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The map label for this gene is ffh [H]

Identifier: 238921089

GI number: 238921089

Start: 3100184

End: 3101545

Strand: Reverse

Name: ffh [H]

Synonym: NT01EI_3224

Alternate gene names: 238921089

Gene position: 3101545-3100184 (Counterclockwise)

Preceding gene: 238921092

Following gene: 238921088

Centisome position: 81.36

GC content: 59.4

Gene sequence:

>1362_bases
ATGTTTGAAAATCTAAGCGATCGATTGTCGCGCACGCTGCGCAACATCAGTGGCCGCGGGCGACTGACCGAAGATAATAT
CAAGGATACCCTGCGCGAGGTGCGCATGGCGCTGCTGGAAGCCGACGTGGCGCTGCCGGTGGTGCGCGAGTTCATCAGTC
GGGTGAAAGAGAGCGCGCTGGGTCAGGAGGTCAACAAGAGTCTGACGCCGGGACAGGAGTTCGTCAAAATCGTTCAGGAC
GAGCTGACCCGCGCAATGGGAGAGGCCAACACCGAGCTGAATCTGGCGGCGCAGCCGCCGGCCGTGGTGCTGATGGCTGG
CTTACAGGGCGCCGGTAAGACGACCAGCGTGGGTAAGCTGGGTAAATTCCTCAAGGAAAAACAGAAGAAGAAAGTGCTGG
TCGTATCAGCCGACGTGTATCGCCCCGCGGCGATCAAACAGCTGGAAACGCTGGCAGAAGGCGTAGGCATCGATTTCTTC
CCTTCCGACGTGCAGGAGCGTCCGCTGGATATCGTGCAGCGCGCGCTGACTCACGCCAAACAGAAGTTTTATGATGTGCT
GATCGTCGATACTGCAGGCCGCCTGCACGTCGATGAAGCGATGATGGATGAGATCAAGCAGATCCACGCGGCGATTAGCC
CGGTGGAAACACTGTTTGTGGTCGATGCGATGACCGGCCAGGATGCGGCCAATACCGCCAGCGCCTTTAACCAGGCGCTG
CCGCTGACCGGAGTGGTACTGACCAAGGTGGACGGCGACGCCCGCGGCGGTGCGGCGCTGTCGATCCGCCATATCACGGG
GAAACCGATCAAGTTCCTCGGTGTCGGTGAGAAGACCGAGGCGCTGGAGCCGTTTTATCCGGATCGCGTGGCCTCGCGCA
TTCTGGGCATGGGCGACGTGCTGTCGCTGATCGAAGAGCTGGAGAGCAAGGTTGATCGCGCCCAGGCTGAGAAGCTGGCG
ACTAAGCTGAAGAAGGGAGACGGATTCGATCTCAACGACTTTATGGATCAGCTCAAGCAGATGCGCAACATGGGGGGGAT
GACCTCCATGCTGGCCAAGCTGCCGGGAGTCGGCCAGTTGCCGGACAACGTGAAGGCGCAGATGGATGACAAGGTGTTGG
TGCGGATGGAGGCGATCATCAGCTCGATGACGCTGAAAGAGCGCAGCAACCCGGAGATCATCAAAGGCTCGCGCAAGCGC
CGCATCGCTCAGGGCTCCGGCATGCAGGTGCAGGATGTGAATCGGCTGTTGAAGCAGTTCGATGAAATGCAGCGCATGAT
GAAAAAGATGAAGAAAGGCGGAATGGCGAAAATGATGCGCGGCATGCGTGGTATGATGCCGCCAGGGTTCCCGGGGCGTT
AA

Upstream 100 bases:

>100_bases
GGGAGAGAATCGCGGGGCTTCGTGTTATACTCGCCGCCATCTTTAGCGATGTCGTCGCCTGACGGCCCGTTTTGCATTGG
TACTACGTTGAGCATAAACC

Downstream 100 bases:

>100_bases
TCGCTGTCGTCGGTGCGAAAGCATATAGTGACAGTTGCTTTTCGCGCCAAAATGAGTAAAATTTTCGGGCTTTTATGTTC
GTATGAACAAGGACACCGGG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFENLSDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFISRVKESALGQEVNKSLTPGQEFVKIVQD
ELTRAMGEANTELNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAEGVGIDFF
PSDVQERPLDIVQRALTHAKQKFYDVLIVDTAGRLHVDEAMMDEIKQIHAAISPVETLFVVDAMTGQDAANTASAFNQAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFYPDRVASRILGMGDVLSLIEELESKVDRAQAEKLA
TKLKKGDGFDLNDFMDQLKQMRNMGGMTSMLAKLPGVGQLPDNVKAQMDDKVLVRMEAIISSMTLKERSNPEIIKGSRKR
RIAQGSGMQVQDVNRLLKQFDEMQRMMKKMKKGGMAKMMRGMRGMMPPGFPGR

