243553008596, Blast_Score=1248, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=709, Percent_Identity=67.7009873060649, Blast_Score=1052, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=34.9659863945578, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI87082193, Length=609, Percent_Identity=34.4827586206897, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1786909, Length=621, Percent_Identity=33.1723027375201, Blast_Score=321, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80053; Mature: 80053

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDILFLCNPSPTFKRIPLEELYAQLRNRGFNIIESTSVDDLLDLVRNNAQLAGVVFDWD
CCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCEEEEEEEECC
TYSLDLCQHITALNEMLPLYAFTNTHSTLDVSLGDLRMNIQFFEYTLGGAADIADKIRQG
CCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCEEEEEEEEEEECCCHHHHHHHHHCC
TDGYIDAIMPPLTKALFNYVKEGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGANTMKSDI
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
SISVSELGSLLDHSGPHKEAEEYIARTFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
EEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDVIPIYLRPTRNAYGILGGIPQSEFTHDTIAKRVKDTPNATWPVH
ECCHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCHHHHHHHHCCCCCCCCEEE
AVVTNSTYDGLFYNAEYIKKTLDVKSIHFDSAWVPYTNFSPIYKGLCGMSGGRVEGKVIY
EEEECCCCCCEEECHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDFNQETFNEAYMMHTSTSPHYGIVASIETAAAMMKGHA
ECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEECCCCCCCEEEEHHHHHHHHHHCCC
GKRLIDDSIARAIRFRKEIKRLRSESDSWFFDVWQPDNIDQVACWKLDPQASWHGFKGID
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCC
DNHMYLDPVKVTLLTPGMKEDGTMADTGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKAMSLLRGLTDFKRAYDLNLRVKNMLPSLYREDPEFYENMRIQELAQGIHALIQHH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPTMVMNPHNAFQQELRGQAEEVYLDEMIGKVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLRQ
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKDILFLCNPSPTFKRIPLEELYAQLRNRGFNIIESTSVDDLLDLVRNNAQLAGVVFDWD
CCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCEEEEEEEECC
TYSLDLCQHITALNEMLPLYAFTNTHSTLDVSLGDLRMNIQFFEYTLGGAADIADKIRQG
CCHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCEEEEEEEEEEECCCHHHHHHHHHCC
TDGYIDAIMPPLTKALFNYVKEGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGANTMKSDI
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCC
SISVSELGSLLDHSGPHKEAEEYIARTFNADRSYMVTNGTSTANKIVGMYSAPAGSTILI
EEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDVIPIYLRPTRNAYGILGGIPQSEFTHDTIAKRVKDTPNATWPVH
ECCHHHHHHHHHHHHCCCEEEEECCCCCCEEECCCCCCCCCHHHHHHHHCCCCCCCCEEE
AVVTNSTYDGLFYNAEYIKKTLDVKSIHFDSAWVPYTNFSPIYKGLCGMSGGRVEGKVIY
EEEECCCCCCEEECHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDFNQETFNEAYMMHTSTSPHYGIVASIETAAAMMKGHA
ECCHHHHHHHHHHCCCEEEEECCCCCHHHCCEEEEECCCCCCCEEEEHHHHHHHHHHCCC
GKRLIDDSIARAIRFRKEIKRLRSESDSWFFDVWQPDNIDQVACWKLDPQASWHGFKGID
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCC
DNHMYLDPVKVTLLTPGMKEDGTMADTGIPASIVAKYLDEHGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKAMSLLRGLTDFKRAYDLNLRVKNMLPSLYREDPEFYENMRIQELAQGIHALIQHH
CCHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPTMVMNPHNAFQQELRGQAEEVYLDEMIGKVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLRQ
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]