Sequences:

>Translated_453_residues
MFENLSDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFISRVKESALGQEVNKSLTPGQEFVKIVQD
ELTRAMGEANTELNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAEGVGIDFF
PSDVQERPLDIVQRALTHAKQKFYDVLIVDTAGRLHVDEAMMDEIKQIHAAISPVETLFVVDAMTGQDAANTASAFNQAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFYPDRVASRILGMGDVLSLIEELESKVDRAQAEKLA
TKLKKGDGFDLNDFMDQLKQMRNMGGMTSMLAKLPGVGQLPDNVKAQMDDKVLVRMEAIISSMTLKERSNPEIIKGSRKR
RIAQGSGMQVQDVNRLLKQFDEMQRMMKKMKKGGMAKMMRGMRGMMPPGFPGR
>Mature_453_residues
MFENLSDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFISRVKESALGQEVNKSLTPGQEFVKIVQD
ELTRAMGEANTELNLAAQPPAVVLMAGLQGAGKTTSVGKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAEGVGIDFF
PSDVQERPLDIVQRALTHAKQKFYDVLIVDTAGRLHVDEAMMDEIKQIHAAISPVETLFVVDAMTGQDAANTASAFNQAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFYPDRVASRILGMGDVLSLIEELESKVDRAQAEKLA
TKLKKGDGFDLNDFMDQLKQMRNMGGMTSMLAKLPGVGQLPDNVKAQMDDKVLVRMEAIISSMTLKERSNPEIIKGSRKR
RIAQGSGMQVQDVNRLLKQFDEMQRMMKKMKKGGMAKMMRGMRGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=31.7673378076063, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI226371618, Length=349, Percent_Identity=34.0974212034384, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=37.5, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=26.578073089701, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=26.578073089701, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=87.19646799117, Blast_Score=782, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=34.6456692913386, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=450, Percent_Identity=30, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI193206261, Length=197, Percent_Identity=34.010152284264, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=444, Percent_Identity=31.5315315315315, Blast_Score=203, Evalue=5e-53,
Organism=Drosophila melanogaster, GI17647949, Length=450, Percent_Identity=29.5555555555556, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24641198, Length=268, Percent_Identity=27.6119402985075, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49836; Mature: 49836

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS50191 CRAL_TRIO ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFISRVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVNKSLTPGQEFVKIVQDELTRAMGEANTELNLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHEEEECCCCCCCCCHHHHH
GKFLKEKQKKKVLVVSADVYRPAAIKQLETLAEGVGIDFFPSDVQERPLDIVQRALTHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHH
QKFYDVLIVDTAGRLHVDEAMMDEIKQIHAAISPVETLFVVDAMTGQDAANTASAFNQAL
HHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFYPDRVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHCCCCCCHHHHHHHHHCHHHH
LSLIEELESKVDRAQAEKLATKLKKGDGFDLNDFMDQLKQMRNMGGMTSMLAKLPGVGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PDNVKAQMDDKVLVRMEAIISSMTLKERSNPEIIKGSRKRRIAQGSGMQVQDVNRLLKQF
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHCCCCCCHHHHHHHHHHH
DEMQRMMKKMKKGGMAKMMRGMRGMMPPGFPGR
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFENLSDRLSRTLRNISGRGRLTEDNIKDTLREVRMALLEADVALPVVREFISRVKESAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVNKSLTPGQEFVKIVQDELTRAMGEANTELNLAAQPPAVVLMAGLQGAGKTTSVGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHEEEECCCCCCCCCHHHHH
GKFLKEKQKKKVLVVSADVYRPAAIKQLETLAEGVGIDFFPSDVQERPLDIVQRALTHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHH
QKFYDVLIVDTAGRLHVDEAMMDEIKQIHAAISPVETLFVVDAMTGQDAANTASAFNQAL
HHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFYPDRVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHCCCCCCHHHHHHHHHCHHHH
LSLIEELESKVDRAQAEKLATKLKKGDGFDLNDFMDQLKQMRNMGGMTSMLAKLPGVGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCC
PDNVKAQMDDKVLVRMEAIISSMTLKERSNPEIIKGSRKRRIAQGSGMQVQDVNRLLKQF
CCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHCCCCCCHHHHHHHHHHH
DEMQRMMKKMKKGGMAKMMRGMRGMMPPGFPGR
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]